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Oligonucleotides in Medical News

It's a knock out: eIF4E-specific anti-sense oligonucleotides knock down cancer

A new study by Jeremy Graff and colleagues from Eli Lilly and Company has demonstrated the anti-cancer effect of a new therapeutic in a mouse model of human tumors and has spawned clinical trials to test the ability of this therapeutic to treat human cancers. As highlighted in the accompanying com...

Orochem Technologies Acquires Oligonet, a Custom Oligo Synthesis Business

... Oligonet has been serving customers in the NIH region for over 10 years with large variety of synthetic oligodeoxynucleotides (DNA), RNA, as well as oligonucleotides labeled with multiple modifications and dyes. About Orochem: Founded in 1996, Orochem provides products and services that support academic, gover...

Isis Scientist Awarded 2009 Ebert Prize

...the Journal of Pharmaceutical Sciences entitled "Oral Delivery of Antisense oligonucleotides in Man." His co-authors are Richard S. Geary, Ph.D. and Gregory E. Hardee, ...d Tillman, Richard S. Geary, Gregory E. Hardee. Oral Delivery of Antisense oligonucleotides in Man. Journal of Pharmaceutical Sciences. 2008; 97 (1): 225-36. AB...

Gen-Probe Reports Strong Financial Results for Third Quarter 2008, Raises Full-Year EPS Guidance

...million, compared to $27.6 million in the prior year period, a decrease of 11% that resulted primarily from the purchase of human papillomavirus (HPV) oligonucleotides from Roche in the prior year period. For the first nine months of 2008, R&D expenses were $76.9 million, compared to $72.8 million in the prior year p...

Industry Experts and Global Regulators to Discuss Oligonucleotide-Based Therapeutics Issues

...ss: siRNAs Non-Hybridization Dependent oligonucleotides Antisense Oligonucleotide Discovery and Develo...As Pathways Clinical applications of Antisense oligonucleotides Clinical Applications of Aptamers Clinical Opportunities for Immunostimulatory oligonucleotides Delivery of...

Bioniche Presents Pre-Clinical Research at Two International Conferences

...(TM)". This new class of molecules with potential clinical anticancer activity and immune modulating properties is composed of short non-antisense DNA oligonucleotides that appear to possess a range of novel pharmacological activities. About MCC MCC is a sterile mycobacterial cell wall-DNA complex composition tha...

Iomai Wins Department of Defense Grant to Develop a Stable, Patch-Based Anthrax Vaccine

...ne and the plague vaccine have been carried out at this site since 2000. Avecia Biotechnology Inc. is a leader in the field of contract manufacture of oligonucleotides at its facility in Milford, Mass. On March 20, 2008 Avecia Biologics Ltd. and PharmAthene, Inc., a biodefense company specializing in the developmen...

MWG and Operon Are Joining Forces

...s. "Enabling Operon and Eurofins Genomics subsidiaries Eurofins MWG and Eurofins Medigenomix to work together strengthens our position in the custom oligonucleotides business and creates new opportunities for further development of additional services in the genomic services field. This will give the market, and in...

Varian, Inc. Offers New Products for the Rapid Purification of Synthetic Oligonucleotides.

...(Nasdaq: VARI ) announced today two new TOP (Trityl-on Oligonucleotide Purification) products, TOP-DNA and TOP-RNA, for the purification of synthetic oligonucleotides (oligos). Synthetic DNA and RNA oligos are used by life science researchers to study the functions of genes and proteins within cells. For oligos to ...

Genta to Present at Bio Investor Forum 2007 Conference

...vering innovative products for the treatment of patients with cancer. The Company's research platform is anchored by two major programs that center on oligonucleotides (RNA- and DNA- based medicines) and small molecules. Genasense(R) (oblimersen sodium) Injection is the Company's lead compound from its oligonucleotid...
Oligonucleotides in Medical Technology

ATL/TV1102 Trial Results Presented at World Congress on Treatment and Research in Multiple Sclerosis

...er Amsterdam, VU University Medical Center, Amsterdam, Netherlands, (3) Antisense Therapeutics Ltd, Melbourne, VIC, Australia. Background: Antisense oligonucleotides (ASOs) are an innovative new class of drugs that inhibit the expression of proteins by sequence-specific binding to the protein's mRNA. ATL1102 is a 2...

