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Osteoclasts in Medical News

Amgen Highlights Data to Be Presented at ASCO

...umab is the first fully human monoclonal antibody in late stage clinical development that specifically targets RANK Ligand, the essential regulator of osteoclasts (the cells that break down bone). Amgen is studying denosumab in numerous tumor types across the spectrum of cancer induced bone disease. Over 11,000 ...

X-Rays Help Predict Permanent Bone Damage From Bisphosphonates

...eoporosis, multiple myeloma, Paget's disease (bone cancers), and bone metastasis from other cancers. These drugs can bond to bone surfaces and prevent osteoclasts (cells that break down bone) from doing their job. Other cells are still working trying to form bone, but it may turn out to be less healthy bone, lea...

Scientists discover way to jumpstart bone's healing process

...nd forth creating a painful phenomenon known as micromotion. As the bone begins healing it must progress through specific, well-defined stages. First, osteoclasts cells that can break down bone clean up any fragments or debris produced during the break. Next, a layer of cartilage called a callus forms aroun...

Scientists discover key factor in controlling the breakdown of bone

... by specialized cells called osteoclasts. Immature osteoclasts circulate within the blood and migrate to the surf... they mature and start to degrade the bone matrix. osteoclasts are the only cells known to degrade bone. Norm...Anthony S. Fauci, M.D. "Understanding how immature osteoclasts are recruited to the bone in the first place and t...

Osteoporosis Drug Prompts Increase in Certain Bone Cells

... a new study says. These women also had "giant" osteoclasts -- single cells fused together -- with as many as ...s is accomplished by two kinds of cells: armies of osteoclasts that erode cavities in the bone, then teams of ost...red with women in the placebo group. The number of osteoclasts increased with the dose, the study found. Twent...

Genetic disorder sheds light on enzyme's role in bone metabolism

...cy of an enzyme known as cathepsin K which hampers osteoclasts (the cells that break down bone in bone modeling a...f bone resorption. The analyses showed that the osteoclasts formed by the patient lacked cathepsin K, which wa...h the resorption was abnormal. In bone resorption, osteoclasts attach to the bone and dissolve bone mineral in th...

Same process discovered to both form skeleton and protect it for life

...blasts are one of two cell types, which coupled together, enable bone to continuously recycle itself and stay strong. Where osteoblasts make new bone, osteoclasts eat aging bone to make way for new bone in a careful balance with osteoblasts. The current study suggests for the first time that Notch signaling ...

Notch controls bone formation and strength

...aintain a healthy skeleton. Future studies may look at the possiblity that loss of Notch interferes with the natural signal between osteoblasts and osteoclasts (bone resorbing cells) and prevents the homeostasis or natural balance between the two. That means the protein Notch and the cellular pathways tha...

Turning on adult stem cells may help repair bone

...ant improvements in bone formation and density. Since current treatments for osteoporosis which target differentiated cells like osteoblasts and the osteoclasts that break down bone have limitations, the ability to direct differentiation of MSCs could be a promising approach to treating osteoporosis and cance...

Diabetes Drug Avandia Could Weaken Bones

... also stimulates the production of osteoclasts, cells whose key function is to degrade bone. Proper bone health is maintained by a balance between osteoclasts and osteoblasts, the cells that build bone up. If either side is out of whack, so to speak, bones become thinner, more fragile and prone to fractur...
Osteoclasts in Medical Technology

Amgen Announces Positive Top-Line Results for Denosumab in Trial for Delay of Skeletal Related Events in Bone Metastases Patients Compared to Zometa(R)

...umab is the first fully human monoclonal antibody in late stage clinical development that specifically targets RANK Ligand, the essential regulator of osteoclasts (the cells that break down bone). With more than 19,000 patients in trials across indications worldwide, the denosumab development program is the larg...

Denosumab Demonstrates Superiority Over Zometa(R) in Pivotal Phase 3 Head-to-Head Trial in Breast Cancer Patients With Bone Metastases

...umab is the first fully human monoclonal antibody in late stage clinical development that specifically targets RANK Ligand, the essential regulator of osteoclasts (the cells that break down bone). With more than 19,000 patients in trials across indications worldwide, the denosumab development program is the larg...
Osteoclasts in Biological News

Small protein may have big role in making more bone and less fat

...nstead of red," he says. And it gets worse: in a classic vicious cycle, the more fat, the more cytokines that stimulate production of bone-destroying osteoclasts and inhibit bone-forming osteoblasts. He recently showed that even the stem cells change with age: their numbers and their ability to differentiate de...

Ring-around-the-cell

...one seal off their work area as they get down to business. The cells, called osteoclasts, have some unique features not seen in any other cell type. osteoclasts move around the bone until they reach a site where they sense that their services are required, at which point they undergo a transformation called po...

