Cell pathway on overdrive prevents cancer response to dietary restriction

FINDINGS: Whitehead Institute researchers have pinpointed a cellular pathway that determines whether cancerous tumors are susceptible to dietary restriction during their development. When this pathway, known as PI3K is permanently turned "on" via mutation, tumors grow and proliferate independent o...

Switching Genes to Overdrive Improves Muscular Dystrophy Symptoms in Mice

BOSTON -- Scientists at Dana-Farber Cancer Institute have shown in a laboratory study that revving up a crucial set of muscle genes counteracts// the damage caused by a form of muscular dystrophy. Reporting in the April 1 issue of Genes and Development, the researchers demonstrated that manip...

Waiting for biopsy results may adversely affect health

... sugar and immune response in a good way when needed," Dr. Lang said. "But when stress becomes chronic, cortisol secretion either goes into continuous overdrive or dries up, leaving the immune system vulnerable and other body functions less well adapted." The women participating in the study underwent large...

Scientists uncover indicator that warns leukemia is progressing to more dangerous form

...onalized therapies for these patients," said staff research associate and co-first author Annelie Abrahamsson. In CML, an enzyme called ABL goes in overdrive because of a chromosomal mix-up that occurs during blood cell development. The genes ABL and BCR fuse and produce a hybrid BCR-ABL enzyme that drives ...

Maximus Rocks the Doors off Rocketown at Cancer Benefit Concert Featuring the Pink Spiders, The Running and SupreX

...h the team at Precious Cargo for all their support in bringing something positive into the lives of the Freeman family," James concluded. Maximus overdrive is a music show exclusive to Maximus hospitality services and will host "Live" performances from the hottest artists staged in intimate venues across ...

Pancreatic Cancer May Have a New Foe

...aid in a news release issued by the conference organizers. The mutated gene, K-RAS, normally promotes growth but in its abnormal form is kicks into overdrive opening a major signaling pathway that help increase cell growth people with pancreatic cancer. In experiments with fruit flies, increased SIAH exp...

Leading pharmacologists to meet in Brighton

...sis. They are also implicated in infectious diseases such as malaria and TB. TLRs have been shown to be over-active in these diseases - they go into overdrive and cause inflammation and damage. There is a consensus emerging that inhibiting them might prove useful to treat these diseases, or, alternatively,...

Depression Heightens Sensitivity to Pain

... reaction to physical discomfort FRIDAY, Nov. 7 (HealthDay News) -- When anticipating pain, the brains of people with depression kick into overdrive and hinder their ability to handle hurt, a new study shows. The November issue of the Archives of General Psychiatry reports brain imaging also r...

Silence the Sleep Apnea "Snorechestra" to Fight Heart Disease, From the Harvard Heart Letter

...eathe now!” signal that briefly wakens the sleeper and makes him or her gasp for air. This signal fires up the same stress hormones that go into overdrive when you are angry or frightened. They make the heart beat faster and boost blood pressure. They stoke inflammation, a key player in heart disease. Th...

Finally ... A Chance for Both Men and Women to Take CTRL(TM) of Their Own Skin!

...e requiring a more balanced product -- Male skin has more androgen sensitive receptors near the surface, which can put oil production into overdrive and overwhelm unsuspecting pores -- Female skin is affected by estrogen and progesterone levels while male skin is affected by testosterone --...

overdrive in Medical Technology

R788 in TASKi3 Clinical Trial Does Not Meet Efficacy Endpoints in RA Patients Who Had Previously Failed Biologic Therapies - Results Incongruent

...debilitating disease, that affects more than 2 million people in the U.S. It is a chronic inflammatory disease that puts the body's immune system into overdrive where it ultimately causes inflammation in the joints and destroys soft tissues, cartilage and bone. Rigel's R788 is a novel, orally available syk ki...

Rigel's R788 Significantly Improves Rheumatoid Arthritis in Phase 2b Clinical Trial

...debilitating disease, that affects more than 2 million people in the U.S. It is a chronic inflammatory disease that puts the body's immune system into overdrive where it ultimately causes inflammation in the joints and destroys soft tissues, cartilage and bone. Rigel's R788 is a novel, orally available syk ki...

