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Olanzapine in Medical News

Olanzapine Long-Acting Injection (LAI) Efficacy and Safety Data Presented at American Psychiatric Association Annual Meeting

... Three-year data show olanzapine LAI safety findings consistent with oral olanzapine except for injection-related events INDIANAPO...on the short- and long-term efficacy and safety of olanzapine long-acting injection (LAI) in the treatment of ad...

Newer Antipsychotics May Boost Weight in Alzheimer's Patients

... according to a new study of more than 400 elderly patients. The drugs, olanzapine and quetiapine, were both associated with significant weight gain. In addition, patients who took olanzapine experienced increases in waist circumference and declines in HDL cholester...

FDA Panel Snubs Seroquel as 1st Choice Depression Treatment

...time, experts said that the overall odds of a heart problem for patients taking this class of medications -- which also includes clozapine (Clozaril), olanzapine (Zyprexa) and risperidone (Risperdal) -- were probably low, and the drugs remained appropriate for certain patients. Still, doctors, families and pati...

Combating weight gain caused by antipsychotic treatments

... Philadelphia, PA, March 26, 2009 Antipsychotic drugs, such as olanzapine (Zyprexa), risperidone (Risperdal) and quetiapine (Seroquel), are commonly used to treat psychotic disorders like schizophrenia, but also bipolar diso...

FDA Approves Symbyax(R) as First Medication for Treatment-Resistant Depression

...evaluated in these studies ranged from 6-18 mg for olanzapine and 25-50 mg for fluoxetine in fixed combination. ...line to endpoint for Symbyax versus fluoxetine and olanzapine alone. A second study of 28 patients who m... in MADRS scores for Symbyax versus fluoxetine and olanzapine alone. A third study demonstrated statist...

Lilly Reports Fourth-Quarter and Full-Year 2008 Results

...final action to the European Commission. -- olanzapine long-acting injection was approved by the European... Patent Court. As a result of this ruling, generic olanzapine has been withdrawn from the German market. ...offset by growth in Japan. As noted above, generic olanzapine has been withdrawn from the German market. ...

Lilly Resolves Investigations of Past Zyprexa Marketing and Promotional Practices

... glucose levels appears to fall on a continuum and olanzapine appears to have a greater association than some ot...d consider the risks and benefits when prescribing olanzapine to patients with an established diagnosis of diabe...ne increased blood glucose levels. Patients taking olanzapine should be monitored regularly for worsening of glu...

Newer Antipsychotics Pose Cardiac Risk: Study

...if ever, take the drugs to treat other conditions, he said. At issue are newer antipsychotic drugs -- clozapine (Clozaril), quetiapine (Seroquel), olanzapine (Zyprexa) and risperidone (Risperdal). Federal health officials have approved the use of the drugs to treat schizophrenia and bipolar disorder, Ray...

Most Newer Antipsychotics No Better Than Older Ones, Just Different

...uality of life, and weight gain, among other measures. The analysis found four second-generation drugs, amisulpride (Solian), clozapine (Clozaril), olanzapine (Zyprexa) and risperidone (Risperdal) were more effective than first-generation drugs, with "small to medium effect sizes." But, other second gener...

Study Calls for Greater Scrutiny of 'Off-Label' Drug Use

...pproved to treat depression, used off-label for anxiety. Trazodone (Desyrel) approved to treat depression, used off-label for sleep disturbance. olanzapine (Zyprexa) approved to treat schizophrenia, used off-label for depression. Epoetin alfa (Procrit, Epogen) approved to treat chronic renal failure, u...
Olanzapine in Medical Technology

FDA Issues a Complete Response Letter for Lilly's Olanzapine LAI for Treatment of Schizophrenia in Adults

INDIANAPOLIS, Jan. 7 /PRNewswire-FirstCall/ -- Eli Lilly and Company (NYSE: LLY ) announced today that it received a complete response letter from the U.S. Food and Drug Administration (FDA) for olanzapine long-acting injection (LAI) for acute and maintenance treatment of schizophrenia in ad...

