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Neutralization in Medical News

VEGF Neutralization Can Damage Brain Vessels, Say Schepens Eye Research Institute Scientists

Could have impact on cancer treatment and other systemic uses of drugs to target vascular endothelial growth factor (VEGF) BOSTON, Feb. 13 /PRNewswire/ -- New research by scientists at Schepens Eye Research Institute may help explain why the anti-cancer drug Avastin, which targets a ...

VEGF neutralization can damage brain vessels, say Schepens Eye Research Institute scientists

New research by scientists at Schepens Eye Research Institute may help explain why the anti-cancer drug Avastin, which targets a growth factor responsible for creation of new blood vessels, causes potentially fatal brain inflammation in certain patients. Institute scientists mimicked the drugs act...

Thomson Reuters Web of Science(R) Provides Insights Into More than a Century of Influenza Research for Today's Health Professionals

... variants of influenza virus. JOURNAL OF EXPERIMENTAL MEDICINE 98 (6): 641-656. (1953) Times Cited: 237 Horsfall, FL. neutralization of epidemic influenza virus - The linear relationship between the quantity of serum and the quantity of virus neutralized. JOURNAL OF ...

Scientists identify lab-made proteins that neutralize multiple strains of seasonal and pandemic flu

...findings, they collaborated with Ruben O. Donis, Ph.D., of the CDC Influenza Division, and found that three of these monoclonal antibodies had broader neutralization capabilities when tested in cell cultures and in mice against representative strains of other known influenza A viruses. Influenza A viruses can i...

New test may help to ensure that dengue vaccines do no harm

... a weakness of the standard test of antibody responses. The assay used originally to analyze the blood of patients in Iquitos was the plaque-reduction neutralization test (PRNT), the recognized gold standard for determining how effectively the human immune system responds to dengue infection. PRNT starts with a she...

Helicobacter pylori can multiply in autophagic vesicles

...n within the autophagosome. The bacterium's residence inside infected cells not only increases its resistance to antibiotic treatment, but also avoids neutralization by anti- H. pylori antibodies. In view of the critical role of dendritic cells in presenting H. pylori antigen to initiate the immune response, it ...

Study sees need for standardized evaluation of antibody response to HIV-1

...eagues released findings on a study of cross-clade neutralization patterns among HIV-1 strains from six major clades...agents, which they used to analyze the cross-clade neutralization patterns. Another key goal of this study was t...pes of antibodies in both traditional primary cell neutralization assays and the newer, more standardized TZM-bl rep...

Scientists Identify Antibodies That Block Human and Animal SARS Viruses

...v. The discovery of two effective antibodies has the advantage that a newly emergent variation of the SARS coronavirus might be insensitive to neutralization with one, but still susceptible to the other. "Our results demonstrate novel potential antibody-based therapeutics against SARS that could be...

Computer Tool Predicts Effectiveness Of Microbicides

...as been well documented by other scientists. "Our results suggest HIV neutralization is achievable if coating thicknesses on the order of 100 microns remain in ...a human hair. "Increased microbicide concentration and potency hasten viral neutralization and diminish penetration of infectious virus through the coating layer, as ...

Multiple Sclerosis Can Be Treated By Blocking Fat Hormone

...iple sclerosis (MS), according to// Italian researchers. Giuseppe Matarese and colleagues from Università di Napoli "Federico II" suggest that leptin neutralization may be a possible way to both prevent and treat MS. Leptin is known to play a critical role in the regulation of food intake, metabolism, and t...
Neutralization in Medical Technology

Novel Valortim(R) Mechanism of Action Data Presented at the Keystone Symposia on Molecular and Cellular Biology

... of Valortim(R) in enhancing the killing of B. anthracis . We hypothesize that Valortim(R) may protect against lethal anthrax infection by its toxin neutralization activity that allows the development of a potent human dendritic cell-mediated adaptive response that rids the host of viable bacteria." Dr. Cros...

Cytokine Demonstrates Oral Efficacy of Small-Molecule MIF Inhibitors

...is linked to many conditions, including arthritis, asthma, cancer, sepsis, inflammatory bowel disease and various infections and autoimmune disorders. neutralization of MIF biological activity has been shown to have a protective effect against these diseases. CPSI has an extensive patent portfolio focused on MIF, c...

Anadys Reports Preclinical Data Showing ANA773 Promotes Anti-Tumor Activity of Natural Killer Cells

... cell cytotoxicity and cytokine secretion against both K562 erythroleukemic cells and transformed B cell lines. These in vitro effects were reduced by neutralization of IFN-alpha, confirming the role of cytokines induced by the TLR7 agonist in the killing of tumor cells. In addition to enhancing direct NK cell...

