Pioneer(R) Surgical Technology's NuBac(R) Nucleus Replacement Device Wins FDA Approval for IDE Pivotal Study
First Company to Reach Pivotal Study for Spine Nucleus
MARQUETTE, Mich., Oct. 30 /PRNewswire/ -- Pioneer Surgical Technology,
Inc. announced today, the U.S. Food and Drug Administration (FDA) granted
approval to proceed to IDE Pivotal Study of the NuBac(R) Nucleus
Initial Evaluation of New Nucleus Removal Device Provides Promising Results
CoreSpine Technologies' device evaluated in cadaver by leading spine surgeon
MINNEAPOLIS, Oct. 18 /PRNewswire/ -- CoreSpine Technologies LLC, an
emerging spinal device company located in Minneapolis, Minnesota announced
today the completion of the company's ini...
Food additive may one day help control blood lipids and reduce disease risk
...function was the distance of the two proteins from each other, according to Semenkovich. PPAR-alpha is a nuclear receptor. That is, it's housed in the nucleus
of the cell. Fatty acid synthase, on the other hand, lives out in the cell body, or cytoplasm.
"The neighborhoods where PPAR-alpha and fatty acid syn...
Scientists discover key event in prostate cancer progression
... of prostate cancer.
The study, published in the July 24, 2009, issue of the journal Cell , focuses on androgen receptors, molecules located in the nucleus
of cells of the prostate gland and other tissues. Male sex hormones androgens bind with these receptors to activate genes that control cell growth. ...
Pioneer Surgical Technology, Inc. Names Thomas J. McLeer as Chief Marketing Officer and General Manager of Spinal Operations
...dition, they offer diverse spinal fusion systems. Pioneer's signature articulating P3(TM) technology - Pioneer PEEK- on-PEEK , is vital to their nucleus
replacement system, NuBac(TM), which is currently in U.S. clinical trials. Pioneer's focus on innovation has resulted in over 100 U.S. and foreign pa...
Two Fred Hutchinson Cancer Research Center Scientists Receive Presidential Early Career Award
...so was appointed a Howard Hughes Medical Institute Early Career Scientist.
Malik studies genetic conflict. He sees battles raging within a cell's nucleus
as genes jockey for evolutionary dominance. These clashes can have a long-term impact on organisms, as they sometimes alter the function of essential ...
Nucleus in Medical Technology
Aching Back? Cholesterol Medication Might Help
...ster "Lovastatin Helps Re-Differentiation of Human nucleus
Pulposus Cells During Monolayer Expansion" during ...ed Degeneration on Regenerative Potential of Human nucleus
Pulposus Cells," at the same meeting. The two stud...pital.
In one study, the researchers removed nucleus
pulposus tissues from six human patients. (Nucleus...
ViroPharma Announces Discontinuation of Maribavir Phase 3 Study in Liver Transplant Patients
...Unlike currently available anti-CMV agents that inhibit CMV DNA polymerase, maribavir inhibits viral DNA assembly and egress of viral capsids from the nucleus
of infected cells. Maribavir also has demonstrated activity in vitro against strains of CMV that are resistant to current anti-CMV therapies.
Findings on Bladder-Brain Link May Point to Better Treatments for Problems in Sleep, Attention
...vious investigations of the neural circuits
between the bladder and the brain, the researchers found that two small
brain structures, the Barrington's nucleus
and the locus ceruleus,
developed abnormal activity as a result of the bladder obstruction. In
particular, the locus ceruleus showed persistently high...
ViroPharma Announces Completion of Enrollment in Phase 3 Study of Maribavir in Stem Cell Transplant Patients
...Unlike currently available anti-CMV agents that
inhibit CMV DNA polymerase, maribavir inhibits viral DNA assembly and
egress of viral capsids from the nucleus
of infected cells. Maribavir also
has demonstrated activity in vitro against strains of CMV that are
resistant to current anti-CMV therapies.
CoreSpine Technologies Expands Spinal Disc Site Preparation Efforts
...oncentrated on generating a complete and selective nucleus
The technology was recently expand...ants and therapies begin
to require more effective nucleus
removal and endplate preparation through
limited a...ndard for preparing the spinal disc for artificial nucleus
and minimally invasive fusion devices,...
