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Nucleosomes in Medical News

Light shines for potential early cancer diagnosis technique

... information not only about individual cells, but it also can look inside the cell and see the cell's fundamental "building blocks," such as proteins, nucleosomes and intracellular membranes, and detect changes to this cell nanoarchitecture. Conventional microscopy cannot do this, and other techniques that can (...

Scientists identify key roadblock to gene expression

...ing forward. "This discovery is important because nucleosomes are barriers to transcription and we now are seein...cerevisiae, revealing that evolution has organized nucleosomes differently in simple life forms compared to more ...as it begins to transcribe the gene. In contrast, nucleosomes are positioned further downstream in fruit flies, ...

Cell Structure Helps Direct Cancer Gene 'Switch'

...stinct changes in the density of structures called nucleosomes within the cells. "The study shows for the firs...nges in nucleosomal occupancy -- or the density of nucleosomes -- in the cell." A process called "DNA cytosin...gene] silencing by enabling the stable presence of nucleosomes at the start sites of cancer-related genes," the r...

Chromatin remodeling complex connected to DNA damage control

...d with proteins known as histones and assembled in histone/DNA units called nucleosomes along the connecting length of a string of DNA. "This structure is often... or DNA repair machinery," Shen says. "Chromatin remodeling shuffles the nucleosomes around to create access to DNA," Shen says. "This moving and sliding of the...

Scientists Map Key Landmarks in Human Genome

... positions of key gene-regulating molecules called nucleosomes throughout the human genome// . The mapping tool c...ts say. Moreover, it may shed light on the role of nucleosomes in the process of "reprogramming" an adult cell to...es how the scientists used the technique to locate nucleosomes in 3,692 promoters (regions of DNA that interact w...
Nucleosomes in Biological News

UC San Diego engineer provides insights to decades-old DNA squabble

...s structure is like a solenoid, where the chain of nucleosomes follows a helical path along the chromatin axis such that adjacent nucleosomes along the chain lie side by side on the chromatin ... path along the chromatin fiber such that adjacent nucleosomes on the chain actually lie on opposite sides of the...

'Normal' cells far from cancer give nanosignals of trouble

...an, a postdoctoral fellow in Backman's research group. PWS can look inside the cell and see those critical building blocks, which include proteins, nucleosomes and intracellular membranes, and detect changes to this nanoarchitecture. Conventional microscopy cannot do this, and other techniques that can (to so...

Scripps Research scientists shed light on how DNA is unwound so that its code can be read

...ound a spool-like bead of histone protein, to form a nucleosome. But there is so much DNA in a single gene that each gene is packed into a necklace of nucleosomes on a DNA string. These beads then become further compressed into twisted ropes that eventually form chromatin, in which DNA is compacted about 10,000 ...

Conaway Lab identifies novel mechanism for regulation of gene expression

...vity of a protein. INO80 is a chromatin remodeling complex that is believed to function in both gene regulation and DNA repair by "unpacking" DNA from nucleosomes to allow access to chromosomal DNA. Previously, the Conaway Lab demonstrated that Uch37 is associated with another multiprotein complex, the prote...

Media highlights in the January issues of Biophysical Journal

...nt Variations Associated with H2A/H2B Depletion of nucleosomes Laimonas Kelbauskas, The Biodesign Institute, A...ining access to regulatory DNA sequences buried in nucleosomes is a major impediment to the action of eukaryotic ...r gene-related diseases. H2A-H2B are released from nucleosomes during the action of several transcription-associa...

University of Toronto scientists map entire yeast genome

...state of a cell by successfully mapping all 70,000 nucleosomes in yeast. nucleosomes wrap DNA before it is transformed into proteins an...to build a software program that can predict where nucleosomes should be. The program worked remarkably well, and...

Researchers identify how to switch off cancer cell genes

...r cells through distinct changes in the density of nucleosomes within the cells. The findings, published in th...ing may be accomplished by the stable placement of nucleosomes into previously vacant positions. DNA cytosine...ad to silencing by enabling the stable presence of nucleosomes at the start sites of cancer-related genes, the st...

