Amgen and Wyeth Statement on FDA Announcement About Tumor Necrosis Factor (TNF) Blockers
THOUSAND OAKS, Calif. and COLLEGEVILLE, Pa., Aug. 4 /PRNewswire-FirstCall/ -- Amgen (Nasdaq: AMGN ) and Wyeth Pharmaceuticals, a division of Wyeth (NYSE: WYE ), issued a statement in response to the Food and Drug Administration (FDA) announcement regarding the results of a safety rev...
Effect of tumor necrosis factor a inhibitors on heart failure risk in RA Patients
A chronic autoimmune disease, rheumatoid arthritis (RA) is characterized by persistent inflammation of the synovial membrane and progressive joint destruction. Beyond loss of mobility, sufferers face a high risk of heart failure. An inflammatory cytokine known for contributing to the development...
Link between treating osteoporosis with bisphosphonates and incidence of bone necrosis examined
BOSTON, Feb. 16, 2008 According to the National Osteoporosis Foundation, osteoporosis affects some 25 million Americans annually, 80 percent of them women. Because the disease causes a thinning of the bone, it can lead to hip fractures, spinal fractures and a whole host of debilitating and someti...
Massive necrosis after trans-catheter treatment is more common in the presence of tumor capsule
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Prognosis of patients with HCC complicating cirrhosis mainly depends on the tumor growth, progression of the underlying liver disease and the effectiveness of antitumoral treatment. Trans-catheter treatment is extensively us...
USC dentist links Fosomax-type drugs to jaw necrosis
Researchers at the University Of Southern California, School Of Dentistry release results of clinical data that links oral bisphosphonates to increased jaw necrosis. The study is among the first to acknowledge that even short-term use of common oral osteoporosis drugs may leave the jaw vulnerable ...
Popular osteoporosis drugs triple risk of bone necrosis
A University of British Columbia and Vancouver Coastal Health Research Institute study has found that a popular class of osteoporosis drugs nearly triples the risk of developing bone necrosis, a condition that can lead to disfigurement and incapacitating pain.
The research is the largest study ...
Necrosis in Medical Technology
TARGETED GENE DELIVERY SIGNALS CANCER VACCINATION IN VIVO: Intravenous Infusions of Rexin-G Followed by Reximmune-C Induce Tumor Necrosis and Recruitment of Tumor Infiltrating Lymphocytes in Cancerous Lesions (ASCO 2008)
SAN MARINO, Calif., May 27 /PRNewswire/ -- Epeius Biotechnologies
( http://www.epeiusbiotech.com ) announced today that the results of a Phase
I Feasibility Study of sequential targeted gene delivery -- using Rexin-G
followed by Reximmune-C -- for cancer vaccination will be presented at the
SIMPONI(TM) (golimumab) Receives Positive Opinion From CHMP for Once-Monthly Subcutaneous Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis
Upon receipt of the corresponding Commission Decision, SIMPONI will be the first and only once-monthly subcutaneous anti-tumor necrosis
factor (TNF) alpha therapy approved in Europe for the simultaneous treatment of RA, PsA, and AS. SIMPONI will be available in two device forms, either...
New Analysis Shows Efficacy of SIMPONI(TM) (golimumab) in Anti-TNF Experienced Rheumatoid Arthritis Patients
...emonstrated that a greater proportion of patients with moderately to severely active rheumatoid arthritis (RA) who had prior treatment with anti-tumor necrosis
factor (TNF)-alpha agents and received subcutaneous injections of SIMPONI(TM) (golimumab) once every four weeks experienced significant improvements i...
New One-Year Data from REMICADE(R) SONIC Trial Show Sustained Efficacy Compared with Azathioprine in Treatment of Crohn's Disease
...tients maintaining steroid-free remission through one year."
The SONIC clinical trial is the first of its kind to compare REMICADE, an anti-tumor necrosis
factor (TNF)-alpha therapy, with an immunomodulator (azathioprine) in patients with moderate to severe Crohn's disease. Azathioprine is not approved ...
PROTECT-1 Phase II/III Induction-Stage Results for ChemoCentryx's Traficet-EN(TM) Presented in Oral Session at DDW 2009 Conference
...tory bowel diseases and many patients do not respond to or cannot tolerate current treatment options, including the newer biologics such as anti-Tumor necrosis
Factor (TNF) agents, which need to be injected or infused. There was no evidence of an increased risk of infection with Traficet-EN in PROTECT-1. Th...
TNFerade(TM) Phase III Data Presented at ASCO
TNFerade, which has not yet been approved for use, is an adenovector, or DNA carrier, which contains the gene for tumor necrosis
factor-alpha (TNF alpha), an immune system protein with potent and well-documented anti-cancer effects, for direct injection into tumors. After admini...
Necrosis in Medical Products
Tumor Necrosis Factor-Alphaby Chemiluminescence
Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
The Targis® System
Description:...rethral microwave thermotherapy -TUMT®) to deliver precisely targeted microwave energy deep into hyperplastic prostate tissue creating coagulative necrosis
for durable clinical outcomes. Dual parameter feedback system continually monitors urethral and rectal temperatures for optimal therapeutic intraprost...