West Nile Virus Screening and Diagnostics Technology Emerges In Step with North American Outbreak

... WNV in serum or cerebrospinal fluid. Because of cross reactivity with other flaviviruses, positive results must be confirmed with a plaque reduction neutralization test (PRNT). FDA-approved ELISA kits for detection of antibody are available from Focus Diagnostics, PANBIO Limited and InBios International, Inc. A...
Neutralization in Medical Products

Platelet Neutralization Procedure

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Partial Thromboplastin Time with Reflex to PTT 1:1 Mix & Platelet Neutralization Procedure

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Hexagonal Phospholipid Neutralization

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

ALS, Total ELISA Test

Description:...ervation that acidification would result in dissociation of the 150 KDa complex into acid-stable IGF (~7.5 KDa) and IGFBP-3 (~50 KDa) components while neutralization of the acidified sample would no longer support formation of the 150 KDa complex [7,8]. The existence of ALS was later confirmed by the finding that ...
Company:Diagnostic Systems Laboratories, Inc.

West Nile Virus IgM Capture ELISA

Description:...e virus infection in patients with clinical symptoms consistent with encephalitis / meningitis. Positive results must be confirmed by plaque reduction neutralization test (PRNT), or by using the current Centers for Disease Control and Prevention (CDC) guidelines for diagnosis of this disease....
Company:PANBIO Inc.

West Nile Detect™ IgM Capture ELISA

Description:...ile virus infection in patients with clinical symptoms consistent with encephalitis/meningitis. Positive results must be confirmed by Plaque Reduction neutralization Test (PRNT), or by using the current CDC guidelines for diagnosis of this disease....
Company:InBios International, Inc.

West Nile Virus IgG Capture DxSelect

Description:...oms of meningioencephalitis, as an aid in the presumptive laboratory diagnosis of West Nile virus infection. Positive results must be confirmed by neutralization test, or by using the current CDC guidelines for diagnosing West Nile encephalitis....
Company:Focus Diagnostics

West Nile Virus IgM Capture DxSelect

Description:...s must be tested using the background subtraction method (either on the initial test or on a repeat test). Positive results must be confirmed by neutralization test, or by using the current CDC guidelines for diagnosing West Nile encephalitis....
Company:Focus Diagnostics

ACE Titanium Large Fragment System

Description:...saving valuable time in the OR. The Large Fragment System contains broad and narrow Active Compression Plates (A.C.P.) which allow for compression, neutralization and buttress modes. Increased screw angulation and axial compression have also been built into the design. The "T" and "L" Plates have slotted prox...
Company:DePuy Orthopaedics, Inc.

Model 360 Humphrey Lens Analyzer

Description:...SPEXAN provide the most comprehensive lensometry for your practice. Simple to operate, the Humphrey Lens Analyzer (LA) gives fast and accurate lens neutralization results for any lens-progressive lenses, prism lenses, contact lenses, polycarbonate and other high-index lens materials....
Company:Carl Zeiss Meditec, Inc.
Neutralization in Biological News

Caltech scientists show why anti-HIV antibodies are ineffective at blocking infection

...the case of HIV. In their PNAS paper, Bjorkman and Klein looked at the neutralization capabilities of two different monoclonal antibodies isolated from HIV-infec... PNAS paper, "Examination of the contributions of size and avidity to the neutralization mechanisms of the anti-HIV antibodies b12 and 4E10," are Caltech research t...

Positive results in Phase 2 trial of treatment of C-difficile-associated diarrhea

...s 60 percent. Recurrence can be difficult to manage and is a challenging complication of CDAD; however, the use of non-antibiotic based approaches to neutralization of C. difficile toxins may be important options needed to facilitate recovery of the GI flora. ...

Exploding chromosomes fuel research about evolution of genetic storage

...ryotes pack their genetic material in a cellular nucleus. Prokaryotes lack a nucleus. "Cations play a very important role in the folding and charge neutralization of DNA in all eukaryotes, but more so in dinoflagellates," Rizzo said. "I find it truly amazing that in all other eukaryotes, histones help in this ch...

Imiquimod, an immune response modifier, is dependent on the OGF-OGFr signaling pathway

...ate cell proliferation by modulating cyclin dependent kinase inhibitors, resulting in a retardation of cells at the G1-S interface of the cell cycle. neutralization of OGF or knockdown of OGFr by siRNA technology eliminated the inhibitory effects of imidazoquinolines on cell replication. "Thus our data," Dr. Zago...

Study defines effective microbicide design for HIV/AIDS prevention

...has been well documented by other scientists. "Our results suggest HIV neutralization is achievable if coating thicknesses on the order of 100 microns remain in ...a human hair. "Increased microbicide concentration and potency hasten viral neutralization and diminish penetration of infectious virus through the coating layer, as ...

