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Neutropenia in Medical News

Scientists identify new congenital neutropenia syndrome and causative gene mutation

A team of scientists has discovered a new syndrome associated with severe congenital neutropenia (SCN), a rare disorder in which children lack sufficient infection-fighting white cells, and identified the genetic cause of the syndrome: mutations in the gene Glucose-6-phosphatase, catalytic subunit...

Function of molecular switch pinpointed in severe congenital neutropenia

CINCINNATI Researchers have for the first time cleared an important hurdle to clarifying the molecular mechanics behind Severe Congenital Neutropenia (SCN), a deadly disease characterized by a deficiency of neutrophils a type of mature white blood cell important to fighting infection and disease...

Centocor Ortho Biotech Statement on the FDA ODAC Opinion Regarding DOXIL(R) for Treatment of Advanced Breast Cancer

...t, absolute neutrophil count, hemoglobin level, or neutropenia with fever) may require dose reduction, delay in a..., or hemorrhage Sepsis occurring during neutropenia has resulted in discontinuation of treatment and i... 5 percent (DOXIL vs topotecan, respectively) were neutropenia (12 percent vs 76 percent) and anemia (6 percent v...

Cell Therapeutics Completes Pixantrone NDA Submission and Requests Priority Review

... The most common grade 3/4 adverse event observed on the pixantrone arm was neutropenia in 41.2% of patients versus 19.4% on the comparator arm. However, the incidence of grade 3/4 febrile neutropenia was only 7.4% versus 3.0% in the comparator arm. Grade 3/4 infections had a...

Favorable Vote From FDA Advisory Committee on SEROQUEL Pediatric Supplemental New Drug Applications

...s of therapy. In these patients, SEROQUEL should be discontinued at the first sign of a decline in WBC absent other causative factors. Patients with neutropenia should be carefully monitored, and SEROQUEL should be discontinued in any patient if the absolute neutrophil count is 1000/mm3. Tardive dyskin...

New survey highlights growing concern about risk of infection in cancer patients

...g. Each year, 60,000 cancer patients are hospitalized for chemotherapy-induced neutropenia, and a patient dies every two hours from this complication. neutropenia also can potentially disrupt chemotherapy treatment, including both dose delays and dose reductions. Studies show that for certain types of cancer, ch...

Poniard Pharmaceuticals Announces Positive Efficacy and Safety Data From Phase 2 Clinical Trial of Picoplatin in Men With Metastatic Prostate Cancer

...literature report evidence of neuropathy in 30 percent of patients, including severe neuropathy (Grade 3/4) in almost 2 percent of patients.i neutropenia was the main hematologic toxicity. In contrast with picoplatin monotherapy in previous studies, thrombocytopenia was less severe and less frequent wit...

New Survey Highlights Growing Concern About Risk of Infection in Cancer Patients and Emerging Antibiotic Resistance

...g. Each year, 60,000 cancer patients are hospitalized for chemotherapy-induced neutropenia, and a patient dies every two hours from this complication. neutropenia also can potentially disrupt chemotherapy treatment, including both dose delays and dose reductions. Studies show that for certain types of cancer, ch...

New Data Demonstrate RISPERDAL(R) CONSTA(R) (Risperidone) Long-Acting Treatment May Improve Health Outcomes and Reduce Hospitalizations in Patients with Schizophrenia

...ld be used with caution in patients with known cardiovascular disease, and conditions that would predispose patients to hypotension. Leukopenia, neutropenia and Agranulocytosis have been reported with antipsychotics, including risperidone. Patients with a pre-existing low white blood cell count (WBC) or ...

FDA Grants Approval for Use of RISPERDAL(R) CONSTA(R) as Both a Monotherapy and Adjunctive Therapy in the Maintenance Treatment of Bipolar I Disorder

... be used with caution in patients with known cardiovascular disease, and conditions that would predispose patients to hypotension. Leukopenia, neutropenia and Agranulocytosis have been reported with antipsychotics, including risperidone. Patients with a pre-existing low white blood cell count (WBC) or ...
Neutropenia in Medical Technology

OPAXIO(TM) Combined with Alimta(R) Well Tolerated in Dose-Ranging Study of Patients with Advanced Non-Small Cell Lung Cancer

...exed. None of the patients in cohort one had an initial dose-limiting toxicity (IDLT) with two cycles of therapy. There was one IDLT of infection with neutropenia in cohort two. Aside from grade 3 fatigue in two patients, there were no grade 3 or greater nonhematologic toxicities. A median of 4.5 cycles was deli...