Genta Initiates First Clinical Trial with New Oral Drug (G4544) to Treat Bone Disease

...vering innovative products for the treatment of patients with cancer. The Company's research platform is anchored by two major programs that center on oligonucleotides (RNA- and DNA- based medicines) and small molecules. Genasense(R) (oblimersen sodium) Injection is the Company's lead compound from its oligonucleotid...

Genasense(R) Data in Melanoma to be Presented in Opening Session at First Worldwide Melanoma Center Meeting of the European Association of Dermato-Oncology

...vering innovative products for the treatment of patients with cancer. The Company's research platform is anchored by two major programs that center on oligonucleotides (RNA- and DNA- based medicines) and small molecules. Genasense(R) (oblimersen sodium) Injection is the Company's lead compound from its oligonucleotid...

Genta Initiates Phase 3 AGENDA Trial of Genasense(R) for Patients with Advanced Melanoma

...vering innovative products for the treatment of patients with cancer. The Company's research platform is anchored by two major programs that center on oligonucleotides (RNA- and DNA- based medicines) and small molecules. Genasense(R) (oblimersen sodium) Injection is the Company's lead compound from its oligonucleotid...

Genta Incorporated Announces Second Quarter 2007 Financial Results and Corporate Highlights

...vering innovative products for the treatment of patients with cancer. The Company's research platform is anchored by two major programs that center on oligonucleotides (RNA- and DNA- based medicines) and small molecules. Genasense(R) (oblimersen sodium) Injection is the Company's lead compound from its oligonucleotid...

Genta Incorporated to Present Multiple Abstracts at the Annual Meeting of the American Society of Clinical Oncology

...vering innovative products for the treatment of patients with cancer. The Company's research platform is anchored by two major programs that center on oligonucleotides (RNA- and DNA- based medicines) and small molecules. Genasense(R) (oblimersen sodium) Injection is the Company's lead compound from its oligonucleotid...

Phase 2 Clinical Results of Ganite Plus Standard Therapy in Patients with Relapsed/Refractory Lymphoma Presented at ASCO

...vering innovative products for the treatment of patients with cancer. The Company's research platform is anchored by two major programs that center on oligonucleotides (RNA- and DNA- based medicines) and small molecules. Genasense(R) (oblimersen sodium) Injection is the Company's lead compound from its oligonucleotid...

Genta Announces Results of Phase 1 Study Using Genasense Administered by Intermittent Subcutaneous Injection

...vering innovative products for the treatment of patients with cancer. The Company's research platform is anchored by two major programs that center on oligonucleotides (RNA- and DNA- based medicines) and small molecules. Genasense(R) (oblimersen sodium) Injection is the Company's lead compound from its oligonucleotid...

The Past, Present and Future of HLA Typing

...es consistently. Several probes could be used to identify an array of HLA alleles. Today, radioactive probes are seldom used, and sequence specific oligonucleotides are now labeled with fluorescent dyes, biotin, digoxigenin, or directly with enzymes such as horseradish peroxidase. The appropriate substrate can be...
Oligonucleotides in Medical Products

NGEN HFE ASRs*

Description:...everal respiratory viruses. Nanogen offers reagents for detection of three mutations associated with Hereditary Hemochromatosis (HH). Reagents include oligonucleotides for the detection of C282Y, H63D, and S65C mutations of the HFE gene. Laboratories may use the reagents to create homebrew tests. *Analyte Spe...
Company:Nanogen, Inc.
Oligonucleotides in Biological News

New DNA and RNA aptamers offer unique therapeutic advantages

...ribed in a comprehensive review article published online ahead of print in oligonucleotides , a peer-reviewed journal published by Mary Ann Liebert, Inc. ( www.liebert...hat our readers should enjoy," says John Rossi, PhD, Co-Editor-in-Chief of oligonucleotides and Professor in the Department of Molecular Biology, Beckman Research Ins...

CSHL scientists harness logic of 'Sudoku' math puzzle to vastly enhance genome-sequencing capability

...nown as multiplexing. In previous multiplexing approaches, scientists first tagged each sample with a barcode a short string of DNA letters known as oligonucleotides before mixing it with other samples that also had unique tags. After the sample mix had been sequenced, scientists could use the barcode tags on the ...

Strong immune response to new siRNA drugs in development may cause toxic side effects

...ics explored in a timely review article published online ahead of print in oligonucleotides , a peer-reviewed journal published by Mary Ann Liebert, Inc. (www.liebertp...using siRNAs therapeutically," says John Rossi, PhD, Co-Editor-in-Chief of oligonucleotides and Professor in the Department of Molecular Biology, Beckman Research Ins...

