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Normalization in Medical News

Hormone Normalization Shows Encouraging Effects In Documented Clinically Deficient Men/Women

Nonprofit Cenegenics Education and Research Foundation partnered with two recognized professors from the University of Miami - Miller School of Medicine to examine testosterone and/or human growth hormone normalization in proven clinically deficient adults, reviewing effects on body composition a...

Avipaxin Is First Entrant in Medical Arsenal for Neuro-Endocrine-Immune Connection(C) Product and Testing Protocols

...es the neurotransmitter acetylcholine to down-regulate elevated pro-inflammatory cytokines. Decreasing pro-inflammatory cytokines leads to an indirect normalization of neurotransmitter levels, leading to a positive effect on mood, concentration, sleep, and other emotional and mental processes. Avipaxin should be c...

Ethicon Endo-Surgery Holds Metabolic Surgery Scientific Forum Featuring Research By Top Scientists

...estyle and pharmacologic therapy." He pointed out that the ADA Guidelines stated that "bariatric surgery has been shown to lead to near or complete normalization of glycemia in 55-95% of patients with type 2 diabetes, depending on the surgical procedure." "Diabetes is a chronic progressive disease," said...

Biomarkers predict brain tumor's response to therapy

...y use of MRI. The researchers measured vascular normalization prior to and one day after patients' received cedi...arkers were measured in 28 patients. "Vascular normalization is an important mechanism of how these drugs work ...howed that those patients whose extent of vascular normalization was greater, had a longer duration of overall surv...

Determining Who Will Respond to Brain Tumor Therapy

...ere able to identify, even after a single dose, people who benefitted from the drug and those who did not. People with a greater degree of vascular normalization had longer overall survival and longer progression-free survival, according to the phase 2 study, which included 31 people. "We found that results ...

Can New Surgery Revolutionize Diabetes Treatment?

... bowel in diabetes." Recent studies have indicated that bariatric surgery, an approach typically used to treat severe obesity, often results in normalization of blood sugar levels and other metabolic abnormalities. This results in a reduction of the overall risk of mortality associated with diabetes in sev...

GeneGo and OmicSoft Announce Integration

... Number platforms (Affymetrix, Illumina, Agilent). It provides analysis modules for Exon/gene arrays, as well as an industry-leading Taqman import and normalization module. With over 40 unique, fully interactive, and highly customizable views, users can create exciting presentations through the program's seamless ...

Drug Improves Survival in Mice With Brain Tumors

..., the study authors said. "This is the first paper to show that vascular normalization alone, without chemotherapy, can be effective against some tumors by contro...are highly resistant to currently used chemotherapy drugs, even if vascular normalization increased drug delivery, there may be little or no additional increase in p...

Angiogenesis inhibitor improves brain tumor survival by reducing edema

...ice receiving cediranib. "This is the first paper to show that vascular normalization alone, without chemotherapy, can be effective against some tumors by contro...are highly resistant to currently used chemotherapy drugs, even if vascular normalization increases drug delivery, there may be little or no additional increase in p...

Libyan Aid Tests 50-Bed BLU-MED Deployable Field Hospital

...rt, provided a tour of the facility for attending dignitaries. Procurement of the BLU-MED deployable medical facility was made possible following normalization of relations between the United States and Libya in recent years. BLU-MED's facilities include state-of-the-industry portable fabric shelters, which e...
Normalization in Medical Technology

AMT Receives EMEA Orphan Drug Designation for Acute Intermittent Porphyria

...rphyric attacks. AMT has demonstrated that its product, AMT-021, results in normalization of the PBGD protein in an animal model of AIP. In this model, the therapy c...y that develops in untreated mice. AMT-021 is intended to provide long-term normalization of the PBGD protein in order to prevent acute porphyric attacks and their c...

Pharmasset Voluntarily Halts Clinical Studies with Clevudine in Hepatitis B Infected Patients

...drugs of the nucleoside class. The primary objective of the studies are to assess the effect of clevudine on reducing levels of virus in the blood and normalization of liver function at 48 weeks after initiating therapy. Conference Call and Webcast Members of Pharmasset's management team will host a conf...

Data from Phase 2 Study of Peramivir in Patients Hospitalized with Influenza Presented at the XI International Symposium on Respiratory Viral Infections

... related to influenza. The primary objective of the study was to evaluate time to clinical stability, which is a composite endpoint comprised of normalization of temperature, oxygen saturation, respiratory rate, systolic blood pressure and heart rate. This type of endpoint has previously been used in pneumo...

