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Overexpressed in Medical News

A new Eph receptor tyrosine kinase overexpressed in gastric cancer was found

The potential role of Eph receptor and ephrin ligand family in human cancer is receiving increasing attention. Compared with other Eph receptors, EphA4 is distinguished by its ability to bind to both type A ephrins and most type B ephrins. EphA4 reportedly forms a hetero receptor complex with FGFR...

Micromet, Inc. Reports Second Quarter 2009 Financial Results

... in a phase 1 clinical trial for the treatment of patients with solid tumors. MT110 binds to the epithelial cell adhesion molecule, or EpCAM, which is overexpressed in many solid tumors. Micromet's human monoclonal antibody adecatumumab (MT201) also binds to EpCAM and is being developed under a collaboration with ...

JNCI news brief: Antibody linked to chemotherapy drug inhibits ovarian cancer in lab

...lished online July 29 in the Journal of the National Cancer Institute . The agent, known as an immunoconjugate, targets a protein, EphA2, which is overexpressed in many human cancers but is absent or expressed at low levels in normal tissues. Anil K. Sood, M.D., of The University of Texas M.D. Anderson Canc...

Study shows PET can measure effectiveness of novel breast cancer treatment

... for other cancers overexpressing different proteins." Much new research has been focused on developing therapies targeted to HER2. This protein is overexpressed in approximately 20 percent of breast cancers and also in some ovarian, prostate and lung cancers. Tumors that have an overabundance of HER2 protein a...

Study pinpoints novel cancer gene and biomarker

...ad only a minimal effect." Intriguing as this finding was, it was hardly enough to prove that GOLPH3 is an oncogene -- a contributor to cancer when overexpressed within a cell. Demonstrating that would require several experiments to ensure that GOLPH3 itself, and not a nearby "shadow" gene, is responsible for t...

Damon Runyon Cancer Research Foundation awards prestigious fellowships to 17 top young scientists

...gulation of ribonucleotide reductases (RNRs), enzymes that play an essential role in making deoxynucleotides (the "building blocks" of DNA). RNRs are overexpressed in cancer cells, making them an ideal target for cancer drugs. Her work will focus on understanding the mechanism of a new drug called Triapine, whic...

Phase 1 Study Initiated with Micromet Anti-GM-CS Human Antibody MT203

... in a phase 1 clinical trial for the treatment of patients with solid tumors. MT110 binds to the epithelial cell adhesion molecule, or EpCAM, which is overexpressed in many solid tumors. Micromet's human monoclonal antibody adecatumumab (MT201) also binds to EpCAM and is being developed under a collaboration with ...

Jefferson researchers identify critical marker of response to gemcitabine in pancreatic cancer

...R (HuR), is a stress response protein found in the cytoplasm of pancreatic tumor cells. In certain experimental settings, pancreatic cancer cells that overexpressed HuR were up to 30-fold more sensitive to gemcitabine (Gemzar), according to Jonathan Brody, Ph.D., assistant professor of Surgery at Jefferson Medical...

Research Reveals How Down Syndrome Shields Against Cancer

...universities around the country are very good at finding targets for intervention in cancer and this study suggests that these two genes, if they were overexpressed in a tumor, could shut down the tumor blood vessels," explained Dr. Arthur E. Frankel, holder of the Tula Lee Stone Chair in Cancer Research at the Te...

Science Zeroes In on New Alzheimer's Drug Target

...e in cognition. But HDAC2 did, and the overexpressing and underexpressing strains exhibited opposing characteristics, Tsai said. Whereas mice that overexpressed HDAC2 were much poorer at learning than unaffected littermates, mice engineered to lack HDAC2 learned better. At the cellular level, overexpressors...
Overexpressed in Medical Technology

Publication Confirms that EpCAM, the Target for Two of Micromet's Product Candidates, Is Overexpressed on Cancer Stem Cells of Certain Cancers

BETHESDA, Md., June 26, 2007 /PRNewswire-FirstCall/ -- Micromet, Inc. , a biopharmaceutical company focusing on the development of novel, proprietary antibody-based products for cancer, inflammatory and autoimmune diseases, announced that a study published recently in the Proceedings of the Nation...

