Basis for DNA ejection from single phage particles
Studying phage, a primitive class of virus that infects bacteria by injecting its genomic DNA into host cells, researchers have gained insight into the driving force behind this poorly understood injection process, which has been proposed in the past to occur through the release of pressure accumulated within the viral particle itself. Almost all phages (also known as bacteriophages) are f...UCSB researchers discover shape matters to macrophages
Researchers at UC Santa Barbara have made a surprising discovery: phagocytosis depends more on particle shape than size. The research, which has far-reaching implications for immunology, vaccine development and drug delivery, is published today online in the Proceedings of the National Academy of Sciences by Samir Mitragotri, a UCSB professor of chemical engineering, and graduate student Julie A....Macrophage signaling may affect hormone resistance in prostate tumors
Interaction between prostate cancer cells and immune cells called macrophages may be a source of inflammatory signals capable of impacting the effectiveness of androgen antagonists, the most common and effective treatment for prostate cancer, according to a new study by researchers at the University of California, San Diego (UCSD) School of Medicine. Male hormones called androgens are es...Pitt phage hunter takes on tuberculosis
One third of the world's people are infected with tuberculosis, and someone new is infected every second. TB is notoriously hard to treat, requiring a course of multiple antibiotics over six to nine months. Many people don't complete the full course of treatment, which leads to increasing antibiotic resistance against the disease. More effective treatments could be on the way, however, wi...The connector rotation hypothesis? Phage do not pack their DNA by rotation
The life cycles of many viruses include a self-assembly stage in which a powerful molecular motor must pack the DNA genome into the virus's preformed shell (the capsid). How it manages this intricate feat has been subject to debate, but we know that the DNA passes into the capsid shell through a channel formed by a structure called the connector. Scientists have speculated that rotation of the co...PhageMaker System from Novagen
Description:Novagens PhageMaker System is optimized for maximum packaging efficiencies of cDNA and genomic DNA inserts ligated with any bacteriophage l vector. Using a test insert with Novagen's l vector arms, efficiencies > 10^7 pfu/g arms (> 4 x 10^8 pfu/g ligated l control DNA) are typically obtained. This one-tube system is extremely easy to use; simply add up to 5 g of ligated vector plus insert to the...Phage Display cDNA Library Screening Kit from Spring Bioscience
Description:Spring offers a large collection of phage display libraries, human adult tissues, fetal tissuea, cell lines, and mouse tissues. All cDNA libraries are constructed in pHD9 vector. The size of cDNA inserts has been verified to be from 200bp to 1000bp by gel electrophoresis of DNA prepared from the amplified libraries....T7 Phage Capture Plate from Novagen
Description:The T7 Phage Capture Plate is a 96-well ELISA-compatible plate (containing 12 x 8-well strips) on which the T7 Tail Fiber Monoclonal Antibody is immobilized by a method that retains maximal binding activity. The antibody specifically recognizes the tail fiber protein of the T7 bacteriophage. This 8-well strip plate has a capacity of 10 phage per well and low non-specific binding. Phag...M13/Phagemid DNA Extraction Protocol
Efficiency of the standard protocols for production of single-stranded DNA may be improved through the use of PLG. For producing M13 ssDNA, mix 2.5 ml plating bacteria (57...M13/Phagemid DNA Extraction Protocol
Efficiency of the standard protocols for production of single-stranded DNA may be improved through the use of PLG. For producing M13 ssDNA, mix 2.5 ml plating bacteria (57...Improved procedure to do laproscopic esophagectomy discovered
Researchers have developed a new improved procedure to do laproscopic esophagectomy on patients who suffers// from the problems of esophagus, including cancer of the esophagus. Currently to test the extent of damage in the esophagus, surgeons had accepted a noninvasive procedure called laproscopic esophagectomy. In this process the surgeons had to make a small incision on the abdomen o...Lymph Cell Growth In Eyes Related To Macrophages
Researchers from Harvard Medical School had discovered a kind of immune cells called macrophages are behind the growth of new lymph vessels in the eyes. These new lymph vessels help in healing of the eyes in case of there being any wounds. // The discovery of this new role for the macrophage, published in the September 2005 Journal of Clinical Investigation, may ultimately inspire inn...Macrophage Inhibitory Factor Causes Multiple Sclerosis Progression
Researchers have found that Migration/Macrophage Inhibitory factor (MIF) which is an immune cell responsible for progression of Multiple Sclerosis. This new pathway can be used in finding drugs which reduces the amount of MIF // in a way progression of Multiple Sclerosis is hindered. Multiple Sclerosis is an autoimmune disease which is caused by non-...Soft Drinks May Reduce Esophageal Cancer Risk
A study conducted by the researchers from the Yale School of Medicine has revealed that diet soda drinkers run a decreased risk of contracting cancer//. Until recently it was believed that there was a 350% higher risk of getting esophageal cancer through consuming carbonated soft drinks. In their study published in the recent of Journal of the National Cancer Institute (JNCI), the researchers rep...PET Can Predict Response To Treatment In Esophageal Cancer Patients
Positron Emission Tomography (PET) is more accurate than traditional radiological methods in predicting the patients' response to chemotherapy// and radiation, says new research at Wake Forest University Baptist Medical Center. The findings of the study are published in the April issue of Annals of Surgery. The researchers examined 64 patients with esophageal cancer with PET, which shows...Combitube® Esophageal/Tracheal Double-Lumen Airway
Description:Rapid intubation of difficult airways. When a difficult airway must be established, time and accuracy are critical. Now you can be assured of rapid intubation and effective ventilation with the Combitube®: Esophageal/Tracheal double-Lumen Airway from Nellcor. Unlike traditional endotracheal tubes, the Combitube airway is designed to establish a nonsurgical patient airway when placed i...400 Series/Regular Tube Esophageal Stethoscope
Description:The pause of a heartbeat. The bodys warmth beneath drapes. The life-giving force of rhythmic breathing. These vital signs are yours to guard, measure, stabilize and cross check. DeRoyals line of Temperature Monitoring products helps you do your job, giving you the information needed to provide the most comfortable and precise management of your patients stability during surgical procedures. These...400 Series/Extra-Long Length Esophageal Stethoscope
Description:The pause of a heartbeat. The bodys warmth beneath drapes. The life-giving force of rhythmic breathing. These vital signs are yours to guard, measure, stabilize and cross check. DeRoyals line of Temperature Monitoring products helps you do your job, giving you the information needed to provide the most comfortable and precise management of your patients stability during surgical procedures. These...400 Series/Soft Tube Esophageal Stethoscope
Description:The pause of a heartbeat. The bodys warmth beneath drapes. The life-giving force of rhythmic breathing. These vital signs are yours to guard, measure, stabilize and cross check. DeRoyals line of Temperature Monitoring products helps you do your job, giving you the information needed to provide the most comfortable and precise management of your patients stability during surgical procedures. These...NCCN Updates Esophageal and Gastric Cancer Guidelines
JENKINTOWN, Pa.--(BUSINESS WIRE)--May 22, 2007 - The NationalComprehensive Cancer Network (NCCN) announces updates to two NCCNClinical Practice Guidelines in Oncology(TM) -- Esophageal Cancerand Gastric Cancer. The NCCN Guidelines are updated continuously bypanels of world-renowned experts and are widely recognized andapplied as the standard of care in oncology in the United States inboth t...Gastroesophageal reflux disease
(the tube from the mouth to th...