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Pharmacokinetics in Medical News

NKTR-105 Demonstrates Superior Antitumor Activity and Improved Pharmacokinetics Over Docetaxel in Preclinical Studies Presented at AACR

DENVER and SAN CARLOS, Calif., April 22 /PRNewswire-FirstCall/ -- Nektar Therapeutics (Nasdaq: NKTR ) presented data today at the American Association for Cancer Research (AACR) 100th Annual Meeting demonstrating that NKTR-105, a novel PEGylated form of docetaxel, has superior antitumor activity...

Mersana's Second Development Candidate, XMT-1107, Shows Superior Pharmacokinetics and Anti-Tumor Activity in Studies Presented at American Association of Cancer Research Meeting

- Data Show Fleximer(R) Extends Exposure to Conjugated Drug - CAMBRIDGE, Mass., April 19 /PRNewswire/ -- Mersana, a platform-based cancer therapeutics company, today announced positive results of preclinical studies for its second development candidate, XMT-1107, in two posters at the 2009 An...

Bellicum Pharmaceuticals Announces Initiation of Phase I/II Clinical Trial of Novel Vaccine for Patients With Advanced Prostate Cancer

...patients leads to controlled activation of the ARGENT-regulated protein iCD40. AP1903 was previously shown by ARIAD to be well-tolerated with defined pharmacokinetics in a Phase 1 clinical trial. "This is an exciting application of ARIAD's dimerizer technology, with the potential for therapeutic benefit linke...

Arena Pharmaceuticals Announces Second Quarter 2009 Financial Results and Recent Developments

...ith development of cardiac valvular insufficiency. Ortho-McNeil-Janssen completed a Phase 1 clinical trial evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of a single ascending dose of APD597 in healthy volunteers. Ortho-McNeil-Janssen has initiated another clinical trial evaluating ...

Boehringer Ingelheim to Commence Phase III Study Investigating the Role of BIBW 2992 as First-Line Treatment for Non-Small Cell Lung Cancer (NSCLC) Patients with EGFR Mutations

...Group (ECOG) performance status of 0-2 with relapsed NSCLC after failure of first- or second-line chemotherapy.(7) The analysis showed that the pharmacokinetics of BIBF 1120 are independent from patient characteristics (e.g., age, weight, height, gender, smoking status, etc.).(7) The most common (greater than ...

Lexicon Pharmaceuticals Provides Clinical Pipeline Update and Reports 2009 Second Quarter Financial Results

... Lexicon completed the multiple ascending-dose portion of a Phase 1 study of its LX4211 drug candidate to evaluate the safety, tolerability, and pharmacokinetics of LX4211 in healthy volunteers over a seven-day dosing period. Top-line results from the Phase 1 clinical trial will be available later this quarter...

96-Week Safety and Efficacy Findings Presented for INTELENCE(TM) (etravirine) As Part of HIV Combination Therapy

...ic Populations Hepatic Impairment: INTELENCE should be used with caution in patients with severe hepatic impairment (Child-Pugh Class C) as pharmacokinetics of INTELENCE have not been evaluated in these patients. Adverse Reactions The most common adverse events (>10%) of any in...

Merrimack Pharmaceuticals Initiates Enrollment in a Phase 1/2 Study of MM-111, a Bispecific Antibody to ErbB2/3

...tumor types. The current Phase 1/2 study will evaluate the human safety and pharmacokinetics (PK) of MM-111. MM-111 is the first bispecific antibody bindng two differen...April. The current Phase 1/2 study will evaluate the human safety and pharmacokinetics (PK) of MM-111. The Phase 1 portion of the study is enrolling patients with...

Sundia MediTech Appoints Dr. Chen Chen as Senior VP of Chemistry

...and GPCRs as drug targets. His knowledge also includes neuropathic pain and metabolic disorders. His research interests extend to clinic and preclinic pharmacokinetics of small molecules and the relationship with their chemical properties. "It is an honor for Sundia to have world class leading scientists as Dr...

