New oncogene gives valuable insight into hepatocellular tumors in humans
Copenhagen, Denmark, Thursday 23 April: The first identification of GP130 somatic activating mutations* in human tumours was announced today at EASL 2009, the Annual Meeting of the European Association for the Study of Liver Disease in Copenhagen, Denmark.
Identification of recurrent somatic m...
Blocking Oncogene Can Stop Spread of Ovarian Cancer
Lab study showed it had effect on 60% Of malignant cells
MONDAY, Dec. 15 (HealthDay News) -- Blocking proteins produced by the oncogene
MYC can stop the spread of ovarian cancer, researchers say.
is a gene that has the potential to help cause cancer.
In up to 60 perce...
Colon Cancer Oncogene Discovered
CDK8 is frequently amplified in these malignancies, study finds
SUNDAY, Sept. 14 (HealthDay News) -- Researchers have identified a new genetic player in the development of colon cancer.
The findings implicate CDK8, a protein that regulates gene expression in the proliferation of co...
New Oncogene for Brain Cancer
An overexpressed gene found at the scene of a variety of tumors is implicated in the development of two types of malignant brain cancer in a paper by researchers at The University of Texas M. D. Anderson Cancer Center to be published in the Proceedings of the National Academy of Sciences.
Pair of MicroRNA Molecules Controls Major Oncogene in Most Common Leukemia
Researchers at Ohio State University have discovered that two microRNA (miRNA) molecules help control the oncogene
responsible for a dangerous form of B-cell chronic// lymphocytic leukemia (B-CLL), the most common human leukemia in the world.
Their findings, published in the December 15 iss...
Gene Connections Key to Brain Tumor Growth
The hub gene is the EGFR (epidermal growth factor receptor) oncogene
on chromosome 7, according to the study. It is amplified in about 45 percen...e researchers reported. A decrease in the function of ANXA7 shoots the EGFR oncogene
into overdrive, contributing to the development and progression of maliciou...
Study pinpoints novel cancer gene and biomarker
...iguing as this finding was, it was hardly enough to prove that GOLPH3 is an oncogene
-- a contributor to cancer when overexpressed within a cell. Demonstrating ...Harvard Medical School.
In addition to identifying GOLPH3 as a bona fide oncogene
and an indicator of whether rapamycin is likely to be effective against spe...
Quest Diagnostics Introduces First Comprehensive Laboratory Test To Analyze KRAS, NRAS, and BRAF Gene Mutations in Reflex Testing Service
...AS family of cancer-promoting oncogenes, which include KRAS and NRAS , are implicated in several cancers, including colorectal cancer. BRAF is an oncogene
of RAF, which is a family of proteins typically activated by RAS and which influence cellular activity.
About Quest Diagnostics
Cancer cells need normal, nonmutated genes to survive
...a tumor, which deprives cells of oxygen. Survival requires a complete kit of stress response tools.
"Researchers often characterize cancer cells as oncogene
addicts, but they're just as reliant on normal genes that alleviate stress," explains senior author Stephen Elledge, a professor at HMS and Brigham an...
NYU Langone Medical Center's tip sheet to the 45th Annual Meeting of ASCO
...ract # 11034, Sunday, May 31, 2009, 2 p.m. to 6 p.m.
Overexpression of an oncogene
linked to worse melanoma prognosis
Iman Osman, M.D., associate professo...r Institute present preliminary evidence that overabundant expression of an oncogene
called Skp2 was associated with a worse melanoma prognosis. The activity of...
Oncogene in Medical Technology
ARUP Laboratories Applauds FDA's Decision on the Value of KRAS-Mutation Testing in Colorectal Cancer
...ular therapeutic strategy should be used by oncologists. Most colorectal cancer is caused by somatic mutations and is not hereditary. Mutations in the oncogene
KRAS are seen in over 40 percent of sporadic colorectal cancers. While several laboratories in the United States offer this test, ARUP Laboratories'...
Boehringer Ingelheim to Present New Phase II Clinical Data on Two Lead Oncology Compounds at ASCO 2009
Li D et al. "BIBW2992, an irreversible EGFR/HER2 inhibitor highlyeffective in preclinical lung cancer models." oncogene
Shih J-Y et al. "A Phase II study of BIBW 2992, a novel irreversible dual EGFR and HER2 tyrosine kinase inhibitor (TKI), in...
