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Neuroblastoma in Medical News

Long-term health and social outcomes for neuroblastoma survivors

Survivors of the childhood cancer neuroblastoma are eight times more likely to have chronic health conditions, less likely to be married, and more likely to have lower incomes than their siblings, according to a study published online July 31 in the Journal of the National Cancer Institute . T...

Gene findings revealing reasons for neuroblastoma risk

Two new studies from The Children's Hospital of Philadelphia advance the search for genetic events that result in neuroblastoma, a puzzling, often-deadly type of childhood cancer. Originating in the peripheral nervous system, neuroblastoma is the most common solid cancer of early childhood and ...

Genes May Raise Risk of Neuroblastoma in Kids

Finding sheds light on cause of lethal cancer, expert says,,,, WEDNESDAY, June 17 (HealthDay News) -- Researchers have identified a genetic trait that appears to boost the risk that a child will develop an often-fatal cancer that targets the nervous system. The findings don't point ...

Immunotherapy effective against neuroblastoma in children

A phase III study has shown that adding an antibody-based therapy that harnesses the body's immune system resulted in a 20 percent increase in the number of children living disease-free for at least two years with neuroblastoma. Neuroblastoma, a hard-to-treat cancer arising from nervous system cel...

Drug therapy reduces neuroblastoma tumor growth in pre-clinical investigation

SAN DIEGO - Researchers from the Children's Cancer Hospital at The University of Texas M. D. Anderson Cancer Center have discovered a new drug combination that significantly hinders tumor growth in neuroblastoma, a childhood cancer. The study was presented today at the 22nd annual meeting of the A...

Drug inhibits neuroblastoma blood supply in pre-clinical tests

SAN DIEGO - Researchers from the Children's Cancer Hospital at The University of Texas M. D. Anderson Cancer Center have found a way to prevent blood vessels from aiding the growth of neuroblastoma, a childhood cancer. The pre-clinical study was presented today in a platform session at the 22nd an...

Novel cancer drug reduces neuroblastoma growth by 75 percent

SAN DIEGO - Researchers from the Children's Cancer Hospital at The University of Texas M. D. Anderson Cancer Center have found a new drug that restricts the growth of neuroblastoma, a childhood brain cancer. The pre-clinical study was presented today in the plenary session at the 22nd annual meeti...

Children's cancer group recommends global evaluation system for neuroblastoma to improve treatment

An international coalition of pediatric cancer physicians and researchers has developed new systems to standardize studies of neuroblastomas across the world. In the December issue of the Journal of Clinical Oncology , the International Neuroblastoma Risk Group (INRG) presents three sets of paper...

Immune Therapy May Aid Kids With Neuroblastoma

Researchers praise new treatment for deadly cancer,, THURSDAY, May 14 (HealthDay News) -- In a phase 3 clinical trial, an experimental immune-based treatment boosted by 20 percent the overall survival of those with tough-to-treat neuroblastoma, which affects mostly children. The fin...

Engineered virus targets and kills apparent cancer stem cells in neuroblastoma

CINCINNATI After identifying an apparent population of cancer stem cells for neuroblastoma, researchers successfully used a reprogrammed herpes virus to block tumor formation in mice by targeting and killing the cells. Published online Jan. 21 by PLoS (Public Library of Science) One , the stu...
Neuroblastoma in Medical Technology

Gene Findings Unlocking Reasons for Neuroblastoma Risk

--Whole-Genome Searches Are Revealing Secrets of a Childhood Cancer-- PHILADELPHIA, June 22 /PRNewswire-USNewswire/ -- Two new studies from The Children's Hospital of Philadelphia advance the search for genetic events that result in neuroblastoma, a puzzling, often-deadly type of childhood ca...

Gene That Causes Childhood Cancer Neuroblastoma Is Found

--May Lead to New Prevention and Treatment Strategies-- PHILADELPHIA, Aug. 25 /PRNewswire-USNewswire/ -- Scientists have discovered gene mutations that are the main cause of the inherited version of the childhood cancer neuroblastoma. In addition, the researchers found that the same mutation...

Researchers Use Poliovirus to Destroy Neuroblastoma Tumors in Mice

PHILADELPHIA, March 15, 2007-- The cause of one notorious childhood disease, poliovirus, could be used to treat the ongoing threat of another childhood disease, neuroblastoma. In the March 15 issue of Cancer Research, researchers from Stony Brook University report that an attenuated -- or non-viru...

In Vitro and In Vivo Data Show Alfacell's Onocanse is Active Against Naive and Chemoresistant Neuroblastoma Cells

Pre-Clinical Results Demonstrate Potential of ONCONASE for Treatment of Neuroblastoma BLOOMFIELD, N.J., June 27, 2007 /PRNewswire-FirstCall/ -- Alfacell Corporation today announced that new data show ONCONASE, the company's lead drug candidate, is active against naive and chemoresistant neuroblast...