R788 in TASKi3 Clinical Trial Does Not Meet Efficacy Endpoints in RA Patients Who Had Previously Failed Biologic Therapies - Results Incongruent

... Had a Dose Reduction 2 3% 21 14% ---------------------- --- --- --- --- neutropenia (ANC less than 1500) 0 0% 3 2% -------------------------------- --- --- --- --- Diarrhea, ...

FDA Accepts sNDA for Alternative Dosing Regimen for Dacogen(R) (decitabine for injection) to Treat Patients with Myelodysplastic Syndromes (MDS)

...ther a child while receiving treatment with Dacogen and for two months afterwards. The most commonly occurring adverse reactions with Dacogen include neutropenia (90 percent), thrombocytopenia (89 percent), anemia (82 percent), pyrexia (53 percent), fatigue (48 percent), nausea (42 percent), cough (40 percent),...

Responses After Completion of Therapy Increase Pixantrone Complete Remission (CR)/Unconfirmed Complete Remission (CRu) Rate to 24% and Overall Response Rate (ORR) to 40% Compared to 7% and 14% for Comparator Agents in Phase III EXTEND Trial in 3rd Line Th

...The most common grade 3, 4 adverse event observed on the pixantrone arm was neutropenia in 41.2% of patients versus 19.4% on the comparator arm. However, the incidence of grade 3, 4 febrile neutropenia was only 7.4% versus 3.0% in the comparator arm. Grade 3, 4 infections had...

Afinitor(R) Phase II Data Show Positive Results for Patients With Multiple Types of Lymphoma, Leading to Phase III Trial

... was well tolerated. The most commonly reported adverse events (grade 3 or 4; >10% patients) in this heavily pretreated population included anemia, neutropenia and thrombocytopenia(1). About non-Hodgkin's lymphoma and Hodgkin's disease Non-Hodgkin's lymphoma and Hodgkin's disease manifest in the ...

Pixantrone in Combination with Chemotherapy Regimens Produces Overall Response Rates of 58-74% with Complete Remission Rates of 37-57% in Relapsed/Refractory Aggressive or Indolent NHL

...y regimens produced encouragingly high rates of overall response (58-74%) including high rates of complete responses (37-57%). As previously reported, neutropenia was the dose limiting toxicity when used as a single agent. "In both preclinical and early clinical studies pixantrone exhibited lower cardiac t...

Investigational Cancer Drug BSI-201 Showed Clinical Benefit in 62% of Patients with Triple-Negative Metastatic Breast Cancer and Significantly Prolonged Survival

...ts included neutropenia [25/57 in patients treated with GC and BSI-201; 31/59 patients treated with GC alone], thrombocytopenia and anemia. No febrile neutropenia was observed in patients receiving BSI-201 combined with chemotherapy. BSI-201 did not add to the frequency or severity of adverse events associated w...

CuraGen Updates CR011-vcMMAE Data at ASCO

...pecia, and pruritus were the most common toxicities in this study. Other adverse events included fatigue, diarrhea, anorexia and nausea. Grade 3 or 4 neutropenia was observed in 5 patients. The absence of rash in the first cycle of treatment predicted a worse PFS. Additionally, in a subset of patients with tum...

Pixantrone Produces High Rates of Complete and Partial Remissions Even Among Aggressive NHL Patients With Extensive Prior Doxorubicin Treatment or Prior Rituximab Treatment

...The most common grade 3, 4 adverse event observed on the pixantrone arm was neutropenia in 41.2% of patients versus 19.4% on the comparator arm. However, the incidence of grade 3, 4 febrile neutropenia was only 7.4% versus 3.0% in the comparator arm. Grade 3, 4 infections had...

Study Showed Lilly's GEMZAR(R) (gemcitabine HCl for injection) Improved Progression-Free Survival in Cervical Cancer Patients

...d due to causes possibly attributed to treatment-related toxicities. Most side effects were hematologic, including anemia (low red blood cell count), neutropenia (low white blood cell count) and thrombocytopenia (low blood platelet count). "While there have been tremendous advances in cervical cancer pre...
Neutropenia in Medical Definition

Hematopathology

...asmacytoma ) Myeloid : Myeloid leukemia ( AML , CML ) • MPD Ph- ( Essential thrombocytosis , Polycythemia vera , Myelofibrosis ) • MDS • neutropenia Red blood cells / anemia / hemoglobinopathy Nutritional anemia: ( Iron deficiency anemia , Plummer-Vinson syndrome , Pernicious anemia ...

