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Phage in Medical News

New Research Shows MicroPhage Test Accurately and Rapidly Detects Serious Bacterial Infections

...sample is challenged with an antibiotic. Because phages depend on host bacteria for growth, any compound that kills or inhibits the microbe will stop phage growth. Only resistant strains allow multiplication of phages and yield a positive signal on the detector strip. Further information about the techno...

XOMA to Present at the Rodman and Renshaw Annual Global Investment Conference on November 11

...) (certolizumab pegol) for Crohn's disease. The Company has a premier antibody discovery and development platform that incorporates leading antibody phage display libraries and XOMA's proprietary Human Engineering(tm) and bacterial cell expression technologies. Bacterial cell expression is a key breakthr...

XOMA to Announce Third Quarter 2008 Financial Results and Host Conference Call on November 10

...) (certolizumab pegol) for Crohn's disease. The Company has a premier antibody discovery and development platform that incorporates leading antibody phage display libraries and XOMA's proprietary Human Engineering(tm) and bacterial cell expression technologies. Bacterial cell expression is a key breakthr...

Sanofi-aventis: Encouraging First-Quarter 2008 Results Further Positive Phase III Results for Eplivanserin

...ivanserin in sleep quality Filing for approval scheduled for the second half of 2008 * Agreement with Dyax on a human monoclonal antibody and on phage Display technology Confirmation of 2008 Guidance The first-quarter results support 2008 full-year guidance at constant EURO/dollar parity (1.37...

New viruses to treat bacterial diseases -- 'My enemies' enemy is my friend'

...using a virus that only attacks bacteria, called a phage and some phages only attack specific types of bac...election of the viruses by DNA analysis to utilise phage with different profiles. Using phages rather th...they are fighting the disease-causing bacteria phage based treatment has been largely ignored until rec...

Experts to Develop New Weapons Against Food Poisoning

... company like GangaGen that is at the forefront of phage technology development. Our team's researc... building a business relationship to commercialise phage technology which has been developed at the University to complement the existing phage expertise of GangaGen. This is part of the Univers...

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Phage in Medical Technology

Pieris Reports Development Progress for Anticalin(R) PRS-050, a Next Generation VEGF Antagonist

...roject Management Angiogenesis. Kristian Jensen joins Pieris from Merck Serono, where he spent almost three years establishing and managing its phage display antibody facility in Geneva, Switzerland. Prior to Merck Serono, he obtained his research management experience during four years as Group Lea...

MicroPhage Successfully Completes Beta Trial for Rapid MRSA Test

...sample is challenged with an antibiotic. Because phages depend on host bacteria for growth, any compound that kills or inhibits the microbe will stop phage growth. Only resistant strains allow multiplication of phages and yield a positive signal on the detector strip. Further information about the techno...

Athera Biotechnologies and Dyax Announce a Collaboration to Discover and Develop Antibodies for Cardiovascular Inflammation

... Athera has identified an exciting potential opportunity for therapeutic antibody treatment of cardiovascular inflammation." "The strength of Dyax's phage display technology, screening capabilities and expertise in drug discovery make them an excellent partner to advance our cardiovascular research progr...

Viral Enzyme Recruited in Fight Against Ear Infection

...lled phages to break out of bacteria they infect by using a special enzyme to destroy the cell walls. The success of the new treatment, which uses a phage enzyme called lysin to kill S. pneumonia, suggests that the strategy could significantly reduce the incidence of acute otitis media in the United Stat...

Preclinical Data on Cytogen's Technology to be Reported at the AACR Annual Meeting

... 8:00 AM -12:00 PM Abstract #645: Studies with long random phage libraries: Epitope-specific peptides recapitulate antibody complement...LGA) nanoparticles coated with active-transport peptides derived from phage libraries. The abstracts are available and can be viewed on-line at no ch...

DX-88 for Hereditary Angioedema Meets Primary and Secondary Endpoints in Phase 3 Trial (EDEMA3)

...(CTS), including CABG and heart valve replacement or repair procedures. Dyax identified DX-88 and other compounds in its pipeline using its patented phage display technology, which rapidly selects compounds that bind with high affinity and specificity to therapeutic targets. Dyax leverages this technolog...

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Phage in Biological News

The connector rotation hypothesis? Phage do not pack their DNA by rotation

The life cycles of many viruses include a self-assembly stage in which a powerful molecular motor must pack the DNA genome into the virus's preformed shell (the capsid). How it manages this intricate feat has been subject to debate, but we know that the DNA passes into the capsid shell through a ch...

