Arena Pharmaceuticals Announces Initiation by Merck of Phase 2 Clinical Trial of Niacin Receptor Agonist

SAN DIEGO, Feb. 18 /PRNewswire-FirstCall/ -- Arena Pharmaceuticals, Inc. (Nasdaq: ARNA ) announced today the initiation of a Phase 2 clinical trial of an orally administered niacin receptor agonist drug candidate being developed by Merck & Co., Inc., under its collaboration with Arena to t...

Simvastatin Plus Niacin May Lower Heart Risks

Treatment combining the cholesterol drug simvastatin with the B vitamin niacin lowers the risk of heart attack and other artery-disease complications by up to 90% in some patients. The study of 160 adults with clogged heart arteries and low HDL (good) cholesterol showed that 3 years of the combo tr...

Nuvilex Cites Study that Suggests Red Yeast Rice, an Active Ingredient in Cinnechol, Can Help to Improve Cardiovascular Health

...th." Cinnechol, which contains red yeast rice extract as well as a blend of other ingredients known to improve cardiovascular function (including niacin and guggul gum extract), may provide a natural alternative for those who have high cholesterol and are intolerant of, or elect not to take, statin dru...

Arena Pharmaceuticals to Receive $100 Million from Deerfield Management

...ied chronically, lorcaserin appears unrivaled in this respect. The value of Arena, however, goes beyond this important drug candidate to the company's niacin receptor program with Merck, its diabetes program with Johnson & Johnson and its ability to discover, develop and partner additional compounds," c...

Abbott Annual Meeting Highlights Outstanding 2008 Results, Continued Strong Outlook

...d), the first fibrate to be approved for use in combination with a statin, and SIMCOR(R), a fixed-dose combination of Niaspan(R) (Abbott's proprietary niacin extended-release) and simvastatin. Similac Advance EarlyShield(TM), an infant formula with a blend of prebiotics, nucleotides and antioxidants...

Colon cancer shuts down receptor that could shut it down

...d the protective cardiovascular effect of niacin, but was activated only if niacin levels in the blood were 1,000 times normal levels. That got the German res...e of colon cancer patients who eat a high fiber diet or receive butyrate or niacin therapy along with taking DNA methylation inhibitors that keep GPR109A open...

ConsumerLab.com Warns of Problems with Mulitivitamins and Vitamin Water

...ine for ingredients such as vitamin A, folic acid, niacin and zinc. Results were reported today on the websi...lead to bone softening and liver problems. ULs for niacin and zinc were also exceeded by some of the products for young children. Excess niacin may cause skin tingling and flushing and high leve...

High Blood Fat Levels Common in Americans

...ed, with 2.6 percent of those in the borderline high group and 3.6 percent of those in the 200-and-higher group taking them. The drugs -- gembifrozil, niacin and fenofibrate --are also prescribed to raise levels of HDL cholesterol, the "good" kind that helps prevent artery blockage. That may be just as w...

Breakthrough Solution Found in Refresh Skin Care Products

...eye creams on the market only address wrinkles, EpiLight Eye Cream inhibits pigment formation through two key active ingredients: Licorice Extract and niacin (Nicatinimide). EpiLight Eye Cream minimizes dark tones within three days of application and produces major results within six weeks. It's also safe -...

Synthetic HDL: A new weapon to fight cholesterol problems

...sterol, LDL, are available, and you can lower LDL through your diet, but it is difficult to raise the good cholesterol, HDL," said Mirkin. "I've taken niacin to try and raise my HDL, but the side effects are bad so I stopped. We are hopeful that our synthetic HDL will one day help fill this gap in useful th...

Niacin in Medical Technology

July 2009 Mayo Clinic Women's HealthSource Highlights Food Storage Safety, Energy Therapies and Vitamins and Minerals

...indings include: Vitamin B-3 (niacin): niacin helps the body convert food to energy and helps im...evels. Researchers have found that, in high doses, niacin can reduce low-density lipoprotein (LDL or "bad" c...mg) per day, can cause liver damage. High doses of niacin should be considered a prescribed medication and t...