New electrostatic-based DNA microarray technique could revolutionize medical diagnostics

...ests and targeted therapies that can stem from assays using a DNA microarray a thumbnail-sized substrate containing thousands of microscopic spots of oligonucleotides (stretches of DNA about 20 base pairs in length) laid out in a grid. Often referred to as "gene chips," DNA microarray assays and their RNA counte...

Cold Spring Harbor Laboratory scientists devise potential approach to treat spinal muscular atrophy

... the gene to include the missing piece. Dr. Krainer and his team sought to change the splicing by introducing synthetic molecules, called antisense oligonucleotides or ASOs, that precisely match various sections of the RNA. They reasoned that if these molecules stuck to the right part of the RNA, they might redire...

Deadly genetic disease prevented before birth in zebrafish

..."The idea is that we can modify the treatment to target a specific mutation and design molecules to alter gene function in the same way the morpholino oligonucleotides can," Gitlin said. The work is an important step toward personalized medicine, which can tailor treatment to an individual's genetic makeup. "Ev...

New human retrovirus originated in mice

...ists of a microarray of some 20,000 characteristic gene sequences -- called oligonucleotides -- representing a vast array of known viruses. The oligonucleotides are deposited as tiny spots on a small glass chip. To detect viruses fro...

Cellular Defects in Premature Aging Disease are Reversible

...t the splicing machinery from cutting in the wrong place. "You can think of it as a molecular Band-Aid®," said Misteli. The researchers inserted their oligonucleotides into the progeria cells and observed that after four days almost all the mutant lamin A transcripts had been eliminated and replaced with the properly...

Products containing specific probes for detecting alternative splice forms protected

...vering microarrays optimised for the discovery of alternative RNA splicing events. The patent protects the probe configuration of a unique set of five oligonucleotides for the detection of each splice variant. There are many applications for this patent, including drug discovery, diagnostics, and compound screenings ...
Oligonucleotides in Biological Technology

LNA-Based RNA oligonucleotides Potently Inhibit Cancer microRNAs

COPENHAGEN, April 20 /PRNewswire/ -- Santaris Pharma announced today promising findings on the in vitro and in vivo activity of microRNA-targeted therapeutics against cancer developed on the basis of its proprietary Locked Nucleic Acid (LNA) Drug Platform. In both in vitro and in vivo models S...

Santaris Pharma - Interim Report for the Period 1 January to 30 June 2009

... Imaging and Drug Development/London/UK - BioEurope Spring/Milan/Italy - microRNAs in human disease/Boston/USA - Girindus Leadership in oligonucleotides Symposium/Ohio/USA - Innov. Biotechn. Seoul, South Korea - microRNA in Denmark, BRIC, Cph. University, Denmark - European Association f...

Sigma-Aldrich Enters Exclusive Supply Agreement With Gene Oracle to Leverage Its Unique GeneIOS Gene Synthesis Platform

...d an agreement to supply high quality services and oligonucleotides to Gene Oracle, an innovative gene synthesis compa...a-Aldrich will be the exclusive supplier of custom oligonucleotides for Gene Oracle, and the two Companies will engage...ity's trust with our consistently high quality DNA oligonucleotides that we believe are an ideal complement to Gene Or...

AngioGenex Presents Data on its Id Targeted Anti-Angiogenesis Inhibitors at Two Scientific Conferences

...nd the therapeutic potential of the novel, anti-Id oligonucleotides invented by Dr. Benezra. An initial report on one of these oligonucleotides (AGX1053) appeared last year in Nature Biotechnolo...l development of its small, patented molecules and oligonucleotides that have potent anti-angiogenic / anti-tumor acti...

NexBio to Present at 2009 Biotech Showcase

...ies. TOSAP has been shown to successfully formulate multiple classes of molecule, such as protein (including peptides and antibodies), small molecule, oligonucleotides (including siRNA) and virus. For more information about NexBio, Inc., please visit http://www.nexbio.com Contact: David Wurtman,...

Rosetta Genomics to Present Multiple Posters at the Annual American Association of Cancer Research (AACR) Conference

...ely 85%, with two-thirds of the samples being classified with high-confidence, reaching accuracy exceeding 90% and specificity of 99%. 3. "Antisense oligonucleotides against microRNA as a novel therapy for hepatocellular carcinoma"; Sunday April 13, exhibit hall B-F, poster section 32, poster board 12, abstract # 1...

