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PXR in Medical News

Drugs Activating PXR May Help In Treating Niemann-Pick type C disease

Scientists at Washington University School of Medicine in St. Louis and other institutions have reported that experimental findings suggest that drugs that activate// pregnane X receptor (PXR) my help in the treatment of Niemann-Pick type C (NPC) disease. NPC is progressive neurodegenerative disor...

JCI online early table of contents: Aug. 1, 2008

...tself regulated by the xenobiotic-sensing proteins pxr and CAR. Developing animal models to determine the relative importance of pxr and CAR for humans to breakdown a specific drug ha...R, mice that lacked CAR, mice that expressed human pxr in place of mouse PXR, and mice that expressed hum...

Study identifies mechanism underlying multidrug resistance in fungi

...showed that this chemical switch also controls drug resistance in an important human pathogenic fungus, Candida glabrata. In humans, a protein called pxr is the drug sensor that turns on genes involved in detoxifying and removing drugs from cells. This intriguing similarity between the regulatory sw...

Treatment for cholesterol-related illnesses likely with the discovery of receptor in mice

...s it does in our diminutive counterparts. In mice, pxr senses the presence of excess cholesterol by-produ...hat remove these toxins. The main problem with the pxr receptors in humans is that they are not activated...lesterol. The study suggested that harnessing pxr could benefit people with high cholesterol worldwi...
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(Date:4/23/2014)... MD (April 23, 2014) The American Gastroenterological ... the 2014 AGA Research Scholars. The AGA Research ... investigators to develop independent and productive research careers ... Scholar Awards fund an additional year allowing for ... committed to supporting junior faculty who are paving ...
(Date:4/23/2014)... scientists led by a researcher from the Cancer Science ... of Singapore has identified the cancer specific stem cell ... possibility of developing new drugs for the treatment of ... research group, led by Dr Chan Shing Leng, Research ... time that a cancer-specific variant of a cell surface ...
(Date:4/23/2014)... endogenous neural precursor cells cannot alone compensate for ... perspective of neural plasticity, Dr. Yun Xiang and ... the effects of functional electrical stimulation treatment on ... basic fibroblast growth factor and epidermal growth factor ... The researchers found that functional electrical stimulation can ...
(Date:4/22/2014)... have characterized a set of clock genes that drive ... of species, from flies to humans. Over 15 mammalian ... are more. A team from the Perelman School of ... approaches could find them. , To accelerate clock-gene ... of Pharmacology and first author Ron Anafi, MD, PhD, ...
(Date:4/22/2014)... 2014: The Association for Molecular Pathology (AMP) released ... Molecular Diagnostics on recommendations for a molecular ... levels of education. The report was prepared by ... of the AMP Training and Education Committee. "Our ... educating future medical laboratory scientists appropriately in order ...
Breaking Medicine News(10 mins):Health News:AGA announces 2014 Class of AGA Research Scholars 2Health News:Scientists identify cancer specific cell for potential treatment of gastric cancer 2Health News:Scientists identify cancer specific cell for potential treatment of gastric cancer 3Health News:Bioinformatics profiling identifies a new mammalian clock gene 2Health News:AMP publishes curriculum recommendations for medical laboratory scientists 2
(Date:4/23/2014)... 2 million Food Standards Agency (FSA) project to map ... workers. , Norovirus outbreaks can rapidly affect large ... frozen strawberries infected 11,000 people in Germany, but there ... strains cause infection and which foods are the most ... will produce data that will help the FSA to ...
(Date:4/22/2014)... Yale researchers will lead a five-year, $3 million study ... is affecting the transport of dissolved organic matter (DOM) ... could alter the chemical composition and water quality of ... from the National Science Foundation,s MacroSystems Biology program, researchers ... watershed, which begins in Canada and runs through five ...
(Date:4/22/2014)... RIVERSIDE, Calif. Inspired by the fist-like club ... by University of California, Riverside, in collaboration with University ... design structure for composite materials that is more impact ... , "The more we study the club of this ... improve so many things we use every day," said ...
Breaking Biology News(10 mins):Connecticut River watershed study will assess impacts of extreme rain events 2Connecticut River watershed study will assess impacts of extreme rain events 3Mantis shrimp stronger than airplanes 2Mantis shrimp stronger than airplanes 3
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