'Artificial Golgi' may provide new insight into key cell structure
...olleagues point out that Golgi bodies are one of the most poorly understood organelles (specialized structures inside cells) in the human body. Scientists already know, however, that the organelles play a key role in producing heparin, a substance that helps prevent clotti...Zebrafish Journal Publishes Skin Pigmentation Studies That Shed Light on the Evolution of Race
... ornamental traits of the guppy, the link between pigment and fish behavior, and pigment dilution mutants in fish models connected to lysosome-related organelles and vesicular traffic genes. Zebrafish is an authoritative peer-reviewed journal published quarterly in print and online. This is the only pe...Transgenomic Obtains Exclusive License to Mitochondrial DNA Damage Detection Technology
...ng increased oxidative damage within mitochondria. Mitochondria are organelles that produce the energy required for cells to function normally. As the "p... About Mitochondrial DNA Tests from Transgenomic Mitochondria are organelles that produce the energy required for cells to function normally. There are...Researchers identify toehold for HIV's assault on brain
...covered that Tat works through the ryanodine receptor to sicken neurons in two ways. Scientists have known that Tat makes vulnerable the mitochondria, organelles within neurons and other cells that are commonly considered the "power packs" or energy sources for cells. The team discovered that Tat destroys the a...NYP/Weill Cornell gene therapy clinical trial yields promising results for Batten disease
... the disease, causing a deficiency in the enzyme TTP-1, which is responsible for ridding cells of the central nervous system of waste materials. Small organelles within the cell, called lysosomes, become clogged with toxic material within the neurons of the brain. "It's like the garbage man of the cell is n...Unexpected role: EGFR protects cancer cells from starving
...se cells died of autophagy - a self-cannibalization response in which a cell under stress or lacking nutrients devours part of its cytoplasm and other organelles to survive. When this response goes on long enough, the cell essentially eats itself until it dies. In cancer research, autophagy is thought to be a s...Mitochondria play role in pathogenesis of AD and estrogen-induced neuroprotection
...tation Award. He also received an AAA travel award. Mitochondria, small organelles within the cells, use a process called Oxidative Phosphorylation to generat...hese include: an increase of mitochondrial efficiency, enhancing the organelles ability to generate energy-laden ATP molecules needed by the brain; incr...Scripps scientists find calcium channel blockers help normalize lysosomal storage disease cells
...osomal storage diseases result from deficient enzyme activity that leads to an accumulation of molecules that the enzymes break down in the lysosomes, organelles or subcellular compartments that normally break down macromolecules utilizing hundreds of degradatory enzymes. In many lysosomal storage diseases, mut...Pathway to cell death redefined in landmark study
...amage caused by the calpain family of cysteine proteases and by neutralizing other cysteine proteases released from injured cellular structures called organelles as they are being digested by the lysosome. As part of their study, Drs. Silverman, Luke and colleagues labeled enzymes within the lysosomes of SRP-6-...Antipodean Pharmaceuticals Announces Completion of Phase 2 Study of Lead Compound MitoQ(R)
...l apoptosis. MitoQ(R) is based on a novel technology, targeted lipophilic cations that transport and concentrate antioxidants into the mitochondria -- organelles inside cells that provide energy for life processes -- where they accumulate up to a thousand fold. About Antipodean Antipodean is a clinical-stag...Protein Found to Shield Pancreatic Cancer Cells from Self-Destruction
...sis, the cells die via damage to their nucleus and DNA, with other cellular organelles preserved. Autophagy kills by degrading those other organelles while sparing the nucleus. Mehta's lab reported in a Cancer Research pape...Protein regulates movement of mitochondria in brain cells
...hat mitochondria play as a calcium buffer. One of the mitochondria's functions is to help control the concentration of calcium in the cell, which the organelles can rapidly absorb and store. This capacity is important, particularly in instances when calcium levels in the cell spike during a stroke, a conditio...Advance in understanding cellulose synthesis
...ment called the actin cytoskeleton that helps move organelles and maintains the cell's shape. They found that it... active cellulose synthase complexes disappear and organelles accumulate just under the plasma membrane. These organelles contain cellulose synthase and are tethered to the...New data on the breakdown of the KRas protein
