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Nucleoside in Medical News

BioCryst Reports Second Quarter 2009 Financial Results And Provides Corporate Update

... autoimmune diseases. BioCryst has two product candidates in pivotal clinical trials; peramivir, an anti-viral for influenza, and forodesine, a purine nucleoside phosphorylase (PNP) inhibitor for cutaneous T-cell lymphoma (CTCL). Utilizing crystallography and structure-based drug design, BioCryst continues to...

Access Pharmaceuticals Announces New MuGard Commercial Strategy in North America

...R), a humanized monoclonal antibody which acts as an anti-angiogenesis factor and is targeted to breast cancer; and Thiarabine , a new generation nucleoside analog which has demonstrated both pre-clinical and clinical activity in certain cancers. For additional information on Access Pharmaceuticals, please...

Access Pharmaceuticals Announces Commercial Launch of MuGard(TM) in Norway by SpePharm

...R), a humanized monoclonal antibody which acts as an anti-angiogenesis factor and is targeted to breast cancer; and Thiarabine , a new generation nucleoside analog which has demonstrated both pre-clinical and clinical activity in certain cancers. For additional information on Access Pharmaceuticals, please...

UPDATE: Access Pharmaceuticals to Present at Jesup & Lamont 2009 Growth Stock Conference

...lix(R), a humanized monoclonal antibody which acts as an anti-angiogenesis factor and is targeted to breast cancer; and Thiarabine, a new generation nucleoside analog which has demonstrated both pre-clinical and clinical activity in certain cancers. For additional information on Access Pharmaceuticals, please...

Access Pharmaceuticals to Present at Jesup & Lamont 2009 Growth Stock Conference

...lix(R), a humanized monoclonal antibody which acts as an anti-angiogenesis factor and is targeted to breast cancer; and Thiarabine, a new generation nucleoside analog which has demonstrated both pre-clinical and clinical activity in certain cancers. For additional information on Access Pharmaceuticals, please...

Access Pharmaceuticals to Present at Jessup & Lamont 2009 Growth Stock Conference

...lix(R), a humanized monoclonal antibody which acts as an anti-angiogenesis factor and is targeted to breast cancer; and Thiarabine, a new generation nucleoside analog which has demonstrated both pre-clinical and clinical activity in certain cancers. For additional information on Access Pharmaceuticals, please...

Pharmasset Nominates PSI-938 as a New Nucleotide Analog Inhibitor of Hepatitis C for Preclinical Development

...lass of compounds which act to inhibit the enzymes required for viral replication. We currently have three clinical-stage product candidates. R7128, a nucleoside analog for chronic HCV infections, is in a Phase 2b clinical trial in combination with Pegasys(R) plus Copegus(R) and is also in INFORM studies, the f...

Access Pharmaceuticals Announces Commercial Launch of MuGard(TM) in Greece by SpePharm

...R), a humanized monoclonal antibody which acts as an anti-angiogenesis factor and is targeted to breast cancer; and Thiarabine , a new generation nucleoside analog which has demonstrated both pre-clinical and clinical activity in certain cancers. For additional information on Access Pharmaceuticals, please...

TriLink BioTechnologies, Inc. Announces Sales and License Agreement With Glen Research Corporation for CleanAmp(TM) Amidites

...etplace," said TriLink CEO, Dr. Richard Hogrefe. About TriLink TriLink Biotechnologies, Inc. manufactures custom oligonucleotides, modified nucleoside triphosphates and CleanAmp(TM) PCR products for the diagnostic and OEM markets. In addition, custom chemistry, contract research services and ISO/QSR ...

Access Pharmaceuticals Announces Initiation of Two New Cobalamin(TM) Oral Insulin Drug Delivery Collaborations

...ngiolix(R), a humanized monoclonal antibody which acts as an anti-angiogenesis factor and is targeted to breast cancer. Thiarabine is a new generation nucleoside analog which has demonstrated both pre-clinical and clinical activity in certain cancers. For additional information on Access Pharmaceuticals, please...
Nucleoside in Medical Technology

Roche and Pharmasset Initiate Phase IIb Clinical Trial of R7128, Most Advanced Nucleoside Polymerase Inhibitor in Development for Chronic Hepatitis C

Start of trial triggers $10 million milestone payment to Pharmasset PRINCETON, N.J., April 24 /PRNewswire-FirstCall/ -- Pharmasset, Inc. (Nasdaq: VRUS ) and Roche (Roche SWX: RO, ROG; Pink Sheets: RHHBY) today announced that the first patient has been dosed in a Phase IIb study of R7128, th...