Agilent Technologies Introduces First Commercial Mouse Microarray for Comparative Genomic Hybridization Research

...munity. Because listeriolysin works optimally at a pH of 5.8, the researchers also deleted the urease C gene of BCG, which normally plays a role in pH neutralization of the phagosome. The lack of urease C allows phagosomal acidification and provides an ideal pH environment for listeriolysin. The new BCG vaccine ...

Researchers Discover Ancient Origins Of Tuberculosis-causing Bacteria

...munity. Because listeriolysin works optimally at a pH of 5.8, the researchers also deleted the urease C gene of BCG, which normally plays a role in pH neutralization of the phagosome. The lack of urease C allows phagosomal acidification and provides an ideal pH environment for listeriolysin. The new BCG vaccine ...

Boosting The BCG Vaccine To Beat Tuberculosis

...munity. Because listeriolysin works optimally at a pH of 5.8, the researchers also deleted the urease C gene of BCG, which normally plays a role in pH neutralization of the phagosome. The lack of urease C allows phagosomal acidification and provides an ideal pH environment for listeriolysin. The new BCG vaccine ...
Neutralization in Biological Technology

Peregrine Pharmaceuticals Licenses Anti-VEGF Antibodies to Affitech

... the r84 antibody minimizes the risk of an immune response against the drug itself, thereby lessening the potential for immunological side effects and neutralization of the treatment effect. As a fully human antibody, r84 may also have better pharmacokinetic properties in patients. About Affitech A/S ...

Cepheid Announces Symposium Speakers and Program Highlights for 19th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)

...m difficile infection Dr. Andrej Weintraub, Karolinska Institutet , Stockholm: Comparison of a multiplex real-time PCR and the cytotoxicity neutralization assay for the diagnosis of Clostridium difficile infections Dr. Jim Gray, Senior Microbiologist, Birmingham Children's Hospital: Experience ...

Confirmation of Bogoch Replikins Influenza Patents by Harvard-CDC and Scripps-Crucell Data

...eases, are the subject of synthetic vaccines in development at the Company. 1. Sui, J. et al. "Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses." Nature Structural and Molecular Biology, published online: Feb. 22, 2009, doi:10.1038-nsmb.1566. 2. Ekei...

Medarex and Massachusetts Biologic Laboratories Announce Primary Objective Achieved in Phase 2 Trial of Monoclonal Antibody Combination for the Treatment of Clostridium difficile Associated Diarrhea (CDAD)

...0 percent.(4) Recurrence can be difficult to manage and is a challenging complication of CDAD; however, the use of non- antibiotic based approaches to neutralization of C. difficile toxins may be important options needed to facilitate recovery of the GI flora.(5) More information on CDAD can be accessed through t...

MedImmune Presents Data Highlighting its Progressive Inflammatory Disease Portfolio at the 72nd Annual Meeting of the American College of Rheumatology

... surface binding to the GM-CSFR alpha chain - Brandon Higgs, Ph.D., Sunday, October 26 from 9:00 a.m. - 11:00 a.m. in Hall A, Abstract: 35 -- neutralization of CXCL13 impacts B-cell trafficking and reduces severity of established experimental arthritis - Matthew Sleeman, Ph.D., Monday, October 27...

A snapshot of the transformation

...ure reaction zones where atoms of adjoining layers diffuse across the interfaces. They are used as customized heat sources for rapid fuses, biological neutralization and joining materials via localized heating rather than global device heating. ...

Monogram HIV Antibody Assay Is Key Component of Innovative Vaccine Development Program

...rences to the use, demand and effectiveness of our neutralization assay technology , the size and timing of clinical...on provided by patents, possible regulation of our neutralization assay and our other products by the FDA, and activ...A/ Cap and the "Research Use Only" offering of our neutralization assay; whether the draft guidance on Multivariate ...

Report recommends off-site disposal of secondary waste

...Pine Bluff, Ark., Umatilla, Ore., and Tooele, Utah, as well as the chemical neutralization facility in Newport, Ind. In evaluating the sites, the committee also drew...nd in different quantities at all four incinerator locations. The chemical neutralization facility does not generate brine solutions or salts; instead it generates V...

Report recommends off-site disposal of secondary waste

...Pine Bluff, Ark., Umatilla, Ore., and Tooele, Utah, as well as the chemical neutralization facility in Newport, Ind. In evaluating the sites, the committee also drew...nd in different quantities at all four incinerator locations. The chemical neutralization facility does not generate brine solutions or salts; instead it generates V...

