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neutralizing in Medical News

Scripps Research Institute and IAVI launch world's first dedicated HIV neutralizing antibody center

LA JOLLA, CA, and NEW YORK, NY, September 30, 2008 The Scripps Research Institute, one of the world's largest independent, non-profit biomedical research organizations, and the International AIDS Vaccine Initiative (IAVI), the world's only global non-profit organization focused solely on AIDS vac...

Micromet, Inc. Reports Second Quarter 2009 Financial Results

...3, is licensed to TRACON Pharmaceuticals, Inc., and is in a phase 1 clinical trial for the treatment of patients with cancer. MT203, a human antibody neutralizing the activity of granulocyte/macrophage colony stimulating factor (GM-CSF), which has potential applications in the treatment of various inflammatory a...

Bayer HealthCare Awards $2.5 Million to Advance Hemophilia Research and Improve Patient Care

...System, Los Angeles, Calif., will address this issue by investigating why black hemophilia A patients are twice as likely as white patients to develop neutralizing antibodies (inhibitors) against replacement Factor VIII proteins. In another study, Early Career Investigator Award recipient Michael P. Horn, Ph.D., ...

New Survey Reveals High Expectations for Popular Aesthetic Injections

...cy with four repeat treatments (proving results following each treatment) Demonstrated safety with 12 repeat treatments No evidence of neutralizing antibodies Clinical trials included both subjects who have and have not previously been treated with a Botulinum Toxin. There was no differen...

Phase 1 Study Initiated with Micromet Anti-GM-CS Human Antibody MT203

...3, is licensed to TRACON Pharmaceuticals, Inc., and is in a phase 1 clinical trial for the treatment of patients with cancer. MT203, a human antibody neutralizing the activity of granulocyte/macrophage colony stimulating factor (GM-CSF), which has potential applications in the treatment of various inflammatory a...

NIAID media availability: New strategy proposed for designing antibody-based HIV vaccine

...vaccine could prime the body to make these broadly neutralizing antibodies before exposure to HIV, they could pote...ch strategy that uses naturally occurring, broadly neutralizing anti-HIV antibodies for the ultimate design of an ...f this strategy include Obtaining new broadly neutralizing antibodies to HIV to expand the pool available for...

Sun Shower(TM) All Natural Super Blends Now 'Light 'N Healthy'

...TM) Protection nutritional package which includes: Vitamin A (Antioxidant) - A powerful vitamin which helps protect your cells by neutralizing free radicals. Vitamin E ( Antioxidant) - Aids your immune system and helps with the formation of red blood cells. Zinc ( A...

Nektar Announces UCB's Cimzia(R) Approved by U.S. FDA for Adult Patients Suffering From Moderate to Severe Rheumatoid Arthritis

... About Cimzia(R) Cimzia(R) is the only PEGylated anti-TNF (Tumor Necrosis Factor). Cimzia(R) has a high affinity for human TNF-alpha, selectively neutralizing the pathophysiological effects of TNF-alpha. Over the past decade, TNF-alpha has emerged as a major target of basic research and clinical investigatio...

Introducing COPPERTONE(R) NutraShield(R) With Dual Defense(R), New Sunscreen Line With Antioxidants To Help Promote Natural Skin Repair

...s COPPERTONE (R) , NutraShield (R) with Dual Defense (R) , a new line of sunscreens enriched with antioxidants to help promote natural skin repair by neutralizing harmful free radicals created by UV exposure. (Photo: http://www.newscom.com/cgi-bin/prnh/20090514/NY16746 ) Topical antioxidants c...

UCB's CIMZIA(R) (certolizumab pegol) Approved by the U.S. FDA for Adult Patients Suffering From Moderate to Severe Rheumatoid Arthritis

...(R) Cimzia (R) is the only PEGylated anti-TNF (Tumor Necrosis Factor). Cimzia (R) has a high affinity for human TNF-alpha, selectively neutralizing the pathophysiological effects of TNF-alpha. Over the past decade, TNF-alpha has emerged as a major target of basic research and clinical investigatio...
neutralizing in Medical Technology

SARS Vaccine Achieves Neutralizing Responses in First U.S. Human Trial

SAN DIEGO, Dec. 9 /PRNewswire-FirstCall/ -- Vical Incorporated (Nasdaq: VICL ) today announced that results from a Phase I clinical trial of a DNA vaccine for severe acute respiratory syndrome (SARS), conducted by the National Institutes of Health (NIH) and published in the November 25 issue of ...