Pathology

...asmacytoma ) Myeloid : Myeloid leukemia ( AML , CML ) • MPD Ph- ( Essential thrombocytosis , Polycythemia vera , Myelofibrosis ) • MDS • neutropenia Red blood cells / anemia / hemoglobinopathy Nutritional anemia: ( Iron deficiency anemia , Plummer-Vinson syndrome , Pernicious anemia ...
Neutropenia in Medical Dictionary

Neutropenia

Neutropenia , from Latin prefix neutro- and Greek suffix -πενία (deficiency) is a hematological disorder characterized by an abnormally low number of a type of white blood cell called a neutrophil. Neutrophils usually make up... Increasing the understanding of neutropenia by providing ...

Monocyte

...tion of bacteria ... What does a low monocyte number indicate? ... Monocyte Count, Monocyte , Macrophage ... Monocyte Count. Neutropenia. neutropenia Causes. Neutrophil ... Monocytes move into tissue and become macrophages ... The IL1A gene is also known by other names, listed below. ... ...

Leukopenia

... to a decrease in the number of circulating ... The terms leukopenia and neutropenia may occasionally be used interchangeably, ... Anemia, Thrombocytopenia...formation about leukopenia in the free online English dictionary and ... neutropenia - leukopenia in which the decrease is primarily in number of ... Pat...

Intravenous

... is most ... Vidal L, Ben dor I, Paul M, Pokroy E, Soares-Weiser K, Leibovici L. Oral versus intravenous antibiotic treatment for febrile neutropenia in cancer patients. ... Information about intravenous in the free online English ... Evidence for intravenous antibiotic therapy in the c...

Agranulocytosis

... Agranulocytosis is an acute condition involving a severe and dangerous leukopenia, particularly of neutrophils, causing a neutropenia in the circulating blood. agranulocytosis n. An acute disease marked by high fever and a sharp drop in circulating ... drugs is known to ...
Neutropenia in Biological News

New potential therapeutic target discovered for genetic disorder -- Barth syndrome

...m which help fight infections. The various symptoms of BTHS, in addition to cardiolipin deficiency, include cardiomyopathy (weakness in heart muscle), neutropenia (a reduction in neutrophils or white blood cells that fight bacterial infections), muscle weakness & fatigue (caused by cellular deficiency), growth d...

Eribulin mesylate demonstrated anti-tumor activity in patients with advanced breast cancer

... neuropathy were included in the study. The most frequently reported Grade 3 (severe) or Grade 4 (disabling or life- threatening) adverse events were neutropenia (a decrease in the number of granular white blood cells, 54%); febrile neutropenia, 5.5%, leukopenia (low white blood cell count, 14%), and weakness/f...

UNC study questions FDA genetic-screening guidelines for cancer drug

...rs analyzed data from nine previous studies of irinotecan. They found that patients who received a medium or high dose of the drug had greater risk of neutropenia if they had two copies of a variation of the gene UGT1A1, known as UGT1A1*28. At lower doses, however, the risk was the same regardless of what UGT1A1...

Eisai announces Phase II data on E7389, a potential new therapy for the treatment of breast cancer

...ry response rate (15%) appears promising. Based on the preliminary results of this study, the predominant serious side effect related to E7389 was neutropenia (low white blood cell counts). Other side effects were considered mild to moderate and included nausea, fatigue, dehydration, arthralgias, dyspnea an...
Neutropenia in Biological Technology

Pixantrone Significantly Increases Complete Remissions, Overall Response Rates, Frequency of Durable Remissions and Progression Free Survival in Patients with Relapsed and Refractory Aggressive Non-Hodgkin's Lymphoma

...The most common grade 3, 4 adverse event observed on the pixantrone arm was neutropenia in 41.2% of patients versus 19.4% on the comparator arm. However, the incidence of grade 3, 4 febrile neutropenia was only 7.4% versus 3.0% in the comparator arm. Grade 3, 4 infections had ...

Centocor Ortho Biotech Data to be Presented at American Society of Clinical Oncology (ASCO) Annual Meeting

...t, absolute neutrophil count, hemoglobin level, or neutropenia with fever) may require dose reduction, delay in a...or hemorrhage Sepsis occurring during neutropenia has resulted in discontinuation of treatment and i... in >5% (DOXIL vs topotecan, respectively) were neutropenia (12% vs 76%) and anemia (6% vs 29%) ...

