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PTEN in Medical News

How does Fu-Zheng-Jie-Du-Decoction act on PTEN expression in hepatocellular carcinoma?

Many hepatocellular carcinoma (HCC) patients in China may be treated with Traditional Chinese medicine (TCM). Some say it works, others doubt its effectiveness. These stated that a research group in China had found TCM can down-regulate the expression of PTEN in HCC, which may suppress tumor cell ...

Mathematical modeling predicts response to Herceptin

... the University of Edinburgh, examined the role of pten protein expression on resistance to Herceptin. pten is a protein that acts as a tumor suppressor gene....treated with Herceptin and found that quantitative pten protein expression was a key determinant of who wo...

U-M researchers link pathway to breast cancer stem cells

..., a journal from the Public Library of Science. pten is the most frequently inactivated tumor suppresso...it is inactivated in about 40 percent of patients. pten is linked to poor outcomes and is associated with ...targeted therapies. The U-M researchers deleted pten in tumors grown in cell cultures and in mice, and ...

Research reveals molecular pathway behind invasive prostate cancers

...eous inactivation of two particular genesknown as pten and Par-4caused the rapid development of invasive ...cademy of Sciences (PNAS) the week of May 18. pten is a well-defined gene shown to be suppressed in p...study is the first to report its relationship with pten mutations and aggressive prostate cancer tumor dev...

Gene helps protect tumor suppressor in breast cancer

...l edition of Cancer Cell . Causes for diminished pten protein levels in breast cancer absent a mutation of the pten gene have eluded researchers, who knew for several...e missing link that explains how Rak can stabilize pten protein to prevent breast cancer development," sai...

Cell pathway on overdrive prevents cancer response to dietary restriction

... Using a DR-resistant tumor cell line in which the pten gene could be switched on or off, Kalaany tested whether a change in the pten gene alone could affect a tumor's sensitivity to DR. When the pten gene was turned off, the cancer cells were not aff...

2 Genes Implicated in Autism

...different candidate autism susceptibility genes -- pten and the serotonin transporter gene -- had more sev...th only a single mutation. Mice with a mutation in pten alone or in the serotonin transporter gene alone h...also found that female mice with a mutation in the pten gene had impaired sociability, and those with muta...

USC researchers identify novel approach for suppressing prostate cancer development

...rs spent more than three years monitoring prostate cancer development in animal models that had been genetically engineered to have both the GRP78 and pten tumor suppressor genes inactivated. The research was conducted by Yong Fu, a Ph.D. candidate at the Keck School of Medicine of USC and the first autho...

Beyond PTEN: Alternate genes linked to breast, thyroid and kidney cancer predisposition

...ders. Mutations of the common tumor suppressor pten are associated with most cases of CS, a poorly rec.... However, about 15% of CS patients do not exhibit pten mutations and the cause for the disorder in these ...s from CS/CS-like individuals that did not possess pten mutations for mitochondrial dysfunction. They iden...

Researchers identify promising cancer drug target in prostate tumors

...could lead to cancer. Mutations that inactivate pten -- in effect releasing the brake on growth signals...r player than p110alpha in tumors that result from pten loss," noted Zhao. "Now the drug companies, which ...ng a low-level but steady growth stimulus and when pten is lost, it becomes an important source of cell pr...
PTEN in Medical Technology

Semafore's SF1126, a Vascular Targeted Pan-PI3K/mTOR Inhibitor, Is Well Tolerated and Demonstrates Activity in Phase I Solid Tumor Patients

...elopment company focused on small molecule modulators of the PI3 kinase and pten cell signaling pathway, a promising target pathway for multiple disorders, ... and one of the first biopharmaceutical companies to focus on both PI3K and pten inhibitors. The Company has successfully discovered and is developing a po...

Clinical Data on Semafore's SF1126, a Vascular Targeted Pan-PI3K/mTOR Inhibitor, to be Presented at the 2009 ASCO Meeting

...elopment company focused on small molecule modulators of the PI3 kinase and pten cell signaling pathway, a promising target pathway for multiple disorders, ... and one of the first biopharmaceutical companies to focus on both PI3K and pten inhibitors. The Company has successfully discovered and is developing a po...