CERVARIX(R) Shown to Provide Longest Duration of Sustained Neutralizing Antibodies to Date

Believed by experts to be important for cervical cancer prevention GRAZ, Austria, May 14 /PRNewswire-FirstCall/ -- New data from an extended follow-up study show that GlaxoSmithKline (NYSE: GSK ) cervical cancer candidate vaccine, CERVARIX(R) generates sustained high levels of neutralizing...

Large Study Shows that Presence of Neutralizing Antibodies Did Not Predict Clinical Response to Betaseron Treatment

WAYNE, N.J., April 02, 2007 /PRNewswire/ -- Berlex, Inc., a U.S. affiliate of Bayer Schering Pharma AG, Germany, announced today the results of a retrospective study demonstrating that the presence of neutralizing antibodies (NAbs) that can develop in response to Betaseron(R) (interferon beta-1b) ...

Micromet's Blinatumomab Achieves Primary Endpoint in Phase 2 Study with Acute Lymphoblastic Leukemia Patients

...h cancer. In addition, Micromet has established a collaboration with Nycomed for the development and commercialization of MT203, a human antibody neutralizing the activity of granulocyte/macrophage colony stimulating factor (GM-CSF), which has potential applications in the treatment of various inflammatory a...

Micromet Presents Update on Blinatumomab's Response Rate and Duration in a Phase 1 Study in Non-Hodgkin's Lymphoma Patients

...h cancer. In addition, Micromet has established a collaboration with Nycomed for the development and commercialization of MT203, a human antibody neutralizing the activity of granulocyte/macrophage colony stimulating factor (GM-CSF), which has potential applications in the treatment of various inflammatory a...

PharmAthene Submits Proposal to BARDA in Response to Broad Agency Announcement for Advanced Research and Development for Valortim(R)

.... Pharmacokinetic analysis suggested that doses as low as 1 mg/kg resulted in circulating levels of antibody after a month, with a similar potency for neutralizing anthrax toxin in vitro as was seen with serum obtained from subjects who had been vaccinated with anthrax vaccine. Anti-toxins such as Valortim(R...

Novel Vaccine Approach Offers Hope in Fight Against HIV

...hool of Medicine. Johnson also is on the University of Pennsylvania faculty. Johnson et al, "Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys," Nature Medicine , published online May 17, 2009. ( http://dx.doi.org/10.1038/nm.1967 )...

Micromet Presents Update on BiTE Antibody Pipeline and Reviews Key AACR Presentations at R&D Day

...nts with cancer. The Company's preclinical programs include MT203 being developed in collaboration with Nycomed. MT203 is a traditional human antibody neutralizing the activity of granulocyte/macrophage colony stimulating factor (GM-CSF), which has potential applications in the treatment of inflammatory and autoi...

Micromet Presents Preclinical Data Showing Activity of Erbitux and Vectibix Based BiTE Antibodies against KRAS- and BRAF-mutated Human Colorectal Cancer Cells

...nts with cancer. The Company's preclinical programs include MT203 being developed in collaboration with Nycomed. MT203 is a traditional human antibody neutralizing the activity of granulocyte/macrophage colony stimulating factor (GM-CSF), which has potential applications in the treatment of inflammatory and autoi...

Micromet Receives Milestone Payment for Filing of the First Clinical Trial Application for MT203

...aceuticals, Inc. MT293 is being developed in a phase 1 clinical trial for the treatment of patients with cancer. MT203 is a traditional human antibody neutralizing the activity of granulocyte/macrophage colony stimulating factor (GM-CSF), which has potential applications in the treatment of inflammatory and autoi...
neutralizing in Medical Products

Varicella Zoster Virus (VZV) IgG EIA

Description:...of contact between susceptible individuals and those with active infection. Antibodies to varicella-zoster have been detected by CF, immunodiffusion, neutralizing antibody, or fluorescent antibody techniques, including the fluorescent-antibody-membrane-antigen (FAMA) assay. The FAMA assay has proven to be very ...
Company:Bio-Rad Laboratories

