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Phenotype in Medical News

A new take on growth factor signaling in tamoxifen resistance

...l-B, ER+ breast cancer subtype. We propose that activation of GF signaling contributes to this highly proliferative, relatively tamoxifen-insensitive, phenotype and that this exists independently of HER2 overexpression. Targeting this pathway and its upstream mediators could prove to be a useful therapeutic st...

Importance of preventing congestion in heart failure

...ndothelial responses, and highlight the importance of preventing congestion. Further investigation is needed to clarify whether the venous endothelial phenotype in unique individuals may ultimately allow us to track the vascular impact of subsequent environmental (i.e. biomechanical and biochemical) stressors,...

Findings in Epilepsy Gene in Animals May Guide Treatment Directions for Infants

...d funding support for this study. Marsh et al, "Targeted loss of Arx results in a developmental epilepsy mouse model and recapitulates the human phenotype in heterozygous females," Brain , published online May 12, 2009. About The Children's Hospital of Philadelphia: The Children's Hospital of Phila...

Biodesix Advances the Field of Personalized Medicine With the Launch of VeriStrat(R)

...r patient's disease. VeriStrat represents a unique advance in the field and is one of the first tests that analyzes proteins instead of genes, or the phenotype instead of the genotype. Using break-through technology to analyze a simple blood sample, VeriStrat classifies patients with different profiles provi...

Wayne State University and Children's Hospital of Michigan Research Team Discover Chemical That Plays a Major Role in Pediatric Obsessive-Compulsive Disorder

...nues the team's study of pediatric OCD patients is the first published report examining the relationship between genetic variation and a neurochemical phenotype in OCD. This study found that there is a significant association between variation in a key glutamate receptor gene and glutamate levels in the brain...

Gene Explains How High-Fructose Diets Lead to Insulin Resistance

...n fructose intake and metabolic disorders." "The findings ... support the emerging role of gene/environment interaction in modulating the metabolic phenotype and disease pathogenesis. Thus, perturbations of the same regulatory motif may produce vastly different metabolic responses, depending on the specific...
Phenotype in Medical Technology

Synvista Therapeutics Highlights New Data Demonstrating the Clinical Benefit of Vitamin E Therapy in Patients Identified on the Basis of Haptoglobin Phenotype Testing

MONTVALE, N.J., Nov. 5 /PRNewswire-FirstCall/ -- Synvista Therapeutics, Inc. (Amex: SYI ) announces results of a clinical trial known as the ICARE study, being presented today at the American Heart Association's (AHA) Scientific Sessions 2007 in Orlando, Florida. The study demonstrated that s...

Spherix Announces Positive Phase 2 Study Results

...hat, in addition to minimizing the extent of atherosclerosis from carbohydrate consumption, a diet enriched in tagatose may favor a more stable plaque phenotype less likely to cause stroke or myocardial infarction. Prior Clinical Trials with Naturlose Eight healthy individuals and eight individuals...

Research Finding Could Revolutionize Asthma Treatment

...ond's article in the Proceedings of the National Academy of Sciences is "Beta2-Adrenoreceptor Signaling Is Required for the Development of an Asthma phenotype in a Murine Model." Executive Director Smith invites members of the public to help fund research to find a cure and better treatments for asthma ...

Inverseon's Founder and SAB Member Published in PNAS

... "Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine model." The article was edited by Robert Lefkowitz, The James B...cise mechanism by which Beta2-adrenoceptor signaling exacerbates the asthma phenotype is not yet known, but is an active area of study. Fully understanding this ...

Cylene Pharmaceuticals Initiates Phase I Trial With CX-4945 -Breakthrough First-in Class Inhibitor of CK2

...xpressed in a wide range of cancers. CK2 drives the excessive proliferation phenotype of cancer cells through its potentiating role in key cell survival pathways...ogenesis, apoptosis and inflammation. Because CK2 contributes to the cancer phenotype via multiple cellular events, CX-4945 has been designed with the objective ...

Bioheart Reports Promising Results From Preclinical Study of Adipose-Derived Acute Cell Therapy

...direct wholly owned subsidiary affiliated with a member of Bioheart's Board of Directors. Study objectives included assessment of the distribution and phenotype of the transplanted ADSCs and complete macroscopic exam and histopathology of selected tissues in a total of six differentiated study groups of approx...
Phenotype in Medical Products

Human Immunodeficiency Virus (HIV) Phenotype Comprehensive

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Antigen Testing, RBC Phenotype Extended

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Alpha-1-Antitrypsin Phenotype (includes Alpha-1-Antitrypsin)

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

HLA-A & B Phenotype

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Antigen Testing, Rh Phenotype

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Alpha-1-Antitrypsin & Alpha-1-Antitrypsin Genotype with Reflex to Alpha-1-Antitrypsin Phenotype

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

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Phenotype in Medical Definition

Autoimmune regulator

...ne disease. [4] References ^ OMIM. [1] ^ Ramsey, C. et al. (2002) Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum Mol Genet 11 (4), 397-409. ^ Anderson, M.S. et al. (2002) Projection of an Immunological Self-Shadow Withi...
Phenotype in Medical Dictionary

Velo-Cardio-Facial Syndrome

...o - Facial Syndrome Information Page ... PURPOSE OF REVIEW: Velo - cardio - facial syndrome has emerged from obscurity to ... The expansive phenotype of velo - cardio - facial syndrome continues to grow with ... A Disability Resources Monthly guide to the best online resources about velo - ...