FDA Advisory Committee Votes in Favor of Zyprexa for Two Adolescent Indications

...in the National Comorbidity Survey Replication (NCS-R). Archives of General Psychiatry, 2005 Jun;62(6):617-27. (8) Mauricio Tohen et al. (2007). olanzapine versus Placebo in the Treatment of Adolescents with Bipolar Mania. Am J Psychiatry 2007, 164: 1547-1556 (9) Diagnostic and Statistical Manual of...

Lilly Announces Inconclusive Phase II Study Results for mGlu2/3 at the International Congress on Schizophrenia Research

...lyses did not demonstrate that any of the four LY2140023 monohydrate doses (5, 20, 40 and 80 mg taken twice daily) separated from placebo. Similarly, olanzapine at 15mg once daily also did not separate from placebo. LY2140023 monohydrate was generally well- tolerated, although convulsions were observed in thre...

Orexigen(R) Therapeutics Announces Changes to Its Clinical Programs and Management Team

...eam. The key aspects of these changes are as follows: -- The exploratory proof-of-concept Phase 2 trials for OREX-003 (zonisamide and olanzapine to mitigate antipsychotic-associated weight gain) and OREX-004 (fluoxetine and naltrexone to reduce symptoms of obsessive- compulsive disorder) will b...

Olanzapine Long-Acting Injection (LAI) Shown to Maintain Treatment Benefit in Schizophrenia for up to Six Months

... meeting in Barcelona suggest that investigational olanzapine long-acting injection (LAI) therapeutic doses show...ix months. A review of pooled safety data from all olanzapine LAI clinical trials was also presented at the meeting. olanzapine LAI is an investigational formulation that combine...

Olanzapine Long-Acting Injection (LAI) Data Presented at First Annual Schizophrenia International Research Society Conference

...nd safety data were generally consistent with oral olanzapine with the exception of injection-relate...als showed that the efficacy and safety profile of olanzapine LAI was generally consistent with that of Zyprexa(...arch Society (SIRS) Conference in Venice, Italy. olanzapine LAI is an investigational formulation that combine...

Intermezzo(R) 3.5 mg Achieves Greater Early Bioavailability Than Ambien(R) 10 mg Despite 65% Lower Dose

...ermezzo(R) and Transcept plans to submit an NDA in the third quarter of 2008. Transcept is also developing TO-2060, a novel, fixed-dose combination of olanzapine and ondansetron for the treatment of dopamine associated psychiatric disorders. For further information, please visit the company's website at: http:...

Transcept Pharmaceuticals Announces Intent to Submit New Drug Application for Intermezzo(R) in Third Quarter 2008

...who awaken in the middle of the night and have difficulty returning to sleep. Transcept is also developing TO-2060, a novel, fixed-dose combination of olanzapine and ondansetron for the treatment of dopamine associated psychiatric disorders. For further information, please visit the Company's website at: http:...

Overview of Asenapine Data from Olympia Trial Program Presented at American Psychiatric Association Annual Meeting

...k trials, asenapine was found to be noninferior to olanzapine on the primary efficacy measure, change in YMRS. ... trial as neither asenapine nor the active control olanzapine differentiated from placebo. A fourth trial of app...nce of clinically significant weight gain (15%) vs olanzapine (36%)." Presentation of the overview of the Olym...

Statement from Eli Lilly and Company: Response to Connecticut Attorney General News Release

... glucose levels appears to fall on a continuum and olanzapine appears to have a greater association than some ot...d consider the risks and benefits when prescribing olanzapine to patients with an established diagnosis of diabe...ine increased blood glucose level. Patients taking olanzapine should be monitored regularly for worsening of glu...
Olanzapine in Medical Dictionary

Intramuscular

...scularly ... Find information on prescribing ZYPREXA® IntraMuscular (olanzapine for injection) ... Concomitant administration of intramuscular olanzapine and parenteral ... progesterone- intramuscular glossary includes a list of progesterone- intramuscular related medical definitions and related...
Olanzapine in Biological News