Keryx Biopharmaceuticals, Inc. Commences Phase 1 Study of KRX-0401 (Perifosine) in Recurrent Pediatric Solid Tumors at Memorial Sloan-Kettering Cancer Center

...hat single agent perifosine not only induced tumor regression and delayed tumor growth, but that perifosine also improved the survival of mice bearing neuroblastoma tumors. Moreover, in a Phase 2 study conducted at Memorial Sloan-Kettering Cancer Center, perifosine induced responses and delayed disease progression...

Bayer Announces Leukine(R) Data Presentations at 45th American Society of Clinical Oncology (ASCO) Annual Meeting

...lphia, PA Abstract 2, Plenary Presentation, Sunday, May 31, 1:00 PM to 4:00 PM, Level 2, West Hall D2 neuroblastoma A phase III randomized trial of the chimeric anti-GD2 antibody ch14.18 with GM-CSF and IL2 as immunotherapy following dose intensive...

New Therapy Enlists Immune System to Boost Cure Rate in a Childhood Cancer

... appears as a solid tumor in the chest or abdomen. neuroblastoma accounts for 7 percent of all childhood cancers, b... childhood cancer deaths. Yu will present the neuroblastoma study results on June 2 at the annual meeting of t...-- the first substantial increase in cure rate for neuroblastoma for more than a decade," said Maris. The rese...

Kosan Presents Preclinical Antitumor and Safety Data On Next-Generation Epothilone KOS-1803 at AACR

...umor xenograft models, KOS-1803 has demonstrated antitumor activity in breast, lung, prostate and colorectal cancers, as well as in ovarian cancer and neuroblastoma where the extent and duration of tumor regression was curative. Kosan is currently advancing KOS-1803 through later-stage preclinical studies with the...

MGI Pharma, Inc. Summarizes Data Presented at the 2007 American Society of Clinical Oncology (ASCO) Annual Meeting

...lofibrosis with myeloid metaplasia" Abstract # 9565 "Decitabine (DAC) in combination with doxorubicin (DOX) and cyclophosphamide (CTX) in relapsed neuroblastoma (NBL): A Children's Oncology Group Study" Abstract # 2036 "Phase II trial of Gliadel plus O6-benzylguanine (O6-BG) for patients with recurrent gli...

MGI Pharma Summarizes Data Presented at the 2007 American Society of Clinical Oncology (ASCO) Annual Meeting

...lofibrosis with myeloid metaplasia" Abstract # 9565 "Decitabine (DAC) in combination with doxorubicin (DOX) and cyclophosphamide (CTX) in relapsed neuroblastoma (NBL): A Children's Oncology Group Study" Abstract # 2036 "Phase II trial of Gliadel plus O6-benzylguanine (O6-BG) for patients with recurrent gli...
Neuroblastoma in Medical Dictionary

Neuroblastoma

Neuroblastoma is the most common extracranial solid cancer in childhood and the most common cancer in infancy, with an annual incidence of about 650 new cases per year in the US. Close to 50 percent of neuroblastoma cases... Expert-reviewed information summary about the treatment of...

MIBG

.... Metaiodobenzylguanidine ( MIBG ) is a substance that concentrates in neuroblastoma ... MIBG will be eliminated through the urine over the next several da...diotherapy with 131I- MIBG and Arsenic Trioxide in Patients with Resistant neuroblastoma or Malignant Chromaffin Cell Tumors ... ...

Abdominal CT scan

..., Cary, Wake County, Research Triangle, Johnston County, North Carolina, NC, Clayton, Apex, Harnett County, ... Lymphoma, malignant - CT scan . neuroblastoma in the liver - CT scan ... Abdominal CT scan . Definition: An abdominal CT scan involves X-ray images of the ... An abdominal ...
Neuroblastoma in Biological News

Researchers identify promising gene target for neuroblastoma therapy

BOSTON--Researchers at Dana-Farber Cancer Institute have identified a set of previously unknown mutations in a single gene in 8 percent of neuroblastomas, tumors of the nervous system that occur in young children and account for approximately 15 percent of all childhood cancer deaths. The disco...

Genetic finding could lead to targeted therapy for neuroblastoma

GAINESVILLE Researchers have identified a genetic glitch that could lead to development of neuroblastoma, a deadly form of cancer that typically strikes children under 2. Two University of Florida scientists are part of the multicenter team of researchers that made the discovery, which could p...

A double-barreled immune cell approach for neuroblastoma

Adding an artificial tumor-specific receptor to immune system cells called T-lymphocytes that target a particular virus extended and improved the cells' ability to fight a form of childhood cancer called neuroblastoma, said researchers form Baylor College of Medicine and Texas Children's Hospital...

Protein that promotes cancer cell growth identified

... and director of the Cancer Center at Burnham, showed that Caspase-8 caused neuroblastoma cancer cells to proliferate and migrate. For the first time, Caspase-8 was ...oliferation regulator protein, MAPK. This same signaling pathway stimulates neuroblastoma cells to migrate and invade neighboring tissues--a critical process in canc...

