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Osteosarcoma in Medical News

Takeda to Acquire IDM Pharma, Adding MEPACT(R) (Mifamurtide), the First Treatment Approved for Osteosarcoma in More Than 20 Years, to Its Oncology Franchise

OSAKA, Japan, and IRVINE, Calif., May 18 /PRNewswire-FirstCall/ -- Takeda Pharmaceutical Company Limited (TSE: 4502) and IDM Pharma, Inc. (Nasdaq: IDMI ) today announced that Takeda America Holdings, Inc., a wholly-owned subsidiary of Takeda (Takeda America), and IDM Pharma have enter...

IDM Pharma Announces Data Supporting Improved Overall Survival Advantage in Newly Diagnosed Patients with Metastatic Osteosarcoma Treated with Mifamurtide (L-MTP-PE)

- Data Presented at the 44th American Society for Clinical Oncology (ASCO) Annual Meeting - IRVINE, Calif., June 2 /PRNewswire-FirstCall/ -- IDM Pharma, Inc. (Nasdaq: IDMI ) today announced the presentation of an analysis from the Phase 3 mifamurtide (L-MTP-PE) clini...

FDA Approves the Opening of a Phase II Registration Protocol Using REXIN-G(R) for Osteosarcoma in California U.S.A.

SAN MARINO, Calif., Nov. 5 /PRNewswire/ -- Epeius Biotechnologies Corporation announced today that the company has taken a major step toward the commercialization of its lead product with the opening of a Phase II Registration Protocol using Rexin-G for osteosarcoma in the United States. Follo...

IDM Pharma's MEPACT(R) (Mifamurtide, L-MTP-PE) Receives Approval in Europe for Treatment of Patients with Non-Metastatic, Resectable Osteosarcoma

First New Agent Approved to Treat Osteosarcoma in More Than 20 Years IRVINE, Calif., March 9 /PRNewswire-FirstCall/ -- IDM Pharma, Inc. (Nasdaq: IDMI ) today announced that the European Commission has formally granted a Centralized marketing authorization for MEPACT(R) (mifamurtide, L-MTP...

Researchers identify potential therapeutic target in osteosarcoma

HOUSTON-A receptor known to be active in bone metastases, but previously unexplored in primary bone tumors, is a potential therapeutic target in osteosarcoma, investigators from The University of Texas M. D. Anderson Cancer Center report in the March 1 issue of Cancer Research . The researche...

Research increases possibilities of personalizing treatment of infant osteosarcoma

This release is available in Spanish . A team of specialists at the University Hospital of Navarra have revealed the existence of genetic variants that have greater resistance to a specific treatment and a greater toxicity of the pharmaceutical drug in some child patients affected by oste...

Novel model of osteosarcoma

In the June 15th issue of G&D, Dr. Stuart Orkin (HHMI, Dana-Farber Cancer Institute, Children's Hospital Boston) and colleagues present a new mouse model of osteosarcoma. Osteosarcoma is the most common type of malignant bone cancer, and one of the most lethal: The 5-year survival rate is only...

Insights into Osteosarcoma in Cats and Dogs may Improve Palliative Care

Researchers at the University of Illinois have found that a molecular pathway known to have a role in the progression of bone cancer in humans is also critical to the pathology// of skeletal tumors in dogs and cats. Their work could lead to advances in the palliative care of companion animals affli...

Effect of Osteosarcoma predicted by scans

Researchers have been studying about the outcome of the hitech scanning technologies recently. A scan that looks at glucose uptake in a tumour shows who has a poor prognosis. Osteosarcoma is a bone tumour which affects mainly younger people. //It's an unusual cancer and one where the outcome tends ...

FDA Approves Expanded Use of Lilly's FORTEO(R) [teriparatide (rDNA origin) injection] to Treat Glucocorticoid-Induced Osteoporosis

...warning section of the label regarding the risk of osteosarcoma to reinforce that FORTEO should not be used in ped...o further evaluate the long-term safety of FORTEO. osteosarcoma is a serious but rare cancer which occurs at a rat... of about four cases per million people, per year. osteosarcoma has been reported rarely in people who took FORTEO...
Osteosarcoma in Medical Technology

IDM Pharma Announces Updated Phase 3 Mifamurtide (L-MTP-PE) Data Confirms Statistically Superior Overall Survival in Osteosarcoma Patients

IRVINE, Calif., Nov. 1 /PRNewswire-FirstCall/ -- IDM Pharma, Inc. (Nasdaq: IDMI ) today announced the presentation of updated survival data from the Phase 3 mifamurtide (L-MTP-PE) clinical trial (INT-0133). The trial was part of a National Cancer Institute (NCI) funded cooperative group study...

Another Study Links Fluoride to Bone Cancer

... levels were significantly higher in patients with osteosarcoma than in control groups, according to research publ... found to be significantly higher in patients with osteosarcoma as compared to the other two groups," writes Randh...ssin showing a link between water fluoridation and osteosarcoma in young boys.(2) A 1992 New Jersey Departmen...

