Oligonucleotide

Quark Pharmaceuticals to Participate in IBC's Oligonucleotide Therapeutics: From Concept to Implementation Conference

FREMONT, Calif., Aug. 3 /PRNewswire/ -- Quark Pharmaceuticals, Inc., a development-stage pharmaceutical company discovering and developing novel RNA interference (RNAi)-based therapeutics, today announced that James D. Thompson, Ph.D., Vice President, Pharmaceutical Development, will par...

Kinovate Life Sciences, Inc. and Nitto Denko Corporation Announce Successful Development of NittoPhase™ HL High Loading Solid Support for Oligonucleotide Synthesis

NittoPhase™ HL Loaded up to 400umol/g delivers Market Leading Economies to Reduce Synthesis Costs and Increase Yields Oceanside, Calif. (PRWEB) May 15, 2009 -- Kinovate Life Sciences, Inc, the market leader in solid support for oligonucleotide synthesis, will be a...

Scientists Reverse Muscular Dystrophy in Mice

...d. "There are a lot of potential issues especially regarding the delivery of the oligonucleotide," Rimer added. "They only test the effects of the oligonucleotide in one muscle, so if you want to apply this to humans you would have to find a way to deliver this to multiple muscles." Also, said Cwik, it isn't ...

Orochem Technologies Acquires Oligonet, a Custom Oligo Synthesis Business

...oteomics markets today announced the acquisition of Oligonet, Inc. a Custom oligonucleotide Synthesis Business located in Gaithersburg, MD. With this acquisition, Oroc... player in the custom oligo synthesis market having already been supporting oligonucleotide synthesis establishment with several products that range from synthesis pla...

TriLink BioTechnologies, Inc. Announces Sales and License Agreement With Glen Research Corporation for CleanAmp(TM) Amidites

...anAmp(TM) Amidites available through Glen Research allows institutions with oligonucleotide synthesis capabilities to manufacture CleanAmp(TM) Primers in-house. Learn ...en Research is dedicated to bringing the very best research products to the oligonucleotide synthesis market. So we are delighted to be able to offer CleanAmp(TM) Amid...

Industry Experts and Global Regulators to Discuss Oligonucleotide-Based Therapeutics Issues

... Association (DIA), in collaboration with the FDA, oligonucleotide Therapeutics Society, Health Canada, and the Ameri...ssociation (DIA)]], in collaboration with the FDA, oligonucleotide Therapeutics Society, Health Canada, and the Ameri...idization Dependent Oligonucleotides Antisense oligonucleotide Discovery and Development Emerging...

Oligonucleotide in Medical Technology

University of Michigan Study Shows SEQUENOM's MassARRAY Technology Identifies HPV Infections Missed by Standard Hybridization Test

...uantitative gene expression analysis, quantitative methylation marker analysis, comparative sequence analysis of haploid organisms, SNP discovery, and oligonucleotide quality control. About SEQUENOM SEQUENOM is a life sciences company committed to providing the best genetic analysis products that tran...

Another LNA-based RNA Inhibitor Enters Clinical Trials

... LNA-based PIK3CA antagonist" "EZN-3042, a novel locked nucleic acid oligonucleotide against survivin, inhibits survivin expression and confers taxol sensitivity" "EZN-3920, an LNA antisense oligonucleotide RNA antagonist, down modulates HER3 expression and PI3K/Akt signaling pathw...

Quark Pharmaceuticals Presents at Asia TIDES Conference

...pson, Ph.D., Vice President, Pharmaceutical Development presented an overview of Quark's novel pipeline of synthetic siRNA compounds at the Asia TIDES oligonucleotide and Peptide(R) Technology and Product Development Conference, held February 24th, 2009 in Tokyo, Japan. Dr. Thompson's presentation, entitled "...

ATL/TV1102 Trial Results Presented at World Congress on Treatment and Research in Multiple Sclerosis

...ill provide login details on its website http://www.antisense.com.au once these are confirmed. Conference abstract follows: VLA-4 Antisense - An oligonucleotide targeting VLA-4 mRNA (ATL1102) significantly reduces new active lesions in patients with RR-MS Volker Limmroth(1), Frederik Barkhof(2), Nuket Desem(...

Genta Clinical Programs Featured at American Society of Hematology Meeting

...a featured press briefing sponsored by ASH on Sunday December 9 at 9:30 am. -- Oblimersen (Genasense(R)), a phosphorothioate Bcl-2 antisense oligonucleotide (ASO), can be safely administered by bolus subcutaneous (SC) injection and brief IV Infusion. Publication. -- Phase 1 assessment of G4544, an o...

