BioCryst Reports Second Quarter 2009 Financial Results And Provides Corporate Update
... autoimmune diseases. BioCryst has two product candidates in pivotal clinical trials; peramivir, an anti-viral for influenza, and forodesine, a purine nucleoside phosphorylase (PNP) inhibitor for cutaneous T-cell lymphoma (CTCL). Utilizing crystallography and structure-based drug design, BioCryst continues to...Access Pharmaceuticals Announces New MuGard Commercial Strategy in North America
...R), a humanized monoclonal antibody which acts as an anti-angiogenesis factor and is targeted to breast cancer; and Thiarabine , a new generation nucleoside analog which has demonstrated both pre-clinical and clinical activity in certain cancers. For additional information on Access Pharmaceuticals, please...Access Pharmaceuticals Announces Commercial Launch of MuGard(TM) in Norway by SpePharm
...R), a humanized monoclonal antibody which acts as an anti-angiogenesis factor and is targeted to breast cancer; and Thiarabine , a new generation nucleoside analog which has demonstrated both pre-clinical and clinical activity in certain cancers. For additional information on Access Pharmaceuticals, please...UPDATE: Access Pharmaceuticals to Present at Jesup & Lamont 2009 Growth Stock Conference
...lix(R), a humanized monoclonal antibody which acts as an anti-angiogenesis factor and is targeted to breast cancer; and Thiarabine, a new generation nucleoside analog which has demonstrated both pre-clinical and clinical activity in certain cancers. For additional information on Access Pharmaceuticals, please...Access Pharmaceuticals to Present at Jesup & Lamont 2009 Growth Stock Conference
...lix(R), a humanized monoclonal antibody which acts as an anti-angiogenesis factor and is targeted to breast cancer; and Thiarabine, a new generation nucleoside analog which has demonstrated both pre-clinical and clinical activity in certain cancers. For additional information on Access Pharmaceuticals, please...Access Pharmaceuticals to Present at Jessup & Lamont 2009 Growth Stock Conference
...lix(R), a humanized monoclonal antibody which acts as an anti-angiogenesis factor and is targeted to breast cancer; and Thiarabine, a new generation nucleoside analog which has demonstrated both pre-clinical and clinical activity in certain cancers. For additional information on Access Pharmaceuticals, please...Access Pharmaceuticals Announces Commercial Launch of MuGard(TM) in Greece by SpePharm
...R), a humanized monoclonal antibody which acts as an anti-angiogenesis factor and is targeted to breast cancer; and Thiarabine , a new generation nucleoside analog which has demonstrated both pre-clinical and clinical activity in certain cancers. For additional information on Access Pharmaceuticals, please...Access Pharmaceuticals Provides Update on ProLindac Clinical Development Program
...R), a humanized monoclonal antibody which acts as an anti-angiogenesis factor and is targeted to breast cancer; and Thiarabine , a new generation nucleoside analog which has demonstrated both pre-clinical and clinical activity in certain cancers. For additional information on Access Pharmaceuticals, please...Schering-Plough Expands Vicriviroc Phase II Study in Treatment-Naive Patients With HIV
...D study group. Class of antiretroviral drugs and the risk of myocardial infarction. N Engl J Med 2007; 356: 1723-35. 7 The DAD study group. Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the DAD study: a multi-cohort collaboration. w...Access Pharmaceuticals Announces Publication of Thiarabine Combination Data
... download from the journal's website. "Thiarabine is a next generation nucleoside analogue, licensed by Access from Southern Research Institute ," stated ...sis factor and is targeted to breast cancer. Thiarabine is a new generation nucleoside analog which has demonstrated both pre-clinical and clinical activity in ce...Pharmasset to Present at Goldman Sachs and Needham Healthcare Conferences
