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PNAS in Medical News

Breakthrough model for human cancer may improve development of cancer drugs; study in PNAS

CAMBRIDGE, Mass., April 6, 2009 AVEO Pharmaceuticals, Inc., a biopharmaceutical company leveraging breakthrough discoveries in cancer biology to discover, develop and commercialize targeted oncology therapies, today announced findings from its novel human-in-mouse (HIM) cancer model system, in wh...

Researchers effectively treat tumors with use of nanotubes

...percent of mice. Researchers say that the finding suggests a potential future cancer treatment for humans. The study appears in the August issue of pnas ( Proceedings of the National Academy of Sciences ). It is the result of a collaborative effort between Wake Forest University School of Medicine, the...

RevGenetics Releases Its New Science-Based Telomere Health Supplement Formulation for DNA and Chromosome Health

...hael P. Manns, Hartmut Hecker, Arnold Ganser, Konstanze Dohner, Andrzej Bartke, Christoph Meissner, Harald Mischak, Zhenyu Ju, and K. Lenhard Rudolph, pnas August 12, 2008 vol. 105 no. 32 11299-11304 ** these statements have not been evaluated by the Food and Drug Administration. This product is not ...

Study reveals current multi-component vaccines may need reworking

...nating their ability to provide protection, according to an article to be published shortly in the Proceedings of the National Academy of Sciences ( pnas ). The authors also suggest, and successfully test, techniques that offer a solution to newly revealed mechanisms that enable some vaccine components ...

Scripps research scientists model 3D structures of proteins that control human clock

... In an Early Edition issue of The Proceedings of the National Academy of Sciences ( pnas ) on April 9, 2009, the researchers report that they have been able to determine the molecular structure of a plant photolyase protein that is surpris...

Pitt, Berkeley researchers reconstruct seashells to model nervous system function

...d online April 7 in the Proceedings of the National Academy of Sciences ( pnas ). G. Bard Ermentrout, a University Professor of Mathematics at Pitt, w...mbination of sensory information and past experience, the team reported in pnas . The project was supported by the National Science Foundation. "These m...

Scripps research scientists engineer new type of vaccination that provides instant immunity

...ia, cancers, and even virulent toxins. The work is being published in the Early Edition of the Proceedings of the National Academy of Sciences ( pnas ) the week of March 2, 2009. The team, led by Scripps Professor Carlos Barbas, III, Ph.D., tested the vaccination method called covalent immunizat...

Technique May Let More Women Use Tamoxifen

...the paper, has filed a patent for the effects of the Foxy-5 peptide on estrogen receptors. In related research, another study in the same issue of pnas found that a protein called lipocalin 2 can indicate how invasive a breast cancer is likely to be. Better yet, levels of the protein can be measured...

PNAS announces 2008 Cozzarelli Prize recipients

...Proceedings of the National Academy of Sciences ( pnas ) Editorial Board has selected six pnas papers for the 2008 Cozzarelli Prize, an award th... from nearly 3,500 research articles published by pnas in 2008 and represent the six broadly defined cla...

Innovative method to starve tumors

...rocess, which may translate into future therapies. These findings were published this week in the Proceedings of the National Academy of Sciences ( pnas ). An innovative method According to the researchers, tumour cells can release "bubbles" called microvesicles, which allow the tumours to commun...
PNAS in Medical Technology

Inverseon's Founder and SAB Member Published in PNAS

SAN FRANCISCO, Feb. 19 /PRNewswire/ -- Inverseon, Inc. ( http://www.inverseon.com ) announces the publication in the February 17, 2009 issue of the Proceedings of the National Academy of Sciences (PNAS) entitled, "Beta2-adrenoceptor signaling is required for the development of an asthma phenotype ...

Protein Tomography(TM) Reveals Molecular Mode of Action of Humax-EGFr Published in PNAS

STOCKHOLM, April 22 /PRNewswire/ -- - Summary: Using Protein Tomography(TM), Sidec Investigated in Collaboration With Genmab the Molecular Mode of Action of Humax- EGFr (Zalutumumab). In This Study Sidec Showed That EGFr is Flexible and That Zalutumumab Locks the EGFr Into a Very Compact Ina...

Genmab A/S - Company Announcement: Novel Insights into HuMax-EGFr Mechanisms of Action Published in PNAS

COPENHAGEN, April 15 /PRNewswire-FirstCall/ -- Summary: Genmab has announced that HuMax-EGFr (zalutumumab) inhibits epidermal growth factor receptor signaling by locking epidermal growth factor receptor (EGFr) molecules into a very compact, inactive conformation. The flexibility of the EGFr is...

