Molecular Switch in Brain May End Smokers' Cravings

...- Blocking a neuropeptide receptor in the brain may be one way to quickly lessen the desire for a cigarette, a new study suggests. Hypocretin-1, or orexin A, a short chain of amino acids found in nerve tissue, appears to initiate a series of closely linked biochemical reactions that makes lab rats crave ...

Study shows that surgical weight loss does not eliminate obstructive sleep apnea

...percent to 90 percent. OSA itself may promote weight gain through ineffective sleep, impaired glucose metabolism and imbalances of leptin, ghrelin and orexin levels. "We were surprised by the severity of the residual sleep apnea in postoperative patients," said principal investigator Christopher J. Lett...

Different Neural Pathways at Work Going Under, Coming Out of Anesthesia

... Mouse study on brain's orexin system could lead to new drugs with fewer side eff...s wakeful state. They found that mice with damaged orexin systems -- similar to humans with narcolepsy -- to...wake from general anesthesia than mice with normal orexin signaling systems. However, the mice with fault...

A Drug That Curbs the Urge for Alcoholic Drinks is Here

.... A compound that effectively blocks the effect of orexin was developed by researchers from Howard Florey ...to treat alcoholics. The craving can be blocked if orexin is blocked. This study may also prove beneficia...nd circumstances that trigger a response from the orexin system. MS ...

Biological Basis Behind a Couch Potato

...ore sensitive to a chemical produced in the brain, orexin A, which stimulates appetite and spontaneous physi...ese, the lean rats had a far greater expression of orexin receptors in the hypothalamus. "The greater expression of orexin receptors suggests the lean rats' brains were more...

Sleepy After A Heavy Lunch? Here's Why

..., which are proteins produced by some nerve cells. In genetically engineered mice, the researchers found that glucose interferes with the behaviour of orexin neurons, thereby halting flow of signals. "We have identified the pore in the membrane of orexin-producing cells that is responsible for the inh...

An After-Dinner Nap Is A Natural Thing, Scientists Proved

...Dr Denis Burdakov, the lead researcher, said: ‘It is the malfunction of the orexin neurons, which can result in the chronic neurological disorder narcolepsy, ...ard seeking, and addiction will result from functioning disabilities of the orexin cells of neurons and it was also been linked to obesity, according to Dr Bu...

Mystery Behind Sleepiness After the Meal Revealed

...lways has adequate glucose.' Malfunction of orexin neurons can lead to narcolepsy, where sufferers ca...ay awake, and obesity; there is also evidence that orexin neurons play a role in learning, reward-seeking an...when hungry. 'Now we know how glucose stops orexin neurons 'firing', we have a better understanding o...

Sleeping Pill To Tackle Obesity Problem Also

...e drowsiness during the daytime, in addition to addiction. // The hormone orexin which is directly connected to sleeping disorders and paralysis will be tar...e memory. The drug is being developed by Actelion. As the new tablet orexin is connected to eating habits, it can also be used for treating obesity. As...

Brain Chemical Identified For Drug Dependent Behavior

...sociated with substance abuse. The chemical called orexin is also involved in feeding, arousal and sleep beh...areas of the brain. This study suggests that orexin may be a factor in modulating reward-seeking chara...einstated by chemically activating these cells and orexin production. These data suggest that this brain sys...

Orexin in Biological News

What happens when we sleep

...s interestingly, that sleep-wake states are regulated by two different types of nerve cells (neurons), melanin-concentrating hormone (MCH) neurons and orexin (Orx) neurons, which occupy the same region of the brain but perform opposite functions. The MNI study is the first to discover that MCH neurons are a...

Natural brain substance blocks weight gain in mice, UT Southwestern researchers discover

...researchers report. Finding a way to boost the orexin system may prove useful as a therapy against obesi...ppetite and sleep. He found that reduced levels of orexin lead to the sleep disorder narcolepsy in both rodents and humans. orexin can boost the appetite in the short term, but, par...

New mechanism explains glucose effect on wakefulness

...in always has adequate glucose." Malfunction of orexin neurons can lead to narcolepsy and obesity, and researchers have also found evidence that orexin neurons play a role in learning, reward-seeking, a...esearchers. "Considering these crucial roles of orexin neurons, their recently described inhibition by gl...

Why we could all do with a siesta

...in always has adequate glucose." Malfunction of orexin neurons can lead to narcolepsy, where sufferers ca...ay awake, and obesity; there is also evidence that orexin neurons play a role in learning, reward-seeking an...eep when hungry. "Now we know how glucose stops orexin neurons 'firing', we have a better understanding o...

How the brain learns to become addicted

...tablished that a short protein, or peptide, called orexin A acts on a brain region central to the adaptation...ically, they found in their studies with rats that orexin A induces an adaptation that is necessary for the ...seek treatment, the peptide signaling pathways for orexin and CRF may prove to be fruitful targets in the se...

Brain-mapping technique aids understanding of sleep, wakefulness

...als awake. In humans, a lack of, or deficiency in, orexin causes narcolepsy, a rare disease in which people ... and why we sleep. Mapping the neurons to which orexin neurons send signals has been relatively easy, Dr....aid, but determining which neurons send signals to orexin neurons has been a challenge. A brain-mapping tech...

Orexin in Biological Technology

Cell lines expressing recombinant aequorin and a G-protein coupled receptor for functional screening

...e (MCH) receptor (SLC-1, HNOP801) Melanocortin receptor MC4 Motilin receptor Nociceptin receptor ORL-1 orexin receptors 1 and 2 Purinergic P2Y2 Serotonin receptors : 5-HT 1B , 5-HT 2B TSH-Receptor This system can be used to...

Orexin in Biological Products

Rabbit Anti-Orexin Prepro Polyclonal Antibody, Unconjugated from Abcam

Description:... Rabbit polyclonal to orexin Prepro ( Abpromise for all tested applications). entrezGeneID: 3060 SwissProtID: O43612...
Company:Abcam

Orexin in Biological Definition

Anabolism

... Adrenalin and other catecholamines Cytokines Newer hormones associated with the balance of the catabolic and anabolic states include orexin and Hypocretin (a hormone pair) Melatonin See also Anabolic steroids ...

Anabolism

... Adrenalin and other catecholamines Cytokines Newer hormones associated with the balance of the catabolic and anabolic states include orexin and Hypocretin (a hormone pair) Melatonin See also Anabolic steroids ...

Hormone

...oid--hence increasing output of thyroid hormones. A recently identified and studied class of hormones is that of the "Hunger Hormones" - ghrelin , orexin and PYY 3-36 - and their antagonists - e.g. leptin . Spelling note Current North American and international usage is estrogen, gonadotropin...