Micromet's Blinatumomab Achieves Primary Endpoint in Phase 2 Study with Acute Lymphoblastic Leukemia Patients

... in a phase 1 clinical trial for the treatment of patients with solid tumors. MT110 binds to the epithelial cell adhesion molecule, or EpCAM, which is overexpressed in many solid tumors. Micromet's human monoclonal antibody adecatumumab (MT201) also binds to EpCAM and is being developed under a collaboration with ...

Micromet Presents Update on Blinatumomab's Response Rate and Duration in a Phase 1 Study in Non-Hodgkin's Lymphoma Patients

... in a phase 1 clinical trial for the treatment of patients with solid tumors. MT110 binds to the epithelial cell adhesion molecule, or EpCAM, which is overexpressed in many solid tumors. Micromet's human monoclonal antibody adecatumumab (MT201) also binds to EpCAM and is being developed under a collaboration with ...

First Candidate from Esperance's Targeted Anti-cancer Platform, EP-100, Establishes Preclinical Proof of Concept

...-100 is a targeted membrane-disrupting peptide and is designed to selectively target luteinizing hormone releasing hormone (LHRH) receptors, which are overexpressed in a wide range of cancers. Results from preclinical in vitro and in vivo studies of EP-100 in ovarian cancer cell lines and ovarian xenograft mod...

Cylene Pharmaceuticals Initiates Phase I Trial With CX-4945 -Breakthrough First-in Class Inhibitor of CK2

...ministered small molecule anticancer agent that delivers highly selective and potent inhibition of CK2, a constitutively active protein kinase that is overexpressed in a wide range of cancers. CK2 drives the excessive proliferation phenotype of cancer cells through its potentiating role in key cell survival pathwa...

SuperGen's PIM Kinase Inhibitor, SGI-1776, Effective in Pre-Clinical Models of Acute Lymphoblastic Leukemia

...SGI-1776, has significant potential in hematologic malignancies," commented Dr. Gregory Berk, Chief Medical Officer of SuperGen. "PIM-1 is known to be overexpressed in ALL, AML, CML, as well as non-Hodgkin's lymphoma. In many of these conditions PIM-1 overexpression is a poor prognostic factor. It has been postula...

Alexion Secures U.S. Patent for ALXN6000, a First-In-Class Anti-CD200 Monoclonal Antibody

...vailable at the http://www.clinicaltrials.gov website maintained by the U.S. National Institutes of Health. About ALXN6000 The CD200 molecule is overexpressed in certain tumor cells and may inhibit the body's immune response to that tumor which could allow for the growth and survival of tumors involved in se...

CuraGen Announces Initiation of Phase II Trial of CR011-vcMMAE in Patients with Advanced Breast Cancer

...is newly initiated study in breast cancer during the first half of 2009." CR011-vcMMAE targets a protein known as glycoprotein NMB (GPNMB), which is overexpressed in a variety of cancers including breast cancer, melanoma, and brain tumors. CR011-vcMMAE is an antibody-drug conjugate comprised of a fully-human mon...

CuraGen Announces Expansion of CR011-vcMMAE Phase II Trial in Melanoma

...s. Enrollment in the study is expected to be completed by the end of 2008. CR011-vcMMAE targets a protein known as GPNMB, which has been shown to be overexpressed in melanoma, breast cancer and brain tumors. Based on the clinical activity observed in the treatment of melanoma, CuraGen anticipates initiating a Ph...

Keryx Biopharmaceuticals, Inc. Announces Phase 1 and Phase 2 Data on KRX-0401 (Perifosine) in Patients with Relapsed/Refractory Multiple Myeloma at 49th Annual Meeting of American Society of Hematology

...otherwise modify signaling through a number of different signal transduction pathways including Akt, MAPK, and JNK. Akt isoforms have been found to be overexpressed in renal, breast, prostate, and pancreatic cancers. Elevated levels of pAkt have been correlated with poor prognosis in patients with gastric, hepatoc...
Overexpressed in Biological News

Protein can help cells or cause cancer, Purdue researcher finds

...t to keep p53 as normal as possible," Liu said. "In about 50 percent of cancers, p53 had lost its function, and there was too much Plk1. Since Plk1 is overexpressed in cancers, it is a cancer therapy target." Topors can also carry out a function called sumoylation, in which Topors binds to p53 molecules and cre...