Pitt phage hunter takes on tuberculosis

One third of the world's people are infected with tuberculosis, and someone new is infected every second. TB is notoriously hard to treat, requiring a course of multiple antibiotics over six to nine months. Many people don't complete the full course of treatment, which leads to increasing antibioti...

Basis for DNA ejection from single phage particles

Studying phage, a primitive class of virus that infects bacteria by injecting its genomic DNA into host cells, researchers have gained insight into the driving force behind this poorly understood injection process, which has been proposed in the past to occur through the release of pressure accumul...

Einstein and Pitt researchers develop new TB test that will dramatically cut diagnosis time

...P) implanted in their genome. Bacteriophages spread by injecting their DNA into bacterial cells. In this case, the GFP gene accompanies the DNA of the phage into the Mycobacterium tuberculosis cell, the bacterium that causes TB, causing the cell to glow. A clinician could detect the glow with equipment ...

Scientists identify human monoclonal antibodies effective against bird and seasonal flu viruses

... medical conditions or advanced age, could all benefit from this new type of therapy." In the study, the team of scientists used a human antibody phage display library to identify 10 mAb that bind to the stem of H5 type HA, the influenza protein responsible for viral entry into the host cell. The scie...

Scientists identify human monoclonal antibodies effective against bird, seasonal flu viruses

...ng medical conditions or advanced age, could all benefit from this new type of therapy." In the study, the team of scientists used a human antibody phage display library to identify 10 mAb that bind to the stem of H5 type HA, the influenza protein responsible for viral entry into the host cell. The scie...
Phage in Biological Technology

Peregrine Pharmaceuticals Licenses Anti-VEGF Antibodies to Affitech

...omising clinical data." Commenting on the licensing agreement, Dr. Achim Kaufhold, chief executive officer of Affitech, said, "Using advanced phage display technologies, Affitech successfully identified fully human, potent and selective anti-VEGF antibodies as part of a previous research and devel...

TechConnect World Publishes Conference Agenda Featuring More than 2,700 Presentations Addressing Nano, Bio and Clean Technologies

... Medical & Biotech Track - focusing on cancer research; drug delivery; nano medicine; Bio-nano materials; biosensors & diagnostics; phage engineering, and other topics. Business & Strategy Track - addressing novel products, investments & business; education & poli...

Frost & Sullivan Recognizes ESBATech's Innovation in Developing Antibody Fragments for Biologic Therapeutics

...able-antigen independent screening platform, Immuna(R), for selecting and optimizing highly-stable, single-chain antibody fragments (scFv) without any phage display." ESBATech's successful screening and characterization of all 1.5 million naturally occurring antibody fragment frameworks resulted in hi...

Calvert Research and Auburn University Announce Joint Venture

... pharmaceutical nanocarriers, such as liposomes, with breast tumor-specific phage proteins may significantly enhance their anti-cancer activity. "This p...Dr. Petrenko said. "Their experts first recognized that the merging of phage nanobiotechnology developed at Auburn with genomics can contribute vigorous...

Using living cells as nanotechnology factories

...emical methods to copy branched DNA structures, and there has also been significant work in using long-stranded DNA sequences replicated from cells or phage viruses to scaffold short helper DNA sequences to form 2-D or 3-D objects," said Yan, who is also a professor in the Department of Chemistry and Bioch...

Strategic Diagnostics Reports Fourth Quarter and Full-Year Financial Results

...ol producing plants for further testing. The Company's joint development program with POET Energies has been suspended. "We remain excited about our phage technology and confident it can bring significant value to the industrial bio-fermentation industry," Mr. Knight commented. "We are considering severa...
Phage in Biological Products

T7 Phage Capture Plate from Novagen

Description: The T7 Phage Capture Plate is a 96-well ELISA-compatible plate (containing 12 x 8-well strips) on which the T7 Tail Fiber Monoclonal Antibody is immobilized by a method that retains maximal binding activity. The antibody specifically recognizes the tail fiber protein of the T7 bacteriophage. This 8...
Company:Novagen

Kilo Sequencing Deletion Kit from Takara Mirus Bio

Description:... The Deletion Kit for Kilo-Sequencing is designed to aid sequence analysis of long DNA fragments cloned into the multiple cloning sites (MCS) of M13 phage vectors (mp18/19) or pUC-related plasmid or phagemid vectors (pUC18/19). The kit is used to create nested unidirectional deletions in the target DNA, ...
Company:Takara Mirus Bio

pCITE-2a(+) DNA from Novagen

Description:... I and Xcm I sites. Subtract 5 bp from all sites beyond Msc I at 522. The f1 origin in pCITE-2a-c(+) vectors is oriented so that infection with helper phage wil produce virions containing single stranded DNA that is complementary to the strand shown on the vector map. Therefore, single stranded sequencing ...
Company:Novagen

pWEB::TNC Deletion Cosmid Transposition Kit from EPICENTRE Biotechnologies

Description:...rized and dephosphorylated pWEB::TNC Cosmid Vector, packaged using ultra-high efficiency MaxPlax™ Lambda Packaging Extracts (>10 9 pfu/ m g for phage lambda), also in the kit, and plated on the supplied EPBOS™ plating cells....
Company:EPICENTRE Biotechnologies

General DNA Sequencing Services from Polymorphic DNA Technologies, Inc.