Phase 1 Study Initiated with Micromet Anti-GM-CS Human Antibody MT203

...human antibody MT203 by its collaboration partner Nycomed. The double-blind, randomized, placebo controlled study will investigate the safety and pharmacokinetics of MT203. GM-CSF has been shown to play a significant role in various autoimmune and inflammatory diseases, including rheumatoid arthritis, multi...
Pharmacokinetics in Medical Technology

Anadys Pharmaceuticals Announces Single Dose Safety and Pharmacokinetics Results for ANA598 in Healthy Volunteers

Phase I Clinical Data and Additional Preclinical Results for Non-Nucleoside HCV Polymerase Inhibitor Being Presented at AASLD SAN DIEGO, Nov. 1 /PRNewswire-FirstCall/ -- Anadys Pharmaceuticals, Inc. (Nasdaq: ANDS ) announced today the results of a Phase I clinical trial of ANA598 in h...

Ardea Biosciences Presents Data Demonstrating Favorable Pharmacokinetics and Efficacy for Mitogen-Activated ERK Kinase (MEK) Inhibitors

- Lead MEK inhibitor, RDEA119, demonstrates potential for once daily oral dosing in preliminary Phase 1 results - - Next generation MEK inhibitor, RDEA436, to enter Phase 1 trials second half of 2008 - SAN DIEGO, April 15 /PRNewswire-FirstCall/ -- Ar...

Pharmasset Reports Positive Preliminary Antiviral Data With PSI-7851 for the Treatment of Hepatitis C

...notype 1. The primary objective was to assess the safety, tolerability, and pharmacokinetics of PSI-7851 after once-daily (QD) dosing for 3 days. The secondary objectiv... QD, respectively. PSI-7851 Pharmacokinetic and Safety Summary pharmacokinetics were similar between healthy subjects in the single ascending dose study an...

Poniard Pharmaceuticals Announces Positive Cardiac Safety Data From Picoplatin Phase 1 Trial Supporting NDA Filing

...ntities. This study evaluated the cardiac safety of picoplatin by determining its effect on the cardiac QT/QTc interval by using time-matched pharmacokinetics and electrocardiograms (ECGs). A total of 45 patients with advanced solid malignancies received 150 mg/m2 picoplatin. The trial was conducted at seven...

R-Tech Ueno, Ltd. Completes Phase 1 Clinical Study on RK-023

...ted applications of RK-023 preparation to the scalp were conducted by a randomized, placebo-controlled, double blind method to evaluate the safety and pharmacokinetics of the drug. In the single-dose study, 2 ml of RK-023 preparation was applied to the vertex region of 6 out of 9 healthy adult males and a placebo to ...

Analysis of Edoxaban Phase II Data Provides Insight Into Reduced Bleeding Events Seen in Once-Daily Dosing

...s) do not dip as low, and the Cmax levels (peaks) do not reach as high as when the compound is delivered once per day. "When we assessed the pharmacokinetics in patients taking edoxaban once a day, lower minimum concentrations and fewer bleeding events were observed, compared to the same total daily dosage ...

Vantia Therapeutics' Lead Candidate VA106483 Demonstrates Positive Anti-diuretic Effect in Phase IIa Trial in Nocturia

...xtensive drug candidate library. The double-blind, placebo-controlled, dose-response study was designed to investigate the pharmacodynamics and pharmacokinetics of single and repeated oral doses of VA106483. The trial involved 27 elderly men aged 65 years or more with a history of nocturia. Based on the...

Covance Announces Integrated Radiolabeled Clinical Pharmacology Studies

... study." The results of AME studies provide essential information about the disposition of a drug by direct characterization of the compound's pharmacokinetics and information related to AME characteristics. Stringent data requirements for AME studies demand experienced radiochemical and chemical analysis se...

Neurocrine Biosciences Presents Elagolix Data

...n parallel groups in which 88% of the participants completed the treatment period. The purpose of this study was to evaluate the safety, tolerability, pharmacokinetics and endocrine effects of elagolix. The results of this study showed that daily administration of elagolix induced partial suppression of gonadotropins...

Trubion Announces Positive Data From a Phase 1 / 2 Study of TRU-016 for the Treatment of Chronic Lymphocytic Leukemia (CLL)

...016 in March 2008. The open-label clinical trial has two components: a Phase 1 dose escalation study designed to evaluate the safety, tolerability and pharmacokinetics of TRU-016, and a Phase 2 expansion cohort designed to further evaluate safety and estimate clinical activity of TRU-016 in patients with previously t...
Pharmacokinetics in Medical Products

The Clinical Reference Laboratories at National Jewish Medical and Research Center

Description:...hey provide comprehensive, and often unique, testing in the areas of immunology and flow cytometry, complement, immunopharmacology, infectious disease pharmacokinetics and mycobacteriology....
Company:The Clinical Reference Laboratories at National Jewish Medical and Research Center

Concise Guide to Drug Interaction Principles for Medical Practice

Features:... An easy-to-read, succinct review of pharmacology, explaining the importance of understanding our metabolic system and pharmacokinetics and P-glycoprotein drug interactions Thorough, carefully referenced reviews of the most clinically relevant phase I and phase II metabolic enzymes hi...
Company:Skyscape, Inc.