PTC Therapeutics Announces Publication of Preclinical Data in PNAS

Data Show PTC124 Addresses Underlying Cause of Genetic Disorders and Restores Protein Function in Cystic Fibrosis Model SOUTH PLAINFIELD, N.J., Feb. 4 /PRNewswire/ -- PTC Therapeutics, Inc. today announced the publication of new preclinical data in the February 12, 2008 edition of ...

Fruitfly Model of a Neuropathic Disease Demonstrates Novel Role for Proteins in the Family of aTyr Pharma's Product Class

...h novel signaling activities to treat a wide variety of diseases, such as inflammation, automimmune, hematopoietic and metabolic disorders." The pnas publication can be accessed at: http://www.pnas.org/content/early/2009/06/25/0905339106.abstract ...

Brain Stem Cells Can Be Awakened, Say Schepens Scientists

...e National Academy of Science (PNAS). An earlier paper (published in the May issue of Stem Cells) by the same scientists laid the foundation for the pnas study findings by demonstrating that neural stem cells exist in every part of the brain, but are mostly kept silent by chemical signals from support c...

Amylin Pharmaceuticals Initiates Phase 2B Dose-Ranging Clinical Study of Pramlintide/Metreleptin Combination Treatment in Obesity

...imens with each compound alone and with placebo. pnas Publication Also today, comprehensive preclinica...therapy." The scientific studies included in the pnas publication provide preclinical and clinical evide...AS, is available online at http://www.pnas.org/ . pnas is one of the world's most prestigious multidiscip...

Calando Pharmaceuticals Publishes the First Non-Human Primate Study on Targeted, Systemic Delivery of siRNA in National Academy of Sciences Journal

... siRNA by the end of 2007." Established in 1914, pnas is one of the world's most-cited multidisciplinary...l sciences, as well as the actions of the Academy. pnas is published weekly in print, and daily online in pnas Early Edition at http://www.pnas.org. About RNA ...

Rapid Response was Crucial to Containing the 1918 Flu Pandemic

...th interventions and epidemic intensity during the 1918 influenza pandemic. pnas DOI: 10.1073/pnas.0610941104 (2007) M Bootsma and N Ferguson. The effect of public health measures on the 1918 influenza pandemic in US cities. pnas DOI: 10.1073/pnas.0611071104 (2007) Visit PandemicFlu.gov (pnas website at http://www.pnas.org and downloaded by subscribers or purchased through the Academy'...

Ambati study published in PNAS

LEXINGTON, Ky. (April 6, 2009) The side effects of an experimental "gene-silencing" treatment that is currently being investigated for a variety of diseases are even more wide-ranging than previously discovered, according to a study by a University of Kentucky researcher. Following up on ground...

Data published in PNAS show antibodies can be made 10 times more toxic to cancer cells

Engineering the "Fc" region of monoclonal antibodies (mAbs) increases their toxicity to cancer cells, potentially improving the utility of targeted cancer therapies, according to research conducted at Xencor, which will be published in the March 14 print issue of the Proceedings of the National Aca...

Structure of protective protein in the eye lens revealed

... explaining the molecular architecture of this kind of protective protein. Their findings, which are published online in the current early edition of pnas ( Proceedings of the National Academy of Sciences ), shed new light on the work of these proteins and may be able to help in the development of new t...

Naming evolution's winners and losers

...at something more subtle explains the evolutionary success of mammals, birds and fish. We need to look for new explanations." Co-authors on the pnas paper are Luke Harmon, a professor of biological sciences at the University of Idaho; Francesco Santini, a UCLA postdoctoral scholar in Alfaro's labo...

Warmer environment means shorter lives for cold-blooded animals

...nger at higher latitudes than at lower latitudes, according to research published this week in the Proceedings of the National Academy of Sciences ( pnas ) online. Assistant Professor Dr. Stephan Munch and Ph.D. candidate Santiago Salinas, both of Stony Brook University's School of Marine and Atmospheri...

Sticky protein helps reinforce fragile muscle membranes

...hat appears to protect cells from mechanical stress. The study, which appears online July 20-24 in Proceedings of the National Academy of Sciences ( pnas ) Early Edition, also helps explain why muscle damage is so severe when this mechanism is disrupted, which occurs in certain congenital and limb-girdl...

Fish on the menu of our ancestors

... the University of British Columbia in Vancouver and Washington University in Saint Louis has shown that this individual was a regular fish consumer ( pnas , 07.07.2009). Freshwater fish are a major part of the diet of many peoples around the world, but it has been unclear when fish became a significan...

Analysis of Copernicus putative remains support identity

...ish scientists in a team consisting of archaeologists, anthropologists and geneticists. The results is published this week in the prestigious journal pnas ( Proceedings of the National Academy of Sciences ). At Uppsala University a DNA analysis was performed of shed hairs found in a book owned by Cop...