Phase III Trial Results Show Elitek(R) (rasburicase) Significantly Reduced Plasma Uric Acid Levels versus Allopurinol in Adults with Hematologic Cancers at Risk for Tumor Lysis Syndrome

...ontrol of PUA concentration and the safety profile in three treatment arms. Among the three treatment arms, plasma uric acid response rate (defined as normalization or maintenance of PUA levels less than or equal to 7.5mg/dl at days 3-7) was 87% of patients treated with Elitek compared to 66% receiving allopurinol...

Human Genome Sciences Reports Positive Long-Term Data for LymphoStat-B in Patients With Active Systemic Lupus Erythematosus

...ntation reporting the safety profile of LymphoStat- B through three years, click here. To view the EULAR poster presentation reporting the progressive normalization of autoantibody, immunoglobulin and complement levels over three years of treatment with LymphoStat-B, click here. To view the EULAR poster presentati...

Analysis of Ulcerative Colitis (UC) Time to Symptom Resolution Data from Pivotal Study of LIALDA(TM) (mesalamine) Presented at DDW

...8g/day: 9 days and 17 days -- Placebo: 14 days and 35 days -- normalization of stool frequency at the first day and first of three days, respect...Placebo: 38 days and 53 days -- Resolution of both rectal bleeding and normalization of stool frequency at the first day and first of three days, respect...

BARACLUDE(R) (Entecavir) Treatment Resulted In Greater Viral Load Suppression Compared to Adefovir at 96 Weeks In Antiviral-Naive Adult Chronic Hepatitis B E-Antigen Positive Patients

... adefovir-treated patients had viral load greater than or equal to 10^5 copies/mL. -- 97 percent (n=28/29) of BARACLUDE patients achieved ALT normalization (ALT of less than or equal one time the upper limit of normal) compared with 85 percent (n=17/20) of adefovir-treated patients. -- 24 percent...

Twelve DOXIL(R) Clinical Studies to be Presented at American Society of Hematology Annual Meeting

...ity of British Columbia (Abstract 2740) -- Sunday, December 9, 2007, 6:00 p.m.-8:00 p.m., Hall B3 and B4 (Poster Board #:930-II) -- Early normalization of Serum Free Light Chain Is Associated with Prolonged Time to Progression Following Bortezomib Pegylated Liposomal Doxorubicin Treatment of ...

Indevus Pharmaceuticals Reports Positive Results of Phase II Octreotide Implant Trial

... Approximately 60% of these implant trial patients achieved a normal age-adjusted IGF-1 concentration. Sandostatin LAR produces a similar age-adjusted normalization of IGF-1 concentrations (51 to 67%). The remaining patients had entered the trial with baseline GH levels >5 ng/mL, and 59% achieved GH suppression ...

Human Genome Sciences Reports Positive Data from Long-Term Treatment with LymphoStat-B(R) in Patients with Active Systemic Lupus Erythematosus

...ported that LymphoStat-B also promoted progressive normalization of autoantibody, immunoglobulin and complement lev...infections or infectious events over time. -- normalization of IgG in patients with elevated IgG at baseline; ... ACR poster presentation reporting the progressive normalization of autoantibody, immunoglobulin and complement lev...
Normalization in Medical Products

Vidiera NsP Nucleic Acid Sample Preparation Platform

Description:...tubes in just two and one half-hours, and performs onboard quantitation and normalization and PCR reaction setup in 30 minutes each. Based on Beckman Coulters propr...y levels. Predefined, editable protocols automate extraction, quantitation, normalization and reaction set-ups, while user-defined protocols accommodate home-brew ex...
Company:Beckman Coulter, Inc.

MammaPrint Breast Cancer Diagnostic Test

Features:... Test consistency: Each patient sample is tested using a constant, standardized reference, normalized to a constant set of breast cancer specific normalization genes. ...
Company:Agendia Corporate

The Natural-Hip Family - Revision/Trauma CoCr Revision

Features:...uding proximal and distal centralizers for correct alignment and even cement mantle and a roughened proximal surface for enhanced cement bonding, with normalization steps providing optimal cement compression....
Company:Zimmer, Inc.

The Natural-Hip Family - Revision/Trauma Nonporous CoCr

Features:...uding proximal and distal centralizers for correct alignment and even cement mantle and a roughened proximal surface for enhanced cement bonding, with normalization steps providing optimal cement compression....
Company:Zimmer, Inc.
Normalization in Biological News

Caffeic acid inhibits colitis in a mouse model -- is a drug-metabolizing gene crucial?

... associated with resolution of allergic inflammation in another model. The normalization of CYP4B1 by caffeic acid treatment was associated with significant lesseni...on cancer, because colitis increases risk for this disease". In summary, normalization of expression of CYP4B1, a drug metabolizing enzyme possibly related to rev...