Access Pharmaceuticals Provides Update on ProLindac Clinical Development Program

...R), a humanized monoclonal antibody which acts as an anti-angiogenesis factor and is targeted to breast cancer; and Thiarabine , a new generation nucleoside analog which has demonstrated both pre-clinical and clinical activity in certain cancers. For additional information on Access Pharmaceuticals, please...

Pharmasset Reports Positive Preliminary Antiviral Data With PSI-7851 for the Treatment of Hepatitis C

...old more potent than Pharmasset's first generation nucleoside polymerase inhibitor, RG7128 (formerly known as R7...llular toxicities that may be associated with some nucleoside analogs. Like RG7128, PSI-7851 has demonstrated pa...three clinical-stage product candidates. RG7128, a nucleoside analog for chronic HCV infections, is in a Phase 2...

Idenix Pharmaceuticals Successfully Completes Proof-of-Concept Study of IDX184 for the Treatment of Hepatitis C Virus (HCV)

...rietary liver-targeting technology. This technology enables the delivery of nucleoside monophosphate to the liver, leading to the formation of high levels of nucleoside triphosphate, potentially maximizing drug efficacy and limiting systemic si...

Schering-Plough Expands Vicriviroc Phase II Study in Treatment-Naive Patients With HIV

...D study group. Class of antiretroviral drugs and the risk of myocardial infarction. N Engl J Med 2007; 356: 1723-35. 7 The DAD study group. Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the DAD study: a multi-cohort collaboration. w...

Thiarabine Demonstrates a Reduction of Both Inflammatory and Erosive Disease Parameters in Rheumatoid Arthritis

...ped for rheumatoid arthritis as well." Thiarabine is a next generation nucleoside analogue that Access has licensed from Southern Research. It has been in tw...ctor and is targeted to breast cancer; and Thiarabine , a new generation nucleoside analog which has demonstrated both pre-clinical and clinical activity in ce...

Access Pharmaceuticals Announces Publication of Thiarabine Combination Data

... download from the journal's website. "Thiarabine is a next generation nucleoside analogue, licensed by Access from Southern Research Institute ," stated ...sis factor and is targeted to breast cancer. Thiarabine is a new generation nucleoside analog which has demonstrated both pre-clinical and clinical activity in ce...

Pharmasset to Present at Goldman Sachs and Needham Healthcare Conferences

...lass of compounds which act to inhibit the enzymes required for viral replication. We currently have three clinical-stage product candidates: R7128, a nucleoside analog for chronic HCV infections, has initiated a Phase 2b clinical trial in combination with Pegasys plus Copegus through a strategic collaboration ...

TriLink BioTechnologies, Inc. Announces Supply Agreement With Osmetech Molecular Diagnostics

...portunity," said TriLink CEO, Dr. Richard Hogrefe. About TriLink TriLink Biotechnologies, Inc. manufactures custom oligonucleotides, modified nucleoside triphosphates and CleanAmp(TM) PCR products for the diagnostic and OEM markets. In addition, custom chemistry, contract research services and ISO/QSR ...

TriLink Launches CleanAmp(TM) dNTPs for Hot Start PCR

... compared to the modified enzymes available on the market." About TriLink TriLink BioTechnologies, Inc. manufactures custom oligonucleotides, nucleoside triphosphates and CleanAmp(TM) Products for research and diagnostic laboratories. In addition, custom chemistry, contract research services and GMP p...
Nucleoside in Medical Dictionary

Lactic acidosis

... because in states of low tissue ... Lactic acidosis is usually associated with laboratory abnormalities indicating ... Lactic Acidosis . nucleoside reverse transcriptase inhibitors (NRTIs) ... with hyperlactatemia and lactic acidosis , people taking ... INTRODUCTION A unique form of lactic...
Nucleoside in Biological News

American Chemical Society's Weekly PressPac -- Sept. 3, 2008

...g strategies to date involves the use of so-called nucleoside analogues, artificial pieces of DNA that inhibit r...ication by substituting for natural segments. Most nucleoside analogues directly target the active site of the p...in preliminary lab studies, could lead to improved nucleoside analogues with fewer side effects, he says. ART...

