Internal Clock and Metabolism May Be Linked
... Bass and his colleagues also found that NAD levels vary according to an animal's internal clock -- the first evidence of a "metabolic oscillator," an oscillator that isn't part of the core circadian clock machinery. The study was published online March 19 in Science . "NAD is an essential nutrient in ou...New research provides dynamic visualization of simplest circadian clock
...he simplest organisms known to possess a circadian oscillator are the cyanobacteria, better known as blue-green algae. The essential components of the circadian oscillator in cyanobacteria are the three clock proteins KaiA...trate that the initial phase of the cyanobacterial oscillator is determined predominantly by the assembly/disass...Researchers Investigate Gene Linked With Circadian Liver Clock
... a functional liver clock. A systemically driven mPer2 transcription cycle would provide the necessary link to synchronize the phase of the peripheral oscillator to that of the central system. Future studies are necessary to illuminate the molecular mechanisms of systemic mPer2 transcription. A number of e...Jet-propelled imaging for an ultrafast light source
...still fly through the glass nozzle without hitting the walls and getting stuck. The frequency at which the droplets emerge can be controlled by an oscillator the researchers call an "acoustic trigger." Tuning the acoustic trigger adjusts the frequency so that each droplet containing a protein or virus meets...MicroRNAs grease the cell's circadian clockwork
... Geneva, Switzerland, reveals that an important regulator of this molecular oscillator is a specific microRNA. The latter belongs to a class of small RNA molecule...one of Professor Schibler's collaborators. Performance of the molecular oscillator The researchers' team has discovered that miR-122 is tightly embedded in ...A novel X-ray source could be brightest in the world
...tists at U.S. Department of Energy's Argonne National Laboratory have devised a new type of next generation light sources. "The free electron laser oscillator (X-FELO) we are proposing can create x-rays up to one hundred million times brighter than currently operating machines," Argonne Distinguished fellow ...Genetic 'tag team' keeps cells on cycle
...ycle over again. Mathematical models constructed by the team showed that the waves of activity driven by such a network could provide a very robust oscillator even without cyclins, Haase said. In fact, cyclins themselves are among the genes targeted by this transcription-activating tag team. Those cyclin...Pourquié lab links beta-catenin gradient to process of somite formation
...e segmentation process that results in the formation of the vertebral column. This process is thought to be controlled by two components: a molecular oscillator (the segmentation clock), and the graded activity of several major signaling pathways (the gradient) in the presomitic mesoderm (PSM). The PSM is the ...Pourquie Lab demonstrates role of growth factor in vertebrae formation
...ions to the currently accepted clock and wavefront explanation of somitogenesis. The theory suggests that a periodic mechanism the segmentation clock oscillator interacts with a molecular wavefront of differentiation, converts information from the clock into positional information, and allows for the formatio...Keeping the body in sync -- The stability of cellular clocks
...of how fast the system reverts to its initial state after being perturbed. “To my knowledge we are the first to discuss how the stability of the oscillator directly affects bioluminescence recordings,?explains Felix Naef, a systems biology professor at EPFL and the Swiss Institute for Experimental Cancer ...Pourquié lab identifies genes involved in formation of vertebral precursors
...and the role of an internal mechanism -- the clock oscillator -- that regulates the formation somites, the precu...on of the genes involved in the segmentation clock oscillator can cause crippling diseases in humans, such as co...work identified many novel genes associated to the oscillator whose mutation could lead to such disease." ...Researchers putting a freeze on oscillator vibrations
University of Oregon physicists have successfully landed a one-two punch on a tiny glass sphere, refrigerating it in liquid helium and then dosing its perimeter with a laser beam, to bring its naturally occurring mechanical vibrations to a near standstill. The findings, published in Nature Phy...'Radio wave cooling' offers new twist on laser cooling
... purpose, physicists at the National Institute of Standards and Technology (NIST) have used radio waves to dampen the motion of a miniature mechanical oscillator containing more than a quadrillion atoms, a cooling technique that may open a new window into the quantum world using smaller and simpler equipment. ...