High Throughput Plasmid DNA Preparation Using A Magnetic Bead Kit On An Automated Workstation

... (Agencourt P/N 001046) - Contains Resuspension/Elution, Lysis, neutralization Buffer and Microparticles in binding buffer - Isopropanol - 70%...ution and shake @ 800-1000 rpm for 5 minutes 4. Add 100 μL neutralization Solution and shake @ 800-1000 rpm for 10 minutes 5. Slowly disp...
Neutralization in Biological Products

Smac/DIABLO, Human, Recombinant, E. coli from Calbiochem

Description:...pressed in and purified from E. coli . Smac/DIABLO is released along with cytochrome c during apoptosis and promotes caspase activation through the neutralization of IAPs, including XIAP (Cat. No. PF137). Biological activity: IC 50 ~500-1500 nM to reverse the inhibition of XIAP (500 nM) on Z-DEVD-AFC (Cat. No. ...
Company:Calbiochem

Anti-Cyclin D2 (G1-phase Cyclin) Ab-2 Monoclonal Antibody, Unconjugated from Lab Vision

Description:...ith cdk4 and/or cdk6. Species Reactivity: Human, Mouse, and Rat. Others-not tested. Comments: NeoMarkers DCS-3.1 MAb is particularly well suited for neutralization of cyclin D2 activity in vivo....
Company:Lab Vision

Rabbit Anti-Mint3 Polyclonal Antibody, Unconjugated from ABR-Affinity BioReagents

Description:...mmunizing peptide corresponds to amino acid residues 1-19 from rat Mint3 protein. PA1-072 immunizing peptide (Cat. # PEP-135) is available for use in neutralization and control experiments.The munc-18 interacting protein (Mint) protein family is a group of evolutionarily conserved adaptor proteins that function in...
Company:ABR-Affinity BioReagents

Mouse resistin Neutralizing Peptide from ABR-Affinity BioReagents

Description:... is (amino to carboxy terminus): S(21) - S - M - P - L - C - P - I - D - E - A - I - D - K - K - I - K - Q - D - C(39). This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and mouse resistin, catalog # PA1-1050. Using a solution of pepti...
Company:ABR-Affinity BioReagents

Human DFF Neutralizing Peptide from ABR-Affinity BioReagents

Description:...e of this peptide is (amino to carboxy terminus): Q(3) - K - P - K - S - V - K - L - R - A - L - R - S - P - R - K(18). This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and the human DFF, catalog # OPA1-01009. Storage: -20 C, Avoid Fr...
Company:ABR-Affinity BioReagents

Interferon Antibody Bioassays Services from PBL InterferonSource

Description:...thic effect inhibition assays, also known as CPE and antiviral assays. The neutralization assay measures the antibody's ability to neutralize the CPE activity of the...provided 2-3 weeks after receipt of samples, although assay times may vary. neutralization assays are offered for Human, Mouse, Rat and Monkey inteferon alpha, beta a...
Company:PBL InterferonSource

Bovine rhodopsin Neutralizing Peptide from ABR-Affinity BioReagents

Description:... The sequence of this peptide is (amino to carboxy terminus): C - S(338) - K - T - E - T - S - Q - V - A - P - A(348). This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and bovine rhodopsin, catalog # PA1-729. Using a solution of pept...
Company:ABR-Affinity BioReagents

HIV-1 p24 ELISA Kit, Alliance (480 Tests) from PerkinElmer

Description:...atably reactive samples should be tested with PerkinElmer HIV-1 p24 Confirmatory Reagents. The HIV-1 p24 Confirmatory Reagents use a specific antibody neutralization step prior to testing with the HIV-1 p24 ELISA kit to indicate the presence of HIV-1 antigen(s). Samples that are neutralized by the HIV-1 p24 Confirm...
Company:PerkinElmer

Rat SCAMP 5 Neutralizing Peptide from ABR-Affinity BioReagents

Description:...ptide is (amino to carboxy terminus): C - N(217) - Q - P - Q - T - Q - Y - S - A - T - P - N - Y - T - Y - S - N(233). This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and the rat SCAMP 5, catalog # PA1-737. Using a solution with equa...
Company:ABR-Affinity BioReagents

Rat SAP97 Neutralizing Peptide from ABR-Affinity BioReagents

Description:...(The C-terminal cysteine has been added to facilitate conjugation and is not a part of the native rat SAP97 sequence.). This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and SAP97, catalog # PA1-741. Using a solution of peptide of equal...
Company:ABR-Affinity BioReagents
Neutralization in Biological Dictionary

Sequential Epitope

... It comprises the minimal sequential B cell epitope (BCE) (H386–400) of the ... induced antibodies to a sequential epitope that mediates neutralization of both ... Mimotopes is a global leader in research-grade custom peptide synthesis, peptide libraries for immunology and drug ... as a sequ...
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