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Neuroprotection in Medical News

Mitochondria play role in pathogenesis of AD and estrogen-induced neuroprotection

As the major source of free radicals in cells, mitochondria contribute to the high levels of oxidative stress believed to play a role in the pathogenesis of Alzheimers disease. Now, a new study from the laboratory of Dr. Roberta Brinton, University of Southern California, demonstrates that estroge...

AlphaRx and Gaia BioPharma Provide GAI-122 Development Update

... AlphaRx's proprietary drug delivery technology, provides significant neuroprotection in animal behavioral models. Gaia BioPharma plans to initiate a clinica...ovide a progress report on GAI-122. GAI-122 offers significant and direct neuroprotection in both in vitro and in vivo ischemic conditions. Experimental evidence sug...

Quark Pharmaceuticals Presents Data on Synthetic siRNAs for Prevention of Ocular and Inner Ear Sensory Cell Damage

...tic siRNAs. Similar data for QPI-1007, Quark's proprietary siRNA composition, were also reported. QPI-1007 was demonstrated to confer effective ocular neuroprotection and is currently in late-stage IND-enabling studies. In addition to studies in the eye, Dr. Feinstein also reported results demonstrating effect...

Michael J. Fox Foundation Awards $2.5 Million for Parkinson's Drug Development Projects Led By Academic Investigators

...evodopa-induced Dyskinesias Angelika Richter, PhD, Freie Universitat Berlin, Germany Identification of a Novel Calcium Selective Antagonist for neuroprotection in PD D. James Surmeier, PhD, and Richard Silverman, PhD, Northwestern University Structural and Chemical Approaches to Understand and Modu...

The world's best brains descend on Canberra

...essor Peter Reilly, Royal Adelaide Hospital, in the annual Eccles Lecture, will examine the future for management of head injuries through prevention, neuroprotection and promoting repair and regeneration. Thursday 5pm Professor Russell Foster, University of Oxford, will describe how linking visual light detectio...

Quark Pharmaceuticals to Present at the 20th Annual Piper Jaffray Health Care Conference

... Presentation to Highlight Results of Ocular neuroprotection Candidate FREMONT, Calif., Dec. 1 /PRNews...heduled to present results on the Company's ocular neuroprotection candidate at the 20th Annual Piper Jaffray Health ... ET As previously announced, the ocular neuroprotection candidate is the Company's first RNAi drug candida...

The future of interventional cardiology presented at TCT 2008

...nts with Coronary Artery Disease EMPIRE: A Multicenter Registry Evaluating neuroprotection During Carotid Stenting with a Novel Flow Reversal System EPIC: A Multicenter Registry Evaluating neuroprotection During Carotid Stenting with a Novel Distal Protection Device First in Huma...

New Journal to Explore Neurodegenerative, Neuroprotective and Euroregenerative Therapies!

...ournal of Neurodegeneration and Regeneration. (ISSN 1932-1481) This new peer-reviewed journal is designed to explore all aspects of neurodegeneration, neuroprotection and neuroregeneration including the molecular mechanisms, experimental approaches and their relevance in treating neurodegenerative disorders and neur...

TCT update: press conference schedule announced for TCT

...nts with Coronary Artery Disease EMPIRE: A Multicenter Registry Evaluating neuroprotection During Carotid Stenting with a Novel Flow Reversal System EPIC: A Multicenter Registry Evaluating neuroprotection During Carotid Stenting with a Novel Distal Protection Device First in Huma...

Umbilical cord blood cell transplants may help ALS patients

...ells could have a protective effect on dying motor neurons. The team had previously shown that hUBC cell transplants reduced inflammation and provided neuroprotection in models of stroke and Alzheimer's disease. "This preclinical study indicates that MNC hUBC cells may protect motor neurons by inhibiting an immu...
Neuroprotection in Medical Technology

Study Demonstrating Aeolus Compound's Neuroprotection in Parkinson's Disease Published in the Journal of Neuroscience

LAGUNA NIGUEL, Calif.--(BUSINESS WIRE)--Apr 26, 2007 - Aeolus Pharmaceuticals, Inc. (OTCBB:AOLS) announced today the publication* in the April 18, 2007 issue of the Journal of Neuroscience a study by researchers at the University of Colorado and National Jewish Medical and Research Center demonstra...

Michael J. Fox Foundation Awards Over $2 Million for Validation of 10 Parkinson's Therapeutic Targets

... eurodegeneration and n euroinflammation in Parkinson ' s d isease Antonio Cuadrado, PhD, Universidad Autonoma de Madrid, Spain neuroprotection by PXDNL, a n ovel h eme-containing p eroxidase J. Timothy Greenamyre, MD, PhD, University of Pittsburgh Validation of Nox1/Ra...

ExonHit Therapeutics Reports Advancements in the Clinical Development of EHT 0202, its Phase II Drug for Alzheimer's Disease

...s were observed clinically. Preclinical studies have shown that EHT 0202 protects cortical neurons against Abeta42-induced stress and that this neuroprotection is associated with sAPPalpha induction. EHT 0202 has also demonstrated pro-cognitive properties in several animal models: age-related memory impairmen...

Neuronascent, Inc. Receives Multiple Fundings for Its Neurogenesis Therapeutic Programs

...mpany's lead compounds, currently in preclinical testing, aim to replace damaged neurons, restore neurons critical to cognition and memory and enhance neuroprotection against neurodegenerative diseases. Results from recent animal studies show a reversal of cognitive loss in aged mice to young levels. "Our lead com...

