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PPAR in Medical News

InteKrin Therapeutics Announces Appointment of Geoffrey M. Parker as Chief Business Officer

... providing powerful glucose control and durability of effect. As a SPPARM, INT131 selectively modulates PPAR-gamma, thereby enabling the separation of ppar gamma anti-diabetic efficacy from the well recognized TZD side effects. About InteKrin ( www.InteKrin.com ) InteKrin Therapeutics is a...

InteKrin Therapeutics Announces INT131 Phase 2a Results at the 2009 American Diabetes Association Annual Meeting

...ng the typical side effect profile." "Translation of the nonclinical profile of INT131 into the clinic is an exciting validation of the selective ppar modulator design of the molecule," added Dr Linda Higgins, Chief Scientific Officer of InteKrin Therapeutics. "INT131 retains or exceeds TZD potency ...

Roche to Commence Phase III Trials with Innovative Treatment Designed to Lower Cardiovascular Risk in Diabetes Patients with Recent Heart Attack

...cal investigations for aleglitazar, its innovative ppar co-agonist R1439 which is uniquely designed to red...tionally designed molecule providing balanced dual ppar alpha/gamma activation. Specifically, it combines ...y (and therefore glycemic control) associated with ppar gamma activation, with improved management of dysl...

New Diabetes Drug Shows Promise in Trial

...r another experimental diabetes drug, aleglitazar. That trial assessed the safety and effectiveness of the drug, one of a class of medications called ppar co-agonists that affect both blood sugar control and fat. In the 16-week trial, 332 patients with type 2 diabetes received either once-daily doses...

Policy experts urge scrutiny of senior tax breaks

...the tax treatment of older people is clearly worth a careful review," said ppar Editor Robert Hudson, PhD. The new ppar devotes four articles to addressing the twin questions of how tax codes di...

Penn scientists map molecular regulation of fat-cell genetics

...ty," says Lazar. The master molecule is called ppar gamma, a gene regulator that is also the target of...tidiabetic drugs, which include Actos and Avandia. ppar gamma binds directly to DNA, regulating the produc...mmended as a first-line therapy. The drugs bind to ppar gamma in the nucleus of fat cells, which affects t...

InteKrin Therapeutics Announces $20 Million Series C Financing

...opment of INT131, a non-TZD selective modulator of ppar gamma (SPPARM) for treatment of Type II diabetes (...d its demonstrated ability to selectively modulate ppar gamma promises to deliver to patients glucose lowe...istic TZD adverse effects while retaining powerful ppar gamma anti-diabetic efficacy, and represents a new...

New potential drug target for the treatment of atherosclerosis

...inflammation and high blood pressure. We show that ppar delta offers a kind of genetic shortcut around eac... Lee. Like the Yin and Yang of fat metabolism, ppar delta the focus of the current study and its counterpart ppar gamma control the storage and burning of fat....

InteKrin Therapeutics, Inc. Appoints Former Amgen Clinical Development Executive Chief Medical Officer

...ptors and metabolism, top scientists formerly with the Food and Drug Administration and key clinical and commercialization leaders who brought earlier ppar agonists to market. InteKrin's lead therapeutic candidate, INT131, is a potent non-TZD SPPARM (Selective Peroxisome Proliferator-Activated Receptor M...

Fat Screen Delivers Plant-derived Chemical With Antidiabetic Effects

...mination were manipulated such that they literally lit up when fat-boosting ppar became active. Further study of harmine's effects in diabetic mice fou...roundabout than, the predominant antidiabetes drugs. Rather than triggering ppar directly, the chemical blocks a pathway that normally inhibits fat cells' p...
PPAR in Biological News

Quails get super fit by simply eating omega-3 diet

...me levels, known as PPAR, Weber could not find any evidence for a change in ppar gene expression in response to the 6 week diets. However, he adds that it does not mean that ppar levels do not change earlier to influence the bird's performance during the...

Pulmonary hypertension in children may result from reduced activity of gene regulator

...they are right, drugs already under study to boost ppar signaling in adults with lung injuries, may help t...essentially identical to humans, agonists to boost ppar activity prevent the usual endothelial dysfunction...rs in the first few weeks after birth. Conversely, ppar antagonists cause endothelial dysfunction without ...

Scientists from Granada find a potential treatment to prevent diabetes and obesity

...al for diabetics". In addition, according to Mesa, "interleukin-6 also increased the expression of important genes related to fats metabolism, such as ppar and UCP2. This suggests that interleukin-6 could be involved in the metabolic control of body weight". However, Vitagenes has also reported that this...

A cherry on top: Tart cherries may alter heart/diabetes factors

... livers of the rats, and the genetic expression of ppar (peroxisome proliferator-activating receptor) in t...nd Type 2 diabetes. Meanwhile, the measure of ppar messenger RNA in the liver reflects the readiness of the liver tissue to express functional PPAR. ppar is important to the process by which the body burn...

Insulin receptor stops progression of Alzheimer's disease

...mer's disease (AD). They found that an agonist for ppar delta, a receptor that is abundant in the brain, h... then administered treatment with three classes of ppar agonists ?alpha, gamma and delta. All are found in...s and organs in the body, including the brain, and ppar gamma is already FDA approved as a treatment for T...
PPAR in Biological Technology

InteKrin Therapeutics to Present at the 27th Annual JP Morgan Healthcare Conference on Tuesday, January 13

...ecular design effort to address the problematic safety concerns of TZD full ppar agonists Actos(R) (pioglitazone) and Avandia(R) (rosiglitazone), which whil...TZDs, INT131 was specifically selected for its ability to separate powerful ppar anti-diabetic efficacy from these serious TZD side effects. INT131 i...

Pharmacopeia Announces Management Team Changes

...well as extensive interaction with the Food and Drug Administration, including leadership of the team responsible for the NDA for muraglitazar, a dual ppar agonist. Dr. Kimball has served as Senior Vice President, Chemistry and Preclinical Chemical Development since September 2007. Previously, he served...
PPAR in Biological Dictionary

N Terminus

...s : Ala 20/Ala 157, 2 miles N of ... S terminus moved to exit 176, I-65, 5 miles N of Montgomery(1983) ... For example, the N terminus of ppar confers the ability to promote adipocyte ... Swapping the DBD along with the N terminus (DBD-/ and DBD-/) has no additional ... Functional anta...
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