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Neuroprotective in Medical News

New Journal to Explore Neurodegenerative, Neuroprotective and Euroregenerative Therapies!

WESTON, Mass., Oct. 2 /PRNewswire/ -- Weston Medical Publishing today announced publication of the first issue of Journal of Neurodegeneration and Regeneration. (ISSN 1932-1481) This new peer-reviewed journal is designed to explore all aspects of neurodegeneration, neuroprotection and neuroreg...

New research shows neuroprotective effect of lovastatin

April 9, 2008 High cholesterol levels are considered to be a risk factor for cardiovascular disease including stroke. Therefore, many cholesterol lowering drugs have been developed by pharmaceutical companies in recent years. One class of these drugs, statins, has been found to reduce the inciden...

Michael J. Fox Foundation Commits up to $3.8 Million to Develop Gene Silencing Neuroprotective Treatment for Parkinson's Disease

NEW YORK, Jan. 4 /PRNewswire-USNewswire/ -- The Michael J. Fox Foundation has committed up to $3.8 million for the development of a gene silencing therapeutic to treat Parkinson's disease by reducing expression of the protein alpha-synuclein. A team of researchers led by Matt Farrer, PhD, of M...

Hard to Treat Diseases, Inc. (HTDS) Experiments with Hyperbaric Oxygenation (HBO) Traumatic Brain Injury

...djunctive therapy over the last 50 years with controversial results, both in experimental and clinical studies. However, the mechanisms underlying the neuroprotective vs. neurodegenerative effects of HBO treatment are still uncertain. The results of the research group revealed that repetitive HBO treatments, which...

Quark Pharmaceuticals to Participate in IBC's Oligonucleotide Therapeutics: From Concept to Implementation Conference

... QPI-1007, a siRNA that utilizes a proprietary structure developed by Quark, is being evaluated in advanced IND-enabling preclinical studies as a neuroprotective agent for eye diseases. In addition, Quark has a broad pipeline of siRNA drug candidates based on novel structures developed internally. The Company e...

Quark Pharmaceuticals Announces Data Indicating Potential Utility of QPI-1007 for Treatment of Glaucoma

... in advanced IND-enabling preclinical studies as a neuroprotective agent for eye diseases. QPI-1007 is Quark'...ously announced studies have demonstrated a robust neuroprotective effect of QPI-1007 in two additional models of ret...are capable of reducing IOP, none act as selective neuroprotective agents. We are encouraged by the QPI-1007 data, wh...

Michael J. Fox Foundation Awards $3.8 Million To Drive Nine Industry Partnerships For Pre-Clinical Parkinson's Drug Development

... drug development projects. Funded investigations aim to push forward novel neuroprotective and improved symptomatic therapies as well as new strategies for addressing...s of their work available to the Parkinson's research community. neuroprotective Approaches Pharmacodynamics of ReS9-S7, a first-in-class, disea...

AlphaRx and Gaia BioPharma Provide GAI-122 Development Update

...122. GAI-122 offers significant and direct neuroprotection in both in vitro and in vivo ischemic conditions. Experimental evidence suggests that the neuroprotective action of GAI-122 is related to its' active inhibition of apoptosis or cell death. GAI-122 shows potential as a major treatment innovation in the mana...

Quark Pharmaceuticals Announces the Presentation of Data Indicating Potential Utility of QPI-1002 in Chronic Kidney Disease at the RNA Interference Summit

...rmaceuticals. QPI-1007, a siRNA that utilizes a proprietary structure developed by Quark, is being evaluated in IND-enabling nonclinical studies as a neuroprotective agent for eye diseases. In addition, Quark has a broad pipeline of siRNA drug candidates based on internally developed novel structures. Quark ...

