Smoking increases potential for metastatic pancreatic cancer
...rsity and a member of the Jefferson Pancreatic, Biliary & Related Cancers Center.
Nicotine promotes the expression osteopontin, and high levels of osteopontin
have been reported in pancreatic ductal carcinoma (PDA). Dr. Arafat and her research team analyzed PDA samples and confirmed that the isoform, called ...
NYU Langone Medical Center's tip sheet to the 45th Annual Meeting of ASCO
... be a promising tool for monitoring early stage lung cancer. In a small study, they found higher levels of an extracellular structural protein called osteopontin
(OPN) in patients with early stage non-small cell lung cancer compared to current or former smokers, and they also found that the levels decreased amo...
Parent Project Muscular Dystrophy Awards Two End Duchenne Grants
... of Neurology at UCLA , who will receive $50,000 to continue her work with osteopontin
as a therapeutic target for Duchenne.
(Logo: http://www.newscom.com... her work. "Ms. Furlong and the grant committee understand the potential of osteopontin
to help reduce inflammation and fibrosis in Duchenne, and they are willing ...
New Tool in the Radiography Approach Will Assist in Earlier Detection of Asbestos-Related Diseases
...nts another first for Karmanos Cancer Institute scientists and physicians. Previously, NCVAC researchers were among the first to discover the value of osteopontin
-- a tumor marker of mesothelioma -- and published this finding in the New England Journal of Medicine. Karmanos workers have also reported the potent...
Primary tumors can drive the growth of distant cancers
...e process is the secretion of a substance known as osteopontin
by the instigating tumor, a finding that may have ...c implications. Indeed, the researchers noted that osteopontin
is present at elevated levels in women with metast... really know how that happens. They also show that osteopontin
is necessary to the process, but that it does not ...
Primary Tumors Fuel Growth of Cancer Cells
The secretion of a substance called osteopontin
by the primary tumor is an important part of this process, said the researchers, who noted that osteopontin
is present at elevated levels in women with metast... know exactly how that occurs. They also know that osteopontin
does not act alone in this process.
NYU Langone Medical Center's tip sheet to the 44th annual meeting of ASCO
...ly Detection of Malignant Pleural Mesothelioma
Abstract # 11074: Plasma osteopontin
is an early detection and prognostic marker
in malignant pleural mesothelio...orkers in the United States who have been exposed to asbestos. The level of osteopontin
(OPN), a protein biomarker, in blood serum has been characterized as an ear...
Jefferson scientists' discovery may help explain smoking-pancreatic cancer link
...rebrospinal fluid, synovial fluid and breast milk. osteopontin
is also present in different organs and plays an i...development. Recent studies have demonstrated that osteopontin
levels are significantly higher in the blood and p...become metastatic.
Dr. Arafat wanted to see if osteopontin
might play a role in the cigarette smoking-pancrea...
Biomarker may be an early predictor of advanced breast cancer
... to more accurately predict breast cancer that will become metastatic and spread to distant organs from the original tumor site.
In normal levels, osteopontin
is a protein used by the immune system to help cells move and migrate. There are three forms of osteopontina, b and cwhich are formed by splicing, or ...
Study identifies key player in the body's immune response to chronic stress
... HOUSTON (Sept. 3, 2007) osteopontin
(OPN), a protein molecule involved in many different cellular processes, plays a significant role in immune deficiency and organ atrophy following chr...
New mediator of smoking recruits
... suggests that smoking increases the production of osteopontin
in the lungs, which contributes to the development...related report by Prasse et al, "Essential role of osteopontin
in smoking-related interstitial lung diseases," ap...cell recruitment in smokers, Prasse et al compared osteopontin
levels from smokers with different types of lung d...
Skin care: new research into scar-free healing
...colleagues at the University of Bristol shows that osteopontin
(OPN) is one of the genes that triggers scarring a...king wound inflammation and fibrosis: knockdown of osteopontin
leads to rapid repair and reduced scarring. The pa...l signals (PDGF) delivered to the wound cells, and osteopontin
itself are now all clear targets for developing me...
Mice stressed in simulated weightlessness show organ atrophy
...search with Japanese scientists employing this model implicated the protein osteopontin
(OPN) in bone mineral loss associated with simulated weightlessness in mice... to occur, pointing to a whole new physiological realm in which the culprit osteopontin
is causing problems. ...