Rampant helper syndrome

... that this cofactor is also common in eukaryotes, where it performs an entirely different function: deazaflavin is involved in DNA repair processes. ( pnas Early Edition online, 1 July 2009) Catalysts assist in chemical reactions without undergoing any alteration of their own. In the cells of living o...

Discovery may provide new treatments for alcohol dependence

...s alcohol dependence. The results will be published in the renowned American scientific journal Proceedings of the National Academy of Sciences ( pnas ). Ghrelin is a hormone produced by the stomach and, by signalling in the brain, increases hunger. The new finding, that it is also involved in alc...
PNAS in Biological Technology

First step to converting solar energy using 'artificial leaf'

...earch findings in the online Early Edition of the pnas journal in the week starting 29 June. Leiden rese...ight, and a light-driven catalyst. The article in pnas is about the first of these: the antenna. Imi...ifferent members, also reported a breakthrough in pnas . In that article he showed how also with a combi...

New Danish research shows how oil gets stuck underground

...ark are made of. Assistant Professor Tue Hassenkam lead the research, whose preliminary results were published in the respected scientific publication pnas ( Proceedings of the National Academy of Sciences ) this week. He says that this is the first time that investigations of this type have been carried ...

MIT, BU team combats antibiotic resistance with engineered viruses

...prize in the National Collegiate Inventors Competition in 2008 for his work with engineered bacteriophages. The engineered viruses described in the pnas paper attack the SOS system, a bacterial DNA repair system enlisted when bacteria are exposed to antibiotics that damage DNA, and other gene networks....

PolyOrg, Inc. Acquires a License to Manufacture and Distribute PNA Monomers Worldwide

..."> alokaroy@polyorginc.com ; Tel : (978) 466-7978. Additional information is also available at http://www.polyorginc.com . About PNA: pnas are oligonucleotide analogs in which the sugar-phosphate backbone of DNA is substituted by amino-ethyl-glycine backbone. Invented in 1991 by scientist...

Protein-printing technique gives snapshots of immune system defense

...s. The first results, imaged and analyzed by graduate student Eliseo Papa of the Harvard/MIT Health Science and Technology Institute, appeared in pnas online the week of November 3. They gave a snapshot of the diversity of B cells that were generated by a series of immunizations designed to mimic a ...

Sea urchin yields a key secret of biomineralization

...nerals, and the first one in which the amorphous calcium carbonate precursor was discovered in 1997 by the same Israeli group co-authoring the current pnas paper. A similar amorphous-to-crystalline transition has since been observed in adult sea urchin spines, in mollusk shells, in zebra fish bones and in...

Study reveals principles behind stability and electronic properties of gold nanoclusters

... A report published in the July 8 issue of the journal Proceedings of the National Academy of Sciences ( pnas ) is the first to describe the principles behind the stability and electronic properties of tiny nanoclusters of metallic gold. The study, which confi...

Carbon hoofprint: Cows supplemented with rbST reduce agriculture's environmental impact

...ornell post-doctoral researcher, and the lead author of "The Environmental Impact of Recombinant Bovine Somatotropin (rbST) Use in Dairy Production," pnas . Joining Capper on the paper: Dale E. Bauman, Cornell professor of animal science and the corresponding author; Euridice Castaneda-Gutierrez, for...

Sidec Announces the First Protein Tomography(TM) Award at Sidec's Executive Forum at PEGS

...orum, Wim, K. Bleeker, Director Translational Research & Pharmacology at Genmab presented the modes of action of HuMax-EGFr (zalutumumab) published in pnas April 22nd and how this was determined together with Sidec using Protein Tomography(TM). Finally, Kathleen Madden Williams, PhD, JD Edwards Agnell P...

PNAS paper and its authors honored for scientific excellence

...ginality from 3,600 research articles published by pnas in 2007. The honored papers represent the six broa...elves. The award was established in 2005 as the pnas Paper of the Year Prize and renamed the Cozzarelli Prize in 2007 to honor late pnas Editor-in-Chief Nicholas R. Cozzarelli. The annual...
PNAS in Biological Definition

Origin of life

...irns Smith illustration of a possible solution using crystalline behaviors of clays Model of origin of life involving zeolite, press release for pnas paper The Birth of Complex Cells, and the oxygen holocaust — by Christian de Duve Possible Connections Between Interstellar Chemistry...

Stem cell

...rom Genome News Network . Stem Cells: Policies and Players . New Scientist's list of stem-cell and cloning related articles it has covered . pnas supplement: "Regenerative medicine" . Stem Cell News . Latest cell therapy progress . Turning your Brain into Blood — How stem cells...
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