Navigation Links
PKC in Medical News

FDA Gives Clinical Trial Green Light on Drug to Treat Alzheimer's Disease

... the brain's normal memory functions." Bryostatin was originally created as an anti-cancer chemotherapy. When BRNI scientists extensively tested pkc activators against Alzheimer's disease models, they discovered the drug's hidden potential to stop Alzheimer's disease. Over the past six years, the d...

Breast Cancer Drug Might Treat Bipolar Disorder

...of the female hormone estrogen in the body. The drug also inhibits the activity of a family of enzymes known as protein kinase C (PKC). Activity of pkc may be altered during the mania state of bipolar disorder, experts say. Existing drugs for the condition, including lithium and valproate sodium, inhi...

JCI table of contents: Dec. 20, 2007

... has revealed a role for activation of the protein pkc in dysregulation of the integrity of the BBB leadi...disruption, and mortality rates all decreased when pkc was inhibited in hypertensive DS rats. These effec...e results provide incentive to investigate whether pkc signaling pathways mediate BBB dysfunction in othe...

Genentech/Roche's Lucentis and Eli Lilly's Ruboxistaurin Will Drive the Diabetic Retinopathy and Nephropathy Drug Markets

...many, Italy, Spain, the United Kingdom and Japan. Additionally, although promising drug classes with potential disease-modifying activity that include pkc inhibitors and aldose reductase inhibitors have suffered a decade of setbacks and disappointing efficacy data, the report finds that longer-term marke...

Manic phase of bipolar disorder benefits from breast cancer medication

...manic phase of bipolar disorder. By pointing to pkc as a target for new medications, the study raises ...xperimentally in this study because it both blocks pkc and is able to enter the brain. Results of t...o build up enough tamoxifen in the brain to dampen pkc activity. The researchers decided to test tamo...

Ruboxistaurin (RBX) may prevent vision loss in diabetic patients

... is required for the normal production of energy in the body, but a-form of pkc has found to cause diabetic complications of the eye. a- pkc is the major signaling pathway which is stimulated by high blood glucose le...
PKC in Medical Technology

Blanchette Rockefeller Neurosciences Institute and Inverness Medical Innovations to Develop Commercial Test to Detect Early Alzheimer's Disease

...tested without the invasive procedures previously required, such as a lumbar tap. The key molecular targets that the BRNI biomarker determines reflect pkc signaling which appears to be compromised very early on during AD and probably well before the onset of clinical symptoms. These pathways could also b...
PKC in Biological News

Researchers uncover 'obesity gene' involved in weight gain response to high-fat diet

...he other hand, mice genetically engineered to lack pkc beta gained relatively little weight and showed mi...ound that mice fed the high-fat diet produced more pkc beta in their fat tissue than did mice eating a re... gene burn fat more rapidly than they would if the pkc beta were present, Mehta said. The research is ...
PKC in Biological Technology

Cerenkov Counting Performance on the TopCountTM Microplate Scintillation and Luminescence Counter

..., Amersham ) was used in the experiment. This assay measures the amount of pkc in a sample by the degree of phosphorylation of a specific peptide with [ 3...ssentially as described in TopCount Topics, TCA-018. 4 Serial dilutions of pkc (P-8289, Sigma ) were used to generate several levels of specific kinase a...

Application of the Bio-Plex Cell Lysis Kit in Western Blot Analysis of Phosphoproteins, Rev A

...s of phosphorylation identified in parentheses: STAT6 (Tyr 641 ), p90RSK (Ser 380 ), Akt (Ser 473 ), ERK1/2 (Thr 202 /Tyr 204 ), pkc (Ser 916 ), STAT3 (Tyr 705 ), NFκB p65 (Ser 536 ), JNK (Thr 183 /Tyr 185 ), p38 MAPK (Thr 180 /Tyr 182 ). Quantitation of P...