Cequent tkRNAi Technology to be Presented at the Centennial Meeting of the American Association for Cancer Research
...g of Cequent's lead drug candidate
Poster CEQ508, an orally administered tkRNAi therapeutic
Presentation targeting the primary oncogene
in FAP (familial adenomatous polyposis). FAP is an
inherited gastrointestinal disea...
Cequent to Present First Proof of Activity of an Oral RNAi Drug in Non-Human Primates at February Keystone Conference
...e CEQ501, an orally administered tk RNAi therapeutic targeting the primary oncogene
(beta-catenin, CTNNB1) in FAP (familial adenomatous polyposis). FAP is an i...cer that our tk RNAi technology effectively suppresses beta-catenin, a key oncogene
in FAP. These new results are very encouraging, and represent another signi...
Ipsogen Launches a New Test to Determine Tumor HER2 Status and Guide Herceptin(R) Prescription in Breast Cancer
The amplification of the HER2-region of chromosome 17 results in the
constitutive overexpression of the HER2 oncogene
protein and fuels
uncontroled tumor growth in approximately 15 to 30% of breast tumors. HER2 is
considered today as a predictive marker for clinical b...
Micromet Presents Data at the 23rd Annual Meeting of the International Society for Biological Therapy of Cancer on the Activity of Human Antibody Adecatumumab against KRAS-mutated Colon Cancer Cells
...beneficial for patients with KRAS wild-type tumors, however, show
limited or no efficacy in the treatment of colon cancer patients with a
mutated KRAS oncogene
in their cancer cells. These findings recently led to
the approval of cetuximab for first-line therapy in patients with KRAS
wild-type tumors. As a co...
Nektar Announces Expanded Phase 2 Clinical Development Plan For NKTR-102 (PEG-irinotecan)
... Phase 2 Study for NKTR-102 Will Target Newly-Identified K-Ras Mutated oncogene
Population in Patients with Advanced Colorectal Cancer
New Phase 2 Clinica... Meeting shows colorectal cancer (CRC) patients
with tumors that have K-Ras oncogene
mutations (K-Ras mutant types) do not
respond to EGFR-inhibitors, such as c...
Use of Sequenom's MassARRAY System Leads to Significant Scientific
Advances in Understanding Cancer, Diabetes and Drug-Resistant
...ighly recognized peer-reviewed journals as follows:
-- In "High-Throughput oncogene
Mutation Profiling in Human
Cancer," published in the February issue of Nat...nsitivity and scalability, utilized
MassARRAY technology to assay 238 known oncogene
1,000 human tumor samples. The results enable researchers ...
News from the Battlefield of Metastatic Cancer: Epeius
Biotechnologies Draws the Sword of Targeted Gene Delivery (Rexin-G)
from the Stone of Chemistry and Physics
...nt of genetic
medicine with the development and commercialization of its
proprietary targeted delivery systems. Credited with innovations
ranging from oncogene
discovery, to designer therapeutic genes, to
pathotropic (disease-seeking) targeting, to high-performance vector
engineering, to advanced biopharmaceu...
Breast Cancer and HER-2/neu: Diagnostic Tools for Targeted Therapy
...eu as a serum marker. This bypasses the need for a tissue specimen and may allow earlier Her-2/neu detection. The Her-2/neu ELISA (Bayer Diagnostics oncogene
Science) is a sandwich-type immunoassay approved to monitor patients with known metastatic breast cancer.
With other methods such as RT-PCR on t...
Oncogene in Biological News
Fox Chase researchers uncover one force behind the MYC oncogene in many cancers
Philadelphia (July 27, 2009) DLX5, a gene crucial for embryonic development, promotes cancer by activating the expression of the known oncogene, MYC, according to researchers from Fox Chase Cancer Center. Since the DLX5 gene is inactive in normal adults, it may be an ideal target for future anti-...
High-throughput oncogene mutation detection in human cancers by mass spectrometry-based genotyping
Researchers have devised a new method to detect a spectrum of known gene mutations in a variety of cancer genes that they say is both sensitive and cost-effective. They say that if validated, this method of genotyping might ultimately be used in "real time" to match patients to available targeted t...
Pair of microRNA molecules controls major oncogene in most common leukemia
Researchers at Ohio State University have discovered that two microRNA (miRNA) molecules help control the oncogene
responsible for a dangerous form of B-cell chronic lymphocytic leukemia (B-CLL), the most common human leukemia in the world.
Their findings, published in the December 15 issue of C...
Protein identified as critical to insulating the body's wiring could also become treatment target
... and Charcot-Marie-Tooth neuropathy, a genetic, progressive disease that weakens muscles.