AHFS Drug Information

Features:...ination of well-established laboratory and test inferences Rigorous investigation of chemistry and stability Scientific coverage of pharmacology and pharmacokinetics Complete lists of commonly available prescription, OTC, ophthalmic, and dermatologic drugs, in addition to vitamins and parenteral nutrition products...
Company:Skyscape, Inc.

A to Z Drug Facts, 6th Edition

Features:...sease state or medical condition Precautions/Warnings for children and elderly, as well as pregnancy, lactation and specific disease states Detailed pharmacokinetics and pharmacodynamics Adverse reactions now include percent of incidence All monographs also feature the Handheldmed MEDconnect© links to quickl...
Company:Mobipocket.com
Pharmacokinetics in Biological News

Funxional successfully completes initial clinical trial of FX125L, an anti-inflammatory drug with a novel mechanism of action

...conducted in the United States. FX125L was well tolerated at all doses studied and no serious adverse events or subject withdrawals were observed. The pharmacokinetics of FX125L was linear over the wide dose range studied and consistent with once-daily oral dosing for patients. We are extremely pleased with the ...

DuoCort: New chronotherapy for adrenal insufficiency

...lts from the phase I study in healthy volunteers, evaluating the safety and pharmacokinetics of the new hydrocortisone tablet, show a physiological diurnal serum cortis...specially as there was little inter- or intra-individual variability in the pharmacokinetics and the drug release profiles look very like the physiological release prof...

Tailor-made recombinant proteins in mammals

...yonic kidney cells). "You can put anything you want on the tagged protein," she says, "You attach small molecule drugs, or polymers that change the pharmacokinetics such as polyethylene glycol polymers, or another protein molecule, or anything you're interested in attaching to a protein." Because of their obvio...

UC Riverside bioengineer receives high honor from chemical engineers

...eliminate the need for diabetics to use needles for blood glucose checks. He also is known internationally for his work on biosensors, biomaterials, pharmacokinetics and membrane processes. Early in his career, he developed methodologies for the production of therapeutic agents on a large scale. Working for a p...

Curry-derived molecules might be too spicy for colorectal cancers

...therapy, said Shibata. According to Shibata, the next step for the researchers is to further examine the drug delivery mechanisms, toxicology and pharmacokinetics of these analogues, before extending the research to clinical trials. Their studies were funded by the Japanese Society for the Promotion of Science a...

PET/MRI scans may help unravel mechanisms of prenatal drug damage

...empted to use PET to noninvasively monitor maternal-fetal drug exchange and pharmacokinetics (how quickly a drug is taken up and distributed among the body's organs), t... PET with high-resolution magnetic resonance imaging (MRI) to track cocaine pharmacokinetics down to the level of the placenta and individual regions of the fetal brain...
Pharmacokinetics in Biological Technology

ANX-530 Demonstrates Equivalent Pharmacokinetics to Navelbine(R) in a Registrational Bioequivalence Clinical Study

ADVENTRX Presents Data at the 2008 American Association for Cancer Research Annual Meeting SAN DIEGO, April 15 /PRNewswire-FirstCall/ -- ADVENTRX Pharmaceuticals, Inc. (Amex: ANX ) announced that it presented pharmacokinetic data from its registrational bioequivalenc...

ANX-514 Reduces Hypersensitivity Reactions Without Impacting Pharmacokinetics or Antitumor Activity in Preclinical Tests

ADVENTRX Presents Results at 2007 AACR-NCI-EORTC International Conference SAN DIEGO, Oct. 25 /PRNewswire-FirstCall/ -- ADVENTRX Pharmaceuticals, Inc. (Amex: ANX ), a biopharmaceutical research and development company focused on commercializing proprietary product candidates for the treatment o...