King Pharmaceuticals Showcases Data From Pain Pipeline of Medicines Designed to Deter Common Methods of Non-Therapeutic Use

... unique composition of short-acting oxycodone HCl, niacin and functional inactive ingredients intended to re... , Safety and Tolerability of Escalating Doses of niacin in Fasted and Fed Healthy Adult Volunteers ACU...e HCl, niacin, and other inactive ingredients. The niacin ingredient can generate a temporary, but increasin...

New Analysis of METEOR Study Demonstrate Effects of AstraZeneca's CRESTOR(R) (Rosuvastatin Calcium) on Atherosclerosis in Patients With Two or More Risk Factors for Cardiovascular Disease

... the patient's individualized goal of therapy. The benefit of further alterations in lipid levels by the combined use of rosuvastatin with fibrates or niacin should be carefully weighed against the potential risks of this combination. Combination therapy with rosuvastatin and gemfibrozil should generally be...

New Data Examines the Effect of Adding a Statin to Optimized Treatment for Patients with Advanced Heart Failure

... the patient's individualized goal of therapy. The benefit of further alterations in lipid levels by the combined use of rosuvastatin with fibrates or niacin should be carefully weighed against the potential risks of this combination. Combination therapy with rosuvastatin and gemfibrozil should generally be...

Isis Pharmaceuticals Updates Its Positive Phase 2 Data for ISIS 301012 in Familial Hypercholesterolemia Patients

... 3.75 g 40 mg lowering 80 mg colesevelam + rosuvastatin + Therapies atorvastatin 1 g niacin 10 mg ezetimibe Age (years) 23 48 32 Lipids: Base- Day % Base- Day % ...

Niacin in Medical Dictionary

Niacin

Niacin , also known as vitamin B3 or nicotinic acid, is a water-soluble vitamin that prevents the deficiency disease pellagra. It is an organic compound with the molecular formula C6H5NO2. It is a derivative of pyridine, with... Niacin (nicotinic acid) is used to to lower choleste...

Vitamin B

...nd Facts ... B1 is the most unstable of the Vitamin B complex. ... High quality Vitamin B can be purchased from Global Herbal Supplies ... niacin ( Vitamin B-3): Reference Guide For Vitamins, Minerals, Herbs. Health Products Information. Read about Alternative Health. Recognize and solve v...

Pellagra

...vitamin deficiency disease caused by lack of niacin (vitamin B3). It can be caused by decreased intak... caused by a ... Pellagra occurs when levels of niacin and tryptophan are low or when conversion ... ...isease caused by lack of the B complex vitamin niacin ... However, there are two types of pellagra . ....

Hypervitaminosis A

..... Vitamin A Toxicity ( Hypervitaminosis A ) Vitamin B1 Deficiency (Beriberi) ... Vitamin D Toxicity ( Hypervitaminosis D) Vitamin Deficiency - niacin (Pellagra) Vitiligo ... Hypervitaminosis A (Vitamin A Toxicity) information center covers Diagnosis & Tests. ... Hypervitaminosis A Ov...

HDL

...can describe the circuit's operation, its... A high HDL cholesterol level helps fight heart disease. Here's how to raise your HDL . ... niacin to boost your HDL , 'good,' cholesterol ... HDL cholesterol, or "good" cholesterol, appears to scour the walls of blood ... HDL levels be...

Niacin in Biological News

Niacin's role in maintaining good cholesterol

...A research team has uncovered the likely target of niacin (vitamin B3) in the liver, which should provide a ...and thus lower the risk of heart disease. While niacin can increase plasma HDL levels, the mechanism of h...s has been mysterious, although it's believed that niacin does not actually increase HDL production. Recent ...

Misusing vitamin to foil drug test may be toxic; plus, it doesn't work

... The Children's Hospital of Philadelphia. "Because niacin is known to affect metabolic processes, there is a...dy of drugs such as cannabis and cocaine. However, niacin is toxic when taken in large amounts." niacin is easily available as an over-the-counter vitamin...