Growth in the Parkinson's Disease Drug Market, Fueled by the Launch of Several New Therapies, Will be Offset by Generic Erosion of Key Agents

... to newly-diagnosed Parkinson's disease patients," said Decision Resources Analyst Sami Fam, Ph.D. "However, the need for a more definitive and robust neuroprotective therapy remains in the indication, and this unmet need is not expected to be fulfilled over the next ten years." About Decision Resources Dec...
Neuroprotective in Medical Technology

Anavex presents neuroprotective effects of Anavex 1-41 at the International Conference on Alzheimer's Disease 2008

CHICAGO, July 30 /PRNewswire-FirstCall/ - ANAVEX Life Sciences Corp. (OTCBB: AVXL), a biopharmaceutical company engaged in the discovery and development of novel therapeutics to treat Central Nervous System (CNS) diseases and cancer, today presented data from the company's novel compound, ANAV...

Michael J. Fox Foundation Announces $5.6-Million Award for Phase 2 Clinical Trial Studying Neuroprotective Potential of Inosine

NEW YORK, April 14 /PRNewswire-USNewswire/ -- The Michael J. Fox Foundation announced a $5.6-million award to drive a Phase 2 clinical trial to investigate the potential of inosine -- a naturally occurring chemical that gives rise to urate in the body -- to slow or stop the progression of Park...

PharmAthene's Recombinant Butyrylcholinesterase (rBChE) May Play A Neuroprotective Role in Alzheimer's Disease

ANNAPOLIS, Md., April 9, 2008 /PRNewswire-FirstCall/ -- PharmAthene, Inc. (Amex: PIP ) a biodefense company specializing in the development and commercialization of medical countermeasures against chemical and biological threats, announced today that scientists from the Hebrew University of J...

Michael J. Fox Foundation Awards Over $2 Million for Validation of 10 Parkinson's Therapeutic Targets

...et for Parkinson ' s disease therapy Yoon-Seong Kim, MD, PhD, Weill Medical College of Cornell University Upregulation of MsrA: A neuroprotective strategy for the t reatment of Parkinson's disease Deniz Kirik, MD, PhD, Lund University (Sweden) and Jean-Christophe Rochet, PhD, Purdue Univer...

Results From Trials of DHA in Alzheimer's Disease and Age-Related Cognitive Decline

... Memory Improvement with DHA Study (MIDAS) Researchers at Martek Biosciences Corporation examined the effects of algal DHA as a possible neuroprotective nutritional supplement for ARCD in their Memory Improvement with DHA Study (MIDAS). Scientists led by Karin Yurko-Mauro, PhD, Associate Direc...

MJFF's Rapid Response Innovation Awards Hit Mid-2009 With Over $1 Million Funded in High-Risk/High-Reward Approaches to Parkinson's Disease

...search, including clinical trials. These include D. James Surmeier, PhD's 2007-2008 investigation of approved high-blood pressure drug isradipine as a neuroprotective approach to PD, which is currently being tested with MJFF support in a Phase 2 controlled clinical trial. The Michael J. Fox Foundation is dedica...

CeNeRx BioPharma Obtains Rights to Novel Drug Candidate for Prevention and Treatment of Neurodegeneration Disorders

...py and other conditions. In preclinical studies, CXB909 enhanced the action of NGF in vitro , amplifying its activity almost seven-fold. CXB909 was neuroprotective in a variety of cellular assays and in animal models of neuropathies and neurodegenerative diseases, including chemotherapy-induced neuropathy, for wh...

Paloma Pharmaceuticals Presents at the Association for Research in Vision and Ophthalmology 2009 Meeting

...ibiting the PI3K/Akt/mTor signal transduction pathway by Palomid 529 may be neuroprotective to photoreceptors and perhaps represents a novel therapy for other retinal ...tachment surgery. Taken together these data suggest that Palomid 529 may be neuroprotective to photoreceptors and reduce the incidence of subretinal fibrosis without o...

D-Pharm Submits Investigational New Drug Application and Special Protocol Assessment to the FDA for Phase III Trial of DP-b99 in Acute Stroke Patients

...ificantly reduce development time since the design of the pivotal protocol has been approved in advance. About DP-b99 DP-b99 is a unique neuroprotective drug that addresses an array of brain damaging processes occurring in stroke patients and emerged from D-Pharm's proprietary Membrane Activated Chelat...