Setting up a kinase profiler with IMAP

... 10 pkc x 5FAM-ERMRPRKRQGSVRRRV-NH 2 ...is an inventory substrate available for pkc x , which is a pkc isoform that is further activated by lip...
PKC in Biological Products

Rabbit Anti-Human ASIP / PAR3 Monoclonal Antibody,, Clone ZMD.283 from Invitrogen

Description:... Clone/PAD: ZMD.283. Immunogen: Fusion protein derived from human ASIP/PAR-3. Specificity: Specific for ASIP/PAR-3 (atypical pkc isotype-specific interacting protein/ partitioning defective 3). This antigen is not related to the protease-activated-receptors also called PAR. Rea...
Company:Invitrogen
PKC in Biological Definition

Long-term potentiation

...transgene". Proc Natl Acad Sci U S A 94 (9), 4761-5. PMID 9114065 ^ Malinow R, Schulman H, Tsien RW (1989) "Inhibition of postsynaptic pkc or CaMKII blocks induction but not expression of LTP". Science 245 (4920), 862-6. PMID 2549638 ^ Otmakhova NA, Otmakhov N, Mortenson LH...
PKC in Biological Dictionary

Isozymes

... In experiment 2, the cellular source of luteal pkc isozymes was determined. ... detected in both SC and EC, with EC expressing higher amounts of pkc isozymes . ... Activity of both ADA isozymes ...r function and alter ... In various model systems, pkc isozymes have variously been found to be either ...
Other Tags
(Date:5/4/2015)... 04, 2015 Each year, the Susan G. ... funds and awareness for breast cancer. This year, Dr. Mark ... featured as the entertainment sponsor for the 25th annual Susan ... 9 at the Lenox Square Mall. , The Komen organization ... to raise $1.2 million. Perimeter Plastic Surgery has not only ...
(Date:5/4/2015)... 04, 2015 Johnson & Wales University (JWU) ... and science academic center on Wednesday, April 22. , Johnson ... land made available by the re-alignment of Interstate-195. JWU’s new ... Friendship and Chestnut streets in Providence, is scheduled to be ... parcel of land the university purchased in 2012. , “It ...
(Date:5/4/2015)... 2015 The Lymphoma Research Foundation (LRF) ... funding innovative lymphoma research and serving the lymphoma community ... and patient services – is set to host its ... in West Orange, NJ on June 1, 2015. Since ... research programs through LRF. , This year, the Lymphoma ...
(Date:5/4/2015)... Fla. (PRWEB) May 04, 2015 ... Heart Association/American Stroke Association’s Get With The Guidelines®-Stroke ... Target: Stroke Honor Roll. The award recognizes the ... patients receive the most appropriate treatment according to ... scientific evidence. , To receive the Gold Plus ...
(Date:5/4/2015)... The U.S. healthcare worker shortage crisis is expected ... senior citizens (1) and 27 million Obamacare-insured Americans (2) ... Additionally, as older healthcare employees retire, there will be ... Census Bureau, the number of American workers 65 and ... those 25 to 54 will likely increase 2%. (3) ...
Breaking Medicine News(10 mins):Health News:Perimeter Plastic Surgery Sponsors 2015 Susan G. Komen Greater Atlanta "Race for the Cure" 2Health News:Johnson & Wales University “Breaks Ground” On New $40 Million Engineering and Science Academic Center 2Health News:Johnson & Wales University “Breaks Ground” On New $40 Million Engineering and Science Academic Center 3Health News:Lymphoma Research Foundation Set to Host Annual Ace Lymphoma Luncheon at Mayfair Farms in West Orange, NJ 2Health News:Baptist Medical Center Jacksonville Receives Top Honor for Stroke Care 2Health News:Baptist Medical Center Jacksonville Receives Top Honor for Stroke Care 3Health News:Baptist Medical Center Jacksonville Receives Top Honor for Stroke Care 4Health News:U.S. Healthcare Worker Shortage Escalating: Sterling Warns Medical Practitioners to Rapidly Reverse Low Employee Retention 2Health News:U.S. Healthcare Worker Shortage Escalating: Sterling Warns Medical Practitioners to Rapidly Reverse Low Employee Retention 3Health News:U.S. Healthcare Worker Shortage Escalating: Sterling Warns Medical Practitioners to Rapidly Reverse Low Employee Retention 4
(Date:4/8/2015)... 8, 2015  Infinisource, a leading provider of SaaS-based ... Morpho, a leading supplier of biometric identification and ... market,s most advanced biometrically-enabled time clock, the companies ... clock is setting a bold, new standard for ... the small and mid-size employer. When connected to ...
(Date:4/2/2015)... , April 2, 2015 At its ... Salt Lake City , the American College of ... five new directors to its Board.  Members of the ... ACMG and for forming and advancing its policies and ... genetics profession. "It,s an eventful time in ...
(Date:4/1/2015)... , Apr. 1, 2015  NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market, ... Wocket smart wallets is underway to early access pre-order ... group includes usage at retail outlets including Walmart, Target, ... Users report Wocket was accepted at all outlets and ...
Breaking Biology News(10 mins):iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4
Other Contents