IDM Pharma Provides Update on Mifamurtide (L-MTP-PE) Regulatory Status Following September Meeting of European Committee for Medicinal Products for Human Use (CHMP)

...rovides a significant overall survival benefit for osteosarcoma patients and meets an important unmet treatment ne...of all childhood cancers are osteosarcoma. Because osteosarcoma usually develops from osteoblasts, it most commonl...d limited movement can occur as the tumor grows. osteosarcoma is an orphan disease with fewer than 1,000 new cas...

IDM Pharma Provides Update on Mifamurtide (L-MTP-PE) Regulatory Status Following June Meeting of European Committee for Medicinal Products for Human Use (CHMP)

...of all childhood cancers are osteosarcoma. Because osteosarcoma usually develops from osteoblasts, it most commonl...d limited movement can occur as the tumor grows. osteosarcoma is an orphan disease with fewer than 1,000 new cas...en's Oncology Group, the survival of children with osteosarcoma has remained at 60-65 percent since the mid-1980s....

IDM Pharma Announces Updated Data From Mifamurtide (L-MTP-PE) Compassionate Access Program

...e 3 clinical trial in patients with non-metastatic osteosarcoma are being supported in patients with lung metastas... Study design and findings Twenty-nine high-risk osteosarcoma patients (ages 10 - 21) were enrolled and 27 have ...the program had documented diagnosis of high grade osteosarcoma with relapsed or recurrent disease (locally or met...

IDM Pharma Announces Availability of Mifamurtide (L-MTP-PE) Through Compassionate Access Study

...ides mifamurtide (L-MTP-PE) to eligible, high-risk osteosarcoma patients through a compassionate access study. "...ent need by providing L-MTP-PE access to high-risk osteosarcoma patients for whom current therapy is not effective...ents will have a confirmed diagnosis of high grade osteosarcoma with relapsed or recurrent disease, locally or met...

IDM Pharma Announces Phase 3 Mifamurtide (L-MTP-PE) Study Demonstrating Improved Survival Published in the Journal of Clinical Oncology

... Chemotherapy Reduced the Risk of Death by 30% in osteosarcoma Patients IRVINE, Calif., Feb. 4 /PRNewswire-Firs...f 662 patients with newly diagnosed non-metastatic osteosarcoma treated in the Phase 3 trial and demonstrated that...amide) in patients with newly diagnosed resectable osteosarcoma without metastatic disease. Patients received on...

IDM Pharma Announces Non-Binding Opinion of the European Committee for Medicinal Products for Human Use (CHMP) that Mifamurtide (L-MTP-PE) Provides a Possible Clinical Benefit in Survival

...d limited movement can occur as the tumor grows. osteosarcoma is an orphan disease with fewer than 1,000 new cas...en's Oncology Group, the survival of children with osteosarcoma has remained at 60-65 percent since the mid-1980s. The standard treatment for osteosarcoma is tumor resection with combination chemotherapy b...

ASEAN News: Epeius Biotechnologies Gains Commercial Approval for Rexin-G(R), a Tumor-Targeted Gene-Based Medicine for Metastatic Cancer

...and sarcoma. Based again on unprecedented single-agent efficacy and over-all safety, the US FDA recently approved a Phase II Registration Protocol for osteosarcoma which includes participation of children and adolescents. For additional information about ongoing clinical trials in the United States, contact our M...

FORTEO(R) Increased Spine Bone Mineral Density in Patients with Glucocorticoid-Induced Osteoporosis

...dies, teriparatide caused some rats to develop osteosarcoma, a bone cancer. osteosarcoma in humans is a serious but very rare cancer. Osteosarcoma occurs in about f... product. FORTEO also has a "boxed warning" in its package insert about the osteosarcoma findings in rats during preclinical testing. For full prescribing informati...
Osteosarcoma in Medical Definition

Pathology

...a - Lipoma / liposarcoma - Leiomyoma / leiomyosarcoma - Rhabdomyoma / rhabdomyosarcoma - Mesothelioma - Angioma / angiosarcoma - Osteoma / osteosarcoma - Chondroma / chondrosarcoma - Glioma - Lymphoma / leukemia Treatment Surgery - Chemotherapy - Radiation therapy - Immunotherapy...

Ocular oncology

...a - Lipoma / liposarcoma - Leiomyoma / leiomyosarcoma - Rhabdomyoma / rhabdomyosarcoma - Mesothelioma - Angioma / angiosarcoma - Osteoma / osteosarcoma - Chondroma / chondrosarcoma - Glioma - Lymphoma / leukemia Treatment Surgery - Chemotherapy - Radiation therapy - Immunotherapy...
Osteosarcoma in Medical Dictionary

Osteosarcoma

Osteosarcoma is the most common type of malignant bone cancer, accounting for 35% of primary bone malignancies. There is a preference for the metaphyseal region of tubular long bones. 50% of cases occur around the knee. It is a malignant connective (soft) tissue tumor... Osteosarcoma is...