Latent memory of cells comes to life

...protein complexes called nucleosomes. Importantly, nucleosomes can carry various chemical modifications that eith...which then each produce a new double-strand. nucleosomes though are not duplicated like the DNA-strands. Ra...ohr Institute has shown that communication between nucleosomes and positive feedback are likely to constitute fun...

Scientists map key landmarks in human genome

... positions of key gene-regulating molecules called nucleosomes throughout the human genome. The mapping tool coul...ts say. Moreover, it may shed light on the role of nucleosomes in the process of "reprogramming" an adult cell to...es how the scientists used the technique to locate nucleosomes in 3,692 promoters (regions of DNA that interact w...

Scientists reveal structure of gateways to gene control

...in very high resolution on a genome-wide scale how nucleosomes control the expression of an organism's genes," sa...ints the locations of certain key gene-controlling nucleosomes -- spool-like structures that wrap short regions o...s they regulate. "We now know exactly where these nucleosomes are positioned on the DNA molecule and which DNA b...
Nucleosomes in Biological Technology

Quantification of Nucleosomes in Serum by the Cell Death Detection ELISAplus

Cell death as a counterpart to cell proliferation plays an essential role in the homeostasis of cell numbers in adult organisms, furthermore in eliminating cells damaged by irradiation, chemotherapeutic drugs, hyperthermi...

Roche Diagnostics Corporation

...Transcriptase in Microarray Analysis Microarray Target Purification Kit and the Microarray Target Synthesis Kit (T7) Quantification of nucleosomes in Serum by the Cell Death Detection ELISAplus Quantitative Measurement of Cell Proliferation Using the BrdU ELISA

Quaternary structure

...polymerase , and ion channels . Other assemblies referred to instead as multiprotein complexes also possess quaternary structure. Examples include nucleosomes and microtubules . Changes in quaternary structure are called conformational changes . It is through such changes, which underlie cooperativity a...
Nucleosomes in Biological Dictionary

Spermiogenesis

... quotes. ... August 6th, 2009, from www.yourdictionary.com/ spermio genesis . Comments: ... During spermiogenesis , histones are displaced from nucleosomes to form DNA ... Steps Of Sperm Cell Formation During Spermiogenesis ... In spermiogenesis , each immature spermatocyte develops an acrosome, and...

Nucleosome

... nucleosomes form the fundamental repeating units of eukaryotic...s while still ensuring appropriate access to it . nucleosomes are folded through a... nucleosome n. Any of ...on) fastens the DNA to the nucleosome core. ... nucleosomes are usually packed together, with the aid of a h...

Histone

...age ... The linker histone , H1, interacts with linker DNA between nucleosomes and ... This gene is intronless and encodes a member of the histone H4 ...H3 and H4 - form ... Histone H1 also associates with linker DNA between nucleosomes to stabilize ... Histone proteins are among the most highly conserve...

Heterochromatin

...f encyclopedia entries, essays, summaries, research information, and more. ... Search " Heterochromatin " ... Euchromatin versus Heterochromatin . nucleosomes and Transcription. The Nucleolus ... Those genes present in heterochromatin are generally inactive; that is, not ... Brightsurf Heterochromatin ...

Euchromatin

...essays, summaries, research information, and more. ... acetylation of euchromatin and heterochromatin ... Euchromatin versus Heterochromatin. nucleosomes and Transcription. The Nucleolus ... The genes in euchromatin are active and thus show ... Zoology information, history, articles and research fr...

Chaperone Proteins

... Chaperone -supervised conversion of prion protein to its protease ... The first protein to be called a chaperone assists the assembly of nucleosomes ... 2 Human chaperone proteins . 2.1 In endoplasmic reticulum ... ... cell to survive such stress is the production of "molecular chaperone...
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