Kosan Presents Preclinical Data on Nuclear Export Inhibitors, Novel Anticancer Agents, at AACR
...s NEIs are potent, specific inhibitors of CRM1, a highly
conserved, essential protein that exports key regulatory proteins ("cargo"
proteins) from the nucleus
to the cytoplasm. Many cargo proteins that
depend on CRM1 for nuclear export, such as p53, Bcr-Abl and FOXO-3a,
function as tumor suppressors or trans...
Nucleus in Medical Products
BD Visitec Nucleus Spatulas
Description: Smooth, round edges allow for safe manipulation within the eye. 1.1mm wide gradually tapers to .50 mm wide. 45, 1.1mm wide, gradually tapers to .50mm wide....
BD Visitec Nucleus Rotator
Description: For rotating nucleus
during phacoemulsification, Also useful for dislocating the nucleus
into the anterior chamber during extracapsular cataract extraction, 45, Blunt, Forked, 9.0mm from end...
BD Visitec Nucleus Chopper
Description: Blunt, round tip facilitates easier separation of the nucleus. 45 6.0mm from tip, Blunt, Angled, 6.0mm from tip, 1.5mm from end...
BD Visitec Nucleus Expression Cannulas
Capsule polisher aka Drysdale Nucleus Manipulator
Description: 0.5X1.5mm Tip, Oval Shape; in Titanium....
Company:Berson & Associates
Nucleus Rotator (Bechert Nucleus Rotator)
Description: 10mm Tip to Bend, 0.3mm Y Tip; In Titanium....
Company:Berson & Associates
Nucleus in Medical Definition
Nuclear physics • Nuclear fission • Nuclear fusion • Radiation • Ionizing radiation • Atomic nucleus
• Nuclear safety • Nuclear chemistry
Nuclear fuel • Fertile material • Thorium • Uranium • Enriched uranium ...
Nucleus in Medical Dictionary
... and ... called a slipped or ruptured) disc is a fragment of the disc nucleus
which is ... Presbyopia, Prostate Cancer, Prostatic Enlargement, Psoria... sometimes referred to as a slipped disc , ... ... disk , Herniated nucleus
pulposus, Prolapsed disk , Ruptured disk , Slipped disk ... Herniated...
... of a herniated disc . ... Penn State Hershey Medical Center provides world class care and services to patients. ... ruptured disk , herniated nucleus
pulposus, prolapsed disk , ruptured ... List of 4 disease causes of Ruptured intervertebral disk , patient stories, diagnostic guides. Dia...
...ce, that cause The Rickettsia are Gram-negative, obligate intracellular bacteria that infect ... Rickettsia replicate in the cytoplasm and nucleus
of their host cell; Coxiella ... Todar's Online Textbook of Bacteriology chapter on Rickettsia bacteria that cause typhus and Rocky Mounta...
...ATION FOR NEUTROPHIL DYSFUNCTION. Bactericidal killing assay. Interpretation ... neutrophil 1. one of the three granular leukocytes having a nucleus
with three to five lobes connected by threads of chromatin, and cytoplasm neutrophil adj. Not stained strongly or definitely by either acid or...
....wikipedia.org /wiki/ Monocyte " ... monocyte ( ) n. A large, circulating, phagocytic white blood cell, having a single well-defined nucleus
and very fine granulation in the cytoplasm monocyte a type of granular leukocyte that functions in the ingestion of bacteria ... What does a l...
... lemniscus ( ′mēdēəl lem′niskəs ) ( anatomy ) A lemniscus arising in the nucleus
gracilis and nucleus
cuneatus of the brain, crossing Medial . Contents of this page: ... M...
Nucleus in Biological News
Mitochondrial genes move to the nucleus -- but it's not for the sex
Why mitochondrial genes ditch their cushy haploid environs to take up residence in a large and chaotic nucleus
has long stumped evolutionary biologists, but Indiana University Bloomington scientists report in this week's Science that they've uncovered an important clue in flowering plants.
First direct mechanical communication of mitochondria, cardiomyocyte nucleus shown
In a paper being presented in two American Physiological Society sessions at Experimental Biology 2006, a joint Estonian-French team demonstrated "for the first time that mitochondria are able to induce nuclear deformation, suggesting that mitochondria may mechanically regulate nuclear function."
Movement of chromosome in nucleus visualized
The cell is understood to be highly organized, with specialized areas for different functions and molecular motors shuttling components around. Researchers from the University of Illinois' Chicago and Urbana-Champaign campuses now offer the first imaging evidence from live cells of ongoing organiza...