...lass of compounds which act to inhibit the enzymes required for viral replication. We currently have three clinical-stage product candidates: R7128, a nucleoside analog for chronic HCV infections, has initiated a Phase 2b clinical trial in combination with Pegasys plus Copegus through a strategic collaboration ...TriLink BioTechnologies, Inc. Announces Supply Agreement With Osmetech Molecular Diagnostics
...portunity," said TriLink CEO, Dr. Richard Hogrefe. About TriLink TriLink Biotechnologies, Inc. manufactures custom oligonucleotides, modified nucleoside triphosphates and CleanAmp(TM) PCR products for the diagnostic and OEM markets. In addition, custom chemistry, contract research services and ISO/QSR ...TriLink Launches CleanAmp(TM) dNTPs for Hot Start PCR
... compared to the modified enzymes available on the market." About TriLink TriLink BioTechnologies, Inc. manufactures custom oligonucleotides, nucleoside triphosphates and CleanAmp(TM) Products for research and diagnostic laboratories. In addition, custom chemistry, contract research services and GMP p...American Chemical Society's Weekly PressPac -- Sept. 3, 2008
...g strategies to date involves the use of so-called nucleoside analogues, artificial pieces of DNA that inhibit r...ication by substituting for natural segments. Most nucleoside analogues directly target the active site of the p...in preliminary lab studies, could lead to improved nucleoside analogues with fewer side effects, he says. ART...Nobel Laureate finds 'elegant' explanation for DNA transcribing enzyme's high fidelity
...cy of the process. The researchers found that a portion of the enzyme known as the trigger loop acts like a “trap door,?swinging beneath a matching nucleoside triphosphate (NTP) building block, to close off the active center and form an extensive network of interactions with the NTP and other parts of the en...Major WHO study concludes calcium supplements can reduce complications during pregnancy
...mbrella term, highly active antiretroviral therapy, or HAART therapy. Current HAART regimens generally include three antiretroviral drugs, usually two nucleoside analogs and either a protease inhibitor or a non-nucleoside reverse-transcriptase inhibitor. This drug regimen has, in some cases, been effective in c...Computer simulation hints at new HIV drug target
...mbrella term, highly active antiretroviral therapy, or HAART therapy. Current HAART regimens generally include three antiretroviral drugs, usually two nucleoside analogs and either a protease inhibitor or a non-nucleoside reverse-transcriptase inhibitor. This drug regimen has, in some cases, been effective in c...Viral 'fitness' explains different resistance patterns to aids drugs
...es either one NNRTI or protease inhibitor (non-boosted or boosted with a small amount of another potent PI) and two different antiretrovirals from the nucleoside reverse transcriptase inhibitor class. ...Hepatitis C responds best to combo of ribavirin and interferon, study concludes
...ll virus cells and inhibiting the ability of viruses to make new copies of themselves and proliferate. Ribavirin belongs to a class of drugs called nucleoside analogues, which includes some anti-HIV drugs such as AZT (zidovudine). Ribavirin used alone does not have any effect on HCV but in combination with i...High fidelity keeps human DNA assembly line humming
...A is made. Burton explains that it is similar to an industrial assembly line, with DNA being a conveyer belt to load building blocks, or bases, called nucleoside triphosphates (NTPs) to hook up with a growing strand of RNA. Burton's insight was to discover that the NTP bases preload to the DNA template sever...InterMune Reports Second Quarter 2009 Financial Results and Business Highlights
... InterMune, Roche and Pharmasset, Inc. reported initial results from the novel Phase 1 INFORM-1 clinical trial evaluating ITMN-191 in combination with nucleoside polymerase inhibitor R7128, but no interferon or ribavirin, in patients with HCV infection. Data from the first four dosage cohorts of the study demo...Pharmasset to Present at Canaccord Adams Conference
...lternative substrates for the viral polymerase thus inhibiting viral replication. We currently have three clinical-stage product candidates: RG7128, a nucleoside analog for chronic HCV infections, is in a Phase 2b clinical trial in combination with Pegasys(R) plus Copegus(R) and is also in INFORM studies, the f...BioCryst Pharmaceuticals to Announce Second Quarter 2009 Financial Results on July 30, 2009
