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Oncogenesis in Medical News

Also in the March 24 JNCI

...ne also induced telomerase activity in both cell types. "In this study, we reveal a novel mechanism through which HCMV may be linked to or modulate oncogenesis by demonstrating that HCMV stimulates hTERT transcription, thereby activating telomerase, which is essential for the immortalization and transformatio...

Non-Profit Gives $800,000 for Melanoma Research in 2009

...a pool of highly competitive applications," said Meenhard Herlyn, D.V.M., D.Sc., co-chair of the MRF's Scientific Advisory Committee and leader of the oncogenesis Program at the Wistar Institute in Philadelphia. "The MRF awards the grants to applicants with the best combination of scientific merit, appropriatel...

Blocking molecular pathway with whimsical name possible therapeutic target for pancreatic cancer

...ic College of Medicine in Minnesota, scientists found a link between the "Seven-In-Absentia" or SINA gene and the aggressive cellular transformation, oncogenesis and metastasis that characterize pancreatic cancer. Scientists already knew that a mutation in the K-RAS gene underlies the abnormal, excessive cel...

2 microRNAs promote spread of tumor cells

...human breast cancer cells that normally does not metastasize, says Qihong Huang, M.D., Ph.D., an assistant professor in Wistars Molecular and Cellular oncogenesis Program and lead author and co-corresponding author on the study. In 2006, miR-373 was identified as a possible oncogene a modified gene that caus...

AACR introduces Cancer Prevention Research

...rimary research categories, each with a unique role in the study of cancer prevention: oncogenesis, intervention, risk assessment and early detection. oncogenesis studies include those that cover the origins of cancer development and the cellular mechanisms that could prevent cancer growth. In addition to transl...

HIV Drug Might Fight Cancer

...will be necessary to determine if this extract has potential as a chemopreventive or therapeutic agent," Dr. Jeffrey E. Green, chief of the Transgenic oncogenesis and Genomics Section at the Center for Cancer Research, said in a statement. And in other HIV news, a study in the August issue of AIDS Patient Ca...

New Therapy for Lipid Disorder Demonstrates Varied Results

...e authors write. 'Accordingly, the beneficial effects of PPAR activation appear to be associated with a variety of untoward effects, which may include oncogenesis [the progression of genetic and cellular changes that culminate in a malignant tumor], renal [kidney] dysfunction, rhabdomyolysis [a condition in whic...

Anti Atherosclerosis Therapies Linked to Leukemia

...op certain chronic inflammatory responses that have been linked to atherosclerosis," says Ellen Puré, Ph.D., a professor in the Molecular and Cellular oncogenesis and Immunology programs at Wistar and senior author on the study. "Now we know that if we go that route, we may also unwittingly be promoting leukemia...

Cancer Causing Proteins Trigger Abnormal Biochemical Reactions In Cells

...n known to cause cancer, is activated and becomes the trigger for the development of cancer, 'We present the hypothesis that an important component of oncogenesis is the ability of proteins to turn on alternative, secondary signaling pathways when overexpressed, rather than simply upregulating primary pathways.'...
Oncogenesis in Medical Technology

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

...anisms involved in cancer. Specifically, panobinostat causes an increased acetylation of both histone and non-histone proteins which are implicated in oncogenesis and thereby modulates their activity. In this way, panobinostat selectively induces the death of tumor cells. To date, objective clinical responses in...
Oncogenesis in Biological News

Singapore scientists elected into National Academy of Sciences

...rior to joining IMCB in 2006, Drs. Copeland and Jenkins were scientists at the National Cancer Institute (NCI). He headed NCI's molecular genetics of oncogenesis section and was director of the mouse cancer genetics program, while she headed the molecular genetics of development section. Since joining A*STA...

Scientists identify novel inhibitor of human microRNA

...unexplored class of targets for the development of therapeutics and diagnostics, says Huang, an assistant professor in Wistar's Molecular and Cellular oncogenesis Program. "This is a totally novel target," he says. "It's very understudied, and still in its infancy, but its potential is tremendous. Because miR...