Description:...ely linked SNP scoring. Our service is also ideal for any short read DNA sequencing application such as bacterial or viral typing (research use only), phage display, confirmation sequencing etc. Our service can also accommodate primer walking projects. For confirmation sequencing, if a reference sequence i...
Company:Polymorphic DNA Technologies, Inc.

TypeOne Restriction Inhibitor from EPICENTRE Biotechnologies

Description:...des a powerful method for increasing transformation efficiencies in bacterial strains with type I R-M systems. Developed as a unique preparation of a phage protein called "ocr", TypeOne Inhibitor is readily electroporated into cells along with transforming DNA. In vivo the protein acts as a molecular de...
Company:EPICENTRE Biotechnologies

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Phage in Biological Definition

Phage

A phage (also called bacteriophage ) (in Greek phageton = food/consumption) is a small virus that infects only bacteria . Like viruses that infect eukaryotes , phages consist of an outer protein hull and the enclosed genetic material (which consists of double-stranded DNA in 95%...

Lambda phage

Enterobacteria phage λ ( lambda phage ) is a temperate phage that lives in E. coli . Once the phage is inside its host , it may integrate itself into the host's DNA . In this state, λ is called a prophage and stays resident within the host's genome , without causing it ...

Antibiotic resistance

...otics 3.1 Prevention 3.2 Vaccines 3.3 phage therapy 4 See also 5 External links ...ting of more effective vaccines is under way. phage therapy phage therapy is a more recent alternative that can cop...

Bioinformatics

...hy 6 External links Major research areas Sequence analysis Main articles: Sequence alignment , Sequence database Since the phage Φ-X174; was sequenced in 1977 , the DNA sequence of more and more organisms is stored in electronic databases. These data are analyzed to de...

Bioinformatics

...hy 6 External links Major research areas Sequence analysis Main articles: Sequence alignment , Sequence database Since the phage Φ-X174; was sequenced in 1977 , the DNA sequence of more and more organisms is stored in electronic databases. These data are analyzed to de...

Hershey-Chase experiment

... of phages and, ultimately, of all organisms. A phage is a small virus that infects bacteria . It con...n coat that encloses the genetic material. When a phage infects a bacterium, it inserts its genetic materi...both experiments, bacteria were separated from the phage coats by blending followed by centrifugation . In...
Phage in Biological Dictionary

Phage

A bacteriophage is any one of a number of viruses that infect bacteria. Bacteriophages are among the most common organisms on Earth. The term is commonly used in its shortened form, phage . Phage therapy is the therapeutic use of bacteriophages to treat pathogenic bacterial infections. ...

Lambda phage

Lambda phage is a virus particle consisting of a head, containing double ... The repressor found in the phage lambda is a notable example of the level of ... lambda phage DNA is either linear, circular, or concatenated. ... Lambda phage concatemers are used as size m...

Shotgun cloning

... DNA. It involves taking the DNA to be cloned and cutting it either using a ... ... of genomic DNA libraries, shotgun cloning , construction of phage display ... Random, double-stranded cleavage of any DNA for shotgun cloning ... Genetics News Genetic Online Research Shotgun -method Job C...

Repressor

...f repressor from the Merriam-Webster Online Dictionary with audio pronunciations, thesaurus, Word of the Day, and word games. Isolation of Lambda phage Repressor ... No one, however, had isolated the repressor nor did they know any of its physical properties. ... Lac Repressor Binding to DNA....

Prophage

... A prophage is a phage genome inserted as part of the linear structure... the DNA chromosome of a bacterium. A temperate phage integrated into the host chromosome or existi...n episome. A bacterial ... A prophage is the phage DNA in its dormant state, and is either integrate...

Phagemid

...ector developed as a hybrid of the filamentous phage M13 and plasmids to produce a vector that can g...ector developed as a hybrid of the filamentous phage M13 and plasmids to produce a vector that De...e phagemid pG8H6 (10) was used to construct the phage display library. ... After incubation overnight, ...

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