Genta Initiates First Clinical Trial with New Oral Drug (G4544) to Treat Bone Disease

...igonucleotides (RNA- and DNA- based medicines) and small molecules. Genasense(R) (oblimersen sodium) Injection is the Company's lead compound from its oligonucleotide program. The leading drug in Genta's small molecule program is Ganite(R) (gallium nitrate injection), which the Company is exclusively marketing in th...

Oligonucleotide in Medical Products

Dynal RELI™ SSO

Description:...rs that flank the specific target region of an HLA locus. This is followed by hybridisation of the resulting amplicon to an array of Sequence Specific oligonucleotide probes immobilised on a nylon membrane. The immobilisation of these probes is referred to as a Reverse Line blot and thus gives rise to the acronym 'R...
Company:Dynal Biotech, LLC

Oligonucleotide in Biological News

ISU researchers find possible treatment for spinal muscular atrophy

...tein because of the presence of a specific intronic sequence in the gene or DNA. To make SMN2 behave as SMN1, Singh has introduced a small antisense oligonucleotide that blocks this specific intronic sequence. When the intronic sequence is blocked, SMN2 produces normal proteins and acts, in effect, like SMN1. ...

Strong immune response to new siRNA drugs in development may cause toxic side effects

...iebert, Inc. (www.liebertpub.com) The article is available free online at www.liebertpub.com/oli siRNAs are duplex structures comprised of short oligonucleotide sequences. The discovery that naturally occurring and synthetic siRNAs can effectively prevent expression of a disease gene sparked intense interest i...

Researchers take first look at the genetic dynamics of inbreeding depression

...e researchers also crossed the three highest inbred lines to one another, creating outbred lines that could be compared with the inbred ones. Using oligonucleotide microarrays, which can measure the activity of all of an organism's genes at once, the researchers were able to see which genes were more or less acti...

A new gene silencing platform -- silence is golden

... polyA tail addition in a gene specific manner. Further, the domains of the oligonucleotide are independent so transcript binding and U1 snRNP binding can be independe...t used 5'-end-mutated U1 snRNA," Gunderson explained. "The U1 Adaptor is an oligonucleotide version of this older method and instead targets the 3' end processing step...

Less can be more, for plant breeders too

...ther crops and it may provide an important new avenue to enhance agronomic performance and nutritional value. Computer software to design the required oligonucleotide sequences and detailed protocols to produce amiRNAs are provided free of charge on the authors web site, at http://wmd2.weigelworld.org. Similarly, th...

Leroy Hood to receive 2008 Pittcon Heritage Award

...d genomics: the DNA and protein sequencers and synthesizers and the ink-jet oligonucleotide synthesizer. The DNA sequencer in particular has revolutionized genomics by...otechnology at the University of Washington, where he developed the ink-jet oligonucleotide synthesizer, which synthesizes DNA chips, and initiated systems studies on ...

Oligonucleotide in Biological Technology

Chromatide and Novasep Have Extended Their Partnership to Develop Large Scale Solid Phase Peptide and Oligonucleotide Synthesis Technology.

POMPEY, France, May 16 /PRNewswire/ -- Chromatide and Novasep have extended their partnership to develop large scale solid phase peptide and oligonucleotide synthesis technology. The resulting systems and equipment will meet the growing needs of biotechnology and pharmaceutical industries for ...

Using the OligoGreen Oligonucleotide Quantitation Reagent in the Gemini XS, Gemini EM and SpectraMax M2 Microplate Readers (MaxLine Application Note #21)

By Yan Zhang., Molecular Devices Corporation, 1311 Orleans Dr., Sunnyvale, CA 94089. Introduction This application note describes how to use the OliGreen Quantitation Kit from Molecular Probes in the Gemini XS, Gemini EM and SpectraMax M2 mic...

USB OptiKinase Eliminates Base Bias in Labeling of Oligonucleotide 5'-Ends

Wild-type T4 Polynucleotide Kinase (PNK) (1,2,3) is commonly used for phosphorylation and labeling of 5'-ends of DNA and oligonucleotides. Labeling, in particular, can be accomplished by two approaches, the forward reaction and the exchange reaction (Fig. 1) (3) . Historically, T4 PNK ha...

SEQUENOM Announces Launch of MassARRAY Compact 96 System

...uantitative gene expression analysis, quantitative methylation marker analysis, comparative sequence analysis of haploid organisms, SNP discovery, and oligonucleotide quality control. About SEQUENOM SEQUENOM is a life sciences company committed to providing the best genetic analysis products that translat...

DNA Software, Inc. Awarded $2.5 M in NIH Funding to Develop Pioneering Nucleic Acid-based Technologies

...so-C, and Iso-G). The company has recently expanded its original DNA and RNA-based, molecular biology solutions to include modified nucleotides, oligonucleotide kinetics, and structural biology. For more information, please contact DNA Software at +1 734 222 9080, info@dnasoftware.com, or www.dnasoftware....

