Tumor suppressor may attenuate fibrotic disease
...c development. However, the consequences of excess pdgf
signaling are not very well understood.
signaling has been implicated in diverse fibrotic ...espread fibrosis, possess antibodies that activate pdgf
Dr. Soriano and Dr. Lorin E. Olson,...
Cancer drugs my build and not tear down blood vessels
...therapy, Cheresh explained.
Cheresh's group found that receptors for VEGF and another growth-promoting protein, PDGF, form a complex that turns off pdgf
and the activity of the blood vessel-support cells. Tumors make too much VEGF in their haste to form blood vessels, which turns on the receptor comple...
NEW DATA FOR PAZOPANIB - GSK'S LATEST INVESTIGATIONAL ANTI-CANCER AGENT - SHOWS PROMISE ACROSS MULTIPLE CANCERS
...h of blood vessels
- a process known as angiogenesis. Angiogenesis plays a pivotal role in the
growth and spread of several tumor types, with VEGF and pdgf
linked to multiple cancers including cancers of the liver, lung, breast,
kidney, bladder, ovaries, and colon.(14) By inhibiting VEGFR, ...
Oregon researchers discover a mechanism leading to cleft palate
...ublication the monthly journal Nature Genetics.
Mutant zebrafish lacking pdgf
had cleft palate similar to many human babies, showing that this growth fac... of how microRNAs and other factors modulate signaling pathways such as the pdgf
pathway during palatogenesis will assuredly continue to provide insights in...
Combination therapy reverses effects of portal hypertension in rats
...APS in Barcelona, examined the effects of VEGF and pdgf
inhibitory drugs on rats with established portal h...is associated with a progressive overexpression of pdgf
as well as VEGF. It also revealed that anti-angio...osystemic collaterization is regulated by VEGF and pdgf
in portal hypertensive rats, the authors conclude....
New Treatment Offers Hope for Systemic Sclerosis
...st cultures from the lesions of five patients with SSc, and six healthy sex- and age-matched controls. All the specimens were stimulated with TGF? and pdgf
and incubated with the inhibitory molecule, imatinib mesylate. Then, applying real-time polymerase chain reaction and various assays, researchers anal...
"Miracle" Cancer Drug Gleevec Can be Toxic to the Heart
...ents to counteract this effect.
In Gleevec, for example, blocking the pdgf
receptor is crucial to its effect in thwarting gastrointestinal stromal tumors. Designing a drug to inhibit the pdgf
receptor but not ABL, then, could still work against such tumors but not ca...
PDGF in Medical Technology
PDGF in Biological News
Scientists uncover the potential to control adult stem cells
...sels from MSCs in the body. This system is called pdgf
receptor signalling, receptors on the surface of t...s cooperation between two types of receptor called pdgf
receptor and neuropilin-1 that respond to growth f...
Possible birthplace of malignant brain tumors identified
...continual source of new brain cells in adults, and pdgf
is known as an important regulator of such cells. Also, pdgf
has been implicated as a key signaling molecule underlying the formation of brain tumors. pdgf
triggers such cell response by plugging into the t...
Scientists closer to new cancer detection method
... cancer protein.
In this case, the target was platelet derived growth factor, or PDGF, a protein that regulates cell growth and division. Elevated pdgf
levels have been linked to different forms of cancer, and have been found in patients with malignancies of the ovaries, kidneys, lung, pancreas and br...
PDGF in Biological Technology
PDGF in Biological Products