Chromosome Deletion Predicts Aggressive Neuroblastoma
When genes are deleted on a particular section of chromosome 11, the result is an aggressive form of the childhood cancer neuroblastoma. A new study suggests that detecting this genetic deletion during the initial evaluation of children with neuroblastoma may indicate to physicians that they should recommend a more aggressive regimen of chemotherapy to fight the cancer. Edward F. Attiyeh,...Metastasis of Neuroblastoma linked to Loss Of Caspase-8 gene
The caspase-8 gene prevents the metastasis of the neuroblastoma. This research was conducted at St. Jude Children's Research Hospital and the University of California// at San Diego (UCSD). Cancer cells that have broken itself from the main primary tumor have lost the function of this gene. Hence it is clear that caspase-8 gene is responsible for inhibiting metastasis. Neurobl...New dosage of medicine gets more results in neuroblastoma
In the second phase of study that is trying new approaches to the neuroblastoma patients, researchers// say that improved dosage of the drug topotecancan be more effective in children than the common procedure. Scientists at St. Jude Children's Research Hospital, US, feel that the cancer drug topotecancan must be fine tuned to suit each child patient of neuroblastoma as not all doses a...The Bottleneck in Neuroblastoma
Neuroblastoma typically occurs as a solid tumor in the abdomen, but also in the neck, chest, and pelvis, developing in the network of the body's sympathetic nervous system. Childhood cancers are fortunately rare, but among them, neuroblastoma is a special case, accounting for 7 percent of all childhood cancers, but 15 percent of childhood cancer deaths. Neuroblastoma is wh...Neuroblastoma Expert Reviews Progress and Challenges in Fighting Difficult Pediatric Cancer
PHILADELPHIA, June 25, 2007 /PRNewswire-USNewswire/ -- Childhoodcancers are fortunately rare, but among them, neuroblastoma is aspecial case, accounting for 7 percent of all childhood cancers,but 15 percent of childhood cancer deaths. It typically occurs as asolid tumor in the abdomen, but also in the neck, chest, andpelvis, developing in the network of the body's sympathetic nervoussyst...Researchers Use Poliovirus to Destroy Neuroblastoma Tumors in Mice
PHILADELPHIA, March 15, 2007-- The cause of one notoriouschildhood disease, poliovirus, could be used to treat the ongoingthreat of another childhood disease, neuroblastoma. In the March 15issue of Cancer Research, researchers from Stony Brook Universityreport that an attenuated -- or non-virulent -- form of poliovirusis effective in obliterating neuroblastoma tumors in mice, evenwhen th...