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Paclitaxel in Medical News

Fox Chase finds that lung cancer patients respond to erlotinib following cetuximab therapy

...reatment and clinical outcomes for a subgroup of patients who had participated in a Fox Chase clinical trial that tested a combination of carboplatin, paclitaxel and cetuximab as first-line treatment for advanced non-small cell lung cancer. Out of 53 patients who had participated in that trial, the investigator...

Amgen's Second Quarter 2009 Adjusted Earnings Per Share Increased 13 Percent To $1.29

...12 or 13. Motesanib: The Company indicated that enrollment has resumed for the Phase 3 MONET1 trial evaluating motesanib in combination with paclitaxel and carboplatin for the first-line treatment of advanced non-small cell lung cancer (NSCLC). The Company also noted that the data from Phase 2 study e...

Nexavar in Combination with Chemotherapy Shown to Extend Progression-Free Survival in Patients with Advanced Breast Cancer

... settings for patients with breast cancer. Among these trials are three ongoing randomized Phase 2 studies, including a trial to evaluate Nexavar plus paclitaxel in the first-line setting, a trial to evaluate Nexavar plus gemcitabine or capecitabine in the first- or second-line setting following progression on ...

Peregrine Pharmaceuticals Reports Financial Results for Fiscal Year 2009

...a Phase II trial evaluating bavituximab in combination with carboplatin and paclitaxel in advanced breast cancer patients, nine of 14, or 64% of evaluable patient...a Phase II trial evaluating bavituximab in combination with carboplatin and paclitaxel in non-small cell lung cancer (NSCLC) patients with locally advanced or met...

Abbott and Oasmia Pharmaceutical Announce Exclusive Distribution Agreement for Paccal(R) Vet, a New Chemotherapeutic Agent for Dogs

... formulation of the active ingredient paclitaxel. paclitaxel has been used in treating cancer in humans since 1993. Traditional formulations of paclitaxel were insoluble in water, thus requiring the medica...7, Oasmia developed a water soluble formulation of paclitaxel (Paccal(R) Vet), that does not require premedicati...

European Medicines Agency (EMEA) Approves Cell Therapeutics, Inc.'s September Meeting Request to Discuss OPAXIO(TM) Marketing Authorization Application

...nside the tumor cell, enzymes metabolize the protein polymer, releasing the paclitaxel chemotherapy. Preclinical and clinical studies support that OPAXIO metaboli...ells may be influenced by estrogen, which could lead to enhanced release of paclitaxel and efficacy in women with lung cancer compared to standard therapies. ...

Abbott Initiates Trial of Next-Generation XIENCE PRIME(TM) Drug Eluting Stent, Building Upon Superior Outcomes from SPIRIT Family of Trials

... technology to clinicians and their patients." In the SPIRIT family of trials, XIENCE V demonstrated superiority to Boston Scientific's TAXUS(R) paclitaxel Eluting Coronary Stent System in two randomized clinical trials. In the SPIRIT II trial, XIENCE V demonstrated a statistically significant 69 percent ...

ASCO Research Foundation Grant Will Support Study of Peregrine's Bavituximab in Lung Cancer

...i-cancer effects. This new study will supplement Peregrine's Phase II clinical trial evaluating bavituximab in combination with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer (NSCLC). In the first cohort of this trial, 11 of 17 evaluable NSCLC patients, or 64.7%, achieve...

Phase 3 Trial Initiated to Evaluate Combination Therapy of Nexavar(R) and Tarceva(R) in Patients with Liver Cancer

...dvanced or metastatic NSCLC showed no clinical benefit with the concurrent administration of Tarceva with platinum-based chemotherapy (carboplatin and paclitaxel or gemcitabine and cisplatin) and its use is not recommended in that setting. In pancreatic cancer, Tarceva is indicated in combination with ge...

Drug May Extend Life When Breast Cancer Spreads

...har, who was the lead author for the study, is also a consultant to Abraxis BioScience. The chemotherapy drugs docetaxel, marketed as Taxotere, and paclitaxel are considered the gold standard for treating breast cancer that has spread to other parts of the body. Abraxane, which is a variant of paclitaxel,...
Paclitaxel in Medical Technology

New Preliminary Data from Two Studies Show Clinical Activity of Neratinib in Combination with Trastuzumab and in Combination with Paclitaxel in Advanced HER-2 Positive Breast Cancer

COLLEGEVILLE, Pa., May 29 /PRNewswire-FirstCall/ -- Wyeth Pharmaceuticals, a division of Wyeth (NYSE: WYE ), today announced preliminary data from two ongoing studies, one evaluating neratinib (HKI-272) in combination with trastuzumab (Herceptin(R), Roche) in HER-2 positive (ErbB-2 positive) bre...