Texas Medical Center researchers win collaborative grants

...ombine their knowledge of nanotechnology and the physiology of extracranial neuroblastoma tumors in children to come up with a delivery system for peptide-based drug...lained that peptides small strings of amino acids are unable to penetrate neuroblastoma cells. But when shaped into fullerenes, they can pass through the cell's wa...

Children's National researchers develop novel anti-tumor vaccine

... WASHINGTON, DCA novel anti-tumor vaccine for neuroblastoma and melanoma developed by scientists and clinicians at Children's National Medical Center in collaboration with investigators from the University o...

Biomarkers allow doctors to match therapy to patient

... ODC1 is associated with poor outcome in childhood neuroblastoma and represents an important therapeutic target: Ab...inhibition delayed or prevented the development of neuroblastoma in a clinically relevant animal model, suggesting ... We could actually delay, and in some cases block, neuroblastoma formation in our transgenic MYCN mouse model by co...

Tumor-targeting viral therapy slows neuroblastoma, malignant peripheral nerve sheath tumors

... of two particularly stubborn solid tumor cancers neuroblastoma and peripheral nerve sheath tumors without harming...ng human cancer cells and mice designed to develop neuroblastoma or peripheral nerve sheath tumors, rQT3 reduced ne...el growth that can feed tumors, Dr. Cripe said. neuroblastoma is a solid tumor cancer that begins in the sympath...

JCI table of contents: Aug. 16, 2007

... as MYCN, which has been associated with many different types of cancer, by neuroblastoma cells decreases their secretion of a soluble factor (CCL2) that attracts NK...Oncogene MYCN regulates localization of NKT cells to the site of disease in neuroblastoma AUTHOR CONTACT: Leonid S. Metelitsa Childrens Hospital Los Angeles, Los ...

3 proteins may play important role in nerve-cell repair

...thor Shigeru Tanaka, a postdoctoral fellow in Saeki's laboratory, and his colleagues used nerve cells obtained from the brain tissue of rats and mouse neuroblastoma cells growing in culture to learn more about the three proteins and their involvement in cAMP regulation. The researchers added additional copie...
Neuroblastoma in Biological Technology

Ascenta Therapeutics Announces Results of Preclinical Evaluation of AT-406 in Multiple Cancer Models

...ania data on chemotherapy resistance patterns in neuroblastoma cell lines, highlighting AT-101's inhibition of Mc...s in the development of chemotherapy resistance in neuroblastoma (Abstract # 3269). Using human-derived neuroblastoma cell lines, these investigators demonstrated diffe...

Keryx Biopharmaceuticals Presents Encouraging Preclinical Data at Annual Meeting of the American Association of Cancer Research

... 3205: Perifosine, as a single agent, inhibits neuroblastoma tumor cell growth in in vitro and in vivo preclini...0, # 13 Abstract Summary: In vitro studies in neuroblastoma cell lines indicate that perifosine treatment indu...rifosine treatment led to significant increases in neuroblastoma tumor bearing mouse survival. In summary, Investi...

Exosome Diagnostics Announces Additions to Management Team

...used as a diagnostic tool for cancers and metabolic diseases. Exosome Diagnostics' lead program is a blood-based diagnostic test for the management of neuroblastoma patients. For more information, visit http://www.exosomedx.com . Media Contacts: Robert Flamm, Ph.D., or David Schull Russo Partners (212)...

Lixte Biotechnology Holdings, Inc. Announces the Initial Trading of Its Common Stock Under the Symbol: LIXT

... in late 2008 or early 2009. Lixte will also evaluate the anti-cancer activity of its new compounds against two life- threatening cancers of children, neuroblastoma and medulloblastoma, and against several common cancers of adults in addition to GBM. About the National Institute of Neurological Disorders and Stro...

The Bio-Rad Silver Stain, Rev E

...d partially reversible for 3 H with a photochemical stain, Anal. Biochem 116, 248255 (1981) 82. Van Zoelen EJ et al., neuroblastoma cells express c-sis and produce a transforming growth factor antigenically related to the platelet-derived growth factor, Mol Ce...

Streamline Your siRNA Transfections

... cell lines, including MCF-7 (breast adenocarcinoma cells), SKOV3 (ovarian cancer cells), A549 (lung carcinoma cells), SKNAS (bone marrow neuroblastoma cells), and BJ cells (primary foreskin fibroblast cells) (data not shown). Figure 2. Efficient Transf...
Neuroblastoma in Biological Definition

Cancer

...peak incidence of cancer in children occurs during the first year of life. neuroblastoma is the most common infant malignancy, followed by the leukemias and the ...ncer. Childhood cancers include, from most frequently occurring to least: neuroblastoma , leukemia , central nervous system, retinoblastoma , Wilms' tumor , ger...
Neuroblastoma in Biological Dictionary

Schwann cells

... or more ... Original Article from The New England Journal of Medicine -- Role of Ploidy, Chromosome 1p, and Schwann Cells in the Maturation of neuroblastoma In this study, we have utilized subarachnoid route to transplant Schwann cells and ... In tracing group, Schwann cells (labeled with Hoechs...
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