'Multi-target' immune therapy improves outcomes of severe lupus nephritis

A new treatment using a combination of drugs targeting different parts of the immune system improves the recovery rate for patients with severe lupus involving the kidneys, according to a report in the October Journal of the American Society of Nephrology (JASN). "In our study, multi-target t...

What killed Naval hero John Paul Jones?

...ey failure as a result of viral or bacterial infection, which stimulated the development of a form of progressive glomerulonephritis. The interstitial nephritis was the end result of this progressive disease. He also had pneumonia, an incidental finding not likely related to his kidney disease." The ach...

JCI table of contents: March 23, 2009

...or kallikrein proteins in anti-GBM antibodyinduced nephritis (a mouse model of Goodpasture syndrome) and spontaneous lupus nephritis in mice and humans. In the study, which was led...systemic lupus erythematosus and spontaneous lupus nephritis were found to be associated with kallikrein genes,...

Lupus is a Significant Cost to Employers, According to Thomson Reuters Study

...gher for lupus patients, though absence costs were not. Lupus patients with nephritis had much higher medical expenses. The mean annual total medical expenditure...atients were almost four times higher than those for lupus patients without nephritis and $46,862 higher than those of the control group. Using similar me...

BioMarin and La Jolla Pharmaceutical Sign Worldwide (Excluding Asia Pacific) Development and Commercialization Agreement for Riquent

...ent reduces the frequency of renal flares in lupus nephritis patients. The ASPEN Phase 3 study is the largest clinical study ever conducted in lupus nephritis and there is increasing evidence that Riquent targ...ceptionally good strategic fit for BioMarin. Lupus nephritis is a serious and potentially fatal orphan disease ...

Ovarian function and fertility preserved in women with severe systemic lupus erythematosus

...d by the difficult nature and impact of the disease itself." In this retrospective evaluation of 61 postmenopausal women with SLE treated for lupus nephritis (n=58), autoimmune hemolytic anemia (n=1) and central nervous system involvement (n=2), 39 patients received prolonged treatment with 1g/m2 intravenou...

Lupus more severe in patients with Southern European ancestry

...ilder mucocutaneous (skin) manifestations of SLE, whereas southern European ancestry contributes to more severe manifestations of the disorder such as nephritis (inflammation of the kidneys) and increased production of specific autoantibodies (antibodies that fail to recognise and therefore attack the body's o...

Researchers investigate ways to detect lupus-associated kidney disease

...mmunology. Given that early intervention in lupus nephritis is associated with better treatment outcome, it is...dy itself. When the antibodies attack the kidneys, nephritis occurs, often shortening a patients life expectanc...and colleagues screened urine from mice with lupus nephritis for the presence of four compounds VCAM-1, P-sele...

Black-white Life Expectancy Gap Reduces, Yet Remains Significant

...erinatal death, although demonstrating favorable trends, continue to keep the black-white gap unnecessarily large, and unfavorable mortality trends in nephritis [kidney disease] and septicemia [bloodstream infection] are currently contributing to widening the gap," the authors write. The authors emphasi...

Nephritis in Medical Technology

Aspreva and Roche Announce Preliminary Results for Phase III Study Evaluating CellCept in Lupus Nephritis

VICTORIA, BC, Canada and BASEL, Switzerland, June 27 /CNW/ - Aspreva Pharmaceuticals Corporation (NASDAQ: ASPV; TSX: ASV) and Roche today released preliminary results for a clinical trial comparing CellCept (oral mycophenolate mofetil, MMF) to intravenous cyclophosphamide (IVC), which is the curren...

Statement From the Lupus Foundation of America Regarding the Release of Top-Line Results From a Study of Rituxan for the Treatment of Lupus

... remember that there are a variety of promising therapies in the near-term pipeline - including an ongoing study of Rituxan for the treatment of lupus nephritis (kidney disease). That study assesses Rituxan's potential in a focused subset of lupus patients with a highly objective outcome. Thus, we remain optim...

Lupus Foundation of America Statement on Results for Clinical Study of CellCept Released by Aspreva Pharmaceutical Company

...e IVC has been referred to as the "standard of care" for treatment of lupus nephritis it has never been approved by the FDA as a treatment for lupus. In ord...ments available might be an important overall improvement in care for lupus nephritis patients. In line with this, the LFA is eager to see some subset analysis, ...