New Study Shows Doxorubicin Plus Paclitaxel Followed by Weekly Paclitaxel as Adjuvant Therapy for High Risk Breast Cancer Warranted in Place of Doxorubicin Plus Cyclophosphamide Followed by Paclitaxel

22 US Oncology Affiliated Physicians Participate in ASCO Proceedings HOUSTON, June 04, 2007 /PRNewswire/ -- A leading cancer researcher affiliated with the US Oncology Research Network presented findings from a randomized, multicenter phase III trial that compared the disease-free survival (DFS) o...

OPAXIO(TM) Combined with Alimta(R) Well Tolerated in Dose-Ranging Study of Patients with Advanced Non-Small Cell Lung Cancer

...day cycles, with cohort one receiving 135 mg/m2 of paclitaxel poliglumex and 500 mg/m2 of pemetrexed, and cohort two receiving 175 mg/m2 of paclitaxel poliglumex and 500 mg/m2 of pemetrexed. None of th...ymes metabolize the protein polymer, releasing the paclitaxel chemotherapy. Preclinical and clinical studies sup...

Oncolytics Biotech(R) Inc. Announces Publication of Research on Synergistic Activity of Reovirus and Chemotherapy in NSCLC

...ctivity in 7 of 9 NSCLC cell lines examined. The combinations demonstrated strong synergistic effects on cell killing. The combination of reovirus and paclitaxel was invariably synergistic in all cell lines tested, regardless of their level of sensitivity to either agent. The investigators concluded that the ...

Peregrine Pharmaceuticals Highlights Promising Early Data From Its Three Phase II Bavituximab Cancer Trials

... II trial evaluating bavituximab in combination with carboplatin and paclitaxel in non-small cell lung cancer (NSCLC) patients with locally advanced... II trial evaluating bavituximab in combination with carboplatin and paclitaxel in advanced breast cancer patients, nine of 14, or 64% of evaluable ...

Paclitaxel Poliglumex (OPAXIO(TM)) Added to Cisplatin and Radiation Produces 45% Pathologic Complete Remissions in Patients With Esophageal Cancer

...al studies have demonstrated that, unlike standard paclitaxel and other chemotherapeutic agents that enhance rad... no evidence of distant metastasis received weekly paclitaxel poliglumex (50mg/m2) and cisplatin 25mg/m2 for six...hors concluded that these preliminary data suggest paclitaxel poliglumex may provide enhanced radiation sensitiz...

Study Showed Lilly's GEMZAR(R) (gemcitabine HCl for injection) Improved Progression-Free Survival in Cervical Cancer Patients

...ma of the pancreas. GEMZAR is also indicated for patients previously treated with 5-FU (another type of chemotherapy). GEMZAR in combination with paclitaxel is approved by the FDA for the first-line treatment of patients with metastatic breast cancer after they have received another type of chemotherapy ca...

Agennix Receives Fast Track Designation From FDA for Talactoferrin in Combination With Sunitinib for Renal Cell Carcinoma

...s. Newly diagnosed patients with Stage IIIB/IV NSCLC will be randomly assigned (1:1) to receive standard first-line chemotherapy with carboplatin and paclitaxel plus either oral talactoferrin or placebo. Agennix has received Fast Track designation from the FDA for both NSCLC indications as well as favorable S...

Boston Scientific Launches Third-Generation Platinum Chromium Drug-Eluting Stent

...d to begin in 2010. This DES employs the Labcoat technology, which has an ultra thin biodegradable abluminal polymer that delivers a very low dose of paclitaxel to the wall of the treated vessel, and no polymer or drug on the inner surface of the stent. Integrating the Element Stent architecture and a platinu...

Journal of American College of Cardiology Article Reports Fewer Repeat Procedures With Boston Scientific's TAXUS(R) Liberte(R) Stent

...nt with our own clinical trial observations, including recently published ARRIVE and ATLAS data, and may reflect the different mechanism of action for paclitaxel compared to the 'olimus agents used in the other drug-eluting stents. The newer and thinner-strut TAXUS Liberte Stent performed better than the TAXUS...
Paclitaxel in Medical Products

CoStar Paclitaxel-eluting Coronary Stent System

Description:... BIOTRONIK AG will be the world wide sole distributor of CONOR Medsystems COSTAR paclitaxel stent. Radically different from conventional drug eluting stents, the CONOR Medsystems stent is the first non-surface-coated drug eluting stent design...
Company:Biotronik GmbH & Co.