Nobel Laureate finds 'elegant' explanation for DNA transcribing enzyme's high fidelity

...cy of the process. The researchers found that a portion of the enzyme known as the trigger loop acts like a “trap door,?swinging beneath a matching nucleoside triphosphate (NTP) building block, to close off the active center and form an extensive network of interactions with the NTP and other parts of the en...

Major WHO study concludes calcium supplements can reduce complications during pregnancy

...mbrella term, highly active antiretroviral therapy, or HAART therapy. Current HAART regimens generally include three antiretroviral drugs, usually two nucleoside analogs and either a protease inhibitor or a non-nucleoside reverse-transcriptase inhibitor. This drug regimen has, in some cases, been effective in c...

Computer simulation hints at new HIV drug target

...mbrella term, highly active antiretroviral therapy, or HAART therapy. Current HAART regimens generally include three antiretroviral drugs, usually two nucleoside analogs and either a protease inhibitor or a non-nucleoside reverse-transcriptase inhibitor. This drug regimen has, in some cases, been effective in c...

Viral 'fitness' explains different resistance patterns to aids drugs

...es either one NNRTI or protease inhibitor (non-boosted or boosted with a small amount of another potent PI) and two different antiretrovirals from the nucleoside reverse transcriptase inhibitor class. ...

Hepatitis C responds best to combo of ribavirin and interferon, study concludes

...ll virus cells and inhibiting the ability of viruses to make new copies of themselves and proliferate. Ribavirin belongs to a class of drugs called nucleoside analogues, which includes some anti-HIV drugs such as AZT (zidovudine). Ribavirin used alone does not have any effect on HCV but in combination with i...

High fidelity keeps human DNA assembly line humming

...A is made. Burton explains that it is similar to an industrial assembly line, with DNA being a conveyer belt to load building blocks, or bases, called nucleoside triphosphates (NTPs) to hook up with a growing strand of RNA. Burton's insight was to discover that the NTP bases preload to the DNA template sever...
Nucleoside in Biological Technology

Isolation and Characterization of Anti-Viral Nucleoside Compounds from the Chinese Herb Taraxacum Mongolicum

Characterization of nucleotide and nucleoside analogs from Taraxacum mongolicum, a Chinese medicinal herb was achieved for the first time using liquid chromatography tandem mass spectrometry (LC/MS/MS). The active ingredients in the herb were characterized using nucleotide and nucleoside ...

InterMune Reports Second Quarter 2009 Financial Results and Business Highlights

... InterMune, Roche and Pharmasset, Inc. reported initial results from the novel Phase 1 INFORM-1 clinical trial evaluating ITMN-191 in combination with nucleoside polymerase inhibitor R7128, but no interferon or ribavirin, in patients with HCV infection. Data from the first four dosage cohorts of the study demo...

Pharmasset to Present at Canaccord Adams Conference

...lternative substrates for the viral polymerase thus inhibiting viral replication. We currently have three clinical-stage product candidates: RG7128, a nucleoside analog for chronic HCV infections, is in a Phase 2b clinical trial in combination with Pegasys(R) plus Copegus(R) and is also in INFORM studies, the f...

Anadys Pharmaceuticals Receives FDA Clearance of Phase II Protocol to Study ANA598 in Combination With Interferon-Alpha and Ribavirin in HCV Patients

...ty in vitro against mutations conferring resistance to protease inhibitors, nucleoside polymerase inhibitors and non-nucleoside polymerase inhibitors that act at binding sites distinct from that of ANA598, and protease and nucleoside polymerase inhibitors retain full activity against mutations conferring res...

BioCryst Pharmaceuticals to Announce Second Quarter 2009 Financial Results on July 30, 2009

... autoimmune diseases. BioCryst has two product candidates in pivotal clinical trials; peramivir, an anti-viral for influenza, and forodesine, a purine nucleoside phosphorylase (PNP) inhibitor for cutaneous T-cell lymphoma (CTCL). Utilizing crystallography and structure-based drug design, BioCryst continues to...