Niacin in Biological Technology

Arena Pharmaceuticals Announces Initiation of Phase 1 Clinical Trial of Second Generation Niacin Receptor Agonist Under Its Collaboration With Merck & Co., Inc.

SAN DIEGO, Jan. 25 /PRNewswire-FirstCall/ -- Arena Pharmaceuticals, Inc. (Nasdaq: ARNA ) announced today that Merck & Co., Inc. initiated a Phase 1 clinical trial of a second generation oral niacin receptor agonist under a collaboration between the companies to discover drugs for the treatmen...

Arena Pharmaceuticals Announces First Quarter 2009 Financial Results

... of a positive randomized, double-blind, placebo-controlled Phase 1 program and the initiation of a Phase 2 clinical trial of a second generation oral niacin receptor agonist intended for the treatment of atherosclerosis in Arena's partnership with Merck. Scheduled Earnings Call ...

Innovative Beverage Products Launches New Product Designed to Enhance the Body's Immune Defense

...age include: -- Green tea extract / polyphenols -- Grape seed extract / grape skin extract -- Mushroom extract -- Vitamin C -- niacin / Vitamin B12 -- Vitamin B6 -- Folate -- Zinc -- Sodium "In our research we found consumers were looking for a convenient, gr...

Arena Pharmaceuticals Announces First Quarter 2008 Financial Results

... group did not meet the ESMB's predetermined stopping criteria. o Announced the initiation of a Phase 1 clinical trial of a second generation oral niacin receptor agonist intended for the treatment of atherosclerosis in partnership with Merck & Co., Inc. o Entered into strategic agreements with Sieg...

Abbott Annual Meeting Highlights Outstanding 2007 Results, International Growth and Near-Term Pipeline

...itis in patients with inadequate response to conventional therapy. -- SIMCOR(R), a fixed-dose combination of Niaspan(R) (Abbott's proprietary niacin extended-release) and simvastatin that targets both "good" and "bad" cholesterol in a single pill, was also approved by the FDA in the first q...

Arena Pharmaceuticals Announces Fourth Quarter and Full Year 2007 Financial Results

...s in the United States. Arena's 2008 Highlights to Date -- Announced the initiation of a Phase 1 clinical trial of a second generation oral niacin receptor agonist intended for the treatment of atherosclerosis under Arena's partnership with Merck. -- Entered into strategic cooperation agr...

Abbott Receives FDA Approval for SIMCOR(R) (Niaspan(R) / simvastatin), a Novel Combination Medicine for Comprehensive Cholesterol Management

...sterol therapies, Niaspan(R) (Abbott's proprietary niacin extended-release) and simvastatin. SIMCOR is appro.... The study is designed to evaluate the effects of niacin extended- release and simvastatin in reducing card...sed when treatment with simvastatin monotherapy or niacin extended-release monotherapy is considered inadequ...

Niacin in Biological Definition

Nicotinamide adenine dinucleotide

... charged nitrogen, and one hydrogen attaches to the carbon atom opposite to the nitrogen. The human body synthesises NAD from the vitamin niacin in the form of nicotinic acid or nicotinamide. See also Adenine Nucleotide References and external links NAD and NAD...

Nicotinamide adenine dinucleotide

... charged nitrogen, and one hydrogen attaches to the carbon atom opposite to the nitrogen. The human body synthesises NAD from the vitamin niacin in the form of nicotinic acid or nicotinamide. See also Adenine Nucleotide References and external links NAD and NAD...

Nicotinamide adenine dinucleotide

... charged nitrogen, and one hydrogen attaches to the carbon atom opposite to the nitrogen. The human body synthesises NAD from the vitamin niacin in the form of nicotinic acid or nicotinamide. See also Adenine Nucleotide References and external links NAD and NAD...

Vitamin

...known as Vitamin B 7 or Vitamin H . Folate Water Discovered by Lucy Wills in 1933 . Also known as Folic Acid or Vitamin M niacin Water Discovered by Conrad Elvehjem in 1937 . Deficiency causes pellagra . Also known as Vitamin B 3 , Vitamin P or Vitamin PP (for pre...