Nephritis in Medical Definition

Pathology

...N39 ) Diseases of the glomerulus Lupus nephritis | Post-infectious glomerulonephritis | Minimal...diseases of the kidney Drug-induced interstitial nephritis | Obstructive nephropathy | Radiation nephritis | Reflux nephropathy | Sarcoidosis Gene...

Nephritis in Medical Dictionary

Nephritis

Nephritis is inflammation of the kidney. The word comes from the Greek nephro- meaning "of the kidney" and -itis meaning "inflammation". Nephritis is often caused by infections, toxins, and auto-immune diseases. More about Nephritis : Causes and symptoms Diagnosis Tre...

Lupus nephritis

Lupus nephritis is an inflammation of the kidney caused by systemic lupus erythematosus (SLE), a disease of the immune system. Apart from the kidneys, SLE can also damage the skin, joints, nervous system and virtually any organ or system in the body. Lupus nephritis is in...

Interstitial nephritis

Interstitial nephritis is a form of nephritis affecting the interstitium of the kidneys surrounding the tubules. This disease can be either acute, which means it occurs suddenly or chronic, meaning it is ongoing and eventually ends in kidney failure. Interstitial nephritis may be ...

Renal biopsy

...INTRODUCTION A percutaneous renal biopsy may be obtained for a number of reasons, ... Indications for renal biopsy in patients with lupus nephritis ... Renal biopsy . Definition. A renal biopsy is the removal of a ... Atheroembolic renal disease. Chronic glomerulonephritis. Complicat...

Renal

... Translational Research on Polyoma Virus (BK Virus) nephritis in Renal Transplant Recipients ... Studies on Renal Transplantation - Newer Immunosuppressive ... Online Medical Dictionary and glossary with ...

Nephrosis

... Sometimes, the kidneys aren't able to do their job properly. Other than kidney infections, the two most common kidney conditions among teens are nephritis and nephrosis . Online Medical Dictionary and glossary with medical definitions ... Nephrosis an be caused by kidney disease, or it may be a...

Inflammation

...rs ... Inflammation is a natural defense of the body to protect against foreign substances or injury. ... Inflammation of kidneys is known as nephritis and may cause ... How does inflammation relate to heart disease and stroke risk? " Inflammation " is the process by which the body respon...

Acute tubular necrosis

... Acute Tubular Necrosis . Prerenal Azotemia. Rate of creatinine rise ... Introduction· Acute Tubular Necrosis (ATN)· Tubulointerstitial nephritis ... most common causes of acute tubular necrosis (ATN) are hypotension and nephrotoxins. ... ACUTE TUBULAR NECROSIS . by Geoffrey K. ...

Acute nephritic syndrome

...hritic syndrome is the result of inflammation of the internal ... nephritic syndrome n. A syndrome comprising the clinical symptoms of nephritis , hematuria, ... acute nephritic syndrome at Dorland's Medical Dictionary ... Acute nephritic syndrome is a group of disorders that c...

Nephritis in Biological Technology

ZymoGenetics and Merck Serono Receive FDA Special Protocol Assessment for Atacicept Pivotal Study in Lupus Nephritis

- Patient enrollment to begin in fourth quarter - SEATTLE, Oct. 4 /PRNewswire-FirstCall/ -- ZymoGenetics, Inc. (Nasdaq: ZGEN) today announced that, together with its collaborator Merck Serono, it has reached agreement with the U.S. Food and Drug Administration (FDA) on a Special Pro...

Nephritis in Biological Definition

Gregor Mendel

...t three times over the next thirty-five years. Mendel died on January 6 , 1884 in Brno , Austria-Hungary (now Czech Republic ), from chronic nephritis . Rediscovery of Mendel's work It was not until the early 20th century that the importance of his ideas was realized. In 1900 , his work w...

Kidney

...dney tumors Wilms tumor Renal cell carcinoma Renal failure (acute and chronic) Glomerulonephritis Diabetic nephropathy Lupus nephritis Dialysis and kidney transplants Generally, one can live fine with just one kidney. If both kidneys do not function properly, dialysis is pe...

Nephritis in Biological Dictionary

Glomerulus

...ften used alone to designate one of the glomeruli of the kidney. ... glomerulus ... glomeruli . cyclooxygenase-2 (COX-2) glomerular. glomeruli . nephritis ... glomerulus synonyms. glomerulus usage examples and glomerulus quotes. ... glomeruli -·li′ (-lī′) any cluster or structure of blood ves...