Nucleotide

Pharmasset Nominates PSI-938 as a New Nucleotide Analog Inhibitor of Hepatitis C for Preclinical Development

PRINCETON, N.J., July 7 /PRNewswire-FirstCall/ -- Pharmasset, Inc. (Nasdaq: VRUS ) announced today the nomination of PSI-352938 ("PSI-938") as a lead development candidate from two series of purine analogs for the treatment of chronic hepatitis C virus (HCV) infection. PSI-938 is a proprietary n...

GenVault's GenSolve(TM) Reagents Enable State-of-the-Art Genomic Analysis of Dried Blood Spots

...es us to reproducibly recover sufficient quantities of DNA, of the correct size and quality, from dry archived FTA cards for analysis of 54,000 single nucleotide polymorphisms on Illumina's BovineSNP50 BeadChip," said Dr. Matthew McClure from the Division of Animal Science at the University of Missouri-Columbia...

Gene linked to increasingly common type of blood cancer

...st three decades. In the first genome-wide association study of non-Hodgkin lymphoma, scientists at UC Berkeley and TGen identified a SNP a single nucleotide polymorphism that could determine susceptibility to follicular lymphoma. The SNP, a DNA variant within the more than 3-billion base pairs in the huma...

New Map of Genomic Variation Will Enable Disease Research

... genome in the July 10 online edition of the journal Genome Research . In contrast to alterations to a single base of DNA, which are single nucleotide polymorphisms, or SNPs, often referred to as "snips," CNVs are larger variations in DNA structure. As changes to a single DNA letter, SNPs might be co...

Variants of 'umami' taste receptor contribute to our individualized flavor worlds

...ed receptor T1R1-T1R3. Comparing DNA structure to the glutamate taste responses of each individual, they found that variations (known as SNPs; single nucleotide polymorphisms) at three sites on the T1R3 gene were associated with increased sensitivity to glutamate taste. A fourth set of studies used in vitro...

Orochem Technologies Acquires Oligonet, a Custom Oligo Synthesis Business

...om single to high throughput formats exemplified by DNA and RNA purification kits, protein purification plates and products for bioanalysis, and oligo nucleotide synthesis and purification. The company's core expertise is in the development of customized individual and high throughput Sample Preparation tools t...

Nucleotide in Medical Technology

Data from Preclinical Studies of Gilead Nucleotide Compound GS 9219 to be Presented at AACR

FOSTER CITY, Calif.--(BUSINESS WIRE)--Mar 15, 2007 - Gilead Sciences, Inc. (Nasdaq:GILD) today announced that the company will present data on a novel nucleotide analog, GS 9219, which has shown evidence of anti-cancer activity in preclinical studies, at the 2007 Annual Meeting of the American Asso...

Pharmasset Reports Positive Preliminary Antiviral Data With PSI-7851 for the Treatment of Hepatitis C

...hepatitis C (HCV). PSI-7851 is a second generation nucleotide polymerase inhibitor of HCV. PSI-7851 Pha...d safety data with PSI-7851, our second generation nucleotide analog," said Michelle Berrey, MD, MPH, Pharmasset...te that we have achieved our goal of identifying a nucleotide analog with good efficacy that can be administered...

Idenix Pharmaceuticals Successfully Completes Proof-of-Concept Study of IDX184 for the Treatment of Hepatitis C Virus (HCV)

...ll data set from this study at a scientific meeting later this year. About IDX184 IDX184 is a novel, liver-targeted 2'-methyl guanosine nucleotide prodrug, which includes Idenix's proprietary liver-targeting technology. This technology enables the delivery of nucleoside monophosphate to the liver...

University of Michigan Study Shows SEQUENOM's MassARRAY Technology Identifies HPV Infections Missed by Standard Hybridization Test

... a rapid, accurate, and cost efficient manner. SEQUENOM's MassARRAY system facilitates a number of nucleic acid analysis applications including single nucleotide polymorphism (SNP) genotyping and allelotyping, copy number variation analysis, quantitative gene expression analysis, quantitative methylation marker...