... autoimmune diseases. BioCryst has two product candidates in pivotal clinical trials; peramivir, an anti-viral for influenza, and forodesine, a purine nucleoside phosphorylase (PNP) inhibitor for cutaneous T-cell lymphoma (CTCL). Utilizing crystallography and structure-based drug design, BioCryst continues to...MuGard Data From UK Study Shows Prevention of Oral Mucositis in Head and Neck Cancer Patients
...R), a humanized monoclonal antibody which acts as an anti-angiogenesis factor and is targeted to breast cancer; and Thiarabine , a new generation nucleoside analog which has demonstrated both pre-clinical and clinical activity in certain cancers. For additional information on Access Pharmaceuticals, please...Access Pharmaceuticals CEO Interviewed on Financial Website
...iolix(R), a humanized monoclonal antibody which acts as an anti-angiogenesis factor and is targeted to breast cancer. Thiarabine is a new generation nucleoside analog which has demonstrated both pre-clinical and clinical activity in certain cancers. For additional information on Access Pharmaceuticals, please...Access Pharmaceuticals Announces Granting of Two US Patents for MuGard(TM)
...iolix(R), a humanized monoclonal antibody which acts as an anti-angiogenesis factor and is targeted to breast cancer; and Thiarabine, a new generation nucleoside analog which has demonstrated both pre-clinical and clinical activity in certain cancers. For additional information on Access Pharmaceuticals, please...Sanofi-aventis U.S. to Acquire Oral Chronic Lymphocytic Leukemia Treatment
...s and purchases Oforta from Bayer Schering Pharma AG. As part of this transaction, sanofi-aventis U.S. will acquire these agreements. Oforta is a nucleoside analogue designed to prevent cancer cells from dividing by inhibiting DNA synthesis. Oforta was granted accelerated review and later received approva...Phosphate Colorimetric Assay Kit, PiBlue from BioAssay Systems
Description:... assays for phosphatase, lipase, nucleoside triphosphatases (ATPase, GTPase etc). HTS and follow up studies for phosphatase inhibitors. Quantitation of phosphate content in protein, lipids, and ...Phosphate Colorimetric Assay Kit from BioAssay Systems
Description:... assays for phosphatase, lipase, nucleoside triphosphatases (ATPase, GTPase etc). HTS and follow up studies for phosphatase inhibitors. Quantitation of phosphate content in protein, lipids, and ...Tunicamycin, Streptomyces lysosuperficus from Calbiochem
Description:... White to off-white solid. A nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against Gram...T4 Polynucleotide Kinase from EPICENTRE Biotechnologies
Description:... T4 Polynucleotide Kinase (PNK) catalyzes the transfer of the gamma-phosphate from ATP to the 5'-hydroxyl of single- and double-stranded DNA, RNA, and nucleoside 3'-monophosphates. The enzyme also removes the 3'-phosphate from 3'-phosphoryl polynucleotides, deoxyribonucleoside 3'-monophosphates, and deoxyribonu...Pyrophosphate Fluorometric (Blue) Assay Kit, EnzChek® from Molecular Probes (Invitrogen)
Description:... the presence of inorganic phosphate (Pi ), the substrate 2-amino-6-mercapto-7-methylpurine ribonucleoside (MESG) is converted enzymatically by purine nucleoside phosphorylase (PNP) to ribose 1-phosphate and 2-amino-6-mercapto-7-methylpurine (Figure 1). Enzymatic conversion of MESG results in a shift in absorba...Phosphate Colorimetric Assay Kit, 'EnzoLyte from AnaSpec
Description:...n 96- and 384-well plates for high-throughput screening of enzyme inhibitors. The kit has been used for assaying phosphatase, phospholipase or lipase, nucleoside triphosphatase (ATPase, GTPase etc) and phytase. The kit has the following components: Highly purified Malachite Green reagent Assay buffer A mix a...Blasticidin S HCl from Invitrogen
Description:... Blasticidin is a nucleoside antibiotic from Streptomyces griseochromogenes. It is a potent translational inhibitor in both prokaryotic and eukaryotic cells. Resistance to blastic...