Quark Pharmaceuticals Presents at Asia TIDES Conference

...chemic optic neuropathy and has demonstrated proof-of-concept efficacy as a neuroprotective agent in animal models of eye diseases . Dr. Thompson commented, "Qu...Quark, is being evaluated in advanced IND-enabling preclinical studies as a neuroprotective agent for eye diseases. In addition, Quark has a broad pipeline of siRNA dr...
Neuroprotective in Biological News

Results from trials of DHA in Alzheimer's disease and age-related cognitive decline

...s added. Memory Improvement with DHA Study (MIDAS) Researchers at Martek Biosciences Corporation examined the effects of algal DHA as a possible neuroprotective nutritional supplement for ARCD in their Memory Improvement with DHA Study (MIDAS). Scientists led by Karin Yurko-Mauro, PhD, Associate Director of...

Preterm birth: Magnesium sulphate cuts cerebral palsy risk

...f the disabling condition, which currently affects around one in every 500 newborn babies overall, but up to one-in-ten very premature babies ( The neuroprotective function of magnesium in preterm babies was first suggested in the early nineties. Cochrane Researchers who carried out a systematic review of the ava...

Tips from the American Journal of Pathology

...tem in a mouse model of MS. They observed decreased severity of disease and more prominent remyelination in these mice. CXCL1, therefore, may play a neuroprotective role in CNS autoimmune demyelination. In future studies, Dr. Raine's group plans to determine how CXCL1 mediates protection in MS. "Exploration of...

3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions

...from degeneration. Furthermore, the group has conducted a structure-activity relationship study to identify substituent groups that are important for neuroprotective efficacy. A previous study by the same group demonstrated that one of these 3-substituted indolones, called GW5074, prevents neurodegeneration and im...

Resveratrol, red wine compound linked to health, also found in dark chocolate and cocoa

...onth in Nutrition Reviews, resveratrol, a naturally occurring antioxidant, was shown to improve insulin sensitivity, blood cholesterol levels and have neuroprotective actions in animal studies. Further, the article states, studies in mice indicate that diets high in resveratrol were associated with increased longev...

Arbor Vita and WRAIR sign CRADA for traumatic brain injury collaboration

...es made from a collaborative effort between AVC and NoNO Inc., of Toronto, Canada, and will explore the use of the companies' NA-1 compound as a novel neuroprotective agent for severe brain injury of soldiers and civilians injured in explosions such as roadside bombs. NA-1 is an investigational compound that target...

Michael J. Fox Foundation PD Therapeutics Conference

... symptomatic interventions for the diagnosis and treatment of PD. Select MJFF-funded investigators will present research on topics including novel neuroprotective agents, innovative mechanisms to address disease symptoms and improvements in relevant animal models, and biomarker discovery/development. In addi...

Michael J. Fox Foundation awards $2.4M for validation of therapeutic targets for Parkinson's

...ahan has already shown that delivering specific inhibitors against NF-kB is neuroprotective in a rodent model of Parkinson's. He will now work to confirm his results i...Massachusetts General Hospital (Harvard University) "Hsp90 as a Target for neuroprotective Agents in Parkinson's Disease" Kalipada Pahan, PhD, Rush University Med...

The Parkinson's Disease Foundation awards $950,000 in seed grants

...ntaneously undergo progressive dopamine neuron loss by similar mechanisms. This would provide an enormously valuable tool for discovering and testing neuroprotective therapies for Parkinson's disease." Because human clinical trials are very expensive and time-consuming, laboratory animals are needed to rapidly...

Green tea compounds beat OSA-related brain deficits

... scavengers, and research has shown that the compounds may reduce the risk of a variety of different diseases. Recent studies have demonstrated the neuroprotective activity of GTP in animal models of neurodegenerative conditions such as Parkinsons and Alzheimers disease, wrote Dr. Gozal. In this study, the re...
Neuroprotective in Biological Technology

Biovista Inc. Announces Positive Efficacy Results in a Pre-Clinical Trial of its BVA-601 Repositioned Drug for Epilepsy

...Kainic acid murine model of temporal lobe epilepsy. BVA-601, an existing drug that Biovista repositioned in epilepsy, exhibits both anti-epileptic and neuroprotective activity. In this pre-clinical trial, BVA-601 induced a statistically significant decrease of epileptic activity in mice pre-treated with Kainic acid....

