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Pharmacodynamic in Medical News

Perforomist-comparable pharmacokinetic and pharmacodynamic profile to DPI formulation

Napa, CA (May 20, 2008) Data presented today at the International Conference of the American Thoracic Society (ATS) demonstrate that Perforomist™ Inhalation Solution (formoterol fumarate inhalation solution; FFIS) has a pharmacodynamic and pharmacokinetic profile that is comparable to the d...

Portola Pharmaceuticals Announces Several Scientific Presentations at International Society on Thrombosis and Haemostasis XII Congress

... July 15, 12:30-2:15 p.m. Location: Poster Area, Patient Oriented Studies of Antiplatelet Therapy ADP-Mediated Aggregation as a pharmacodynamic Assay Underestimates the Antithrombotic Activity of Elinogrel, a Competitive, Reversible P2Y12 Inhibitor, Relative to Clopidogrel (Presentation #PP-TH...

Amira Pharmaceuticals Announces Initial Positive Phase 1 Clinical Data for AM211, a Novel Product Candidate for the Treatment of Respiratory Diseases

...udy of AM211, the company's oral selective antagonist of the DP2 (also known as CRTH2) receptor. The interim results demonstrate that a sustained pharmacodynamic (PD) effect can be achieved with a single dose of AM211. The pharmacokinetic profile indicates safety multiples as compared to exposures observed in s...

Novo Nordisk Insulin Analogs Have Proven Safety Profiles

...ulin, particularly when given intravenously or in settings of poor glycemic control, may cause hypokalemia. Because NovoLog(R) Mix 70/30 has peak pharmacodynamic activity 1 hour after injection, it should be administered with meals. Because of differences in the action of NovoLog(R) Mix 70/30 and other insulin...

Arete Therapeutics Presents Positive Clinical and Preclinical Data for AR9281

...led studies, demonstrated that AR9281 was safe and well tolerated in healthy volunteers. The studies met all safety, tolerability, pharmacokinetic and pharmacodynamic endpoints. In addition, AR9281 has shown favorable results in various published and proprietary in vitro and in vivo assays for potency, selectivi...

Hyperion Therapeutics Announces Results of Phase I Study in Patients With Liver Cirrhosis

... http://www.newscom.com/cgi-bin/prnh/20070905/AQW076LOGO ) This open-label study was designed to determine the safety, tolerability, and PK and pharmacodynamic (PD) profiles of HPN-100 administered orally to subjects with hepatic impairment and cirrhosis and to subjects with normal hepatic function. A total o...

An efficient approach to monitor gastrointestinal microflora changes

...nities. A molecular marker was identified for Pi-deficiency in rats. The pharmacodynamic evaluating system, including identified molecular markers (net integral are...n the screening of active compounds in relative Chinese materia medicas and pharmacodynamic study in Pi-deficiency. ...

Neurocrine Announces Full Year Results from 603 Study (Petal Study) of Elagolix for Treatment of Endometriosis Pain

...Equally notable is the observation that much of this improvement was sustained post-treatment. Estradiol and Ovulation: The previously reported pharmacodynamic effect of elagolix was confirmed. Median estradiol values were maintained in the low baseline range while on treatment and, most importantly, were not...

Forest Laboratories, Inc. and Cypress Bioscience, Inc. Announce Commercial Availability of Savella(TM)

...ce higher rates of genitourinary adverse events. Savella is unlikely to be involved in clinically significant pharmacokinetic drug interactions. pharmacodynamic interactions of Savella with other drugs can occur. In clinical trials, the most frequently occurring adverse reactions (greater than or equal to...

Forest Laboratories, Inc. and Cypress Bioscience, Inc. Announce Revised Timing for Commercial Availability of Savella(TM)

...nce higher rates of genitourinary adverse events. Savella is unlikely to be involved in clinically significant pharmacokinetic drug interactions. pharmacodynamic interactions of Savella with other drugs can occur. Savella contains FD&C Yellow No. 5, which may cause allergic-type reactions in susceptibl...
Pharmacodynamic in Medical Technology

Updated Phase 1 Data for Exelixis' XL184 Demonstrate Pharmacodynamic and Clinical Anti-Tumor Activity

-Encouraging signs of anti-tumor activity observed in patients with medullary thyroid cancer- SAN FRANCISCO, Oct. 23 /PRNewswire-FirstCall/ -- Exelixis, Inc. (Nasdaq: EXEL ) today reported encouraging data from an ongoing phase 1 trial of XL184, a potent inhibitor of M...