Cancer is an issue because the ErbB2 receptor also is an oncogene
highly expressed in tumors. ErbB2 helps cancer cells grow and spread so finding its role in the receptor's stability and function provides a potential...
CSHL team develops mouse models of leukemia that predict response to chemotherapy
...tions identified by Lowe's team in AML patients have been well studied. The oncogene
AML1/ETO previously has been associated with a favorable therapeutic outcom...be correct. Just as in humans, leukemias in mice that received the AML1/ETO oncogene
were also sensitive to chemotherapy and soon regressed, whereas MLL-trigger...
Skin cancer study uncovers new tumor suppressor gene
...led to slow -- and in some cases even sped up -- tumor growth.
Now, it turns out that one of the most often mutated MMP genes in melanoma is not an oncogene
at all. In its study, the team led by researchers from the National Human Genome Research Institute (NHGRI) found that MMP-8 actually serves as a tumo...
Small molecules block cancer gene
... HOUSTON (March 10, 2009) Finding molecules that block the activity of the oncogene
Stat 3 (signal transducer and activator of transcription) required screening literally millions of compounds, using computers that compared the struct...
NYU Langone Medical Center researchers find micro RNA plays a key role in melanoma metastasis
...und a miRNA is over-expressed in metastatic melanoma cell lines and tissues. The lab found that the elevated expression of miRNA 182 turns it into an oncogene
(a gene involved in cancer tumor initiation or progression), by increasing the invasive capacity of melanoma cells in vitro and stimulating the cell's...
Cancer-causing gene discovery suggests new therapies
...r on the paper with Barna. "The ability of the Myc oncogene
to directly alter this process may well explain th... in DNA activity in the cell nucleus. But how the oncogene
affected the subsequent production of proteins, a ...ne that was cancer-prone and overexpressed the Myc oncogene
and one that was newly engineered to lower protein...
Festschrift Issue honoring Judah Folkman, M.D. in Lymphatic Research and Biology
...e Lymphangiogenesis?," Yihai Cao explains the processes behind increased lymphatic supply to cancerous lesions. Dean Felsher explores the phenomena of oncogene
addiction, cellular senescence, and the angiogenic switch in a report entitled, "Reversing Cancer From Inside and Out." In a forward-looking review, S...
Oncogene in Biological Technology
EpiCept to Present Pre-clinical Advances of Myc Oncogene Directed Drug Discovery at Assays and Cellular Targets Conference
TARRYTOWN, N.Y., Oct. 15 /PRNewswire-FirstCall/ -- EpiCept Corporation
(Nasdaq and OMX Nordic Exchange: EPCT) today announced that Dr. John Drewe,
Senior Director of Lead Discovery, will be presenting at the IBC conference
on Assays and Cellular Targets at the Hotel Del Coronado in San Diego, ...
Cequent Names F. Stephen Laroux, Ph.D., Director, Immunology and Inflammatory Diseases
...house IBD program.
"While we are furthest along with our drug candidate CEQ508, an orally administered tk RNAi therapeutic targeting the primary oncogene
(beta-catenin, CTNNB1) in FAP (familial adenomatous polyposis) -- our IBD program is actually the company's largest, and Stephen has been critical to ...
NFGC Conducts Multi-Institutional Research Project in Ovarian Cancer
...ject in ovarian cancer.
For the first phase of the project, the group will use a biologically-driven approach to characterize gene expression and oncogene
activation of copy number and point mutations in preclinical models by profiling ovarian cancer cells and ovarian cancer stem cells. The consortium wi...
Festschrift Issue Honoring Judah Folkman, M.D. in Lymphatic Research and Biology
...mphangiogenesis?," Yihai Cao explains the processes behind increased lymphatic supply to cancerous lesions. Dean Felsher explores the phenomena of oncogene
addiction, cellular senescence, and the angiogenic switch in a report entitled, "Reversing Cancer From Inside and Out." In a forward-looking review, ...
Oncomine(TM) Again Key to Prostate Cancer Discovery
...Ph.D., in his continued role as a
research investigator at the University of Michigan, led the Oncomine
analysis that identified SPINK1 as a candidate oncogene
in prostate cancer.
Further experimental work by many of the same scientists that previously
identified ETS-family gene fusions in prostate cancer usi...
Ortho Biotech Oncology Research & Development Unites Johnson & Johnson Biopharmaceutical Oncology R&D Assets
...of ORD has the potential
to generate new opportunities to improve cancer care."