Scientists identify a candidate gene for osteoporosis

...teoporosis in humans. The protein encoded by DARC binds to chemokines—or small signaling proteins—that are involved in osteoclast formation. osteoclasts break down bone in a process called bone resorption, releasing important minerals such as calcium, phosphate, and magnesium into the bloodstream. Thi...

'Best of both worlds' -- Targeting a single gene could inhibit bone decay and stimulate bone growth

...he quality of bone even better. "Our discovery proves that inhibiting osteoclasts while simultaneously stimulating new bone formation can be done." Bon...p6v0d2 in mice results in dramatically increased bone mass due to defective osteoclasts as well as enhanced bone formation. These findings may provide some clarity...

'Trojan Horse' agent halts bone metastasis in mice

...o the VEGF protein secreted by cancer cells. When activated by maturation factors including VEGF, the pre-osteoclasts differentiated into mature osteoclasts and chew up bone tissue, providing the tumor new space to grow. The mature osteoclast cells themselves do not express the Flt-1 receptor. Accor...

Bones hold the key to blood renewal

...st, breaks it down and reassimilates the material. osteoclasts are formed when several cells (which themselves or...et and colleagues, found that the bone-dismantling osteoclasts are instrumental in releasing hematopoietic stem c...y operates at a leisurely pace into high gear. The osteoclasts not only clear away bone, they also break up 'nurt...

First human study confirms that immune cells can be a primary cause of bone loss in gum disease

... hope this work will help us save people's teeth in the future." Research Overview RANKL is a protein that is a major factor in the regulation of osteoclasts (cells that destroy bone). Dr. Kawai's research examined the receptor activator of NF-kB ligand, (RANKL)-mediated osteoclastogeneis, and the pivotal r...

New weapon in battle against osteoporosis

...CB2 receptor. Dr. Karsak summarises what happened: "The animals gradually lost their stabilising trabeculae. We found in these mice that the number of osteoclasts ?special cells that can break down the bone tissue –increases by almost 50 per cent." Signal molecules regulate bone density Together with a r...

UCSD medical/bioengineering reseachers show titanium debris satobtage artificial joints

...small- and medium-sized titanium particles concentrated inside cells. Increased production of the protein RANKL by osteoblasts recruited and activated osteoclasts at the insertion sites, further weakening the bone. Larger titanium particles also activated metalloproteinases, which chop up the extracellular matri...

Gene therapy converts dead bone graft to new, living tissue

...nd as a kind of "calcium bank." If calcium, which is necessary for such important functions as maintaining the brain and heart, runs low, cells called osteoclasts dig out the calcium from our bones. This is why doctors encourage post-menopausal women to take calcium supplements, so that the body doesn't raid the...
Osteoclasts in Biological Technology

Amgen to Participate in Reproductive Health Drugs Advisory Committee Meeting in August

...sumab is the first fully human monoclonal antibody in late stage clinical development that specifically targets RANK Ligand, an essential regulator of osteoclasts (the cells that break down bone). Denosumab is being investigated for its potential to inhibit all stages of osteoclast activity through a targeted me...

FDA Accepts Amgen's Submission and Files Biologics License Application for Denosumab

...sumab is the first fully human monoclonal antibody in late stage clinical development that specifically targets RANK Ligand, an essential regulator of osteoclasts (the cells that break down bone). Denosumab is being investigated for its potential to inhibit all stages of osteoclast activity through a targeted me...

New Drug to Prevent Bone Loss Caused by Breast Cancer Treatment

... Symposium by Georgiana Ellis, MD, from the Seattle Cancer Care Alliance. Denosumab is a highly specific antibody that interrupts the development of osteoclasts -- specialized cells that break down bone. Because it is highly specific, the chance of systemic effects in other parts of the body is low, so patient...
Osteoclasts in Biological Products

Osteoclasts Culture Kit from B-Bridge International

Description:... Osteoclast cells form from a hematopoietic stem cells called monocytes. osteoclasts resorb bone by attaching to the bone surface and lowering the surrounding pH to an acidic level of around 4.5. The bone mineral is then solubilized an...
Company:B-Bridge International
Osteoclasts in Biological Definition

Bone

...nclude osteoblasts , so called Bone Lining Cells , osteocytes and osteoclasts . Osteoblasts are typically viewed as bone forming cells. They are located...esponse to stress. If osteoblasts can be described as bone forming cells, osteoclasts role is the reverse: its destruction. These are large, multinucleated cells...
Osteoclasts in Biological Dictionary

Lacunae

...memory, music, our, searles ... Observe the cartilage matrix with lacunae containing chondrocytes. ... Look for the multinucleated eosinophilic osteoclasts in Howship's lacunae . ... Osteocyte lacunae are visible between the lamellae. ... Canaliculi, radiate from the lacunae into the surrounding b...
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