King Pharmaceuticals Showcases Data From Pain Pipeline of Medicines Designed to Deter Common Methods of Non-Therapeutic Use

..., very few studies have examined the extent of the pharmacokinetic (PK) and pharmacodynamic (PD) interaction between them, particularly when taken at therapeutic doses...and select opioids at the studied doses does not appear to produce additive pharmacodynamic effects, while the pharmacokinetic profiles may be affected for certain oth...

Acute Lymphoblastic Leukemia, the Most Common Childhood Cancer, Is Curable Without Preventive Cranial Radiation

...ss," Campana said. St. Jude investigators applied personalized therapy based on molecular genetics of ALL, pharmacogenetic traits of patients and pharmacodynamic principles. "We prospectively determined the activity of drug-metabolizing enzymes of each patient and adjusted the dosage of chemotherapy accordingly...

Tolerx Presents Data at 69th Scientific Sessions of the American Diabetes Association

... mouse model of autoimmune diabetes. Tolerx researchers conducted dose-ranging studies to establish the minimum effective dose and to investigate pharmacodynamic (PD) parameters, including T-cell receptor (TCR) modulation, that correlate with efficacy in a preclinical model of diabetes. Evaluation of a dose of...

Micromet Presents Update on Blinatumomab's Response Rate and Duration in a Phase 1 Study in Non-Hodgkin's Lymphoma Patients

...relapsed NHL patients including a follow-up on response duration as well as pharmacodynamic activity(1). A dose-dependent clinical activity has been observed in these ...dical Officer, Carsten Reinhardt, M.D. (1) Klinger, M. et al. (2009). pharmacodynamic analyses of peripheral blood from relapsed B-NHL patients treated with anti...

Semafore's SF1126, a Vascular Targeted Pan-PI3K/mTOR Inhibitor, Is Well Tolerated and Demonstrates Activity in Phase I Solid Tumor Patients

... These specific tumor types are associated with aberrations of the PI3K pathway that commonly lead to resistance and poor prognostic outcomes. pharmacodynamic analysis of tumor tissue confirmed inhibition of the PI3K pathway by complete absence of a downstream target (pS6). In contrast, a normal tissue (ski...

Final Results of Boceprevir Phase II HCV SPRINT-1 Study Showed Significantly Higher SVR Rates Compared to Standard of Care in Treatment-Naive Genotype 1 Hepatitis C Patients

...ases in viral load (HCV RNA) from baseline at day 8. SCH 900518 was well tolerated, with no drug related serious adverse events. Pharmacokinetic and pharmacodynamic modeling from this study was used to design the ongoing Phase IIa dose-finding study of SCH 900518 with ritonavir in combination with PEGINTRON and RE...

Pharmacyclics Initiates Phase 1 Clinical Trial of Novel Oral Btk Inhibitor for Refractory B-cell Non-Hodgkin's Lymphoma

...niversity , MD Anderson Cancer Center and the University of Chicago using a 28-day dose-escalation design. The study is also utilizing a proprietary pharmacodynamic assay developed by Pharmacyclics to directly assess Btk drug occupancy. Preliminary results from the Phase I trial shows good patient tolerability un...

Radius Initiates Phase 2a Clinical Trial of RAD1901 in Menopausal Hot Flashes

... will be 28 days. The primary endpoint of the study is the frequency and severity of hot flashes relative to baseline. In addition, data on changes in pharmacodynamic markers of estrogen effect--follicle-stimulating hormone (FSH), luteinizing hormone (LH), and lipid profile effect--will be collected. About RAD...

Amicus Therapeutics Suspends Enrollment for Phase 2 Clinical Trial of AT2220 for Pompe Disease

...the study is to evaluate the safety and tolerability of different dosing regimens of AT2220 over a 12-week period. The study will also explore certain pharmacodynamic and pharmacokinetic measures including the effect of treatment with AT2220 on GAA activity and on glycogen levels in various cells and tissues. Additi...
Pharmacodynamic in Biological News

Versartis presents positive preclinical data on 2 product candidates at ENDO 09

...f Versartis. "Our preclinical data presented today show that VRS-317 demonstrated in vivo potency equal to daily hGH, and sustained plasma levels and pharmacodynamic responses in monkeys without toxicity. Potential benefits of VRS-317 include its stability at room temperature in a liquid formulation and the abilit...