Noninsulin-dependent diabetes mellitus

... Non-Insulin - Dependent Diabetes Mellitus : Thrifty Genotype or Thrifty ... Type 2 ( non-insulin - dependent ) diabetes mellitus : the thrifty phenotype hypothesis. ... Diabetes ... ClinicalTrials.gov: Diabetes Mellitus (National Institutes of Health) ClinicalTrials.gov: Diabetes Mellitus ,...

Myotonic Dystrophy

...ic dystrophy in previous generations. ... Clinical findings in myotonic dystrophy type 1 (DM1) span a continuum from mild to severe. ... of phenotype and CTG Repeat Length in Myotonic Dystrophy Type 1 ... Myotonic Dystrophy information including symptoms, diagnosis, misdiagnosis, treatme...

Hermaphroditism

...e in other ... Pseudohermaphroditism or pseudo- hermaphroditism , is a name used to describe organism born with secondary sex characteristics or a phenotype which is different from what would be expected based upon the gonadal tissue . True hermaphroditism requires the presence of both ovarian ... ...

Hemoglobinopathy

...ther academic journal articles, magazine arti... Definition of Sickling phenotype in the Medical Dictionary. Sickling phenotype explanation. ... hemoglobinopathy /he·mo·glo·bin·op·a·thy/ (-op'ah-the) ....

Haptoglobin

...or haptoglobin types are; Hp1-1 which is monomeric (98kD), Hp1-2 is ... Correspondence from The New England Journal of Medicine -- Haptoglobin phenotype and Vascular Complications in Patients with Diabetes Cytokines & Cells Online Pathfinder Encyclopaedia ... Haptoglobin is one of the acute ...
Phenotype in Biological News

Mary had a lot of lambs: Researchers identify way to accelerate sheep breeding

...u said, "so there are a lot of genes controlling it." Mateescu observed the phenotype the physical expression of the gene in the researchers' flock during a po...nce of the protein. This means that it may be an accurate indicator for the phenotype of breeding out of season, though it's uncertain whether the gene actually ...

La Jolla Institute discovers novel tumor suppressor

...rgic diseases, so we began working with mice genetically engineered not to have that enzyme," he said. "We noticed that these mice developed a strange phenotype myeloproliferation and a variety of tumors including lymphomas and some carcinomas." Dr. Kawakami said this surprising occurrence suggested that P...

Protecting cells from their neighbors

...tagonistic mechanism that protects is also universal", explains Casanova. In the 1960s, Drosophila was the model in which researchers described a phenotype named pole hole. Embryos, that did not survive, showed a cavity in one of the poles of the egg in which cells were lacking. "It was thought that this ...

UCLA cancer researchers develop model that may help identify cancer stem cells

...s can be maintained over time in this environment, and we can live sort candidate lung cancer stem cells from these primary cultures to evaluate their phenotype in various bioassays." Batra and his team were successful seven out of seven times in growing heterogeneous cell cultures from seven different pati...

American Society for Microbiology honors George Liu

...golden color imparted by carotenoid pigments of Staphylococcus aureus became the next focus of Dr. Liu's work. He demonstrated a role of this hallmark phenotype in virulence. Dr. Liu received his Ph.D. from the University of Cambridge, England and his M.D. from the University of California, San Diego. ...

Plant Min protein sits tight and rescues E. coli

... expressed the Arabidopsis MinD gene (AtMinD), in E. coli cells that lacked the bacterial genes for both MinD and MinE. Surprisingly, the minicell phenotype of this E. coli HL1 mutant (MinDE) was rescued by the plant AtMinD gene, even though the dynamic MinE protein was absent. The Arabidopsis homologu...
Phenotype in Biological Technology

Transposagen Creates a Rat Model of the Human Immune System

...ogy companies. "Transposagen is pleased to have characterized the world's first rat model of SCID. We now have intellectual property covering the SCID phenotype in rat and will be offering the SCID rat and other rat models of the immune system in the near future," said Dr. Eric Ostertag , CEO of Transposage...

First-Ever Egg Donor Web Portal Becomes One of The Largest Resources for Aspiring Parents in the U.S.

...e perfect donor, the comprehensive yet easy-to-use database enables intended parents to search specific donor parameters such as ethnicity, education, phenotype and more. The system then automatically generates an email that is sent directly to the registered donor agency of the individual donors. Populat...

