Mutation In PALB2 Elevates Risk of Cancer
Cancer is a complex and common disease caused by a combination of both genetic and environmental factors.
Recent research shows that the constitutional mutation in PALB2
gene elevates the risk of breast cancer four-fold. //
Previous studies have shown that genes are responsible for at lea...
'Personalized' genome sequencing reveals coding error in gene for inherited pancreatic cancer
...eatic cancer to locate a mutation in a gene called palb2
that is responsible for initiating the disease. T...midine.
The research team then scanned for the palb2
gene in 96 other individuals with pancreatic cance...ic cancer. Three of them had coding errors in the palb2
gene that shortened the protein in a similar way. ...
Gene elevating breast cancer risk also causes prostate cancer
...in Boston identified a novel BRCA2 binding factor, palb2
that regulates certain key functions of normal BRC...step was to set out to evaluate the newly detected palb2
gene as a potential heritable breast cancer suscep...ncer families. The same constitutional mutation in palb2
was observed in three families. It was later showe...