TAXUS Express2 Monorail Paclitaxel-Eluting Coronary Stent System

Features:...form drug distribution. An Effective Drug The unique properties of paclitaxel may contribute to the efficacy of the TAXUS Stent. Paclitaxel's multi-fu...ilize microtubules and inhibit activities that contribute to restenosis. paclitaxel is highly lipophilic, which may contribute to more uniform drug distributio...
Company:Boston Scientific Corporation

TAXUS Express2 Over-the-wire Paclitaxel-Eluting Coronary Stent System

Features:...orm drug distribution. An Effective Drug The unique properties of paclitaxel may contribute to the efficacy of the TAXUS Stent. Paclitaxel's multi-f...ilize microtubules and inhibit activities that contribute to restenosis. paclitaxel is highly lipophilic, which may contribute to more uniform drug distributio...
Company:Boston Scientific Corporation
Paclitaxel in Biological News

Common chemotherapy drug triggers fatal allergic reactions

..., and were being treated with Cremophor-containing paclitaxel to prevent the cancer from coming back. Both of t... recently in Orlando, Fla. Cremophor-containing paclitaxel has been associated with hypersensitivity reaction...ent U.S. product labeling for Cremophor containing paclitaxel includes a black-box warning alerting physicians a...

New drug shows promise in treating drug-resistant prostate cancer

...nism of that relapse and to try to develop drugs that prevent that renewed resistance." For years, no treatment was available for CRPC; recently paclitaxel a strongly cytotoxic drug was approved. ...

Slipping through cell walls, nanotubes deliver high-potency punch to cancer tumors in mice

... to be highly effective delivery vehicles when the researchers attached the paclitaxel to the tips of the branches. Dai's team has found in earlier work (Proce...nd much longer than free medication would circulate. Although attaching the paclitaxel to the PEG turned out to reduce the circulation time, it proved to still be...

Death, division or cancer? Newly discovered checkpoint process holds the line in cell division

...tance of cancer cells to chemotherapies. Certain cancer drugs, such as paclitaxel and gemcitabine, exploit the mechanisms of mitosis to kill cancer cells. Although they act through very different mechanisms, both paclitaxel and gemcitabine sabotage the events monitored by the checkpoint proteins, w...

Surprising origin of cell's internal highways

...ow cancer cells invade distant tissues. Because microtubules play a central role in cell division, cancer drugs like colchicine, vincristine and paclitaxel (Taxol) can block cell division by altering microtubule dynamics. "Many classic chemotherapy strategies affect microtubules, although it's not q...

Penn researchers show how nanocylinders deliver medicine better than nanospheres

... were able sustain delivery of the anticancer drug paclitaxel to an animal model of lung cancer ten times longer... synthetic polymers to deliver the anticancer drug paclitaxel to a human lung tumor tissue implanted in mice. Th...d lengths approaching the size of blood cells. The paclitaxel shrunk the tumors and, because the cylinders remai...

Injection may prevent infertility in men receiving cancer chemotherapy

...said that his work showed for the first time that the injection of a drug that enhances the immune system could protect the testis from the effects of paclitaxel (Taxol), a widely used chemotherapy drug. "The effects of chemotherapy treatment on fertility are an important issue for long-term survivors of canc...

Nano-particles effective in killing cancer with one-two punch of chemotherapeutics

...-assembling ?the structure spontaneously forms when all of the components are suitably mixed together. "Recent studies have shown that cocktails of paclitaxel and doxorubicin lead to better tumor regression than either drug alone, but there hasn't been any carrier system that can carry both drugs as efficien...

Bevacizumab Combined With Chemotherapy Improves Progression-Free Survival for Patients With Advanced Breast Cancer

...h standard chemotherapy consisting of single-agent paclitaxel had a delay in worsening of their cancer by four m...ths, on average, compared to patients treated with paclitaxel chemotherapy alone. This difference is statistical...xel. The second group received the same regimen of paclitaxel with the addition of bevacizumab. Patients whos...

Nanoparticle Breast Cancer Drug Approved by FDA

...30 minutes. This contrasts with Taxol, in which paclitaxel is dissolved in a toxic solvent, which requires pr...e that of participants receiving the solvent-based paclitaxel injection. Without toxic solvents, Abraxane could ...o be due to preferential delivery of albumin-bound paclitaxel to cancer cells. Abraxane was developed by Amer...
Paclitaxel in Biological Technology

Oncolytics Biotech Inc. Starts Patient Enrolment in U.S. Phase 2 Clinical Trial Investigating REOLYSIN(R) in Combination with Paclitaxel and Carboplatin

CALGARY, Sept. 8 /PRNewswire-FirstCall/ - Oncolytics Biotech Inc. ("Oncolytics") (TSX:ONC, NASDAQ:ONCY) announced today that that it has started patient enrolment in a Phase 2 clinical trial using intravenous administration of REOLYSIN(R) in combination with paclitaxel and carboplatin in patie...