Prometheus Research Signs 3-Year Contract With Simons Foundation to Expand HTSQL Informatics System for Autism Research

...e Simons Foundation. "This web-based tool offers researchers unprecedented access to DNA specimens on affected families, combined with high quality phenotype data," Johnson said. The SFARI mission is to improve the diagnosis, treatment, and prevention of autism and related developmental disorders. The ...

Former GE Healthcare Director, Per Foss Appointed CEO for HUNT Biosciences

...que HUNT Study, which for the past 25 years has gathered blood samples from the general population of the Nord-Trondelag region together with detailed phenotype and environmental data. Foss joins just as recruitment for the third phase, HUNT III has closed, again with an astonishing high inclusion rate of 60%....

Atherotech to Exhibit its VAP(R) Cholesterol Test at Internal Medicine 2009 in Philadelphia

...place April 23-25, 2009, at the Pennsylvania Convention Center in Philadelphia. Used in more than 100 clinical trials, including the Heredity and phenotype Intervention (HAPI) Heart Study recently published in Science , the VAP (Vertical Auto Profile) Test is the most accurate cholesterol test available ...

Heart Disease: An Epidemic For Firefighters

...netic screen of more than a million genes including newly identified KIF6 (statin responsiveness gene) and 9p21 (myocardial infarction gene), advanced phenotype (blood) and imaging analyses, diet and exercise review over the year-long study. Results and explanations were presented to the groups followed by in...
Phenotype in Biological Products

Mouse Anti-CDX-2 Monoclonal Antibody, Unconjugated, Clone CDX2-88 from BioGenex

Description:...actor that regulates both proliferation and differentiation in intestinal epithelial cells. It plays an important role in triggering cells towards the phenotype of differentiated villus enterocytes as well as in the maintenance of the phenotype. Clone CDX2-88 reacts with a conserved epitope of the 40kD CDX2 pr...
Company:BioGenex

BL21 Competent Cell Set* from Novagen

Description:...oplasm for proper folding and activity, and alleviating codon usage incompatibilities. Every strain of Novagen’s competent cells is verified for phenotype and purity, and transformation efficiency is guaranteed. The standard aliquot is 0.2 ml, which provides enough cells for 10 transformations; pack size...
Company:Novagen
Phenotype in Biological Definition

Phenotype

The phenotype of an individual organism is either its total physical appearance and constitution, or a specific manifestation of a trait, such as size or eye color, that varies between individuals. Phenotype is determined to some extent by genotype , or by the identity of the alleles that a...

Allele

...hemselves in the phenotype. One exception is incomplete dominance (sometimes called blending inheritance ) when alleles blend their traits in the phenotype . An example of this would be seen if, when crossing flowers with codominant "blue" and "purple" alleles for petal color, the resulting offspring wou...

Biology

...ssary for synthesizing proteins, which, in turn play a large role in influencing, although, in many instances, do not completely determine, the final phenotype of the organism. Developmental biology studies the process by which organisms grow and develop. Originating in embryology , today developmental bi...

Cloning

...(usually via a vector ), where it can be used and studied. Cloning a gene sometimes can refer to success in identifying a gene associated with some phenotype . For example, when biologists say that the gene for disease X has been cloned, they mean that the gene's location and DNA sequence has been identifi...

Morphogenesis

... reciprocal signaling by Hedgehog and Wingless stabilizes the boundary between each segment. The Wingless protein is called "wingless" because of the phenotype of some wingless mutants. Wingless also functioned during metamorphosis to coordinate wing formation. The transcription factors that are coded ...

Epigenetics

...ich seemed to postulate a one-to-one correspondence between genotype and phenotype , could not explain cell differentiation. They developed a theory that eac...es the causal interactions between genes and their products which bring the phenotype into being”. However the term goes back at least to 1896 (see Refere...
Phenotype in Biological Dictionary

Phenotype

A phenotype is any observable characteristic or trait of an organism: such as its morphology, development, biochemical or physiological properties, or behavior. Phenotypes result from the expression of an organism's genes as... phenotype ( ) n. The observable physical or biochemic...

Transformed phenotype

We have investigated whether the transformed phenotype is due to Rho activation. ... Other effects of Ras transformation must contribute to the phenotype . ... ... alter the phenotype of 3T3 cells transformed by an ... autocrine loops contribute to the transformed phenotype of a...

Wild-type

... Wild type refers to the phenotype of the typical form of a species as it occurs in nature. Originally, the wild type was conceptualized as a product of the standard, "normal&...

Wildtype

... Wild type refers to the phenotype of the typical form of a species as it occurs in nature. Originally, the wild type was conceptualized as a product of the standard, ... Michig...

Wild type

... Wild type refers to the phenotype of the typical form of a species as it occurs in nature. Originally, the wild type was conceptualized as a product of the standard, "normal&...

True-breeding

...t;breed true " means that two organisms with a particular, heritable phenotype produce only offspring with that... (Redirected from Breeding t...homozygous, alternate alleles are identical, ... The recessive trait's phenotype only appears in true - breeding (homozygous) individuals ... That is ...
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