Organotypic

Cell microenvironments hold key to future stem cell therapies

... actual in vivo conditions and enables us to perform highly parallel functional analysis of combinatorial microenvironments, and image analysis of 3-D organotypic cultures and micro patterned culture substrata," said LaBarge. "The 3-D capability is crucial because our studies show that orientation of the stem or...

Genetic breakdown in Fanconi anemia may have link to HPV-associated cancer

...utations in the FANCA gene. The HPV cancer genes E6/E7 were artificially introduced to FANCA-patient skin cells and grown in the three-dimensional organotypic raft culture that simulates skin. The investigators observed irregular cell growth and increased skin thickness in the culture. Restoring FANCA gene f...

Organotypic in Medical Technology

At the 2007 Alzheimer's Association International Conference on the Prevention of Dementia - Neurochem's U.S. Principal Investigator Presents Update on Tramiprosate (Alzhemed)

... A.M. to 4:30 P.M. (ET). - Presentation P-187, entitled Tramiprosate Is Neuroprotective and Reduces the Levels of Secreted Amyloid-ss in organotypic Hippocampal Slice Cultures, will be presented by lead author Mounia Azzi. - Andre Galarneau will present GABA-Dependent Pathways in the ...

Organotypic in Biological News

Time (and PPAR-beta/delta) heals all wounds

...t could communicate with each other," says Tan. "Organotypic skin cultures are a really good technique for this." First developed in the 1980s (3), organotypic skin cultures (OTCs) are made by embedding dermal fibroblasts in a gel of extracellular matrix proteins. Keratinocytes are seeded on top of this gel a...

Cells united against cancer

...und and suppresses oncogene function. "We were amazed to find out that the formation of organized mammary epithelial architecture in three-dimensional organotypic cell culture correlated with complete loss of oncogenic activities of c-Myc cancer gene" says Klefstrom. Johanna Partanen, a graduate student in Kl...

Organotypic in Biological Technology

Biolistic Transfection of Organotypic Brain Slices

A. Kimberley McAllister, Nina Tang, Lawrence C. Katz, and Donald C. Lo. Department of Neurobiology, Box 3209, Duke University Medical Center, Durham, NC 27710 Introduction The introduction of genetic material ...