OFP400 Oil-Free Vacuum Pump

Description:...rganic solvents Small compact footprint Easily connects to any SpeedVac system Comes complete with ANT100 Post Trap for adding trapping and neutralizing solutions ...
Company:ThermoFisher Scientific
neutralizing in Biological News

Human trial proves ricin vaccine safe, induces neutralizing antibodies; further tests planned

Scientists have completed the first human clinical trial of a recombinant vaccine for the deadly toxin ricin ?a potential bioterror threat ?and the results indicate the vaccine is safe and effective in eliciting ricin-neutralizing antibodies, the UT Southwestern Medical Center researchers report. ...

First human gets new antibody aimed at hepatitis C virus

...have little or no side-effects, additional dosages of the new antibody could, theoretically, be given immediately after transplant surgery to continue neutralizing any remaining virus. It is also possible, researchers theorize, that the antibody could be used in combination with new antiviral drugs for treatme...

Penn-Wistar team gains insight into HIV vaccine failure

...ticipants who had previous immunity in the form of neutralizing antibodies to the adenovirus 5 (Ad5) vector used t...hese individuals were found to have high blood Ad5 neutralizing antibody (nAb) titers, the main immune gatekeeper .... "There was nothing to indicate that pre-existing neutralizing antibodies correlated with numbers of activated CD...

Princeton team's analysis of flu virus could lead to better vaccines

...ks a human, the body mounts a defense, producing antibodies custom-designed to attach themselves to the virus, blocking it from action and effectively neutralizing its harmful effects on the body. Analyzing data about viral structure, antibody types and the reactions between them produced by virology laborato...

Hebrew University researchers neutralize tumor growth in embryonic stem cell therapy

...re normal tissues. The survivin gene is especially highly expressed in undifferentiated human embryonic stem cells and in their derived tumors. By neutralizing the activity of survivin in the undifferentiated cells as well as in the tumors, the researchers were able to initiate programmed cell death (apoptosi...

Novel antibody prevents infection by hepatitis C virus

...have little or no side-effects, additional dosages of the new antibody could, theoretically, be given immediately after transplant surgery to continue neutralizing any remaining virus. It is also possible, researchers theorize, that the antibody could be used in combination with new antiviral drugs for treatm...

Caltech scientists show why anti-HIV antibodies are ineffective at blocking infection

...en so elusive." Y-shaped antibodies are best at neutralizing viruses--i.e., blocking their entry into cells and...ersions of the b12 antibody were less effective at neutralizing HIV than two-armed versions. When they looked at t...ral anti-HIV antibodies are much less effective at neutralizing HIV than they should be. But why? "The story...

A natural approach for HIV vaccine

...ifferent antibodies that individually have limited neutralizing abilities but together are quite powerful," says N...ach targeted, and gauged how effective each was in neutralizing the virus. In the process, he identified a new str...hows that it's common for these antibodies to have neutralizing activity, says Nussenzweig. But each antibody alon...

Scientists identify human monoclonal antibodies effective against bird and seasonal flu viruses

...cells and the rise of escape mutants. "The head portion of hemaglutinin is highly mutable, leading to the rise of forms of the virus that can evade neutralizing antibodies," said Robert Liddington, Ph.D., professor and director, Infectious and Inflammatory Disease Center at Burnham and one of the investigators...

Scientists identify human monoclonal antibodies effective against bird, seasonal flu viruses

...cells and the rise of escape mutants. "The head portion of hemaglutinin is highly mutable, leading to the rise of forms of the virus that can evade neutralizing antibodies," said Robert Liddington, Ph.D., professor and director, Infectious and Inflammatory Disease Center at Burnham and one of the investigators...
neutralizing in Biological Technology

Micromet Closes $80.5 Million Public Offering of Common Stock

...3, is licensed to TRACON Pharmaceuticals, Inc., and is in a phase 1 clinical trial for the treatment of patients with cancer. MT203, a human antibody neutralizing the activity of granulocyte/macrophage colony stimulating factor (GM-CSF), which has potential applications in the treatment of various inflammatory a...