Data Published in Cell Stem Cell Demonstrates Potent Anti-Cancer Activity for OncoMed Pharmaceuticals' Lead Antibody

...omoting cell differentiation. OMP-21M18 is currently in a Phase 1 clinical trial in patients with advanced solid tumors. This trial will also assess pharmacokinetics and provide initial indications of efficacy. OMP-21M18 is part of OncoMed's Notch pathway collaboration with GlaxoSmithKline. About OncoMed ...

Poniard Pharmaceuticals Reports Second Quarter 2009 Financial Results and Provides a Corporate Update

...ug Administration (FDA), and evaluated the cardiac safety of picoplatin by determining its effect on the cardiac QT/QTc interval by using time-matched pharmacokinetics and electrocardiograms. A total of 45 patients with advanced solid malignancies received 150 mg/meter squared of picoplatin at seven clinical sites i...

Sunesis Reports Financial Results for the Second Quarter 2009

... voreloxin can induce durable complete remissions across several dosing schedules. The Phase 1b/2 trial is designed to evaluate the safety, pharmacokinetics and anti-leukemic activity of escalating doses of voreloxin when administered on days one and four with cytarabine given either as a continuous infusi...

Inspiration Biopharmaceuticals Presents Safety Data on IB1001, a Novel Recombinant Factor IX for the Treatment of Hemophilia at the International Society on Thrombosis and Haemostasis (ISTH) Annual Meeting

... has completed preclinical testing and is currently being evaluated in a Phase 1/2-3 clinical study. In the study, the safety, toxicology and pharmacokinetics of IB1001 were evaluated in animal models and compared to commercially available Factor IX products. Results showed that IB1001 has an excellent safe...

MacroGenics Announces the Initiation of a Phase 2 Clinical Trial to Evaluate the Safety and Efficacy of Monoclonal Antibody MGAWN1 in Subjects with Suspected Central Nervous System Infection Due to West Nile Virus

... completed treatment in late 2008. This randomized, double-blind, dose-escalation cohort study was designed to evaluate the safety, tolerability, and pharmacokinetics of a single infusion of MGAWN1 in healthy adults. The study demonstrated the drug to be safe and well tolerated at all doses tested. "We a...

Funxional Successfully Completes Initial Clinical Trial of FX125L, an Anti-Inflammatory Drug With a Novel Mechanism of Action

...conducted in the United States. FX125L was well tolerated at all doses studied and no serious adverse events or subject withdrawals were observed. The pharmacokinetics of FX125L was linear over the wide dose range studied and consistent with once-daily oral dosing for patients. "We are extremely pleased with t...

VisEn Launches New Cat-K FAST(TM) Fluorescence Molecular Imaging Agent

...rm. FAST agents are based on high-performance, activatable smaller molecules that combine biomarker specificity with optimized biocompatibility and pharmacokinetics for precise measurement and monitoring of key disease biomarkers in vivo . VisEn's proprietary fluorescence imaging agents and labels are desig...

HUYA Bioscience Announces Strategic Collaboration With the Shenyang Pharmaceutical University

...nees. It is a national leader in the synthesis and screening of novel pharmaceutical compounds, pharmaceutical formulation development and evaluation, pharmacokinetics and pharmacodynamics, pharmacology and toxicology, and identification and purification of active ingredients from Traditional Chinese Medicines and na...
Pharmacokinetics in Biological Products

BAS 2500 Image Analysis System from FUJIFILM Life Science

Description:... The BAS-2500 is ideal for the following applications: Molecular Biology (1D electrophoresis, 2D electrophoresis, DNA, protein blots, Macroarrays); pharmacokinetics & Toxicology (whole body autoradiography, thin layer chromatography); Physical and Material Structural Analysis (x-ray crystallography, semiconductor ...
Company:FUJIFILM Life Science
Pharmacokinetics in Biological Dictionary

Competitive inhibition

... ... Competitive inhibition usually involves inhibitors, commonly called poisons, ... Competitive inhibition is of particular importance in pharmacokinetics (drug therapy) ... Derive a Rate Law For Non- Competitive Inhibition ... Provides a basic introduction to enzymes, their ... Competitive inhi...
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Breaking Biology News(10 mins):Microbes in Central Park soil: If they can make it there, they can make it anywhere 2Microbes in Central Park soil: If they can make it there, they can make it anywhere 3The cultural side of science communication 2NIH taps lab to develop sophisticated electrode array system to monitor brain act 2NIH taps lab to develop sophisticated electrode array system to monitor brain act 3
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