OncoGenex Pharmaceuticals announces out-license of TOCOSOL Paclitaxel to Eagle Pharmaceuticals

BOTHELL, WA and VANCOUVER, Sept. 2 /PRNewswire-FirstCall/ - OncoGenex Pharmaceuticals, Inc. (NASDAQ: OGXI ) ("OncoGenex" or the "Company") has announced today that it has granted to Eagle Pharmaceuticals, Inc. the exclusive worldwide rights to develop and commercialize TOCOSOL(R) Paclitaxel. ...

Oncolytics Biotech Inc. Announces U.S. Phase 2 Clinical Trial Investigating REOLYSIN(R) in Combination with Paclitaxel and Carboplatin

CALGARY, June 20 /PRNewswire-FirstCall/ - Oncolytics Biotech Inc. ("Oncolytics") (TSX:ONC, NASDAQ:ONCY) announced today that following U.S. Food and Drug Administration (FDA) review, the Company is initiating a U.S. Phase 2 clinical trial using intravenous administration of REOLYSIN(R) in comb...

Oncolytics Biotech Inc. Starts Patient Enrolment in U.K. Phase II Clinical Trial Investigating REOLYSIN(R) in Combination with Paclitaxel and Carboplatin

CALGARY, June 5 /PRNewswire-FirstCall/ - Oncolytics Biotech Inc. ("Oncolytics") (TSX:ONC, NASDAQ:ONCY) announced today that that it has started patient enrolment in a Phase II clinical trial using intravenous administration of REOLYSIN(R) in combination with paclitaxel and carboplatin in patie...

Oncolytics Biotech Inc. Announces U.K. Phase II Clinical Trial Investigating REOLYSIN(R) in Combination with Paclitaxel and Carboplatin

CALGARY, May 14 /PRNewswire-FirstCall/ - Oncolytics Biotech Inc. ("Oncolytics") (TSX:ONC, NASDAQ:ONCY) announced today that that it has received a letter of approval from the U.K. Medicines and Healthcare products Regulatory Agency (MHRA) for its Clinical Trial Application (CTA) to begin a Pha...

A Screen of shRNAs Targeting Tumor Suppressor Genes to Identify Factors Involved in Paclitaxel Sensitivity

Diana Ji, Stacy L. Deeds, and Edward J. Weinstein RNA interference methodologies have been utilized in small to large scale screening projects. The technology has allowed researchers to perform gene-silencing experiments in timeframes and target cells prev...

Angiotech Pharmaceuticals announces FDA approval of TAXUS(R) Liberte(R) Long Stent

...oval of the TAXUS Liberte Long Stent, along with the approval of the TAXUS Liberte Atom(TM) Stent in May, demonstrates the strength and breadth of the paclitaxel platform," said Dr. William Hunter, President and CEO of Angiotech. "We are pleased with the progress that Boston Scientific continues to make with TA...

Oncolytics Biotech(R) Inc. Completes Patient Enrolment in U.K. Combination REOLYSIN(R) and Paclitaxel/Carboplatin Head and Neck Cancer Trial

... Securities Exchange Act of 1934, as amended. Forward-looking statements, including the Company's expectations related to the U.K. Phase I/II REOLYSIN paclitaxel and carboplatin trial and the Company's belief as to the potential of REOLYSIN as a cancer therapeutic, involve known and unknown risks and uncertaint...

Clinical Data on Peregrine's Bavituximab Cancer Program to Be Discussed in Two Presentations at 2009 ASCO Annual Meeting

...he body's immune system to destroy the tumor and the tumor blood vessels. Bavituximab currently is in two separate Phase II trials in combination with paclitaxel and carboplatin for the treatment of advanced breast cancer and non-small cell lung cancer, and in a third Phase II trial in combination with docetaxe...

Angiotech's corporate partner, Boston Scientific, announces launch of third-generation TAXUS(R) Element(TM) Stent

...third-generation TAXUS stent demonstrates the efficacy and longevity of the paclitaxel platform in treating patients with heart disease." The platinum chromium ...ultra thin biodegradable abluminal polymer that delivers a very low dose of paclitaxel to the wall of the treated vessel, and no polymer or drug on the inner surf...
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