Identified Protein To Inhibit Cell Migration
CIB1 plays a prominent role in the activation of pak1
and potentially may be another important player in...regulation of this kinase. The other activators of pak1
include relatives of the notorious Ras family of t...ing the role that CIB1 plays in cell migration and pak1
activation, the authors used a new method known as...
A step forward in virology
...ach one of the suspected proteins to examine their function,and narrowed the vast number of proteins down to 140 potential culprits. The enzyme kinase pak1
turned out to be an especially helpful citizen of Troy. Without PAK1, the pathogens trick did not work and the cell did not form any evaginations. ...
Fox Chase researchers discover a method for clamping down on a cancer-promoting enzyme
...now identified a molecule capable of shutting down pak1
before the enzyme becomes active. Previous studies have linked pak1
activity with breast cancer and have shown the enz...e molecule is capable of blocking signaling by the pak1
Previous work suggested that hyperact...
Protein found that slows hepatitis C growth in liver cells
...ition to presenting the researchers?discovery that pak1
controls the rate at which hepatitis C virus repli...er describes the biochemical pathways that lead to pak1
activation and the specific mechanisms by which pak1
interferes with the ability of hepatitis C to hija...
Pak1 expression increases tamoxifen resistance in breast cancer patients
...iversity in Malmö, Sweden, and colleagues examined pak1
expression in 403 premenopausal women with breast ...ent. The authors examined whether tumor levels of pak1
were associated with the women's chances of breast...xifen therapy.
The authors found that increased pak1
expression was associated with increased resistanc...
UNC scientists discover new role for protein as fundamental inhibitor of cell movement
... "CIB1 plays a prominent role in the activation of pak1
and potentially may be another important player in...his kinase," she added.
The other activators of pak1
include relatives of the notorious Ras family of t...s different from these GTPases.
"CIB1 activates pak1
before Rac and Cdc42," said Dr. Leslie V. Parise, ...