Risks and benefits of antipsychotics in children and adolescents

...n this population are risperidone, quetiapine, and olanzapine (Castro-Fornieles et al., in press). Recently, the... patients treated with risperidone, quetiapine, or olanzapine for six months (Castro-Fornieles et al., in press)...chosis patients, weight gain was also greater with olanzapine than with risperidone or quetiapine (Castro-Fornie...
Olanzapine in Biological Technology

SAPHRIS(R) (asenapine) Meets Primary Endpoint in Long-Term Extension Study in Patients With Predominant, Persistent Negative Symptoms of Schizophrenia

...udy, SAPHRIS was significantly more effective than olanzapine in the reduction of negative symptoms as measured ...6 total score were -15.8 for SAPHRIS vs. -11.0 for olanzapine (P=0.015). Full results of the trial, including e...dy design and protocol in which both asenapine and olanzapine reduced negative symptoms after one year of treatm...

Lilly Highlights Transformation Strategy for Wall Street, Reviews Robust Pipeline and Sets 2009 Financial Guidance

...f 2009. European regulatory submission is expected in late 2009. -- olanzapine long-acting injection - The European Commission recently approved Zypadhera... years. Future Zyprexa sales should benefit from a long-acting formulation, olanzapine LAI, which was recently approved in Europe and is under review by the FDA. ...

Lilly to Take Charge to Earnings Related to Pending Federal and State Investigations of Past Practices

... glucose levels appears to fall on a continuum and olanzapine appears to have a greater association than some ot...d consider the risks and benefits when prescribing olanzapine to patients with an established diagnosis of diabe...ne increased blood glucose levels. Patients taking olanzapine should be monitored regularly for worsening of glu...

Orexigen(R) Therapeutics Initiates First Clinical Trial of OREX-003 for the Mitigation of Antipsychotic-Associated Weight Gain

...olled clinical trial evaluating the combination of olanzapine plus zonisamide SR versus olanzapine plus placebo in 75 patients with schizophrenia ove...ht gain and elevated blood glucose associated with olanzapine through novel mechanisms. The clinical trial is cu...

OREXIGEN(R) Therapeutics Receives Notice of Allowance for U.S. Patent Covering the Composition of Matter in OREX-003

...y sustained release formulation of zonisamide plus olanzapine (marketed as Zyprexa(R)). Preclinical studies cond...lanzapine alone. Zonisamide appears to reverse the olanzapine effects on appetite pathways in the brain as well ...ight gain and elevated blood sugar associated with olanzapine treatment. OZ-101, the Company's Phase II proof of...

Transcept Pharmaceuticals Appoints Key Senior Executives

...ermezzo(R) and Transcept plans to submit an NDA in the third quarter of 2008. Transcept is also developing TO-2060, a novel, fixed-dose combination of olanzapine and ondansetron for the treatment of dopamine associated psychiatric disorders. For further information, please visit the Company's website at: http:...

Organon's Asenapine Further Demonstrates Efficacy in Reducing Mania Symptoms for the Treatment of Bipolar I Disorder

...ks. At day 21 in both studies, both asenapine and olanzapine produced significant mean improvements in mania sy...8% in the asenapine groups, 46.8% and 52.9% in the olanzapine groups, and 27.6% and 36.2% in the placebo groups.... 7.2% in the asenapine group, 6.8% and 7.9% in the olanzapine group, and 3.1% and 2.9% in the placebo group. As...

Transcept Pharmaceuticals to Participate in Middle-of-the-Night (MOTN) Insomnia Investor Panel

...iddle of the night and have difficulty returning to sleep. Another product being developed by Transcept is TO-2060, a novel, fixed-dose combination of olanzapine and ondansetron for the treatment of dopamine associated psychiatric disorders. TO-2060 is currently the subject of an initial proof of concept trial ...
Olanzapine in Biological Dictionary

Okazaki fragments

... What is Okazaki fragments ? Meaning of Okazaki fragments medical term. What does ... Okazaki fragments . OKG. Okie. OKT cell. OL. olamine. olanzapine ... is one correct reason why Okazaki fragments are created during lagging strand DNA synthesis. ... discontinuous replication, Okazaki fr...
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