PharmAthene Signs Definitive Agreement to Acquire Biodefense Vaccines Business From Avecia

...ne and the plague vaccine, have been carried out at this site since 2000. Avecia Biotechnology Inc is a leader in the field of contract manufacture of oligonucleotides at its facility in Milford Massachusetts. Forward Looking Statement Except for the historical information presented herein, matters discussed may ...

Aktiv-Dry Awarded Research Grant to Explore Inhalable siRNA Dry Powder Targeting RSV

...ude delivering to the respiratory system short interfering ribonucleic acid oligonucleotides (siRNAs), the molecules that induce RNA interference. Quinn will use Aktiv-...de the production of dry powders consisting of micro- and nano-particles of oligonucleotides intended for long-term storage. For more information, contact 303-350-3060,...

Gen-Probe Reports Strong Financial Results for Third Quarter 2007, Raises Full-Year Guidance for Earnings Per Share and Total Revenues

...on in the prior year period, an increase of 14%. This increase, which was expected, resulted primarily from the purchase of human papillomavirus (HPV) oligonucleotides from Roche. For the first nine months of 2007, R&D expenses were $72.8 million, compared to $63.8 million in the prior year period, an increase of 14%...

New method of selecting DNA for resequencing accelerates discovery of subtle DNA variations

...cting subtle genetic variability among individuals. The Emory scientists believe that goal will be much more obtainable thanks to MGS. MGS uses DNA oligonucleotides (probes) arrayed on a chip at high density (microarray) to directly capture and extract the target region(s) from the genome. The probes are chosen fr...
Oligonucleotides in Biological Products

Standard and Modified Oligonucleotides Service from Yorkshire Bioscience Ltd

Description: Standard and modified oligonucleotides up to 150 nt-long at any scale for broad applications. Price starts from 30p/base (10 nmole scale)....
Company:Yorkshire Bioscience Ltd

Antisense oligonucleotides from Thermo Scientific

Description: Phosphothioate (PTO) oligonucleotides: PTOs are internucleotide modifications, where one oxygen atom in the phosphate backbone is replaced by a sulphur atom. This modification stabilises the oligonucleotide against nuclease degradation. PTOs are available as Full-PTOs All internucleotide link...
Company:Thermo Scientific

Gtporator (4 ml) from GEN-TREND s.r.o.

Description:... Highly efficient electroporation solution suitable for transfection of plasmid DNA, oligonucleotides and siRNA. Compatible with all common electroporators....
Company:GEN-TREND s.r.o.

Silencer Pre-designed siRNA, HPLC purified, annealed from Ambion

Description:...nteed >97% pure. To ensure that the siRNAs are of highest quality, all RNA oligonucleotides are assessed by MALDI-TOF (matrix-assisted laser desorption ionization tim...e-of-flight) mass spectrometry and the purity of all HPLC and PAGE purified oligonucleotides by analytical HPLC. Ambion also analyzes each annealed siRNA by gel electro...
Company:Ambion

Silencer Pre-designed siRNA, standard purity from Ambion

Description:...nteed >97% pure. To ensure that the siRNAs are of highest quality, all RNA oligonucleotides are assessed by MALDI-TOF (matrix-assisted laser desorption ionization tim...e-of-flight) mass spectrometry and the purity of all HPLC and PAGE purified oligonucleotides by analytical HPLC. Ambion also analyzes each annealed siRNA by gel electro...
Company:Ambion

Custom siRNA, PAGE purified from Ambion

Description:...nteed >97% pure. To ensure that the siRNAs are of highest quality, all RNA oligonucleotides are assessed by MALDI-TOF (matrix-assisted laser desorption ionization tim...e-of-flight) mass spectrometry and the purity of all HPLC and PAGE purified oligonucleotides by analytical HPLC. Ambion also analyzes each annealed siRNA by gel electro...
Company:Ambion

Silencer Pre-designed siRNA, HPLC purified from Ambion

Description:...nteed >97% pure. To ensure that the siRNAs are of highest quality, all RNA oligonucleotides are assessed by MALDI-TOF (matrix-assisted laser desorption ionization tim...e-of-flight) mass spectrometry and the purity of all HPLC and PAGE purified oligonucleotides by analytical HPLC. Ambion also analyzes each annealed siRNA by gel electro...
Company:Ambion

Custom siRNA, PAGE purified, annealed from Ambion

Description:...nteed >97% pure. To ensure that the siRNAs are of highest quality, all RNA oligonucleotides are assessed by MALDI-TOF (matrix-assisted laser desorption ionization tim...e-of-flight) mass spectrometry and the purity of all HPLC and PAGE purified oligonucleotides by analytical HPLC. Ambion also analyzes each annealed siRNA by gel electro...
Company:Ambion