Axel Ullrich named winner of 2009 Dr. Paul Janssen Award for Biomedical Research

... human insulin, the first therapeutic derived from gene cloning. In 1987, Ullrich and collaborators discovered that the neu/HER2 gene is amplified and overexpressed in more than 30 percent of invasive breast cancers. HER2 was chosen for the development of an entirely novel cancer therapy, culminating in the produc...

Scientists uncover mode of action of enzyme linked with several types of cancer

...ral defects in their genome," explains Damien D'Amours, Principal Investigator at IRIC and director of the study, "We discovered that the polo kinase, overexpressed in a broad range of human tumours, tells the chromosomes exactly when to condense during cell division." Misregulation of the polo kinase is assoc...

Newly discovered epidermal growth factor receptor active in human pancreatic cancers

...sies. As a first step, his team has gone through the scientific literature to create a compendium of several hundred proteins and genes reported to be overexpressed in pancreatic cancers, making them excellent candidates for further study. The compendium already is being used by a consortium of investigators who a...

Compendium of pancreatic cancer biomarkers established as strategic approach to early-detection

...oS Medicine . They systematically cataloged the genes and proteins that are overexpressed in pancreatic cancer patients, then characterized and compared these biomar...rtlisted because they were reported in four or more published studies to be overexpressed meaning that the proteins they make are in higher abundance in people with...

Lipid droplets lead a Spartin existence

... the protein caused an increase in both the organelle's size and number. In turn, Spartin is regulated by ubiquitination by the ubiquitin ligase WWP1. overexpressed WWP1 removed Spartin from LDs and promoted its degradation. A truncated form of Spartin found in a rare neuronal disease called Troyer syndrome did...

U-M researchers ID gene involved in pancreatic cancer

... ANN ARBOR, Mich. Researchers from the University of Michigan Comprehensive Cancer Center have identified a gene that is overexpressed in 90 percent of pancreatic cancers, the most deadly type of cancer. Expression of the gene, Ataxia Telangiectasia Group D Complementing gene, call...

Cancer-causing gene discovery suggests new therapies

...her protein production induced by Myc played a role in cancer, the UCSF- led team genetically crossed two types of mice: one that was cancer-prone and overexpressed the Myc oncogene and one that was newly engineered to lower protein production. The new cross of mice possessed not only the well-known destructive M...

Team finds breast cancer gene linked to disease spread

...s scientists were able to re-examine the tumor samples. "By analyzing 250 breast tumor samples from patients, we found that this gene is amplified and overexpressed in over 30 to 40 percent of breast cancer cases," Kang said. "This indicates that new drugs against Metadherin may potentially benefit a large populat...

UC Davis researchers find molecule that targets brain tumors

...tudy, they identified a molecule called LXY1 that binds with high specificity to a particular cell-surface protein called alpha-3 integrin, which is overexpressed on cancer cells. They also tested the molecule's ability to target brain cancer by implanting human glioblastoma cells both beneath the skin and in...
Overexpressed in Biological Technology

Micromet Closes $80.5 Million Public Offering of Common Stock

... in a phase 1 clinical trial for the treatment of patients with solid tumors. MT110 binds to the epithelial cell adhesion molecule, or EpCAM, which is overexpressed in many solid tumors. Micromet's human monoclonal antibody adecatumumab (MT201) also binds to EpCAM and is being developed under a collaboration with ...

Micromet Receives European Orphan Drug Designation for Treatment of Acute Lymphoblastic Leukemia with BiTE Antibody Blinatumomab

... in a phase 1 clinical trial for the treatment of patients with solid tumors. MT110 binds to the epithelial cell adhesion molecule, or EpCAM, which is overexpressed in many solid tumors. Micromet's human monoclonal antibody adecatumumab (MT201) also binds to EpCAM and is being developed under a collaboration with ...

