Drugs Activating PXR May Help In Treating Niemann-Pick type C disease
Scientists at Washington University School of Medicine in St. Louis and other institutions have reported that experimental findings suggest that drugs that activate// pregnane X receptor (PXR) my help in the treatment of Niemann-Pick type C (NPC) disease. NPC is progressive neurodegenerative disor...
JCI online early table of contents: Aug. 1, 2008
...tself regulated by the xenobiotic-sensing proteins pxr
and CAR. Developing animal models to determine the relative importance of pxr
and CAR for humans to breakdown a specific drug ha...R, mice that lacked CAR, mice that expressed human pxr
in place of mouse PXR, and mice that expressed hum...
Study identifies mechanism underlying multidrug resistance in fungi
...showed that this chemical switch also controls drug resistance in an important human pathogenic fungus, Candida glabrata. In humans, a protein called pxr
is the drug sensor that turns on genes involved in detoxifying and removing drugs from cells.
This intriguing similarity between the regulatory sw...
Treatment for cholesterol-related illnesses likely with the discovery of receptor in mice
...s it does in our diminutive counterparts. In mice, pxr
senses the presence of excess cholesterol by-produ...hat remove these toxins. The main problem with the pxr
receptors in humans is that they are not activated...lesterol.
The study suggested that harnessing pxr
could benefit people with high cholesterol worldwi...