Semafore Achieves a Preclinical Milestone with SF2626, a PI3K-MEK Dual Pathway Kinase Inhibitor

... About Semafore Semafore is a clinical stage drug discovery and development company focused on small molecule modulators of the PI3 kinase and pten cell signaling pathway, a promising target pathway for multiple disorders, including the company's focus - cancer. Semafore is a leader in the develo...

SF1126, Semafore's PI3 Kinase Inhibitor, Found to Block Angiogenic Signaling From Both VEGF and Bv8 in Multiple Cell Lines

...nt." About Semafore Semafore is a clinical stage drug discovery and development company focused on small molecule modulators of the PI3 kinase and pten cell signaling pathway, a promising target pathway for multiple disorders, including the company's focus - cancer. Semafore is a leader in the develop...

Semafore Broadens Pipeline With Multi-Targeted Kinase Inhibitors

...ts." About Semafore Semafore is a clinical stage drug discovery and development company focused on small molecule modulators of the PI3 kinase and pten cell signaling pathway, a promising target pathway for multiple disorders, including the company's focus -- cancer. Semafore is a leader in the develo...

Semafore Pharmaceuticals Reports Positive Interim Results from a Phase I Study of SF1126, a Targeted Pan-PI3K Inhibitor, in Patients with Advanced Solid Tumors

...elopment company focused on small-molecule modulators of the PI3 kinase and pten cell signaling pathway, a promising target pathway for multiple disorders, ...e is one of the first biopharmaceutical companies to focus on both PI3K and pten and has successfully discovered and is developing a portfolio of drug candi...

Kosan Presents Preclinical Data on Nuclear Export Inhibitors, Novel Anticancer Agents, at AACR

...results in upregulation of p53, while only a transient upregulation of p53 is observed in normal cells exposed to NEIs. In cancer cell lines harboring pten mutations, NEI-induced nuclear entrapment of FOXO, which is regulated by the PTEN/PI3K/Akt pathway, is directly linked to the induction of apoptosis. ...

Semafore's PI3 Kinase Inhibitor SF1126 is a Vascular Targeted Conjugate in Phase I Clinical Trials in Solid Tumors and Multiple Myeloma

...elopment company focused on small molecule modulators of the PI3 kinase and pten cell signaling pathway, a promising target pathway for multiple disorders, ...e is one of the first biopharmaceutical companies to focus on both PI3K and pten and has successfully discovered and is developing a portfolio of drug candi...

Semafore's SF1126 Exhibits Antitumor and Antiangiogenic Activity

...elopment company focused on small molecule modulators of the PI3 kinase and pten cell signaling pathway, a promising target pathway for multiple disorders, ...e is one of the first biopharmaceutical companies to focus on both PI3K and pten and has successfully discovered and is developing a portfolio of drug candi...

Semafore's PI3 Kinase Inhibitor SF1126 is Active Against Tumor and Tumor Cells and Synergizes with Standard Chemotherapy Agents

...fects. About Semafore Semafore is a clinical stage drug discovery and development company focused on small molecule modulators of the PI3 kinase and pten cell signaling pathway, a promising target pathway for multiple disorders, including the company's focus--cancer. Semafore is one of the first biophar...
PTEN in Medical Dictionary

Proteus Syndrome

.... Find out more about the rare condition called Proteus syndrome . ... When an individual with Proteus syndrome is found to have a germline pten ... ...
PTEN in Biological News

New insights into the regulation of PTEN tumor suppression function

BOSTON -- The PTEN tumor suppressor gene controls numerous biological processes including cell proliferation, cell growth and death. But PTEN is frequently lost or mutated; in fact, alteration of the gene is so common among various types of human cancer that PTEN has become one of the most frequen...

Johns Hopkins scientists pull protein's tail to curtail cancer

...o acids act to "glue" the tail back to the body of pten and prevent the attachment of pten to the membrane. By genetically removing PTEN's ta...they cannot be modified, the researchers persuaded pten to move to the cell membrane where it goes about i...