Micromet Announces Pricing of Public Offering of Common Stock

... in a phase 1 clinical trial for the treatment of patients with solid tumors. MT110 binds to the epithelial cell adhesion molecule, or EpCAM, which is overexpressed in many solid tumors. Micromet's human monoclonal antibody adecatumumab (MT201) also binds to EpCAM and is being developed under a collaboration with ...

Micromet Announces Public Offering of Common Stock

... in a phase 1 clinical trial for the treatment of patients with solid tumors. MT110 binds to the epithelial cell adhesion molecule, or EpCAM, which is overexpressed in many solid tumors. Micromet's human monoclonal antibody adecatumumab (MT201) also binds to EpCAM and is being developed under a collaboration with ...

Micromet, Inc. to Host Conference Call and Webcast to Report Second Quarter 2009 Financial Results on August 6, 2009

... in a phase 1 clinical trial for the treatment of patients with solid tumors. MT110 binds to the epithelial cell adhesion molecule, or EpCAM, which is overexpressed in many solid tumors. Micromet's human monoclonal antibody adecatumumab (MT201) also binds to EpCAM and is being developed under a collaboration with ...

Video: Axel Ullrich Named Winner of 2009 Dr. Paul Janssen Award for Biomedical Research

... human insulin, the first therapeutic derived from gene cloning. In 1987, Ullrich and collaborators discovered that the neu/HER2 gene is amplified and overexpressed in more than 30 percent of invasive breast cancers. HER2 was chosen for the development of an entirely novel cancer therapy, culminating in the produc...

Micromet Added to Russell 3000 Index

... in a phase 1 clinical trial for the treatment of patients with solid tumors. MT110 binds to the epithelial cell adhesion molecule, or EpCAM, which is overexpressed in many solid tumors. Micromet's human monoclonal antibody adecatumumab (MT201) also binds to EpCAM and is being developed under a collaboration with ...

Micromet to Host Conference Call and Webcast to Discuss Blinatumomab Data Presented at EHA on June 8, 2009

... in a phase 1 clinical trial for the treatment of patients with solid tumors. MT110 binds to the epithelial cell adhesion molecule, or EpCAM, which is overexpressed in many solid tumors. Micromet's human monoclonal antibody adecatumumab (MT201) also binds to EpCAM and is being developed under a collaboration with ...

Micromet Presents Update at ASCO 2009 on a Phase 1b Combination Study of Adecatumumab and Docetaxel

... in a phase 1 clinical trial for the treatment of patients with solid tumors. MT110 binds to the epithelial cell adhesion molecule, or EpCAM, which is overexpressed in many solid tumors. Micromet's human monoclonal antibody adecatumumab (MT201) also binds to EpCAM and is being developed under a collaboration with ...

Cynvec LLC(SM) to Present at the Cowen and Company 29th Annual Health Care Conference

...otechnology company, is developing proprietary cancer therapies based on the apoptotic sindbis oncolytic viral vector, a novel technology that targets overexpressed laminin receptors on the surface of many solid tumors without affecting normal cells. Under an exclusive worldwide license from the NYU School of Med...
Overexpressed in Biological Definition

Apoptosis

...f cancer. Hgg, which conveys an anti-apoptotic signal, has been found to be overexpressed in pancreatic adenocarcinoma tissues. Development Programmed cel...lls). They found that the X-linked inhibitor of apoptosis protein (XIAP) is overexpressed in H460 cells. XIAPs bind to the processed form of caspase-9, and suppress ...
Overexpressed in Biological Dictionary

B lymphocytes

...ells) ... The most common types of lymphocytes are. B lymphocytes (" B cells" ... Information about B lymphocytes in the free online ... overexpressed Bcl-2 in T and B lymphocytes had a marked decrease in apoptosis at ... Information about B lymphocyte in the free online English ... PDB ...
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