About Our Compound Targets
Human Double Minute 2 (Hdm2)
The Hdm2 oncogene
is activated in cancers through various mechanisms,
including gene amplification and deletion of upstream tumor suppressors.
Hdm2 over-expression indu...
Micromet is Presenting Four Posters on BiTE(R) Antibodies at the International AACR-NCI-EORTC Conference
... proto- oncogenes (abstract C175). This establishes EpCAM as a signal
transducer of cancer cells and explains how EpCAM induces cell
proliferation and oncogene
expression. EpCAM is found widely expressed on
human cancers and is also found on so called 'cancer stem cells' from
colon, pancreas, prostate and bre...
Micromet Data Presented at the International AACR-NCI-EORTC Conference Support the Development of Adecatumumab (MT201) in Earlier Stage Cancer Disease Settings
...ct C175). These data not
only establish EpCAM as a signal transducer of cancer cells, but could
explain how the protein induces cell proliferation and oncogene
and support a critical role of EpCAM in cancer stem cell regulation. "All of these new findings correlate well together and highlight the...
New Insights Into DNA Decontamination
...tion of mouse skin endothelial
cells in vivo by direct
application of plasmid DNA encoding the human
T24 H-ras oncogene. oncogene
Research Tools for Analysis of ZAP-70
1. Palacios, E.H. and Weiss, A. (2004) Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. oncogene
2. Abraham, R.T. and Weiss, A. (2004) Jurkat T cells and development of the T-cell receptor signalling paradigm. Nature Rev...
Oncogene in Biological Products
Oncogene in Biological Definition
is a gene that can cause a cell to develop into a tumor cell, possibly resulting in cancer .
2.1 Growth factors
2.2 Protein kinases and related proteins
...mutations in both types of genes are necessary, as a mutation limited to an oncogene
would be suppressed by normal mitosis control.
Mutations can have various... retroviruses , herpesviruses and papillomaviruses , usually carry some oncogene
or tumor suppressor inactivating gene in their genome .
It is impossible...
Oncogene in Biological Dictionary
is a gene that, when mutated or expressed at high levels, helps turn a normal cell into a cancer cell. genetic material that carries the ability to induce cancer. An oncogene
is a sequence of deoxyribonucleic acid (DNA) that has been altered or mutated from its original...
If the viral LTRs are close enough to that oncogene
, they will upregulate ... called viral - oncogene
(v-onc), and the infected cell is transformed as soon as ... v-rel reticuloendotheliosis viral oncogene
homolog (avian), also known as REL, is a human gene. The protein ...
...on: Discuss topics of TransVersion ) - this ... ... efficiently extended implicating O2-Et-dT in transversion mutagenesis in vivo. ... of the oncogene
neu by an A.T----T.A transversion event in rat neuroblastomas. ... The promoter sequence having this transversion has a higher promoter ...
...se specialized trans - splicing reactions are very efficient. In mammals, however, trans - splicing of conventional pre-mRNAs appears to be ... oncogene
is one of the world's leading cancer journals. ... In mammals, trans - splicing can be used to reprogram or interfere with specific ... Trans ...
... An oncogene
is a gene that, when mutated or expressed at hi...l cell into a cancer cell. The RET proto - oncogene
encodes a receptor tyrosine kinase for member...with the... ... of this gene is "ret proto - oncogene
." RET is the gene's official symbol. ... ret pro...
... and cancer. Human gene count drops again ... MicroRNA . Diophantine equations. Cytokine storms ... Pair Of MicroRNA Molecules Controls Major oncogene
In Most Common Leukemia (12 ... Labels: cancer, let-7, microRNA , Myc, news dump, stem cells ... He also presents recent discoveries in the m...
...al chromatids), the cell moves onto the G2 phase . G2 Phase ... oncogene
is one of the world's leading cancer journals. ... Once induced in G2 ... D1 expression became Ras independent through the next G1 phase . ... oncogene
is one of the world's leading cancer journals. ... UV radiation causes bo...
...ted Press ( AP ), and the Bowl Championship Series (BCS) ... AP Top 25. Rankings Not Available. USA Today Poll. 1 . Florida (53) 0-0 1 ,466 ... oncogene
is one of the world's leading cancer journals. ... Upon induction, TAM-67 was expressed and AP - 1 activity was inhibited in these cells. ... S...
...es the acetylationof of lysines in preparation for mass ... After acetylation the amino terminus of the protein should be modified giving ... oncogene
is one of the world's leading cancer journals. ... The cytoplasmic amino - terminus provides the structural information whereby ... The polype...