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Oligodendrocyte in Medical News

Stem Cell Breakthrough May Lead to MS Treatments

...me regulatory circuitry and use the same molecules (including both FGF2 and SHH), FGF2 behaves differently in each species. In mice, FGF2 promotes oligodendrocyte maturation; in humans, it inhibits the process. "This finding is actually quite significant scientifically," said Zhang, "because even [though] th...

UCI behind world's first embryonic stem cell study in humans

... In laboratory tests, Keirstead and his colleague, Dr. Gabriel Nistor, developed a technique for prompting human embryonic stem cells to develop into oligodendrocyte cells. Injected into rats with spinal cord injuries, the precursor cells turned into oligodendrocytes and migrated to the injured area of the spina...

News Tips from the Journal of Neuroscience

...Sinha et al. constructed a new one, RTL551, from the outer domains of the I-A b class II molecule and an encephalitogenic peptide derived from myelin oligodendrocyte protein (MOG-35-55). RTL551 reduced the severity of active and passive MOG-induced EAE in mice. For passively transferred EAE, the authors introduced ...

Brains White Matter: More Talkative Than Once Thought

...ng to other cells in the white matter, says Dwight Bergles, Ph.D., an associate professor of neuroscience at Hopkins. The discovery focuses on oligodendrocyte precursor cells (OPCs), whose main role when they mature into oligodendrocytes is to wrap themselves around and insulate nerves with a whitish coat of...

Blame Myelin for Many Neuropsychiatric Disorders

...to treat Alzheimer’s) and nicotine patches. “Through these rather benign interventions,” Bartzokis said, “such effects on the brain’s vulnerable oligodendrocyte populations may offer exciting opportunities for the prevention of both developmental and degenerative brain disorders. They deserve much closer scrut...

Hyaluronic Acid – A Boon To The Problem Of Premature Infant

...blished between damage to white matter in the brain associated with premature birth, and damage to immature cells in the brain and spinal cord, called oligodendrocyte progenitors. These cells normally mature to become oligodendrocytes that make myelin (the insulating sheath surrounding nerve fibres in the brain...
Oligodendrocyte in Medical Technology

Data to be presented at AAN Meeting -Study results of drug candidate for MS

...: We investigated the role of sphingosine-1-phosphate receptors (S1P-Rs) on oligodendrocytes and determined the direct effects of FTY720 on increasing oligodendrocyte numbers. Conclusion/Relevance: We have shown that FTY720P increases oligodendrocyte numbers in both immature and mature lineages. We propose that FT...

Opexa Presents Tovaxin Research at Federation of Clinical Immunology Societies Annual Meeting

...say (EAA)) have allowed Opexa to identify several myelin protein peptides from myelin basic protein (MBP), myelin proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein (MOG) as being immunodominant, including some peptides never before reported, and others as being non-reactive, -- The EAA can be ut...
Oligodendrocyte in Biological News

MS study offers theory for why repair of brain's wiring fails

... contributing to three key stages in the repair process the recruitment of oligodendrocyte precursors to the site of injury, the maturation of those cells into functi...ted that the Wnt pathway activation was creating a roadblock that prolonged oligodendrocyte precursor development. "While the animals eventually showed repair, it w...

One size does not fit all

...f MS, following an immune system attack on myelin, oligodendrocyte progenitor cells or stem cells in the CNS are recr...decrease not only in myelin production but also in oligodendrocyte number as a result of simvastatin treatment. The f...simvastatin inhibits CNS remyelination by blocking oligodendrocyte progenitor cell differentiation or maturation into...

Human ES cells progress slowly in myelin's direction

...between mouse and human ES cells: a growth factor called Fgf2 that promotes oligodendrocyte development in mouse ES cells actually stalls it in human ES cells. As D...mportance. 'We are now able to generate a relatively enriched population of oligodendrocyte precursor cells that may be used to repair lost myelin sheaths. These findi...

In the war against diseases, nerve cells need their armor

... paranodal junctions in place, and thereby maintain the structure of myelin. The paranodal junction is a highly specialized region of contact where an oligodendrocyte cell attaches itself to the nerve cell's axon. This juncture acts as a molecular fence, which organizes and segregates the distribution of key protein...

Turning back the clock for Schwann cells

...stem. Unlike Schwann cells, oligodendrocytes, the myelin makers in the central nervous system, cant revert to an immature state. Whether c-Jun affects oligodendrocyte differentiation isnt known. ...

Brain's white matter -- More 'talkative' than once thought

...lking to other cells in the white matter,?says Dwight Bergles, Ph.D., an associate professor of neuroscience at Hopkins. The discovery focuses on oligodendrocyte precursor cells (OPCs), whose main role when they mature into oligodendrocytes is to wrap themselves around and insulate nerves with a whitish coat of...

Molecular Partners Required For Appropriate Neuronal Gene Repression

...evealed a link between the white matter brain damage associated with premature birth and damage to immature cells in the brain and spinal cord, called oligodendrocyte progenitors. These precursor cells give rise to all of the mature oligodendrocytes that make myelin throughout life. Back's lab provided the team w...

OHSU researchers discover potential mechanism to repair brain damage linked to Multiple Sclerosis

...evealed a link between the white matter brain damage associated with premature birth and damage to immature cells in the brain and spinal cord, called oligodendrocyte progenitors. These precursor cells give rise to all of the mature oligodendrocytes that make myelin throughout life. Back's lab provided the team w...

Stem cell treatment improves mobility after spinal cord injury

...yonic stem cells to differentiate into early-stage oligodendrocyte cells. Oligodendrocytes are the building blocks of...oups, the early-stage cells formed into full-grown oligodendrocyte cells and migrated to appropriate neuronal sites w...days after the injury, myelin tissue formed as the oligodendrocyte cells wrapped around damaged neurons in the spinal...
Oligodendrocyte in Biological Products

Mouse Oligodendrocyte Differentiation Kit from R&D Systems

Description: For the differentiation of mouse embryonic stem cells tooligodendrocytes....
Company:R&D Systems

Human Neural Stem Cell Functional Identification Kit from R&D Systems

Description:...lements, which can be used for the short-term maintenance, differentiation, and expansion of NSCs and the induction of NSCs into astrocyte, neuron and oligodendrocyte lineages. An antibody panel consisting of mouse anti-human Nestin, mouse anti-human Glial Fibrillary Acidic Protein (GFAP), mouse anti-Neuron-specific...
Company:R&D Systems

Mouse/Rat Neural Stem Cell Functional Identification Kit from R&D Systems

Description:...d media supplements, which can be used for the short-term maintenance and expansion of NSCs and the differentiation of NSCs into astrocyte, neuron and oligodendrocyte lineages. An antibody panel consisting of goat anti-rat Nestin, sheep anti-human Glial Fibrillary Acidic Protein (GFAP), mouse anti-Neuron-specific be...
Company:R&D Systems
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