Rigel's R788 Demonstrates Significant Improvement in Rheumatoid Arthritis in Phase 2 Clinical Study

...debilitating disease, that affects more than 2 million people in the U.S. It is a chronic inflammatory disease that puts the body's immune system into overdrive where it ultimately causes inflammation in the joints and destroys soft tissues, cartilage and bone. Rigel's R788 is a novel, orally available syk kin...

overdrive in Medical Products

PACE 101 H

Description:... The Oscor PACE 101 H is an external single chamber cardiac demand pacemaker. The PACE 101 H feature an option for a atrial overdrive stimulation....
Company:Oscor Inc.

overdrive in Biological News

Smoke from cigarettes, cooking oil, wood, shift male cardiovascular system into overdrive

NEW ORLEANS (April 17, 2009) Secondhand tobacco smoke and smoke from cooking oil and wood smoke affected cardiovascular function of men and women who were exposed to small doses of the smoke for as little as 10 minutes, according to a study from the University of Kentucky. The study confirmed ...

Smoke from cigarettes, cooking oil, wood, shift male cardiovascular system into overdrive

NEW ORLEANS (April 17, 2009) Secondhand tobacco smoke and smoke from cooking oil and wood smoke affected cardiovascular function of men and women who were exposed to small doses of the smoke for as little as 10 minutes, according to a study from the University of Kentucky. The study confirmed ...

Switching genes to overdrive improves muscular dystrophy symptoms in mice

Scientists at Dana-Farber Cancer Institute have shown in a laboratory study that revving up a crucial set of muscle genes counteracts the damage caused by a form of muscular dystrophy. Reporting in the April 1 issue of Genes and Development, the researchers demonstrated that manipulating a geneti...

Stop and smell the flowers -- the scent really can soothe stress

...nd lymphocytes key parts of the immune system to near-normal levels. Inhaling linalool also reduced the activity of more than 100 genes that go into overdrive in stressful situations. The findings could form the basis of new blood tests for identifying fragrances that can soothe stress, the researchers say. ...

Ten genes identified in connection with sudden cardiac death

... ANN ARBOR, Mich.---You're sitting at your desk and suddenly your heart is beating in overdrive or worse, lurching along like a car on fumes. It is a shocking, uncomfortable and frightening sensation. Irregular heart rhythms are a common caus...

Modified plants may yield more biofuel

... crops such as ryegrass and clover is that they have too much lignin, which can cause ruminants like cows to get sick. Their digestive enzymes go into overdrive to break down the lignin, creating a lot of gas and digestion problems for the animals. "All animals produce enzymes in their digestive process th...

2 new compounds show promise for eliminating breast cancer tumors

...s it causes no harm. But in breast cancer patients, the protein is abnormally active. It never shuts off." When that happens, the protein goes into overdrive and is bent on supporting the proliferation of breast cancer cells. The protein even creates a network of blood vessels to feed the cancer cells, supp...

Two new compounds show promise for eliminating breast cancer tumors

...s it causes no harm. But in breast cancer patients, the protein is abnormally active. It never shuts off." When that happens, the protein goes into overdrive and is bent on supporting the proliferation of breast cancer cells. The protein even creates a network of blood vessels to feed the cancer cells, supp...

Vitiligo skin disorder could yield clues in fight against melanoma

...new treatments for melanoma, the deadliest form of skin cancer. Vitiligo appears to be an auto-immune disease, in which the immune system goes into overdrive and kills pigment cells, which give skin its color. Loyola researcher Caroline Le Poole, PhD, is studying how to stop vitiligo. The goal is to adjust ...

UC Davis researchers discover new drug target for inflammatory disease

...esearchers can be much more successful in screening potential drugs that can block the binding process and hopefully the immune response it kicks into overdrive as well." In the current study, Takada and team evaluated the possibility of integrin binding by sPLA2-IIA using a computer program that predicts ...