Bone tumors

...ely rare. ... back pain, doctors will usually order a bone scan, a CT scan (CAT scan), or an MRI. ... ... treatment and prognosis of canine osteosarcoma ( bone cancer) ... Bone tumors are tender so it is usually clear what part of the limb should be radiographed. ... ...

Bone cancer

.... ... Boys who drink fluoridated water have an increased risk of a deadly bone cancer , a new study suggests. ... water got bone cancer -- osteosarcoma -- more often ... Bone cancer information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, pr...
Osteosarcoma in Biological News

A longer lasting tumor blocker

...he structural support they need to grow. Meanwhile, the scaffold of mice treated with anti-VEGF remained intact. M-CSF levels soar in patients with osteosarcoma (a malignant bone cancer), breast cancer and prostate cancer, making these cancers potentially the most responsive to M-CSF-blocking drugs Whether or ...
Osteosarcoma in Biological Technology

Epeius Biotechnologies' Tumor-Targeted Rexin-G Receives FDA Orphan Drug Designation for the Treatment of Osteosarcoma

SAN MARINO, Calif., July 8 /PRNewswire/ -- Epeius Biotechnologies Corporation today announced that Rexin-G has been granted Orphan Drug Designation by the U.S. Food and Drug Administration (FDA) for the treatment of osteosarcoma. Based on several criteria, including the rarity, seriousness, an...

IDM Pharma Receives Not Approvable Letter for Mifamurtide (L-MTP-PE) for the Treatment of Osteosarcoma

- Company Amending NDA and Committed to Addressing Unmet Needs of Critically Ill Children and Young Adults - - Conference Call Scheduled for 4:30 p.m. ET - IRVINE, Calif., Aug. 27 /PRNewswire-FirstCall/ -- IDM Pharma, Inc. (Nasdaq: IDMI ) announced today that it r...

IDM Pharma Reports 2008 Financial Results

... acquisition transaction. "2008 was a significant year for the Company with December's recommendation for approval of MEPACT for the treatment of osteosarcoma in Europe and the formal approval of the centralized marketing authorization following in early March of 2009," said Timothy P. Walbert, president and...

Oncolytics Biotech Inc.'s REOLYSIN(R) Exceeds Primary Statistical Endpoint in U.S. Phase 2 Sarcoma Study

...----------- Ewing's sarcoma 9* SD ------------------------------------------------------------------------- osteosarcoma 9* SD (tumour resection after cycle 4) -----------------...

Rexin-G Returns to The Big Apple: Clinical Trials for Pancreatic Cancer and Breast Cancer Open in Manhattan

...of these clinical trials to the East Coast. Rexin-G has gained orphan drug status from the U.S. FDA for three clinical indications: pancreatic cancer, osteosarcoma and soft tissue sarcoma. The New York clinical trials will be conducted at the Bruckner Oncology Center in Manhattan, New York with Howard W. Bruckn...

Epeius Biotechnologies Awarded U.S. Patent for Targeted Injectable Gene Delivery In Vivo

...e breast or pancreas and for bone and soft tissue sarcoma respectively. Additionally, a Phase II Registration Protocol is underway for chemo-resistant osteosarcoma in Los Angeles, California. About Epeius Biotechnologies Epeius Biotechnologies Corporation is a privately held biopharmaceutical company dedicate...

IDM Pharma Names Dr. Jeffrey W. Sherman Chief Medical Officer and Senior Vice President of Research and Development

... Company's Phase 3 trial do not provide substantial evidence of effectiveness of L-MTP-PE in the treatment of patients with non-metastatic, resectable osteosarcoma receiving combination chemotherapy would have upon the determination by the FDA whether to approve the marketing application for L- MTP-PE, which woul...
Osteosarcoma in Biological Definition

Cancer

...cancer , mesothelioma - in the pleura or pericardium , oral cancer , osteosarcoma - in bones , ovarian cancer , pancreatic cancer , prostate cancer , r...a (MEN types 1, 2a, 2b) Li-Fraumeni syndrome (various tumors such as osteosarcoma , breast cancer, soft-tissue sarcoma , brain tumors ) due to mutations of ...

Tumor

...ors of mesenchymal origin: connective tissue: fibroma , fibrosarcoma myxoma , myxosarcoma chondroma , chondrosarcoma osteoma , osteosarcoma (osteogenic sarcoma) lipoma , liposarcoma muscle: leiomyoma , leiomyosarcoma rhabdomyoma , rhabdomyosarcoma endothelium:...
Osteosarcoma in Biological Dictionary

Viral oncogene

...om 176 cDNA libraries. ... Homo sapiens FBJ murine osteosarcoma viral oncogene -like B variant 8 (FOSB) mRNA, ....5 (avian) - Bioportfolio FOS - v-fos FBJ murine osteosarcoma viral oncogene homolog - Bioportfolio ... v-fos FBJ murine osteosarcoma viral oncogene homolog. c-Fos interacts with ....
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