SAFC Supply Solutions(R) Announces Raw Materials Line Developed Specifically to Meet Molecular Diagnostics Manufacturing Requirements

...ager George Crowell, who commented: "SAFC Supply Solutions provides a strong molecular diagnostics offer for this industry. By including the Company's oligonucleotide custom synthesis capabilities and specialty molecular products, we believe that the breadth of this offer is now unrivalled in our industry. Additiona...

Oligonucleotide in Biological Products

Custom LNA Oligonucleotide synthesis from Exiqon

Description: Custom LNA Oligonucleotide synthesis High quality Custom LNA Oligonucleotides are available for a variety of different specialty applications and innovative products. Please inquire for further details....
Company:Exiqon

Custom 60-mer Oligonucleotide Microarrays from Agilent Technologies

Description: These extended-length microarrays are custom designed to meet your needs. Two probe density format configurations are available: 8,455 features per array (2 arrays/1" x 3" glass slide) or 22,575 features per array (1 array/slide). Features 60-mer oligonucleotide probe length - This extended l...
Company:Agilent Technologies

Oligo Synthesis from Biosearch Technologies

Description:... Since the early 80s Biosearch Technologies has been at the forefront providing advanced oligonucleotide tools to accelerate the discovery and application of genomic information. Whether you need dual-labeled FRET probes and primers or 100 or 100,000 cust...
Company:Biosearch Technologies

XpressPack™ Luminescent Amplification Detection System, required for luminescent XpressPack™ from CHEMICON

Description:...tured under alkali conditions to separate the two DNA strands. The single-stranded amplicon is captured to the plate via hybridization with a specific oligonucleotide probe immobilized to the reaction well (target specific probe-coated plate included in the XpressPack gene-specific kit). The hybrid complex is then r...
Company:CHEMICON

XpressPack™ Colorimetric Amplification Detection System, required for colorimetric XpressPack™ from CHEMICON

Description:...atured under alkali conditions separating the two DNA strands. The single-stranded amplicon is captured to the plate via hybridization with a specific oligonucleotide probe immobilized to the reaction well (target specific probe-coated plate included in the XpressPack™ gene-specific kit). The hybrid complex is...
Company:CHEMICON

Amplifluor UniPrimer II Fluorescein from CHEMICON

Description:...mer-fluorescein is a hairpin primer labeled with a fluorescent energy transfer pair (fluorescein and non-fluorescent quencher) and a 3 single-stranded oligonucleotide tail. The UniPrimer is identical to the UniPrimer provided in the Amplifluor Universal Detection System (S7901) and is provided at a concentration of...
Company:CHEMICON

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Oligonucleotide in Biological Dictionary

Oligonucleotide

An oligonucleotide is a short nucleic acid polymer, typically with twenty or fewer bases. Although they can be formed by bond cleavage of longer segments, they are now more commonly synthesized by polymerizing individual nucleotide precursors. Automated synthesizers... Oligonucleotide ...

Primer extension

...ex assay design, bio-rad bioplex Primer Extension . • Allele Specific oligonucleotide Ligation. • Sequencing ... One can label the primer and apply the extens...of DNA sequence is ... 2.4 Primer extension . 2.5 5'- nuclease. 2.6 oligonucleotide ligase assay ... Because, primer extension is based on the highly acc...

Oligodeoxyribonucleotide

...ve online resource for all laboratory protocols ... Versatile synthesis of oligodeoxyribonucleotide –oligo spermine conjugates ... An antisense oligonucleotide phosphorothioate, previously shown to inhibit HIV-1 viral expression in chronically infected H9 cells, was fluorescently labeled to ... ... modi...

Melting temperature

...SECONDARY STRUCTURE & MELTING TEMPERATURE . REPEATS, SECONDARY STRUCTURE ... Knowing the melting temperature of a fragment of DNA or of an oligonucleotide is ... Freezing and Melting | World of Earth Science. Freezing and Melting summary with 4 pages of encyclopedia ... a solid to a liquid as the...

Gene silencing

...de a breakthrough in understanding the phenomenon of nucleolar dominance, the silencing of an entire parental set of ribosomal RNA genes in a ... oligonucleotide probes used to silence gene expression ... ProbeDB > Applications > Gene Silencing . PubMed. All ... Comparison of gene silencing str...

Gene expression

... expression information in MGI. ... Gene Expression Notebook (GEN) Mouse Phenome Database (MPD) Deltagen and Lexicon Knockout Mice ... long oligonucleotide arrays for gene expression analysis including tiling expression , mutiplex expression for a broad range of prokaryotic and eukaryotic genomes ...