D-Pharm Receives FDA Clearance to Commence a Phase III Trial of DP-b99 in Acute Stroke Patients

...arfarin in healthy volunteers, as well as scale-up and optimization of the DP-b99 manufacturing process. About DP-b99 DP-b99 is a unique neuroprotective drug that addresses an array of brain damaging processes occurring in stroke patients and emerged from D-Pharm's proprietary Membrane Activated Chelat...

Quark Pharmaceuticals Presented At ARVO Data Showing That PF-04523655 Enters Retinal Cells And Elicits Its Pharmacologic Effect Via Target Gene Knock-Down Without Activating TLR3

... QPI-1007, a siRNA that utilizes a proprietary structure developed by Quark, is being evaluated in advanced IND-enabling preclinical studies as a neuroprotective agent for eye diseases. In addition, Quark has a broad pipeline of siRNA drug candidates based on novel structures developed internally. The Company e...

Quark Pharmaceuticals to Present at American Society for Pharmacology and Experimental Therapeutics Annual Meeting

... QPI-1007, a siRNA that utilizes a proprietary structure developed by Quark, is being evaluated in advanced IND-enabling preclinical studies as a neuroprotective agent for eye diseases. In addition, Quark has a broad pipeline of siRNA drug candidates based on novel structures developed internally. The Company e...

ExonHit Therapeutics Invested Strongly in 2008 for Pivotal 2009 Results

...the potential to be the first in a new class of disease modifying Alzheimer's disease therapies that stimulate the ÿ±-secretase pathway and may have neuroprotective and procognitive effects in addition to a symptomatic action. As part of our repositioning efforts, several proprietary compounds are being eva...

Sangamo BioSciences Announces Results From Diabetic Neuropathy Clinical Trial SB-509-601

...egulate the expression of the gene encoding vascular endothelial growth factor (VEGF- A). VEGF-A has been demonstrated to have direct neurotrophic and neuroprotective properties. In preclinical animal efficacy studies in a diabetic rat model (Diabetes, June 1, 2006; 55(6): 1847-1854), SB-509 has proven effective in ...

Jellyfish Protein Shows Potential to Help With Memory

... the calcium binding proteins found in the human nervous system which become depleted in age-related diseases like Alzheimer's. Data demonstrating the neuroprotective ability of this protein was first presented at the Society for Neuroscience meeting in 2006. "Having strong science is the key to helping people tha...

Neuralstem Fills Key Product Development Position

...ing diseases and injuries of the spinal cord for its first human trials, including ALS and Paraplegia. The company has also developed neurogenic and neuroprotective small molecule compounds targeted at treating depression. For further information, please visit http://www.neuralstem.com . Cautionary Statement Re...

Zenobia Therapeutics, Inc. Receives Michael J. Fox Foundation for Parkinson's Research Award for Work on PD-implicated Protein LRRK2

...overactive in PD patients. The goal is to preserve brain function by stopping the effects of the overactivity. If successful, the work could lead to a neuroprotective treatment for PD with potential to slow or stop the course of the disease -- something no currently available therapy has been proven to do. Current t...

Brian Levy, OD, MSc, Named Chief Operating Officer of Danube Pharmaceuticals

...ation. In preclinical studies DNB-001 has been shown through novel mechanisms of action to both lower intraocular pressure (IOP) and to provide direct neuroprotective benefits to the optic nerve and its retinal ganglion cells, providing a dual approach to glaucoma therapy not provided by any currently marketed produ...
Neuroprotective in Biological Products

PARP Inhibitor XI, DR2313 from Calbiochem

Description:...hown to inhibit H 2 O 2 -induced PAR formation and neuronal cell death in primary rat cerebral cortex culture in vitro (EC 50 = 270 nM) and exhibit neuroprotective effects in both permanent and transient focal ischemia models in rat in in vivo . Purity: ≥98% by HPLC. Soluble in H 2 O. CAS 284028-90-6, M.W. ...
Company:Calbiochem
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