...how the KRas protein is actively transported from the cell membrane, where most of its known activity takes place, to the lysosomes. The lysosomes are organelles responsible for breaking down proteins; this breakdown pathway was unknown in the case of KRas. Thanks to videomicroscopy techniques using a confocal ...Self-digestion as a means of survival
...cess - known as autophagy - takes place in special organelles called autophagosomes. It is a strategy that simpl...ble for getting rid of misfolded proteins, damaged organelles or disease-causing bacteria. If this process m...how autophagosomes know exactly which proteins and organelles they should degrade. "Although autophagy has be...Artificial cells, simple model for complex structure
...t fills the cell and is crowded with very large molecules. It surrounds the organelles -- tiny organs like mitochondria and the nucleus. Unlike organelles, the cy... is interesting as a major player in cell function. Creating a cell with organelles would be a monumental task, but creating one that exhibits molecular crowdi...Weizmann Institute scientists show extra copies of a gene carry extra risk
...to discover LIS1's tie to lissencephaly, in 1993. Their latest study shows that it works by helping to determine polarity in the cell how the various organelles are arranged inside the cell as well as where it connects to neighboring cells. Neurons alter their polarity several times during development, especia...Fluorescent proteins illuminating biomedical research
...usha employed the FTs to demonstrate for the first time how a protein called LAMP-2A, which scavenges cellular debris, is transported to intracellular organelles called lysosomes, where the debris is digested. Understanding this process, which maintains the health of cells and organs, may lead to treatments to...Mayo Clinic: Brain disorder suggests common mechanism may underlie many neurodegenerative diseases
..., M.D., professor of neurology at Mayo Clinic. Molecules, vesicles and organelles within a cell are constantly carried via a network of crisscrossing microtu...," says Dr. Farrer. "The insides of neurons are very dynamic. Molecules and organelles are constantly being moved to where they are needed, so it makes sense that...Novel technique for fluorescence tomography of tumors in living animals
...limited, since beyond a penetration depth of a few hundred micrometers the photons are massively scattered due to interactions with cell membranes and organelles which results in blurred images. In the latest issue of the journal Proceedings of the National Academy of Sciences Prof. Ntziachristos and his team...Cells Exhibition Opens at Maryland Science Center
...alth. Visitors to the exhibition become "cell explorers" in The World Inside a Cell section, where they interact with human-sized cell organelles in an interactive environment enhanced with floating layers of translucent membranes, pulsing light, music and sounds of water. Cell explorers virtual...Glossary for The BioPharm Guide to Fermentation and Cell Culture
...that produce antibodies. lysosomes Cell organelles containing enzymes, responsible for degrading ...ed eye. microtubules Cellular organelles common in microorganisms: thin tubes tha...ular movement. mitochondria Animal-cell organelles that reproduce using their own DNA. They...Optimization of Biolistic Transformation Using the Helium-Driven PDS-1000/He System
...n, et al., 1988 a, b), animal (Williams, et al., 1991), and microbial species (Shark, et al., 1991), as well as into subcellular organelles (Johnston, et al., 1988; Daniell, et al., 1991). Achieving high rates of DNA expression in each of these cases often requires th...Essential Data: Centrifugation from Promega
Description:....C. Ford and J.T. Steensgaard (1994) Compiles core data required by researchers carrying out any centrifugal separation, whether working with cells, organelles or macromolecules....Endoplasmic Reticulum Isolation Kit from Sigma-Aldrich
Description:...nd Benefits: Specially formulated extraction reagents for research scale applications - save time and minimize waste Produces functional intact organelles - resulting ER are suitable for metabolic assays and disease state analysis Compatible with products for structure confirmation - easily confirm ...PDS-1000 He System from Bio-Rad
Description:...ssure helium gas to accelerate micron-size nucleic acid-coated gold or tungsten microparticles to velocities necessary to transfect cells, tissues, or organelles without dependence or interaction with the cell surface. The system includes helium pressure regulator, solenoid, spacer rods, microcarrier launch ass...