Anavex presents neuroprotective effects of Anavex 1-41 at the International Conference on Alzheimer's Disease 2008

...rance 2. Anavex Life Sciences, Pallini, Greece. The presentation notes: neuroprotection was attained in the ANAVEX 1-41 compound at very low doses (0,1mg/kg) in mi...s, as well as the anti-apoptotic and the anti-oxidative stress potential. neuroprotection is the most important component necessary to attain long-term benefits in n...

FASgen Announces New Discovery for Treatment of Stroke

...gnificant neuroprotection in the case of ischemic stroke. In the stroke models tested, the Company's compound C-75 reduced AMPK levels and resulted in neuroprotection by reduced stroke damage, even when administered poststroke. These remarkable findings were recently published in the article, "Neuroprotective Effect...
Neuroprotection in Biological News

Debate on admin. of magnesium sulfate to pregnant women to prevent cerebral palsy in pre-term infants

... placebo-controlled trials of antenatal magnesium sulfate (MgSO4) for fetal neuroprotection have recently been conducted and reported. The results of these trials prov...rs of early preterm birth. In the United States, the use of MgSO4 for fetal neuroprotection has the potential to prevent 1000 cases of handicapping cerebral palsy annu...

Is vitamin D deficiency linked to Alzheimer's disease and vascular dementia?

...with induction of human cathelicidin by 1,25-dihydroxyvitamin D being the mechanism. There is also laboratory evidence for the role of vitamin D in neuroprotection and reducing inflammation, and ample biological evidence to suggest an important role for vitamin D in brain development and function. Given these ...

Tips from the American Journal of Pathology

...affords novel therapeutic avenues to enhance the limited remyelination typically seen in MS." Omari KM, Lutz SE, Santambrogio L, Lira SA, Raine CS: neuroprotection and remyelination after autoimmune demyelination in mice that inducibly overexpress CXCL1. Am J Pathol 2009, 174:164-176 New Candidate to P...

Arbor Vita and WRAIR sign CRADA for traumatic brain injury collaboration

...arch approach of WRAIR brain trauma scientists and neuroprotection experts and the neuroscience research teams of AVC...ue opportunity for conducting advanced preclinical neuroprotection research in a model of brain injury that mimics so...aging preclinical results, almost all Phase II/III neuroprotection clinical trials for stroke and TBI have failed to ...

Stroke and SIDS in Alaska topics of neuroscience conference

...logy, which is a National Institutes of Health supported SNRP whose goal is to expand and stimulate basic neuroscience research at UAF with a focus on neuroprotection and adaptation. The ABNP is an integral part of UAF's initiative addressing health disparities of Native Alaskans and Arctic populations. "SIDS is...

Michael J. Fox Foundation awards $2.4M for validation of therapeutic targets for Parkinson's

...eptors as a Drug Target for Treating Motor Fluctuations in PD" Malu G. Tansey, PhD, University of Texas Southwestern Medical Center "Dopaminergic neuroprotection by Regulator of G-protein Signaling 10 (RGS10)" Stephen F. Traynelis, PhD, and Stella Papa, MD, Emory University School of Medicine "Validation o...

Children with gene show reduced cognitive function

...e OHSU School of Medicine discovered that 7- to 10-year-olds with a member of a family of genes implicated in development, nerve cell regeneration and neuroprotection display reduced spatial learning and memory, associated with later-life cognitive impairments. Results of the study, presented today at Neuroscien...

The endocannabinoids: Functional roles and therapeutic opportunities

...upreme joy in Sanscrit), and another one from the intestines named 2-arachidonoyl glycerol (2-AG) (Devane et al., 1992; Mechoulam et al., 1995). neuroprotection The major endocannabinoid (2-AG) has been identified both in the central nervous system and in the periphery. Stressful stimuli traumatic brain in...

20th ECNP Congress 2007, Oct. 13-17, Vienna, Austria

... has not only helped us to advance our understanding of cannabis use and its effects, but has also made key contributions with regard to understanding neuroprotection and has opened the door for the development of new drugs. The influence of opioid receptors in the brain: The opioid system controls pain, rew...

Gene therapy injected into the brains' of mice with Huntington's disease

...owed diminished hind limb clasping, (a simulation of motor control behavior in HD patients). Perhaps most importantly, gene delivery of GDNF provided neuroprotection in the brain, with reduced density of brain inclusions and less cell death. The authors wrote "Although GDNF's exact role in preventing cell death ...
Neuroprotection in Biological Technology

New Report Analyzes Key Controversies in Multiple Sclerosis Treatment

...nd predicts where they will fall on the safety/efficacy spectrum. -- The status and potential of a number of vaccine approaches. -- Intriguing neuroprotection / neuroregeneration strategies, including LINGO, anti-myelin-associated-glycoprotein MAb and remyelination MAb. Drugs/Mechanisms mentioned in thi...

The Parkinson's Disease Foundation Commemorates its 50th Anniversary with Special Scientific Symposium on Parkinson's Disease

... Parkinson's Disease and Other Movement Disorders at Columbia University, will cover a wide range of topics including epidemiology, biomarkers for PD, neuroprotection and gene therapy. "This is going to be a comprehensive review of where we have been and where we are going in Parkinson's research, presented by premi...
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