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PDGF in Medical News

Tumor suppressor may attenuate fibrotic disease

...c development. However, the consequences of excess pdgf signaling are not very well understood. "Aberrant pdgf signaling has been implicated in diverse fibrotic ...espread fibrosis, possess antibodies that activate pdgf receptors." Dr. Soriano and Dr. Lorin E. Olson,...

Cancer drugs my build and not tear down blood vessels

...therapy, Cheresh explained. Cheresh's group found that receptors for VEGF and another growth-promoting protein, PDGF, form a complex that turns off pdgf and the activity of the blood vessel-support cells. Tumors make too much VEGF in their haste to form blood vessels, which turns on the receptor comple...

NEW DATA FOR PAZOPANIB - GSK'S LATEST INVESTIGATIONAL ANTI-CANCER AGENT - SHOWS PROMISE ACROSS MULTIPLE CANCERS

...h of blood vessels - a process known as angiogenesis. Angiogenesis plays a pivotal role in the growth and spread of several tumor types, with VEGF and pdgf overexpression linked to multiple cancers including cancers of the liver, lung, breast, kidney, bladder, ovaries, and colon.(14) By inhibiting VEGFR, ...

Oregon researchers discover a mechanism leading to cleft palate

...ublication the monthly journal Nature Genetics. Mutant zebrafish lacking pdgf had cleft palate similar to many human babies, showing that this growth fac... of how microRNAs and other factors modulate signaling pathways such as the pdgf pathway during palatogenesis will assuredly continue to provide insights in...

Combination therapy reverses effects of portal hypertension in rats

...APS in Barcelona, examined the effects of VEGF and pdgf inhibitory drugs on rats with established portal h...is associated with a progressive overexpression of pdgf as well as VEGF. It also revealed that anti-angio...osystemic collaterization is regulated by VEGF and pdgf in portal hypertensive rats, the authors conclude....

New Treatment Offers Hope for Systemic Sclerosis

...st cultures from the lesions of five patients with SSc, and six healthy sex- and age-matched controls. All the specimens were stimulated with TGF? and pdgf and incubated with the inhibitory molecule, imatinib mesylate. Then, applying real-time polymerase chain reaction and various assays, researchers anal...

"Miracle" Cancer Drug Gleevec Can be Toxic to the Heart

...ents to counteract this effect. In Gleevec, for example, blocking the pdgf receptor is crucial to its effect in thwarting gastrointestinal stromal tumors. Designing a drug to inhibit the pdgf receptor but not ABL, then, could still work against such tumors but not ca...
PDGF in Medical Technology

Millennium Presents New Data on Investigational Drugs for Novel Cancer Targets at EORTC-NCI-AACR Symposium

...small molecule selective inhibitor of the tyrosine kinases for the VEGF and pdgf receptor families. New non-clinical TAK-593 data presented at EORTC show po...ound, TAK-593, a highly potent and selective inhibitor against VEGF and pdgf tyrosine kinases -- Lead investigator: A. Mizutani, Takeda Pharmaceuti...

Early Data Show Potential for Imatinib Mesylate Tablets to Treat Life-Threatening Form of Pulmonary Artery Disease

... Schermuly RT et al. Reversal of experimental pulmonary hypertension by pdgf inhibition. J Clin Invest. 2005 Oct;115(10):2811-21. 2. National Library o... http://www.nlm.nih.gov/medlineplus/ency/article/000112.htm . 3. Barst RJ. pdgf signaling in pulmonary arterial hypertension. J Clin Invest. 2005 Oct;1...

Data Show SuperGen's Multi-Targeted Tyrosine Kinase Inhibitor Suppresses Critical Double-Stranded DNA Repair Protein, Rad51

... combination with Tarceva was more effective than either treatment alone in the inhibition of cell proliferation and phosphorylation of Akt in EGF and pdgf pathways. Moreover, in combination with Tarceva, MP470 inhibited Akt phosphorylation in LNCaP prostate cells. Finally, the MP470/Tarceva treatment was...
PDGF in Biological News

Scientists uncover the potential to control adult stem cells

...sels from MSCs in the body. This system is called pdgf receptor signalling. In pdgf receptor signalling, receptors on the surface of t...s cooperation between two types of receptor called pdgf receptor and neuropilin-1 that respond to growth f...

Possible birthplace of malignant brain tumors identified

...continual source of new brain cells in adults, and pdgf is known as an important regulator of such cells. Also, pdgf has been implicated as a key signaling molecule underlying the formation of brain tumors. pdgf triggers such cell response by plugging into the t...

Scientists closer to new cancer detection method

... cancer protein. In this case, the target was platelet derived growth factor, or PDGF, a protein that regulates cell growth and division. Elevated pdgf levels have been linked to different forms of cancer, and have been found in patients with malignancies of the ovaries, kidneys, lung, pancreas and br...
PDGF in Biological Technology

Cardium Announces New Orthobiologics Product Initiative Extending Gene Activated Matrix Technology to Deliver Bone Growth Factors

...): 745-756); (2) Engineering of Tooth-Supporting Structures by Delivery of pdgf Gene Therapy Vectors, (Jin, et al., Mol Ther , 2004 April; 9(4): 519-526)...any and its collaborators demonstrates the potential safety and benefits of pdgf gene therapy for periodontal tissue repair and regeneration. In addition, ...
PDGF in Biological Products

Mouse Anti-Human PDGF R beta Monoclonal Antibody, Unconjugated, Clone PR7212 from R&D Systems

Description: Human PDGF R beta MAb (Clone # PR7212)...
Company:R&D Systems
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