Drug Might Restore Sense of Smell
...reviously discovered that people with hyposmia had reduced levels of cyclic nucleotides in their saliva and nasal mucous, and that treatment with theophylline had ...this growth factor and restored some of the sense of smell. These cyclic nucleotides are growth factors for olfactory (related to smell) and other neural tissue...The GenoMEL project identifies a new region of the genome associated with the risk of melanoma
...nd Dr. Josep Malvehy are the only Spanish authors of this article. Single-nucleotide polymorphisms (SNPs) are small variations in the sequence of nucleotides that make up DNA and can be associated with many genetic diseases. The study published in Nature Genetics performs an exhaustive search for SNPs in ...RNA snippet suppresses spread of aggressive breast cancer
...s laboratory, screened patient breast cancer samples for microRNAs with potential roles in metastasis. MicroRNAs are single strands of RNA about 21-23 nucleotides long. Within a cell, a single microRNA can fine-tune the expression of dozens of genes simultaneously. This capability could be particularly important...Ovarian Cancer Breakthrough Heralds New Era of Treatment
...ity news release. In the study, researchers decoded four granulosa cell tumors using "next generation" sequencing machines that decode billions of nucleotides at rapid speed and new computer techniques to quickly assemble the data. While most types of cancer, including ovarian cancers, have a broad range ...Abbott Annual Meeting Highlights Outstanding 2008 Results, Continued Strong Outlook
...(Abbott's proprietary niacin extended-release) and simvastatin. Similac Advance EarlyShield(TM), an infant formula with a blend of prebiotics, nucleotides and antioxidants to support a baby's natural immune system. It uses a new SimplePac(TM) package that has a one-hand grip, hinged lid and scoop in the...New tool isolates RNA within specific cells
... Health and HHMI. Cleary's group built its tool with the enzyme uracil phosphoribosyltransferase (UPRT), a nucleotide salvage enzyme that prepares nucleotides for incorporation into newly synthesized RNA. By altering the nucleotide analog 4-thiouracil, the UPRT enzyme caused RNA to become tagged with thioura...Penn biologists discover how 'silent' mutations influence protein production
...orescent protein by as much as 250-fold, without changing the properties of the protein. Codon bias, the probability that one codon of three adjacent nucleotides will code for one amino acid over another, was previously thought to be the cause for protein expression variance, but it did not correlate with gene ...New therapeutic strategy could target toxic protein in most patients with Huntington's disease
...s written with four letters, A, C, T, and G, which stand for the four nucleotides, adenosine, cytidine, thymidine, and guanosine. The pattern of these nucleotides dictates which protein is encoded by a given gene. DNA in the nucleus is transcribed as messenger RNA, which leaves the nucleus and begins making prot...Malaria parasite zeroes in on molecule to enhance its survival, team finds
...ism takes up nutrients from the environment and converts them to energy and the molecular building blocks that cells use to grow. Amino acids, sugars, nucleotides and vitamins are all metabolites. To conduct the study, the team used a mass spectrometry-based method developed in the neighboring laboratory of J...Study: Fluid buildup in lungs is part of the damage done by the flu
...ucing and replication machinery of the cell. Those nucleotides then bind to receptors of other cells in a series ...ver the lungs and cell surfaces, you release these nucleotides and generate fluid so you can cough up the bacteri... earlier research to block the generation of these nucleotides to prove the fluid clearance mechanism behind a di...Tailor-made recombinant proteins in mammals
...se, into the nonstandard amino acid residue formylglycine. "Formyl" is another name for a simple aldehyde group. "So all we had to do was clone the nucleotides encoding those six residues from the sulfatase sequence into the DNA of the target protein we want to produce, at the site corresponding to where we w...New cow genome sequence released
...th independent genetic maps, and a more complete representation of cow genes, than alternative assemblies. The new assembly places some 150 million nucleotides (6%) more DNA sequence data onto chromosomes than the other draft assembly currently available, BosTau4.0 from the Baylor College of Medicine (BCM4). ...Molecular sleuths track evolution through the ribosome
...970s, he and his colleagues found consistent differences in the sequence of nucleotides that spell out the RNA of the ribosome in bacteria and archaea. These "mole...e the assembly of new proteins. The researchers analyzed the sequence of nucleotides (the building blocks of RNA) and amino acids (the building blocks of protei...Pacific Biosciences Raises $100 Million to Fund Commercial Product Development
...he field of DNA sequencing. The first is the SMRT(TM) chip, which enables observation of individual fluorophores against a dense background of labeled nucleotides by maintaining a high signal-to-noise ratio. The second are phospholinked nucleotides, which produce a completely natural DNA strand through fast, acc...Pacific Biosciences Acquires Single Molecule Sequencing Technology from LI-COR Biosciences
...it has acquired "sequencing by incorporation" technology from LI-COR Biosciences of Lincoln Nebraska. Sequencing by incorporation generally identifies nucleotides in a DNA sequence based upon synthesis of a complementary DNA strand. The technology acquired from LI-COR broadens Pacific Biosciences' existing intel...QXL 520 C2 maleimide from AnaSpec
Description:...ns, the single isomers are increasingly preferred for labeling peptides and nucleotides because they give better resolution in HPLC purification that is often requ... labeling peptides and proteins. 6-TAMRA is predominately used for labeling nucleotides and sequencing nucleic acids. Minimum Purity: 95%. Abs (max): 547 nm; Em (m...EDTA, 0.5 M solution from GE Healthcare, formerly Amersham Biosciences
Description:... EDTA, 0.5 M solution, 100 ml. Ethylene diaminetetraacetic acid.Sterile, nuclease-free. Category: nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....X-Gal from GE Healthcare, formerly Amersham Biosciences
Description:...o-3-indolyl-b-d-galactoside.Histochemical substrate for b-galactosidase, used in blue/white screening.Store at -20 C. Protect from moisture. Category: nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....3-O-Methylguanosine 5-Triphosphate, Sodium from GE Healthcare, formerly Amersham Biosciences
Description:... 3'-O-Methylguanosine 5'-Triphosphate, Sodium, 1 umol. Category: nucleotides & Enzymes & Biochemicals, Nucleotides, Additional Nucleotide Products....EGTA from GE Healthcare, formerly Amersham Biosciences
Description:... EGTA, 10 g. Ethylene glycol-O,O-bis-[2-amino-ethyl]-N,N,N,N,-tetraacetic acid.Assay: > 99.0%. Category: nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....EGTA from GE Healthcare, formerly Amersham Biosciences
Description:... EGTA, 50 g. Ethylene glycol-O,O-bis-[2-amino-ethyl]-N,N,N,N,-tetraacetic acid.Assay: > 99.0%. Category: nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....