Reprogramming human cells without inserting genes
...n expressing proteins, the team found those proteins migrated back into the nucleus
of the skin cells, precisely as would occur in induced pluripotent stem cel...at WPI and lead author on the paper. "Having these proteins localize to the nucleus
is the first step of reprogramming these cells."
Even more surprising, t...
Study reveals a reprogrammed role for the androgen receptor
...ir growth is by producing their own androgen, scientists have discovered. Another way involves the androgen receptor itself the "keyhole" in the cell nucleus
that androgen molecules fit into but the actual mechanism by which it operates hasn't been known.
To find that mechanism, Brown's team, including...
Chasing tiny vehicles
...es move randomly, often downright erratically inside the cell, until a so-called motor protein binds them and quickly transports them towards the cell nucleus
the ultimate target for the gene.
The research team is now in a position to characterize and describe in great detail the individual steps along ...
Nucleus in Biological Technology
Biomimetic-engineering design can replace spaghetti tangle of nanotubes in novel material
...arbon nanotubes. The template for this thermal material's design is a living cell, specifically, the hierarchical protein networks that allow a cell's nucleus
to communicate with the cell's outermost regions.
"The structure now used when designing materials with carbon nanotubes resembles spaghetti," said...
Researchers develop new way to see single RNA molecules inside living cells
...gate viral pathogenesis and other biological phenomena.
"We are excited to use this imaging strategy to study how single viral RNAs travel from the nucleus
of a cell to a virus assembly site, how mRNAs are regulated by location and time, and RNA trafficking in neurons," added Santangelo.
Cochlear Americas Provides Support for Cochlear Implant Recipients to Pursue Higher Education
... "Cochlear Americas is dedicated to empowering our nucleus
recipients with an opportunity to pursue higher go...iversity , was born profoundly deaf and received a nucleus
cochlear implant at age 2. Emily is enrolled in t...e age of 9 months, and at age 4 received her first nucleus
cochlear implant. She received a second cochlear ...
Pioneer(R) Surgical Technology, Inc. Wins Frost & Sullivan's 2009 North American Orthopaedic Tissue Engineering Technology Innovation Award
...iverse spinal fusion systems and
advanced biologics. Pioneer's signature articulating P3(TM) Technology
-- Pioneer PEEK-on-PEEK, is key to the leading nucleus
NuBac(TM) currently in U.S. clinical trials. Pioneer's focus on innovation has
resulted in over 100 U.S. and foreign patents with n...
Smallest ever quantum dots bring real world applications closer
...d atoms, all the atoms pool their electrons to "sing with one voice", that is, the electrons are shared and coordinated as if there is only one atomic nucleus
at the centre. That property enables numerous revolutionary schemes for electronic devices.
Research project leader Robert A. Wolkow described the...
Sigma-Aldrich and Sangamo BioSciences Announce the Achievement of Key Throughput Milestone in Research Reagents Agreement
...) are the dominant class of naturally-occurring transcription factors in organisms from yeast to humans. Transcription factors, which are found in the nucleus
of every cell, bind to DNA to regulate gene expression. Though there are many kinds of transcription factors, only ZFPs are amenable to engineering an...
Nucleus in Biological Products
Rabbit Anti-ARG. Vasopressin Polyclonal Antibody, Unconjugated from GeneTex
Description:...Rabbit Antibody to ARG. Vasopressin The antibody blocks with the arginine vasopression peptide. Cells are found in the paraventricular and supraoptic nucleus
and fibers are found throughout the hypothalmus in rat brain of 4% FA perfused tissue. Immunogen: Arginine Vasopression Cys-Tyr-Phe-Gln-Asn-Cys-Pr...
Rabbit Anti-CRF Polyclonal Antibody, Unconjugated from GeneTex
Description:...e antibody blocks specificially with the ovine CRF sequence that it was raised against. Cells and fibres are found in the paraventricular hypothalamic nucleus
of rat brain in colchicine treated 4% FA perfused tissue. Immunogen: CRF: Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-...
Rabbit Anti-HDAC4 Polyclonal Antibody, Unconjugated from GeneTex
Description:...id residues. Its C-terminal sequence is highly similar to the deacetylase domain of yeast HDA1. HDAC4, unlike other deacetylases, shuttles between the nucleus
and cytoplasm in a process involving active nuclear export. Association of HDAC4 with 14-3-3 results in sequestration of HDAC 4 protein in the cytopla...