Landon Foundation-AACR INNOVATOR Awards

...ancer prevention and international collaboration, respectively. Carlo Maley, Ph.D., assistant professor in the Department of Molecular and Cellular oncogenesis at the Wistar Institute in Philadelphia is the recipient of the first Landon Foundation-AACR INNNOVATOR Award for Cancer Prevention Research. The awa...

Study examines genetic defects linked to body abnormalities in patients with childhood cancer

...ed morphological abnormalities in pediatric patients with cancer indicates that constitutional genetic defects play a more important role in pediatric oncogenesis than is currently estimated. Furthermore, the detection of patterns of morphological abnormalities allows identification of new tumor predisposition s...

Newly identified mechanism for silencing genes points to possible anti-cancer strategies

...get them for destruction," explains Ramin Shiekhattar, Ph.D., a professor"in the Gene Expression and Regulation Program and the Molecular and Cellular oncogenesis Program at Wistar and senior author on the new study. "That’s one way we know that microRNAs can silence genes. That mechanism requires extraordinary ...

Novel antigen-cloning technique may boost efforts to develop a melanoma vaccine

...ly for cancer but also for infectious diseases, says Dorothee Herlyn, D.V.M., senior author on the study and a professor in the Molecular and Cellular oncogenesis and Immunology programs at Wistar. "Most of the melanoma vaccines currently in development work to activate a type of white blood cell called cyt...

Does natural selection drive the evolution of cancer?

...or cell population is constantly evolving through natural selection," says Carlo C. Maley, Ph.D., an assistant professor in the Molecular and Cellular oncogenesis Program at Wistar whose own research focuses on this area. He is senior author on the new review. "The mutations that benefit the survival and reprodu...

Researchers create pigs that produce heart-healthy omega-3 fatty acids

...researchers have actually studied the disease this way," says Maley, lead author on the study and an assistant professor in the molecular and cellular oncogenesis program at Wistar. "We wanted to know: If we measured a precancerous tumor's genetic diversity at baseline, could we predict who would go on to get ca...

Evolutionary biology research techniques predict cancer

...researchers have actually studied the disease this way," says Maley, lead author on the study and an assistant professor in the molecular and cellular oncogenesis program at Wistar. "We wanted to know: If we measured a precancerous tumor's genetic diversity at baseline, could we predict who would go on to get ca...

Melanoma vaccine strategy shows promise in laboratory experiments

...ated with this peptide," says Dorothee Herlyn, D.V.M., senior author on the study and a professor in the Immunology Program and Molecular and Cellular oncogenesis Program at Wistar. "The results emphasize the potential of this approach for creating an effective melanoma vaccine, and we hope to move toward human ...
Oncogenesis in Biological Technology

The let-7 microRNA Family Regulates RAS: Implications for Development and Oncogenesis

Research Summary Drs. Frank Slack, Steven Johnson, and Helge Grosshans, and Ms. Kristy Reinert at Yale University, in collaboration with Ambion scientists, discovered that the let-7 microRNA (miRNA) famil...

Samtheo Announces License Agreement with Moffitt Cancer Center for Exclusive Rights to Novel Akt Inhibitor

...selectively inhibits the activation of all three isoforms of Akt. Persistent activation of the Akt pathway has been found to play an important role in oncogenesis and chemo- and radiation-resistance and to be responsible for cancer cell proliferation, survival and invasiveness Co-inventors are Jin Q. Cheng,...

Cancer-Related miRNAs Uncovered by the mirVana miRNA Microarray Platform

... handful of miRNAs that are differentially regulated in tumors, suggesting a possible link between miRNAs and oncogenesis [2-4]. We used the mir Vana miRNA microarray platform (see, mirVana Microarray Platform for Sensitive miRN...
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