Low Occurrence of Severe Cardiac Side Effects Despite Extensive Prior Doxorubicin Treatment Reported in Pixantrone Pivotal Trial

...) with no patients in the standard chemotherapy arm achieving a confirmed complete remission. Pixantrone recipients had a low incidence of severe neutropenia complicated by either fever or documented infections, or severe vomiting or diarrhea. Pixantrone patients also experienced a low incidence of hair los...

Vanda Pharmaceuticals to Present Data on Fanapt(TM) and Tasimelteon at the 162nd American Psychiatric Association Annual Meeting

...c malignant syndrome; tardive dyskinesia; hyperglycemia and diabetes mellitus; weight gain; seizures; orthostatic hypotension and syncope; leukopenia, neutropenia and agranulocytosis; hyperprolactinemia; body temperature regulation; dysphagia; suicide; priapism; potential for cognitive and motor impairment. ...

Poniard Pharmaceuticals Presents Final Results of Phase 1 Study of Picoplatin in Patients with Metastatic Colorectal Cancer

...icity) or ototoxicity (hearing toxicity). The dose limiting toxicities for both the every-four-week regimen and the every-two-week regimen were neutropenia and thrombocytopenia, which were reversible. The maximum tolerated dose of picoplatin in the every-four-week FOLPI schedule was 150 mg/m squared. 150...

Poniard Pharmaceuticals Announces New Efficacy and Safety Data from a Phase 2 Picoplatin Trial in Patients with Prostate Cancer

...12 percent in patients treated with docetaxel alone. These data indicate that picoplatin can be safely administered with full-dose docetaxel. neutropenia was the main hematologic toxicity. Thrombocytopenia was less severe and less frequent with picoplatin administered in combination with docetaxel compa...

Poniard Pharmaceuticals Announces Positive Tumor Response and Neuropathy Data from Phase 2 Clinical Trial of Picoplatin in Metastatic Colorectal Cancer

...ed patients. Nonhematologic adverse events, including acute gastrointestinal toxicity, were similar between the treatment groups. Thrombocytopenia and neutropenia were more frequent and severe with the FOLPI regimen, but manageable. Anti-tumor activity also was similar in the FOLPI and FOLFOX groups. Of pat...

Sunesis Pharmaceuticals Provides Year-End Clinical Update on Voreloxin

...s generally well-tolerated at 48 and 60 mg/m2, with an incidence of febrile neutropenia of below 10%. An increase in febrile neutropenia is observed at 75 mg/m2, although the incidence remains below 20%. ...

FDA Accepts Cell Therapeutics' Zevalin sBLA and Grants Priority Review

...rable to that seen with Zevalin's use in approved indications. Zevalin-treated patients had reversible Grade 3 or 4 hematologic side effects including neutropenia in 67 percent, thrombocytopenia in 61 percent, and anemia in 3 percent of patients. Nonhematologic toxicities were 24 percent Grade 3, 5 percent Grade...

Poniard Announces Positive Incremental Efficacy and Safety Data from Phase 2 Picoplatin Trial in Patients With Metastatic Colorectal Cancer

...c tolerability was similar between the two treatment groups. Acute gastrointestinal toxicity was similar in the two groups, while thrombocytopenia and neutropenia were more frequent and severe in the FOLPI- treated patients, but considered to be manageable. These findings confirm and extend earlier results prese...
Neutropenia in Biological Definition

Colchicine

...e treatment of gout and also for familial Mediterranean fever , amyloidosis , and scleroderma . Side-effects include gastro-intestinal upset and neutropenia . Starting the drug early during an attack of gout can exacerbate the symptoms. High doses can also damage bone marrow and lead to anemia . It's no...
Neutropenia in Biological Dictionary

Neutrophils

...e at the sites of infection and ... Read about neutropenia, a condition of an abnormally low number of neutrophils (white blood cells). Causes of neutropenia include infections, medications, vitamin ... Lifestyle, fitness & health information about Neutrophils . ... extreme -- just a little anem...

Granulocyte

...locyte mean? ... granulocyte /gran·u·lo·cyte/ (gran'u-lo-sīt ... Granulocyte ... Granulocyte autoantibodies are the main cause of autoimmune neutropenia (AIN).1 ... Serum granulocyte colony-stimulating factor levels are not increased in patients ... Eosinophil Granulocyte . Extraglomerular Mesang...
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