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PKC in Medical News

FDA Gives Clinical Trial Green Light on Drug to Treat Alzheimer's Disease

... the brain's normal memory functions." Bryostatin was originally created as an anti-cancer chemotherapy. When BRNI scientists extensively tested pkc activators against Alzheimer's disease models, they discovered the drug's hidden potential to stop Alzheimer's disease. Over the past six years, the d...

Breast Cancer Drug Might Treat Bipolar Disorder

...of the female hormone estrogen in the body. The drug also inhibits the activity of a family of enzymes known as protein kinase C (PKC). Activity of pkc may be altered during the mania state of bipolar disorder, experts say. Existing drugs for the condition, including lithium and valproate sodium, inhi...

JCI table of contents: Dec. 20, 2007

... has revealed a role for activation of the protein pkc in dysregulation of the integrity of the BBB leadi...disruption, and mortality rates all decreased when pkc was inhibited in hypertensive DS rats. These effec...e results provide incentive to investigate whether pkc signaling pathways mediate BBB dysfunction in othe...

Genentech/Roche's Lucentis and Eli Lilly's Ruboxistaurin Will Drive the Diabetic Retinopathy and Nephropathy Drug Markets

...many, Italy, Spain, the United Kingdom and Japan. Additionally, although promising drug classes with potential disease-modifying activity that include pkc inhibitors and aldose reductase inhibitors have suffered a decade of setbacks and disappointing efficacy data, the report finds that longer-term marke...

Manic phase of bipolar disorder benefits from breast cancer medication

...manic phase of bipolar disorder. By pointing to pkc as a target for new medications, the study raises ...xperimentally in this study because it both blocks pkc and is able to enter the brain. Results of t...o build up enough tamoxifen in the brain to dampen pkc activity. The researchers decided to test tamo...

Ruboxistaurin (RBX) may prevent vision loss in diabetic patients

... is required for the normal production of energy in the body, but a-form of pkc has found to cause diabetic complications of the eye. a- pkc is the major signaling pathway which is stimulated by high blood glucose le...
PKC in Medical Technology

Blanchette Rockefeller Neurosciences Institute and Inverness Medical Innovations to Develop Commercial Test to Detect Early Alzheimer's Disease

...tested without the invasive procedures previously required, such as a lumbar tap. The key molecular targets that the BRNI biomarker determines reflect pkc signaling which appears to be compromised very early on during AD and probably well before the onset of clinical symptoms. These pathways could also b...
PKC in Biological News

Researchers uncover 'obesity gene' involved in weight gain response to high-fat diet

...he other hand, mice genetically engineered to lack pkc beta gained relatively little weight and showed mi...ound that mice fed the high-fat diet produced more pkc beta in their fat tissue than did mice eating a re... gene burn fat more rapidly than they would if the pkc beta were present, Mehta said. The research is ...
PKC in Biological Technology

Cerenkov Counting Performance on the TopCountTM Microplate Scintillation and Luminescence Counter

..., Amersham ) was used in the experiment. This assay measures the amount of pkc in a sample by the degree of phosphorylation of a specific peptide with [ 3...ssentially as described in TopCount Topics, TCA-018. 4 Serial dilutions of pkc (P-8289, Sigma ) were used to generate several levels of specific kinase a...

Application of the Bio-Plex Cell Lysis Kit in Western Blot Analysis of Phosphoproteins, Rev A

...s of phosphorylation identified in parentheses: STAT6 (Tyr 641 ), p90RSK (Ser 380 ), Akt (Ser 473 ), ERK1/2 (Thr 202 /Tyr 204 ), pkc (Ser 916 ), STAT3 (Tyr 705 ), NFκB p65 (Ser 536 ), JNK (Thr 183 /Tyr 185 ), p38 MAPK (Thr 180 /Tyr 182 ). Quantitation of P...

Setting up a kinase profiler with IMAP

... 10 pkc x 5FAM-ERMRPRKRQGSVRRRV-NH 2 ...is an inventory substrate available for pkc x , which is a pkc isoform that is further activated by lip...
PKC in Biological Products

Rabbit Anti-Human ASIP / PAR3 Monoclonal Antibody,, Clone ZMD.283 from Invitrogen

Description:... Clone/PAD: ZMD.283. Immunogen: Fusion protein derived from human ASIP/PAR-3. Specificity: Specific for ASIP/PAR-3 (atypical pkc isotype-specific interacting protein/ partitioning defective 3). This antigen is not related to the protease-activated-receptors also called PAR. Rea...
Company:Invitrogen
PKC in Biological Definition

Long-term potentiation

...transgene". Proc Natl Acad Sci U S A 94 (9), 4761-5. PMID 9114065 ^ Malinow R, Schulman H, Tsien RW (1989) "Inhibition of postsynaptic pkc or CaMKII blocks induction but not expression of LTP". Science 245 (4920), 862-6. PMID 2549638 ^ Otmakhova NA, Otmakhov N, Mortenson LH...
PKC in Biological Dictionary

Isozymes

... In experiment 2, the cellular source of luteal pkc isozymes was determined. ... detected in both SC and EC, with EC expressing higher amounts of pkc isozymes . ... Activity of both ADA isozymes ...r function and alter ... In various model systems, pkc isozymes have variously been found to be either ...
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