NAP-10 Columns from GE Healthcare, formerly Amersham Biosciences

Description:... NAP-10 Columns, 50. For rapid and efficient purification of DNA and oligonucleotides (> 10-mers) in less than 15 minutes by gravity flow.Prepacked with Sephadex G-25 DNA Grade in distilled water containing 0.15% Kathon CG/ICP Biocide.A...
Company:GE Healthcare, formerly Amersham Biosciences

DNA DipStick Kit from Invitrogen

Description:... The DNA DipStick Kit is ideal for estimating nucleic acid concentrations and approximate yields. Works with ss- and ds-DNA, RNA, and oligonucleotides at concentrations as low as 0.1 ng/l....
Company:Invitrogen
Oligonucleotides in Biological Definition

Gel electrophoresis

...l is a crosslinked polymer whose porosity can be controlled by the scientist. When separating proteins or small nucleic acids ( DNA , RNA , or oligonucleotides ) the gel is usually made with different concentrations of acrylamide and a cross-linker , producing different sized mesh networks of polyacrylamid...

Gel electrophoresis

...l is a crosslinked polymer whose porosity can be controlled by the scientist. When separating proteins or small nucleic acids ( DNA , RNA , or oligonucleotides ) the gel is usually made with different concentrations of acrylamide and a cross-linker , producing different sized mesh networks of polyacrylamid...

Har Gobind Khorana

... delivered on December 12,1968. Dr.Khorana was also the first to synthesize oligonucleotides , that is, strings of nucleotides. These custom designed pieces of artifici...g, cloning and engineering new plants and animals.Dr.khorana's invention of oligonucleotides has become indispensable tools in biotechnology. This invention of DrKhoran...
Oligonucleotides in Biological Dictionary

SnRNP

..... early 5′ splice site/tri- snRNP interaction requires ATP, occurs in ... Antisense probing of the human U4U6 snRNP with biotinylated 2′-OMe RNA oligonucleotides ... Surprisingly, instead of U1A we have identified a novel U1 snRNP -specific protein, TbU1-24K. ... role of the U1 snRNP , early 5' splice sit...

Saturation mutagenesis

...create a library of mutants ... Recently, a report of a new approach, termed saturation mutagenesis , was published (3) ... to offer optimized oligonucleotides for saturation mutagenesis . ... These were subjected to saturation mutagenesis to ... saturation mutagenesis at residues 211/212, plott...

S1 nuclease

...n endonuclease that is active against single-stranded DNA and RNA molecules. It is five times more active on DNA than RNA. Its reaction products are oligonucleotides or single nucleotides with 5' phosphoryl groups. Although its primary substrate is single-stranded, it can also occasionally introduce single-st...

RNAi

... Services siRNA Collections and Databases RNAi ... The term RNA interference ( RNAi ) was coined to describe this phenomenon and, ... Designing oligonucleotides for RNAi Expression Vectors ... Nature - RNAi Animation ... RNA interference ( RNAi ) is a process in which double-stranded ... The applicati...

RAPD

...nces using ... The RAPD (random amplified polymorphic DNA) technique (10, 12) has been widely ... RAPD markers are detected by the use of short oligonucleotides of arbitrary ... In this study, the RAPD (Random Amplified Polymorphic DNA) technique was ... three herbal medicines was determined when RAPD r...

Polymorphic loci

... of Strains of Mycobacterium leprae ... we have identified nine additional polymorphic loci in a small set of four ... Polymers of random short oligonucleotides detect polymorphic loci in the human genome. ... Wyman AR, White R. A highly polymorphic locus in human DNA. ... www.PharmCast.com is t...

Denaturing Gel

...HORESIS (DGGE): AN OVERVIEW. By Fatou Diarrassouba Ly ... Denaturing Gradient Gel Electrophoresis (DGGE) is such a technique ... PURIFICATIONOF oligonucleotides USING DENATURING POLYACRYLAMIDE GEL ELECTROPHORESIS ... gel during electrophoresisis desirable since it helps to denature the ... ... dena...

Base modification

...spitals which, on ... Modified Alternative Base ... satisfaction, the modified base hospital must ... Sequence analysis of PCR product from oligonucleotides containing. 8-oxodG base modifications . ... 8-oxodA and abasic base modifications . ... For example, the tRNA base modification m1G37 is...
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