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Pak1 in Medical News

Identified Protein To Inhibit Cell Migration

... CIB1 plays a prominent role in the activation of pak1 and potentially may be another important player in...regulation of this kinase. The other activators of pak1 include relatives of the notorious Ras family of t...ing the role that CIB1 plays in cell migration and pak1 activation, the authors used a new method known as...
Pak1 in Biological News

A step forward in virology

...ach one of the suspected proteins to examine their function,and narrowed the vast number of proteins down to 140 potential culprits. The enzyme kinase pak1 turned out to be an especially helpful citizen of Troy. Without PAK1, the pathogens trick did not work and the cell did not form any evaginations. ...

Fox Chase researchers discover a method for clamping down on a cancer-promoting enzyme

...now identified a molecule capable of shutting down pak1 before the enzyme becomes active. Previous studies have linked pak1 activity with breast cancer and have shown the enz...e molecule is capable of blocking signaling by the pak1 pathway. Previous work suggested that hyperact...

Protein found that slows hepatitis C growth in liver cells

...ition to presenting the researchers?discovery that pak1 controls the rate at which hepatitis C virus repli...er describes the biochemical pathways that lead to pak1 activation and the specific mechanisms by which pak1 interferes with the ability of hepatitis C to hija...

Pak1 expression increases tamoxifen resistance in breast cancer patients

...iversity in Malmö, Sweden, and colleagues examined pak1 expression in 403 premenopausal women with breast ...ent. The authors examined whether tumor levels of pak1 were associated with the women's chances of breast...xifen therapy. The authors found that increased pak1 expression was associated with increased resistanc...

UNC scientists discover new role for protein as fundamental inhibitor of cell movement

... "CIB1 plays a prominent role in the activation of pak1 and potentially may be another important player in...his kinase," she added. The other activators of pak1 include relatives of the notorious Ras family of t...s different from these GTPases. "CIB1 activates pak1 before Rac and Cdc42," said Dr. Leslie V. Parise, ...
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