Random picks better than complicated process in gene identification

... C. Hale have provided evidence that a step called normalization is no longer necessary with recent advances in DNA... to sort through them. DeWoody and Hale believe normalization is not necessary given the vast amount of data tha...wamp the signal of rare genes," DeWoody said. "But normalization also discards valuable information about the relat...

FANTOM findings boost for biologists

... as an integrated web resource ( http://fantom.gsc.riken.jp/4/ ). Further research published in BMC Bioinformatics highlights two new data-driven normalization methods for quantitative reverse transcriptase polymerase chain reaction (qPCR) experiments with larger data sets. Another study published in Genome ...

Normalizing tumor vessels to improve cancer therapy

...or capillary cell mechanosensing and contractility in the formation of irregular tumor vessels, and have identified potential new targets for vascular normalization therapy that might be implemented in the clinic someday," Ghosh says. ...

Effective cancer immune therapy through order in the blood vessels

...oding the Rgs5 signal protein is switched off, the investigators observed a normalization of blood vessels in the tumor. Tumor-specifically activated immune cells th...rmann-Josef Grne, Gnter J. Hmmerling, Bernd Arnold and Ruth Ganss: Vascular normalization in Rgs5-deficient tumours promotes immune destruction. Nature 2008, DOI: 10...

Power of molecular imaging reveals secrets of the heart

...at had undergone recanalization but did not receive CPCs. In the CPC group, normalization of glucose metabolism and coronary blood flow was seen in nearly 50 percent...ronary recanalization and CPC administration may lead to treatment-specific normalization and reduce the risk of cardiac events over longer periods. For decades, nu...

Is hybridoma production about to take a quantum leap forward?

...in NPD-based mediaThis result might not reflect greater secretion per cell, but rather greater proliferation of cells with a similar secretion. After normalization of this biased situation, the researchers calculated that the secretion of monoclonal antibody in NPD-based media is roughly twice that obtained in DI...

HGS announces positive Phase 2 LymphoStat-B at ACR meeting

...te poster presentation reported that LymphoStat-B also promoted progressive normalization of autoantibody, immunoglobulin and complement levels over 2.5 years of the...bulins, with no increase in infections or infectious events over time. normalization of IgG in patients with elevated IgG at baseline; from 45% to 57% of patien...

Gene therapy study shows safety and statistically significant improvement in Parkinson's disease

...he brain are impressive. Moreover, the PET results offer an important window into the function of the living brain in these patients, which supports a normalization of brain activity specific to the treated hemisphere.” The study used an adeno-associated virus (AAV) vector to deliver an inhibitory gene (gluta...

Color perception is not in the eye of the beholder: It's in the brain

...s the same color experience despite this really profound difference in the front-end of their visual system," says Hofer. "That points to some kind of normalization or auto-calibration mechanism--some kind of circuit in the brain that balances the colors for you no matter what the hardware is." In a related exp...
Normalization in Biological Technology

Veteran-Owned Biotech Startup Company Charges Health Agency (NYSDOH) with Blackballing its Initiatives

... to blood, as reported by researchers in Italy, Germany, Russia, and Japan. Such immune enhancement is said to lead to viral load reduction and to the normalization of liver enzyme levels. Dr. Sunnen added, "This study carried special significance for Egypt which is overwhelmed with the highest prevalence of hepat...

China Biologic Products Announces Strong 2008 Results

...es for 2008 rose 27.6% to $12.4 million and selling expenses decreased 50.1% to $2.2 million. The substantial decrease in selling expense reflects the normalization of the marketing strategy that the Company initiated in the third quarter of 2007. Due to those marketing efforts in 2007, the Company was able to obt...

GeneCopoeia Introduces Genome-Wide MicroRNA (miRNA) Functional Analysis Tools

...al reporter genes, which provides a ready-for-use and single vector solution for both transcriptional regulation reporting and an internal control for normalization reporting. In addition to the two types of expression constructs, GeneCopoeia plans to launch All-in-One(TM) miRNA RT-qPCR system in the next few...

Technical Note: E-PAGE(TM) 48- and 96-Well Gels on the Odyssey(R) Infrared Imaging System

...e, multiplex detection can be accomplished, increasing the number of analytes to as many as 192; alternatively, one of the wavelengths can be used for normalization to improve quantification accuracy. Altogether, this system provides a rapid, convenient, quantitative, and highly sensitive means for analyzing prote...

BioCryst Reports Third Quarter 2008 Financial Results and Provides Corporate Update

...enza. The primary objective of the study was to evaluate a novel composite endpoint, time to clinical stability, which is comprised of normalization of temperature, oxygen saturation, respiratory rate, systolic blood pressure and heart rate. Secondary objectives of the study included eva...