MuGard Data From UK Study Shows Prevention of Oral Mucositis in Head and Neck Cancer Patients

...R), a humanized monoclonal antibody which acts as an anti-angiogenesis factor and is targeted to breast cancer; and Thiarabine , a new generation nucleoside analog which has demonstrated both pre-clinical and clinical activity in certain cancers. For additional information on Access Pharmaceuticals, please...

Access Pharmaceuticals CEO Interviewed on Financial Website

...iolix(R), a humanized monoclonal antibody which acts as an anti-angiogenesis factor and is targeted to breast cancer. Thiarabine is a new generation nucleoside analog which has demonstrated both pre-clinical and clinical activity in certain cancers. For additional information on Access Pharmaceuticals, please...

Phase II Trial Demonstrates Elacytarabine May Increase Survival Threefold in Patients With Late-Stage Leukaemia

...Notes to Editors About Elacytarabine Elacytarabine is a novel nucleoside drug designed to overcome the shortcomings of cytarabine, an established an...ke of elacytarabine by cancer cells is not dependent on the presence of the nucleoside transporter, hENT1. As a result, elacytarabine is taken up by cancer cells ...

Access Pharmaceuticals Announces Granting of Two US Patents for MuGard(TM)

...iolix(R), a humanized monoclonal antibody which acts as an anti-angiogenesis factor and is targeted to breast cancer; and Thiarabine, a new generation nucleoside analog which has demonstrated both pre-clinical and clinical activity in certain cancers. For additional information on Access Pharmaceuticals, please...

Sanofi-aventis U.S. to Acquire Oral Chronic Lymphocytic Leukemia Treatment

...s and purchases Oforta from Bayer Schering Pharma AG. As part of this transaction, sanofi-aventis U.S. will acquire these agreements. Oforta is a nucleoside analogue designed to prevent cancer cells from dividing by inhibiting DNA synthesis. Oforta was granted accelerated review and later received approva...
Nucleoside in Biological Products

Phosphate Colorimetric Assay Kit, PiBlue™ from BioAssay Systems

Description:... assays for phosphatase, lipase, nucleoside triphosphatases (ATPase, GTPase etc). HTS and follow up studies for phosphatase inhibitors. Quantitation of phosphate content in protein, lipids, and ...
Company:BioAssay Systems

Phosphate Colorimetric Assay Kit from BioAssay Systems

Description:... assays for phosphatase, lipase, nucleoside triphosphatases (ATPase, GTPase etc). HTS and follow up studies for phosphatase inhibitors. Quantitation of phosphate content in protein, lipids, and ...
Company:BioAssay Systems

Tunicamycin, Streptomyces lysosuperficus from Calbiochem

Description:... White to off-white solid. A nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against Gram...
Company:Calbiochem

T4 Polynucleotide Kinase from EPICENTRE Biotechnologies

Description:... T4 Polynucleotide Kinase (PNK) catalyzes the transfer of the gamma-phosphate from ATP to the 5'-hydroxyl of single- and double-stranded DNA, RNA, and nucleoside 3'-monophosphates. The enzyme also removes the 3'-phosphate from 3'-phosphoryl polynucleotides, deoxyribonucleoside 3'-monophosphates, and deoxyribonu...
Company:EPICENTRE Biotechnologies

Pyrophosphate Fluorometric (Blue) Assay Kit, EnzChek® from Molecular Probes (Invitrogen)

Description:... the presence of inorganic phosphate (Pi ), the substrate 2-amino-6-mercapto-7-methylpurine ribonucleoside (MESG) is converted enzymatically by purine nucleoside phosphorylase (PNP) to ribose 1-phosphate and 2-amino-6-mercapto-7-methylpurine (Figure 1). Enzymatic conversion of MESG results in a shift in absorba...
Company:Molecular Probes (Invitrogen)

Phosphate Colorimetric Assay Kit, 'EnzoLyte from AnaSpec

Description:...n 96- and 384-well plates for high-throughput screening of enzyme inhibitors. The kit has been used for assaying phosphatase, phospholipase or lipase, nucleoside triphosphatase (ATPase, GTPase etc) and phytase. The kit has the following components: Highly purified Malachite Green reagent Assay buffer A mix a...
Company:AnaSpec

Blasticidin S HCl from Invitrogen

Description:... Blasticidin is a nucleoside antibiotic from Streptomyces griseochromogenes. It is a potent translational inhibitor in both prokaryotic and eukaryotic cells. Resistance to blastic...
Company:Invitrogen
Nucleoside in Biological Definition

Nucleoside

Nucleobase Nucleoside Deoxynucleoside Adenine Adenosine A Deoxyadenosine dA Guanine Guanosine G Deoxyguanosine dG Thymine Thymidine T Deoxythymidine dT Uracil Uridine U Deoxyuridine dU C...

