A Detail Analysis of Head and Neck Cancer
...ular interactions and can be used in the potential treatment that could prevent both pathways from being initiated. Inside the LARG segment there is a pdz
domain which when introduced into the tumor cell, it binds up all available CD44 and EGFR, leaving them unavailable to initiate the deadly twin molecu...
Researchers Identify Sipa 1 Gene, Responsible For Cancer Metastasis
...o threonine substitution in a protein-protein interaction domain known as a pdz
Sipa1 is a mitogen inducidble gene that encodes a GTPase acti...ly been found to interact with the water channel aquaporin 2 (AQP2), by its pdz
domain, so the authors used AQP2 to see if the Alanine to threonine substit...
PDZ in Biological News
'Disordered' amino acids may really be there to provide wiggle room for signaling protein
...ions of the protein are comprised of two so-called pdz
domains components well known to scientists as an...nveniently fits into a cleft on the surface of the pdz
domains, but assumes a helical structure, which is...enable the protein to work. That is, it allows the pdz
binding module to "bite" its own ezrin-binding tai...
Arbor Vita presents new data on cancer diagnostic at EUrogin
...rvical Cancer Programs Johannes Schweizer, Ph.D., presented results of a prototype rapid cervical cancer diagnostic test that was designed using AVC's pdz
discovery platform. This E6 strip test, now in development, detects the E6 oncoprotein produced by the human papillomavirus (HPV), the principal cause...
Arbor Vita and WRAIR sign CRADA for traumatic brain injury collaboration
...NA-1 is an investigational compound that targets a pdz
protein and is in clinical trials for the treatmen...as a novel drug development strategy targeting the pdz
family of proteins critical elements that organiz...any signaling pathways in cells. The disruption of pdz
interactions provides a means to control specific ...
Arbor Vita rapid H5N1 flu diagnostic presented at ICEID meeting
...rotein (NP). Antigen capture is mediated through a pdz
protein, which binds the C-terminal region of the ...NS1 protein differs for each influenza sub-type, a pdz
protein with high affinity to NS1 protein of H5 st...the role of the capture antibody is performed by a pdz
protein, which provides superior specificity and b...
PDZ in Biological Technology
PDZ in Biological Products
Mouse Anti-PSD-95, PDZ Domain Monoclonal Antibody, Unconjugated, Clone K28/86.2 from Upstate
Description: Anti-PSD-95, clone K28/86.2, PDZ
Domain GenBank Accession Number : NM_007864 Immunogen : GST fusion to residues 77-299 of human-PSD-95 (PDZ Domain) Formulation: 0.01M Tris pH 7.4, 0.075M NaCl containing 0.05% sodium azide Quality Assurance: routinely evaluated by immunoblot on rat brain microsoma...
Rabbit Anti-Mint3 Polyclonal Antibody, Unconjugated from ABR-Affinity BioReagents
Description:...ct with munc-18. Mint3 has been found to interact with the Alzheimers Disease-related amyloid precursor protein (APP) and does so through its PTB and pdz
domains. It has been suggested that mint3 links APP to other transport machinery components, thereby regulating it transport, endocytosis, and metabo...