Flatworm helps researchers study stem cells and cancer

...ly mutated genes in human cancer. They found that pten was present in many planaria cell types, including stem cells. Additionally, disruption of pten pathways in the cell resulted in abnormal growths,...ally, death. This research demonstrates that pten is not only important to cell proliferation in mam...

TG2 identified as potential therapeutic target in chemo-resistant ovarian cancer

... TG2 overexpression causes the degradation of the tumor-suppressing protein pten in pancreatic cancer, Mehta and colleagues reported in Clinical Cancer Research in April. With pten out of the picture, pancreatic cancer is protected from a separate type of ...

Evidence now suggests eating soy foods in puberty protects against breast cancer

... Other associated research has found that the genes that genistein appears to activate in developing mammary glands are well known --- BRCA1, p53, and pten tumor suppressors, Hilakivi-Clarke says. These genes repair genetic damage and control cell survival and death, and they may also help control stem ce...

New study reveals for first time how BRCA1 mutations cause breast cancer

...ed with very poor prognoses. Now that we know that pten is involved, we finally have a target for therapy ... cancer, as well as in brain and prostate cancers. pten is now recognized to be mutated in about 30 percen...ost mutated gene in cancer after p53. Knocking out pten sends a strong pro-growth signal on tumor cells. T...

Linheng Li Lab documents the development of cancer stem cells

...ion of beta-catenin -- including Serine552. "We found that a loss of pten in intestinal epithelial cells accompanied by a loss of pten in stromal cells can lead to changes that may increase the number of stem c...

Mutant mice show key autism traits

...e aspects of ASD that are not recapitulated in the pten mutants. For example, the pten mutants do not display the expression of abnormal ...ote, "as appropriately pointed out by the authors, pten deletion is restricted to postmitotic neurons in t...

PTEN: the Treg's handbrake

...ed their suppressive function in vitro and in vivo, indicating that loss of pten by Tregs only affects their proliferative capabilities in response to IL-2 and not their other functions. These results identify pten as a key protein that regulates the lack of responsiveness of Tregs to IL-2...

Scientists discover a genetic switch that links animal growth and cancer

...rchers discovered that a tumor suppressor known as pten also functions to keep the animal in a waiting sta...lt switch is controlled by PTEN. When the gene for pten is defective, the animals attempt to grow and beco...ayers," said Rothman. The research team found that pten functions with two other proteins –?known as prote...
PTEN in Biological Technology

Semafore to Present at BIO CEO & Investor Conference

...elopment company focused on small molecule modulators of the PI3 kinase and pten cell signaling pathway, a promising target pathway for multiple disorders, ...e is one of the first biopharmaceutical companies to focus on both PI3K and pten and has successfully discovered and is developing a portfolio of drug candi...
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(Date:9/18/2014)... proven it true: exercise is good for you. But ... exercise may have an added benefit for cancer patients ... model of melanoma, found that combining exercise with chemotherapy ... Libonati, an associate professor in the School of Nursing ... Nursing Research, was the senior author on the study, ...
(Date:9/18/2014)... Lambertville, NJ (PRWEB) September 18, 2014 ... consulting firm, announced today that President and co-founder ... Business Journal’s Innovation Award Winners for 2014, recognizing ... naming him as an emerging executive of the ... health care and life sciences that continue to ...
(Date:9/18/2014)... Ben Quirk, CEO of Quirk Healthcare ... Award by the Savannah Science Seminar in recognition for ... the nation and especially in Savannah. , “I am ... “The Savannah Science Seminar is an amazing program that ... have gone through the program,” he added. Eleventh graders ...
(Date:9/18/2014)... group of international scientists have developed a new method ... here . , The Wildlife Conservation Society (WCS)-led research, ... Diseases , describes the use of fecal samples from ... been exposed to the virus. This represents a new ... potentially change the way Ebola virus is studied and ...
(Date:9/18/2014)... The National Institutes of Health (NIH) recently awarded ... million grant to the Los Angeles Biomedical Research Institute ... of a vaccine to protect patients from the healthcare-related ... (MRSA). , The National Institute of Allergy ... grant to LA BioMed infectious disease specialists John E. ...
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