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PDZ in Medical News

A Detail Analysis of Head and Neck Cancer

...ular interactions and can be used in the potential treatment that could prevent both pathways from being initiated. Inside the LARG segment there is a pdz domain which when introduced into the tumor cell, it binds up all available CD44 and EGFR, leaving them unavailable to initiate the deadly twin molecu...

Researchers Identify Sipa 1 Gene, Responsible For Cancer Metastasis

...o threonine substitution in a protein-protein interaction domain known as a pdz domain. Sipa1 is a mitogen inducidble gene that encodes a GTPase acti...ly been found to interact with the water channel aquaporin 2 (AQP2), by its pdz domain, so the authors used AQP2 to see if the Alanine to threonine substit...
PDZ in Biological News

'Disordered' amino acids may really be there to provide wiggle room for signaling protein

...ions of the protein are comprised of two so-called pdz domains components well known to scientists as an...nveniently fits into a cleft on the surface of the pdz domains, but assumes a helical structure, which is...enable the protein to work. That is, it allows the pdz binding module to "bite" its own ezrin-binding tai...

Arbor Vita presents new data on cancer diagnostic at EUrogin

...rvical Cancer Programs Johannes Schweizer, Ph.D., presented results of a prototype rapid cervical cancer diagnostic test that was designed using AVC's pdz discovery platform. This E6 strip test, now in development, detects the E6 oncoprotein produced by the human papillomavirus (HPV), the principal cause...

Arbor Vita and WRAIR sign CRADA for traumatic brain injury collaboration

...NA-1 is an investigational compound that targets a pdz protein and is in clinical trials for the treatmen...as a novel drug development strategy targeting the pdz family of proteins critical elements that organiz...any signaling pathways in cells. The disruption of pdz interactions provides a means to control specific ...

Arbor Vita rapid H5N1 flu diagnostic presented at ICEID meeting

...rotein (NP). Antigen capture is mediated through a pdz protein, which binds the C-terminal region of the ...NS1 protein differs for each influenza sub-type, a pdz protein with high affinity to NS1 protein of H5 st...the role of the capture antibody is performed by a pdz protein, which provides superior specificity and b...
PDZ in Biological Technology

Dr. Linda McAllister Joins Arbor Vita Corporation as Vice President of Diagnostics

...a management team, and to help translate the company's elegant and powerful pdz biology from research to the clinic," stated Linda McAllister, M.D., Ph.D. ...agnostics addressing disease through a new family of targets, PDZ proteins. pdz proteins are critical elements that organize and regulate many signaling pa...
PDZ in Biological Products

Mouse Anti-PSD-95, PDZ Domain Monoclonal Antibody, Unconjugated, Clone K28/86.2 from Upstate

Description: Anti-PSD-95, clone K28/86.2, PDZ Domain GenBank Accession Number : NM_007864 Immunogen : GST fusion to residues 77-299 of human-PSD-95 (PDZ Domain) Formulation: 0.01M Tris pH 7.4, 0.075M NaCl containing 0.05% sodium azide Quality Assurance: routinely evaluated by immunoblot on rat brain microsoma...
Company:Upstate

Rabbit Anti-Mint3 Polyclonal Antibody, Unconjugated from ABR-Affinity BioReagents

Description:...ct with munc-18. Mint3 has been found to interact with the Alzheimers Disease-related amyloid precursor protein (APP) and does so through its PTB and pdz domains. It has been suggested that mint3 links APP to other transport machinery components, thereby regulating it transport, endocytosis, and metabo...
Company:ABR-Affinity BioReagents
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