DAPI from KPL
Description:... DAPI (4,6-diamidine-2-phenylindole, dihydrochloride) is a fluorescent counterstain which stains the nucleus
blue in color. The bright blue fluorescence provides excellent contrast to red fluorochromes such as rhodamine, Cy3, Texas Red, or R-Phycoerythrin. DA...
Propidium Iodide from KPL
Description:...dide (PI) is a fluorescent nucleic acid dye which binds only to double-stranded nucleic acids. As a nuclear counterstain, propidium iodide stains the nucleus
light to dark red in color. The fluorescent red color provides excellent contrast to green or blue fluorochromes such as FITC, Cy2 or AMCA. Propidiu...
Nuclear Matrix Protein ELISA Kit from Calbiochem
Description:... DO NOT FREEZE. Nuclear matrix proteins (NMPs) make up the internal structural framework of the nucleus
and are associated with such functions as DNA replication, RNA synthesis, and hormone receptor binding. Although the nuclear matrix has been shown to ...
Nucleus in Biological Definition
In cell biology , the nucleus
(from Latin nucleus
or nuculeus , kernel) is an organelle , found in the majority of eukaryotic cells , which contains most of the cell's genetic material. Nuclei have two primary functions: to control chemical reactions within the cytoplasm and to s...
... were probably retained from an ingested green alga. Those of the chlorarchniophytes contain a small nucleomorph, which is the remnant of the alga's nucleus
. It has been suggested that the euglenid chloroplasts only have three membranes because they were acquired through myzocytosis rather than phagocy...
...ng molecules, an event that sends signals from the nucleus
for the mitochondrion to start the apoptotic proce... ( DNA and its packaging proteins ) in the cell nucleus
) undergoes initial degradation and condensation (...this stage, the double membrane that surrounds the nucleus
still appears complete; however, as observed by Ki...
...yotes arose through fusion of an archaean and eubacterium, which became the nucleus
and cytoplasm, which accounts for various genetic similarities but runs int...Press. ISBN 0-19-511183-4
Lake, J.A. (1988). Origin of the eukaryotic nucleus
determined by rate-invariant analysis of rRNA sequences. Nature 331 18...
...erium ) are a major group of living organisms . They are microscopic and mostly unicellular, with a relatively simple cell structure lacking a cell nucleus
, cytoskeleton, and organelles such as mitochondria and chloroplasts . Their cell structure is further described in the article about prokaryotes ...
... human arterial blood is approximately 7.40.
The corpuscles are:
Red blood cells or erythrocytes (96%). In mammals, these corpuscles lack a nucleus
and organelles , so are not cells strictly speaking. They contain the blood's hemoglobin and distribute oxygen. The red blood cells (together with...
Nucleus in Biological Dictionary
In cell biology, the nucleus
, also sometimes referred to as the "control center", is a membrane-enclosed organelle found in eukaryotic cells. It contains most of the cell's genetic material, organized as multiple long linear... Nucleus
(neuroanatomy), a central nervou...
In cell biology, the nucleus
, also sometimes referred to as the "control center", is a membrane-enclosed organelle found in eukaryotic cells. It contains most of the cell 's genetic material, organized as multiple long linear... Cell nucleus
The largest of the membrane...
...opment" is controlled at both the ... Prokaryote, relatively simple unicellular organism, such as a bacterium, characterized by the absence of a nucleus
and other specialized cell... Scientists discover microRNAs in the unicellular green alga, Chlamydomonas reinhardtii. This is the first finding ...
...f one or more... ubiquitin ( yü′bikwə′tin ) ( biochemistry ) A small, 76-amino-acid, highly conserved protein present in the cytoplasm and nucleus
of all eukaryotes Ubiquitin ligase A ubiquitin ligase (also called an E3 ubiquitin ligase) is a protein that covalently attaches ubiq...
...within the E1A unit , the insertion of the ... The EIB transcription unit was the only early gene affected, and complementation ... ... nucleus
which define the three major classes of eukaryotic transcription unit : ... Class II Transcription Units ... Class III Transcription Units ...
...vertebrates differ from the mammalian thrombocytes not only in having a nucleus
and thus resembling B lymphocytes, but also these nucleated thrombocytes ...es ... megakaryocyte ( ) n. A large bone marrow cell with a lobulate nucleus
that ... for the production of blood thrombocytes (platelets), which are...