CHIs 5th Biomarker World Congress: Signature Event with Cutting-Edge Agenda

...Translational Medicine, Wyeth Research Paul J. Fielder, Ph.D., Senior Director & Senior Scientist, Early Development Pharmacokinetics, pharmacodynamic and Bioanalytical Sciences, Genentech, Inc.     Mark Fidock, Ph.D., Head, Biochemical and Molecular BioMarkers, Experimenta...
Pharmacodynamic in Biological Technology

Nebulized Formoterol Fumarate Has Comparable Pharmacokinetic and Pharmacodynamic Profile to Dry Powder Formulation

- Data from two clinical trials presented at International ATS Conference - NAPA, Calif., May 20 /PRNewswire/ -- Data presented today at the International Conference of the American Thoracic Society (ATS) demonstrate that Perforomist(TM) Inhalation Solution (formoterol fumarate inhalation soluti...

Repligen Reports First Quarter Fiscal Year 2010 Financial Results

...tified several potential clinical candidates and are further characterizing these leads in preclinical models for their pharmacologic, toxicologic and pharmacodynamic profiles. Quarterly Conference Call Repligen will host a conference call and webcast on Thursday, August 6th at 10:00 a.m. EDT, to review f...

Palatin Technologies, Inc. Receives U.S. Patent Allowance for Heart Failure Drug Candidate

...ce to neutral endopeptidase, an endogenous enzyme that degrades natriuretic peptides. The result is a drug candidate with improved pharmacokinetic and pharmacodynamic properties. About Heart Failure Heart failure affects over 5.7 million people in the United States, with 670,000 new cases diagnosed eac...

Anadys Pharmaceuticals Reports Second Quarter 2009 Financial Results and Program Highlights

...ential path to continue the development of ANA773. Reported PK/PD Data for ANA773 in HCV at EASL. In April 2009, the pharmacokinetic (PK) and pharmacodynamic (PD) data from the healthy volunteer portion of the Phase I clinical trial of ANA773 in HCV were reported at the EASL conference. ANA773 was generall...

Schering-Plough Announces Phase II and III Data for Corifollitropin Alfa

...cipating in an Assisted Reproductive Technology (ART) program. Corifollitropin alfa is designed as a sustained follicle stimulant (SFS) with the same pharmacodynamic profile as rFSH, but with a markedly prolonged duration of FSH activity. Due to its ability to initiate and sustain multiple follicular growth for an...

Repligen Reports Fourth Quarter and Fiscal Year 2009 Financial Results

... identified several potential clinical candidates and are further characterizing these leads in animal models for their pharmacologic, toxicologic and pharmacodynamic profiles. Bioprocessing Business Repligen has supplied recombinant Protein A products, a consumable used in the manufacture of therapeutic mo...

Oncolytics Biotech(R) Inc. Collaborators Present Positive Phase II Sarcoma Trial Results at ASCO Annual Meeting

... a total disease control rate (CR (Complete Response)+PR+SD) of 70%. Dr. Sanjay Goel and colleagues delivered a poster entitled "Dose Escalation and pharmacodynamic Study of Intravenous Administration of REOLYSIN, a Live Replication Competent RNA Virus in Patients with Advanced Solid Tumors." The results, which we...

OncoGenex Pharmaceuticals Announces OGX-011 Treatment Provides Survival Benefit in Randomized Phase 2 Trial in Advanced Metastatic Prostate Cancer

...ued for adverse events, 7 of these patients experienced adverse events during the 8th and 9th treatment cycles. - Evidence of a pharmacodynamic effect in the OGX-011 plus docetaxel arm was observed with statistically significant declines in serum clusterin levels within the fir...

Oncothyreon announces clinical data from three product candidates presented at American Society of Clinical Oncology (ASCO) Annual Meeting

... disease as their best response. Three of these patients remain on therapy. pharmacodynamic monitoring has demonstrated inhibition of PI-3 kinase activity at doses as ...a. These trials in 32 patients were designed to assess the tolerability and pharmacodynamic activity of both 24-hour and 72-hour infusions of PX-12. In both trials, do...

Micromet to Present New Clinical Data on Blinatumomab at EHA and on Adecatumumab at ASCO

...phase II study. 14th Congress of EHA (2009), abstract number 482; oral presentation on June 6 in Hall 15.2 at 8:15 AM. (2) Klinger, et al. (2009) pharmacodynamic analyses of peripheral blood from relapsed B-NHL patients treated with anti-CD19/-CD3 bispecific BiTE(R) antibody blinatumomab. 14th Congress of EHA (...
Pharmacodynamic in Biological Dictionary

Proteasome

...e multicatalytic proteasome is the ubiquitous ... The Pharmacokinetic and pharmacodynamic Profiles of Proteasome Inhibitors ... Proteasome Inhibitors in Disease: The multicatalytic proteasome is the ... The Pharmacokinetic and pharmacodynamic Profiles of Proteasome Inhibitors ... ... Processing by Proteasomes ....
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