BioCryst Reports Results From the First-Ever Completed Active-Controlled Phase 2 Study in Hospitalized Influenza

... upcoming medical meeting. The primary objective of the study was to evaluate time to clinical stability, which is a composite endpoint comprised of normalization of temperature, oxygen saturation, respiratory rate, systolic blood pressure and heart rate. This type of endpoint has previously been used in pneumon...

PTC124 Shows Promising Activity in Cystic Fibrosis; Phase 2 Proof-of-Concept Data Published in the Lancet

...ansport with over half of the patients entering the normal range during at least one treatment course. PTC124 induced chloride transport responses and normalization of CFTR activity across the variety of patient genotypes tested. Improvements in lung function values and body weight were also observed. PTC124 was g...

Genta Completes Appeal of FDA Decision for Genasense(R) in CLL

...ant. - Complete response confers clinical benefit in CLL. By definition, a complete response requires elimination of all evidence of disease, normalization of blood counts, and resolution of symptoms. - The median duration of complete response in patients who received Genasense has exceeded 3 years, ...

Fine Tuning Your Data Analysis: Tunable Parameters of the Affymetrix Expression Analysis Statistical Algorithms

...ameter, termed Perturbation, which operates on the normalization factor applied to the arrays during the comparison...lization Perturbation Factor) Effective normalization between arrays being compared is essential to dete...wo arrays, the Statistical Algorithm uses multiple normalization factors derived from a fundamental...

Measuring siRNA-mediated knockdown of IL-8 mRNA

...ntal results (data not shown), we determined that Cyclophilin B (PPIB) demonstrated more stable expression than GAPDH and subsequently was used as the normalization control. Following stimulation and siRNA transfection, the mRNA levels of each gene were measured from four replicate treatments of each experimental ...
Normalization in Biological Products

TRIMMER-Direct cDNA Normalization Kit from Evrogen JSC

Description: cDNA normalization is essential for hunting and analyzing the rare transcripts using high-throughput approaches, such as EST sequencing projects, microarrays, functional screenings etc. The Evrogen TRIMMER-DIRECT kit is developed for normalization of cDNA enriched with full-length sequences and int...
Company:Evrogen JSC

mirVana™ qRT-PCR Primer Set for Normalization (5S) from Ambion

Description: 53 new primer sets added in Dec 2005 Quantitative results in less than 3 hours Detection from as little as 25 pg of total RNA Specific primers available for hundreds of mammalian miRNAs Suitable for either real-time or end-point RT-PCR Ideal for validating expression profiling d...
Company:Ambion

TRIMMER cDNA Normalization Kit from Evrogen JSC

Description: cDNA normalization is essential for hunting and analyzing the rare transcripts using high-throughput approaches, such as EST sequencing projects, microarrays, functional screenings etc. Most normalization methods are not well suited for the normalization of long cDNA. The Evrogen TRIMMER kit, thoug...
Company:Evrogen JSC

ArrayControl RNA Spikes from Ambion

Description:... PCR Spots, Oligo Spots and complementary RNA Spikes for the normalization and control of microarray experiments. Use for glass array printing and for...s. Control PCR Spots and Oligo Spots, and complementary RNA Spikes for the normalization and control of microarray experiments....
Company:Ambion

Freedom EVO 150 from Tecan

Description:...tion set-up PCR set-up PCR PCR clean-up Genotyping single nucleotide polymorphism (SNP) scoring Spot array printing, hybridization, and DNA normalization Gene expression in situ hybridization (ISH), fluorescence in situ hybridization (FISH), immunohistochemistry (IHC) applications Proteomics Prot...
Company:Tecan

GeneTraffic from Iobion Informatics

Description:...Accessible :Access and share your GeneTraffic data from any PC on your Local Area Web. Analysis : Intuitive, graphical selection of filter and normalization criteria. Perform data classification tasks, including k-means and hierarchical cluster analyses, on data youve mined using gene and spot parameters o...
Company:Iobion Informatics

Shimadzu Phoretix 2D from Shimadzu Biotech

Description:...spot detection are easily entered using the set-up wizard. Background subtraction is flexible and fully informative. Intensity calibration and normalization features enable quantitative accuracy. An extensive set of user-friendly tools make editing a quick and simple process. Generate spot picking ...
Company:Shimadzu Biotech
Normalization in Biological Dictionary

Normalization

In the field of relational database design, normalization is a systematic way of ensuring that a database structure is suitable for general-purpose querying and free of certain undesirable characteristics—insertion, update,... Broadly, normalization is any process that makes something more n...
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