Micromet Receives European Orphan Drug Designation for Treatment of Acute Lymphoblastic Leukemia with BiTE Antibody Blinatumomab

...3, is licensed to TRACON Pharmaceuticals, Inc., and is in a phase 1 clinical trial for the treatment of patients with cancer. MT203, a human antibody neutralizing the activity of granulocyte/macrophage colony stimulating factor (GM-CSF), which has potential applications in the treatment of various inflammatory a...

Micromet Announces Pricing of Public Offering of Common Stock

...3, is licensed to TRACON Pharmaceuticals, Inc., and is in a phase 1 clinical trial for the treatment of patients with cancer. MT203, a human antibody neutralizing the activity of granulocyte/macrophage colony stimulating factor (GM-CSF), which has potential applications in the treatment of various inflammatory a...

Micromet Announces Public Offering of Common Stock

...3, is licensed to TRACON Pharmaceuticals, Inc., and is in a phase 1 clinical trial for the treatment of patients with cancer. MT203, a human antibody neutralizing the activity of granulocyte/macrophage colony stimulating factor (GM-CSF), which has potential applications in the treatment of various inflammatory a...

Micromet, Inc. to Host Conference Call and Webcast to Report Second Quarter 2009 Financial Results on August 6, 2009

...3, is licensed to TRACON Pharmaceuticals, Inc., and is in a phase 1 clinical trial for the treatment of patients with cancer. MT203, a human antibody neutralizing the activity of granulocyte/macrophage colony stimulating factor (GM-CSF), which has potential applications in the treatment of various inflammatory a...

Novavax Announces Selection of a Respiratory Syncytial Virus Vaccine Candidate for Advanced Preclinical Studies

...with and without adjuvant. The study showed that the RSV-F vaccine induced neutralizing antibody responses at all doses evaluated. The highest titers were observe...talizations for severe RSV disease, suggesting that a vaccine which induces neutralizing antibody against RSV-F has the potential to be a powerful weapon against th...

MacroGenics Announces the Initiation of a Phase 2 Clinical Trial to Evaluate the Safety and Efficacy of Monoclonal Antibody MGAWN1 in Subjects with Suspected Central Nervous System Infection Due to West Nile Virus

... About MGAWN1 MGAWN1 is a humanized monoclonal antibody that specifically recognizes the envelope (E) protein of WNV. MGAWN1 exhibits potent neutralizing and fusion-inhibitory activity against WNV in laboratory studies conducted in vitro and in vivo. MGAWN1 has a specific activity that is orders of magn...

Micromet Added to Russell 3000 Index

...3, is licensed to TRACON Pharmaceuticals, Inc., and is in a phase 1 clinical trial for the treatment of patients with cancer. MT203, a human antibody neutralizing the activity of granulocyte/macrophage colony stimulating factor (GM-CSF), which has potential applications in the treatment of various inflammatory a...

Micromet to Host Conference Call and Webcast to Discuss Blinatumomab Data Presented at EHA on June 8, 2009

...h cancer. In addition, Micromet has established a collaboration with Nycomed for the development and commercialization of MT203, a human antibody neutralizing the activity of granulocyte/macrophage colony stimulating factor (GM-CSF), which has potential applications in the treatment of various inflammatory a...

Micromet Presents Update at ASCO 2009 on a Phase 1b Combination Study of Adecatumumab and Docetaxel

...h cancer. In addition, Micromet has established a collaboration with Nycomed for the development and commercialization of MT203, a human antibody neutralizing the activity of granulocyte/macrophage colony stimulating factor (GM-CSF), which has potential applications in the treatment of various inflammatory a...
neutralizing in Biological Products

Rabbit Anti-Human IFN-Alpha / Beta R2 (IFNAR2) (CD118) Neutralizing Polyclonal Antibody, Unconjugated from PBL InterferonSource

Description: PAb to Hu-IFN-Alpha/Beta R2 [(IFNAR2) CD118], Rabbit Serum, neutralizing Binds to but does not neutralize human interferon alpha/beta receptor...
Company:PBL InterferonSource