Cordex Signs European Development Partnership for ATPotent(TM) Sperm Motility Drug

... for the in vitro treatment of human and animal sperm, in which the active ingredient is adenosine 5'-triphosphate (ATP). ATP is a ubiquitous purine nucleotide found in every cell of the human body where it plays a critical role in cellular metabolism and constitutes the source of energy for all bodily functi...

Pharmasset to Present at Goldman Sachs and Needham Healthcare Conferences

...2b clinical trial in combination with Pegasys plus Copegus through a strategic collaboration with Roche; PSI-7851, an unpartnered, next generation HCV nucleotide analog, which recently began Phase 1 clinical studies and Racivir, for the treatment of HIV that has completed a Phase 2 clinical trial. Pegasys(...

Nucleotide in Medical Products

Prothrombin Nucleotide 20210 G/A Gene Mutation (Factor II), Fetal

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Prothrombin Nucleotide 20210 G/A Gene Mutation (Factor II)

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

DyNA Quant™ 200 Fluorometer

Description:...tection of double-stranded DNA using the standard Hoechst 33258 dye binding assay, which minimizes interference from the presence of protein, RNA, and nucleotide contaminants....
Company:GE Healthcare

Dynal RELI™ SSO

Description:...riate wash conditions, the probes remain bound only to their complementary sequence in the amplified DNA. The sensitivity of the system enables single nucleotide differences to be distinguished. The presence of the amplicon/probe complex is detected using a simple colorimetric reaction and appears as a blue pre...
Company:Dynal Biotech, LLC

NanoChip Molecular Biology Workstation

Description:...olecular Biology Workstation is an automated multi-purpose instrument that facilitates detection of known sequences, such as in the analysis of Single nucleotide Polymorphisms (SNPs) and Short Tandem Repeats (STRs) using the NanoChip Electronic Microarray. The unique, open-architecture design permits researcher...
Company:Nanogen, Inc.

ABI PRISM 7900HT Sequence Detection System

Description:...t the high-throughput requirements of todays drug discovery process. Key applications include gene expression quantitation and the detection of single nucleotide polymorphisms (SNPs) using the fluorogenic 5 nuclease assay. Real-Time Throughput: Over 5,000 sample wells per day with 384-well block configuratio...
Company:Applied Biosystems

Nucleotide in Biological News

New nucleotide could revolutionize epigenetics

Anyone who studied a little genetics in high school has heard of adenine, thymine, guanine and cytosine the A,T,G and C that make up the DNA code. But those are not the whole story. The rise of epigenetics in the past decade has drawn attention to a fifth nucleotide, 5-methylcytosine (5-mC), that...

Understanding how weeds are resistant to herbicides

...hemp is the first weed to be partially sequenced using this technology. The pyrosequencing machine emits a light signal that's captured every time a nucleotide is incorporated into a growing DNA strand. "The reason it's so fast is that it's done in parallel," said Tranel. "The plate has thousands of tiny well...

Scientists discover gene mutation responsible for hereditary neuroendocrine tumor

...ter and his colleagues sequenced the hSDH5 gene in three individuals with PGL2 from a previously described Dutch lineage. They identified a single DNA nucleotide change which resulted in a mutation in the most conserved region of the protein. Of the 45 individuals within the affected lineage who inherited the m...

DNA template could explain evolutionary shifts

...hers studying reasons for genetic mutations or changes looked at molecular "typos" in this process, tiny changes in the As, Ts, Cs or Gs called single nucleotide polymorphism (SNPs). They changed the message of the gene. However, in the early 1990s, Lupski was one of the early champions of a newly discovered me...

Identification of genetic variants affecting age at menopause could help improve fertility treatment

...cular Health Study, the ARIC study, the HAPI Heart Study), Iceland (AGES-Reykjavik) and Italy (the InCHIANTI study). The scientists found 20 single nucleotide polymorphisms (SNPs) in four different places on chromosomes 19 and 20. SNPs are common genetic variants that influence how humans look, behave, deve...

