FDA Gives Clinical Trial Green Light on Drug to Treat Alzheimer's Disease
... the brain's normal memory functions."
Bryostatin was originally created as an anti-cancer chemotherapy. When BRNI scientists extensively tested pkc
activators against Alzheimer's disease models, they discovered the drug's hidden potential to stop Alzheimer's disease. Over the past six years, the d...
Breast Cancer Drug Might Treat Bipolar Disorder
...of the female hormone estrogen in the body.
The drug also inhibits the activity of a family of enzymes known as protein kinase C (PKC). Activity of pkc
may be altered during the mania state of bipolar disorder, experts say. Existing drugs for the condition, including lithium and valproate sodium, inhi...
JCI table of contents: Dec. 20, 2007
... has revealed a role for activation of the protein pkc
in dysregulation of the integrity of the BBB leadi...disruption, and mortality rates all decreased when pkc
was inhibited in hypertensive DS rats. These effec...e results provide incentive to investigate whether pkc
signaling pathways mediate BBB dysfunction in othe...
Genentech/Roche's Lucentis and Eli Lilly's Ruboxistaurin Will Drive the Diabetic Retinopathy and Nephropathy Drug Markets
...many, Italy, Spain, the United Kingdom and Japan.
Additionally, although promising drug classes with potential
disease-modifying activity that include pkc
inhibitors and aldose reductase
inhibitors have suffered a decade of setbacks and disappointing efficacy
data, the report finds that longer-term marke...
Manic phase of bipolar disorder benefits from breast cancer medication
...manic phase of bipolar disorder.
By pointing to pkc
as a target for new medications, the study raises ...xperimentally in this study because it both blocks pkc
and is able to enter the brain.
Results of t...o build up enough tamoxifen in the brain to dampen pkc
The researchers decided to test tamo...
Ruboxistaurin (RBX) may prevent vision loss in diabetic patients
... is required for the normal production of energy in the body, but a-form of pkc
has found to cause diabetic complications of the eye. a- pkc
is the major signaling pathway which is stimulated by high blood glucose le...
PKC in Medical Technology
PKC in Biological News
PKC in Biological Technology
Cerenkov Counting Performance on the TopCountTM Microplate Scintillation and Luminescence Counter
..., Amersham ) was used in the experiment. This assay measures the amount of pkc
in a sample by the degree of phosphorylation of a specific peptide with [ 3...ssentially as described in TopCount Topics, TCA-018. 4 Serial dilutions of pkc
(P-8289, Sigma ) were used to generate several levels of specific kinase a...
Application of the Bio-Plex Cell Lysis Kit in Western Blot Analysis of Phosphoproteins, Rev A
...s of phosphorylation
identified in parentheses: STAT6 (Tyr 641 ), p90RSK (Ser 380 ), Akt (Ser 473 ),
ERK1/2 (Thr 202 /Tyr 204 ), pkc
(Ser 916 ), STAT3 (Tyr 705 ), NFκB p65 (Ser 536 ),
JNK (Thr 183 /Tyr 185 ), p38 MAPK (Thr 180 /Tyr 182 ).
Quantitation of P...
Setting up a kinase profiler with IMAP
...is an inventory substrate available for
x , which is a pkc
isoform that is further
activated by lip...
PKC in Biological Products
PKC in Biological Definition
...transgene". Proc Natl Acad Sci U S A 94 (9), 4761-5. PMID 9114065
^ Malinow R, Schulman H, Tsien RW (1989) "Inhibition of postsynaptic pkc
or CaMKII blocks induction but not expression of LTP". Science 245 (4920), 862-6. PMID 2549638
^ Otmakhova NA, Otmakhov N, Mortenson LH...
PKC in Biological Dictionary
... In experiment 2, the cellular source of luteal pkc
isozymes was determined. ... detected in both SC and EC, with EC expressing higher amounts of pkc
isozymes . ... Activity of both ADA isozymes ...r function and alter ... In various model systems, pkc
isozymes have variously been found to be either ...