Adenosine triphosphate

...n. Other triphosphates Living cells also have other "high-energy" nucleoside triphosphates, such as guanosine triphosphate . Between them and ATP, energy can be easily transferred with reactions such as those catalyzed by nucleoside diphosphokinase : Energy is released when hydrolysis of the phosphate-ph...

Nucleotide

... ribose in RNA, and the phosphate chain can be a monophosphate, diphosphate, or triphosphate. A nucleotide that lacks the phosphate group is called nucleoside . Contents showTocToggle("show","hide") 1 Nomenclature 2 Chemical structures 2.1 Nucleotides 2.2 Deoxynucleotides ...
Nucleoside in Biological Dictionary

Nucleoside

Nucleosides are glycosylamines consisting of a nucleobase (often referred to ... Retrieved from "http://en.wikipedia.org /wiki/ Nucleoside " ... nucleobase, nucleoside , nucleotide and nucleic acid metabolic process. • DNA modification ... Purine nucleoside phospho...

Transcriptase

...t retroviruses need to reproduce. Information about transcriptase in the free online ... non-nucleoside reverse transcriptase inhibitor. NRTI. nucleoside analogue ... Shop for Transcriptase French Edition - Books at Shop.com. Magazines Transcriptase French Edition Books Psychology research, i...

Pyrimidine

...h as ... Information on EC 2.4.2.2 - pyrimidine -nucleoside phosphorylase ... Use of 4-thiouridine and 4-thiothymidine in studies on pyrimidine nucleoside phosphorylases ... Definition and other additional information on Pyrimidine from Biology-Online.org dictionary. ... It is the parent compound ...

Purine

...ctionary.com a free ... purine derivatives, ... Link To purine . Best - Gout Treatments. Latest Gout Treatment News. What ... Purine -specific nucleoside N-ribohydrolase from Trypanosoma brucei brucei. ... EGO entry for GO code 0008477: purine nucleosidase ... Purine . You don't need to be Edit...

Oligonucleotide

... HISTOCHEMISTRY. Terminal ... For a 48 base oligonucleotide , 0.1µM is ... oligonucleotide at 1.5µM final ... Specialty oligonucleotide and nucleoside synthesis service. Oglionucletide Theraputic Society, Inc., is. ... and development of oligonucleotide therapeutics (RNAi, CpG, ... © Oligonucl...

Nucleotide

...... Nucleic acids are polymeric macromolecules made from nucleotide monomers. ... nucleotide n. Any of various compounds consisting of a nucleoside combined with a phosphate group and forming the basic constituent of DNA and RNA nucleotide a phosphoric ester of a nucleoside; the basic stru...

Guanine

...rivative of purine, consisting of a ... The main ones are cytosine, guanine , adenine , thymine and uracil , abbreviated ... Guanosine is a nucleoside comprising guanine attached to a ribose ring via a ? ... Calculated Properties of Guanine . Electron Density: relectron ... Links to other data...

Cytosine

...of the four main bases found in DNA and RNA. It is a pyrimidine derivative, with a heterocyclic aromatic ring and two substituents attached . The nucleoside of cytosine is cytidine. In Watson-Crick base pairing, it forms three hydrogen bonds with... cytosine ( ) n. ( Abbr. C ) A pyrimidine base...

Adenosine diphosphate

... Adenosine diphosphate , abbreviated ADP, is a nucleotide. It is an ester of pyrophosphoric acid with the nucleoside adenosine . ADP consists of the pyrophosphate group, the pentose sugar ribose, and the nucleobase adenine. Aspects of the topic adenosine - diph...

Adenosine

... Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond. The adenosine A2A ...
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