Immune genes adapt to parasites

...enes into risk factors for intestinal disorders. Parasite-driven selection leaves a footprint on our DNA in the form of mutations known as "single nucleotide polymorphisms" (SNPs). Making sure that genetic variation (in the form of multiple SNPs) is maintained within certain immune genes over time helps ens...

Nucleotide in Biological Technology

Genotyping Single Nucleotide Polymorphisms with Molecular Beacons

Stratagenes custom molecular beacon synthesis assists in detecting SNPs quickly and easily Fei Bao University of Colorado Health Sciences Center, Denver, Colorado We used Stratagenes custom molecular beacons ff, to detect a single nucleotide polymor...

Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon Allelic Discrimination Kits

Allelic discrimination kits with excellent specificity, sensitivity, and assay throughput Xiuyuan Hu Lingyu Chen Stratagene Because of their unique hairpin conformation, molecular beacon probes can recognize single base differences, making them ideal fo...

Pharmasset to Present at Canaccord Adams Conference

...re being conducted through a strategic collaboration with Roche. Our other clinical stage candidates are PSI-7851, an unpartnered, next generation HCV nucleotide analog which recently began Phase 1 clinical studies and Racivir, for the treatment of HIV, which has completed a Phase 2 clinical trial. Pegas...

SEQUENOM Announces Launch of MassARRAY Compact 96 System

...ke changes to assays and biomarkers throughout the validation process. MassARRAY technology supports key genomic applications, including single nucleotide polymorphism (SNP) genotyping, quantitative gene expression, and copy number variation (CNV) analysis, providing a multi-faceted view of a researcher'...

Idenix Pharmaceuticals Reports Second Quarter and Six Month 2009 Financial Results

...y that it had successfully completed a proof-of-concept study of its lead HCV antiviral development program, IDX184, a novel once-daily liver-targeted nucleotide prodrug. This double-blind, placebo-controlled, monotherapy, dose-escalation study in HCV genotype-1-infected patients evaluated the safety and antivi...

Frost & Sullivan Awards Precision Biosciences for Technology Innovation and Molecular Design Process in the Genomics Market

...egree of specificity is uncommon in natural proteins and is an inherent property of the I-CreI enzyme, which can recognize and modify a distinctive 22 nucleotide DNA 'address' in the genome of certain algae. "Precision successfully adapted this natural DNA editing system for use in biotechnology by modifyi...

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Nucleotide in Biological Products

Chicken Anti-DCTD (dCMP deaminase) Polyclonal Antibody, Unconjugated from GenWay Biotech, Inc.

Description:...cession Number: NP_001912.1 MW: 20016 Description: FUNCTION: Supplies the nucleotide substrate for thymidylate synthetase. CATALYTIC ACTIVITY: dCMP + H 2 O = dU...tabolism; One-Carbon Group Transferases; Dna Polymerase; Purine Metabolism; nucleotide Sugars Metabolism; Esterases; Glycosyltransferases; Cell Division; Ligases;...
Company:GenWay Biotech, Inc.

3-O-Methylguanosine 5-Triphosphate, Sodium from GE Healthcare, formerly Amersham Biosciences

Description:... 3'-O-Methylguanosine 5'-Triphosphate, Sodium, 1 umol. Category: Nucleotides & Enzymes & Biochemicals, Nucleotides, Additional nucleotide Products....
Company:GE Healthcare, formerly Amersham Biosciences

GFX PCR DNA,Gel Band Purif,100 from GE Healthcare, formerly Amersham Biosciences

Description:... GFX PCR DNA,Gel Band Purif,100, 1 EA. Category: nucleotide Sample Handling....
Company:GE Healthcare, formerly Amersham Biosciences

Cytidine 5-Triphosphate, Sodium (CTP) from GE Healthcare, formerly Amersham Biosciences

Description:... Cytidine 5'-Triphosphate, Sodium (CTP), 1 g. Category: Nucleotides & Enzymes & Biochemicals, Nucleotides, Additional nucleotide Products....
Company:GE Healthcare, formerly Amersham Biosciences

Nick Translation System from Invitrogen

Description:...tive labeling of DNA. The Nick Translation System: Provides five pre-mixed nucleotide solutions for flexibility in labeled nucleotide incorporation Yields >10 8 cpm/g control DNA using [-32P]-dCTP Includes ...
Company:Invitrogen

DNA Sequencing from Dominion Pharmakine S.L.