Mouse resistin Neutralizing Peptide from ABR-Affinity BioReagents

Description: PEP-165 is an 18 amino acid synthetic peptide whose sequences are derived from mouse resistin protein. The sequence of this peptide is (amino to carboxy terminus): S(21) - S - M - P - L - C - P - I - D - E - A - I - D - K - K - I - K - Q - D - C(39). This peptide may be used for neutralization a...
Company:ABR-Affinity BioReagents

Human DFF Neutralizing Peptide from ABR-Affinity BioReagents

Description: Neutralizing synthetic peptide for OPA1-01009, OPEP-01009 is a 16 amino acid (amino acids 3-18) synthetic peptide whose sequence is from human DNA fragmentation factor (DFF). The sequence of this peptide is (amino to carboxy terminus): Q(3) - K - P - K - S - V - K - L - R - A - L - R - S - P - R -...
Company:ABR-Affinity BioReagents

Bovine rhodopsin Neutralizing Peptide from ABR-Affinity BioReagents

Description: PEP-174 is a 12 amino acid synthetic peptide whose sequence is derived from bovine rhodopsin protein. The sequence of this peptide is (amino to carboxy terminus): C - S(338) - K - T - E - T - S - Q - V - A - P - A(348). This peptide may be used for neutralization and control experiments with th...
Company:ABR-Affinity BioReagents

Rat SCAMP 5 Neutralizing Peptide from ABR-Affinity BioReagents

Description: PEP-152 is a 17 amino acid synthetic peptide whose sequence is from rat SCAMP 5. The sequence of this peptide is (amino to carboxy terminus): C - N(217) - Q - P - Q - T - Q - Y - S - A - T - P - N - Y - T - Y - S - N(233). This peptide may be used for neutralization and control experiments with...
Company:ABR-Affinity BioReagents

Rat SAP97 Neutralizing Peptide from ABR-Affinity BioReagents

Description: PEP-055 is a 20 amino acid synthetic peptide whose sequence corresponds to residues 115-133 of rat SAP97. The sequence of this peptide is (amino to carboxy terminus): V115 - L - P - S - E - R - I - S - P - Q - V - P - N - E - V - L - G - P - E133 (C) (The C-terminal cysteine has been added to fac...
Company:ABR-Affinity BioReagents

Rat rab 3D Neutralizing Peptide from ABR-Affinity BioReagents

Description: PEP-126 is an 18 amino acid synthetic peptide whose sequence corresponds to residues 1-18 from rat rab 3D. The sequence of this peptide is (amino to carboxy terminus): M(1) - A - S - A - S - E - P - P - A - S - P - R - D - A - A - D - Q - N(18). This peptide may be used for neutralization and co...
Company:ABR-Affinity BioReagents

Human and Mouse RAR Neutralizing Peptide from ABR-Affinity BioReagents

Description: PEP-005 is a synthetic peptide whose sequence is from the C-terminal end of the mouse retinoic acid receptor beta (RAR*). The 21 amino acid sequence extends from amino acids 429 to 448 of RAR*. The sequence of PEP-005 is (amino to carboxy terminus): C - P - S - V - S - P - S - S - V - E - N - S -...
Company:ABR-Affinity BioReagents

DNA120 OP SpeedVac System from Thermo Scientific

Description:...OP is specifically engineered for efficient drying down of synthetic oligos. Its sturdy design incorporates a glass cover and a post-trap with ammonia neutralizing solution for fully automated, unattended, odor-free processing of samples in ammonium hydroxide. Complete Concentration/Drying System for Syntheti...
Company:Thermo Scientific

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neutralizing in Biological Definition

Vaccine

...eign, destroys them, and 'remembers' them. When the virulent version of an agent comes along, the immune system is thus prepared to respond, by (1) neutralizing the target agent before it can enter cells, and (2) by recognizing and destroying infected cells before that agent can multiply to vast numbers. Va...
neutralizing in Biological Dictionary

Epitope

..... Deciphering epitope specificities within polyserum using affinity selection of ... Generation, Characterization and Epitope Mapping of Two neutralizing and ... Online Shopping at DirectTextBook.com - Save up to 80%, buy or rent. New and used books like Epitope Recognition Since Landsteiners Disco...
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