Description:... DNA sequencing is the experimental process of determining the nucleotide sequence of a DNA region. The automated DNA Sequencing is based on Sangers enzymatic method with a thermostable DNA polymerase, which allows cycle seq...
Company:Dominion Pharmakine S.L.

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Nucleotide in Biological Definition

Nucleotide

Nucleotide codes Code Equivalence Complement A A T or U C C G G G C T or U T A M A or C K R A or G Y W A or T W S C or G S Y C or T R K G or T M...

Adenosine triphosphate

... For other uses of the initials ATP, see ATP (disambiguation) Adenosine triphosphate ( ATP ) is the nucleotide known in biochemistry as the " molecular currency" of intracellular energy transfer; that is, ATP is able to store and transport chemical energy...

AMP

...tter abbreviation AMP can refer to the following: In biology , the nucleotide adenosine monophosphate As a flavour enhancer , the nucleotide adenosine monophosphate AngryMutantPenguin, a famous fan of The Elder...

Anticodon

...s complementary to specific codons on a strand of mRNA . See also protein synthesis . The first base on the anticodon can be modified to another nucleotide such as inosine which allows that base to pair with cytosine , adenine , and uracil on the codon. The first base on the anticodon can also have...

BLAST

... extremely fast alternative to BLAST that compares nucleotide sequences to the genome is BLAT ( B last L ike A...the six-frame conceptual translation products of a nucleotide query sequence (both strands) against a protein se...LAST family. It translates both query and target nucleotide sequences in all six possible frames and compares ...

Cell nucleus

...is a liquid with a gel-like consistency (similar in this respect to the cytoplasm ), in which many substances are dissolved. These substances include nucleotide triphospates, enzymes , proteins , and transcription factors . Genetic material ( DNA ) is also present in the nucleus, the DNA is present as a DNA...

Nucleotide in Biological Dictionary

Nucleotide

A nucleotide is composed of a nucleobase (nitrogenous base) and a five-carbon ... Nucleic acids are polymeric macromolecules made from nucleotide monomers. ... nucleotide n. Any of various compounds consisting of a nucleoside combined with a phosphate group and forming the basi...

VNTR

... A Variable Number Tandem Repeat (or VNTR ) is a location in a genome where a short nucleotide sequence is organized as a tandem repeat. These can be found on many chromosomes, and often show variations in length between... VNTR alleles...

UvrA

...ative aminopeptidase gene (pepP) ... Here we suggest that uvrA and the nucleotide excision repair pathway are ... groups, it was necessary to inactivate the uvrA dependent nucleotide excision repair gene. ... mutant strain deficient in alkA tagA and uvrA...

Uracil

...out uracil at Encyclopedia.com. ... uracil , organic base of the ... nucleotide derivatives of uracil perform important functions ... uracil DNA N-...ree ... News Scan: ==> Uracil News <== Genetics101 News ... The nucleotide derivatives of uracil perform important functions in cellular ... Since ...

Untranslated region

...ranslated region ... ... based predictions of secondary structure of the 3' untranslated region (UTR) ... 4 vaccine candidate with a 30 nucleotide deletion in its 3'- untranslated region . ... ... the 5'- untranslated region (-575) of the p27 gene and (b) the antibiotic ... The -57...

Transversion

...rsion : Webster's Revised Unabridged, 1913 Edition ... Quick definitions ( transversion ) ... The G-to-T transversion , although affecting the 11 nucleotide of the 3' ... These results indicated that the GT transversion at the first position of exon 5 ... ... of tools for the Oracle world: the sche...

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