Description:...is designed to treat or help prevent lower extremity disorders associated with immobility such as hip displasia, foot drop, contractures and pressure necrosis
at the calcaneus. A comfortable Kodel lining provides a comfortable wicking interface for the patient. The anti-rotation bar is easily rotated and lo...
Company:Sky Medical, Inc.
ndigo OPTIMA Laser System
Description:... interstitial laser coagulation, the laser delivers a controlled level of laser energy to heat the targeted tissue to a temperature range where tissue necrosis
rapidly occurs, but below temperatures at which carbonization begins. When used to ablate or cut tissue, the laser delivers a controlled level of lase...
Company:Johnson and Johnson
TherMatrx® Dose Optimized Thermotherapy™
The TherMatrx treatment catheter delivers a carefully controlled dose of heat directly to the periurethral tissue. This tissue is heated above the necrosis
threshold of 45, resulting in symptom relief. (In TURP procedures, this is the tissue that is resected.) Heat is not directed towards sensitive tissue...
Mayfield Adult Horseshoe Headrest
Adjustable pad base accommodates various head sizes
Fluid resistant gel pads provide comfort and reduce the incidence of pressure necrosis
Pulley Rod attachment for skeletal traction
Company:Integra LifeSciences Corporation
Necrosis in Medical Definition
...xact mechanism in which these diseases cause cachexia is poorly understood, but there is probably a role for inflammatory cytokines such as tumor necrosis
factor alpha (TNF-α) -which is also nicknamed cachexin for this reason-, Interferon gamma (IFNɣ), and Interleukin 6 (IL-6), as well as the tum...
Society for Hematopathology
v • d • e
Principles of pathology
Disease - necrosis
- Infection - Ischemia - Inflammation - Wound healing - Neoplasia
Surgical pathology - Cyto...
...rs its replacement by a different cell type. 
is the irreversible destruction of cells as a result of severe injury in a... • e
Principles of pathology
Disease - necrosis
- Infection - Ischemia - Inflammation - Wound healing - ...
Necrosis in Medical Dictionary
is the premature death of cells and living tissue. Necrosis
is caused by external factors, such as infection, toxins, or trauma. This is in contrast to apoptosis, which is a naturally occurring cause of cellular... necrosis
( nə′krōsəs ) ( medicine ) Death of a cell or group ...
Avascular necrosis necrosis
, ischemic bone necrosis
, and AVN) is a disease resulting from the temporary or permanent loss of the blood supply to an area of bone. Without blood, the bone tissue dies and the bone collapses. If... Avascular necrosis
(osteonecrosis) — Comprehensive ...
Acute tubular necrosis
Acute tubular necrosis
or (ATN) is a medical condition involving the death of tubular cells that form the tubule that transports urine to the ureters while reabsorbing 99% of the water . Tubular cells continually replace themselves and if the cause of ATN is removed... Acute tubu...
...What are the symptoms of a poisonous snake bite ? ... Snake bite are sometime an occupational hazard for those associated with forest, ... necrosis
and secondary infection, a common cause of death in snake bite patients. ... When a poisonous snake bites its victim, the venom passe...
... Purpura . Authoritative facts about the skin from the New Zealand Dermatological Society. ... Heparin induced thrombocytopaenia – purpura and necrosis
due to ... Typical symptoms include palpable purpura (small hemorrhages in the skin), joint ... "1990 criteria for the classification of Heno...
...AVOIDANCE! PREVENTION. Risk assessment ... Vitamin C—500 mg BID decreases surface area of pressure ulcer ... Pressure ulcers are areas of necrosis
and ulceration where tissues are ... A score < 14 indicates a high risk of pressure ulcer development. ... A pressure ulcer is an area...
Necrosis in Biological News
Older men more likely than women to die after pneumonia
...burgh School of Medicine and corresponding author of the study.
The researchers measured blood levels of inflammatory indicators, including tumor necrosis
factor (TNF) and interleukins 6 and 10, coagulation indicators including Factor IX, and fibrinolysis indicators including D-dimer concentrations. They...
Vitamin D deficiency related to increased inflammation in healthy women
...son will determine the effectiveness of Vitamin D in reducing disease symptoms and reducing blood glucose levels in diabetics. The study, "Serum tumor necrosis
factor-alpha concentrations are negatively correlated with serum 25(OH) D concentrations in healthy women," was published in the Journal of Inflammat...
Team identifies a molecular switch linking infectious disease and depression
...n analysis of gene regulation in the mouse brains showed that exposure to BCG increased expression of IDO and two cytokines known to induce IDO: tumor necrosis
factor-alpha and interferon-gamma.
Because IDO degrades tryptophan, which is the precursor of serotonin, a brain chemical known to positively infl...
A worm-and-mouse tale: B cells deserve more respect
...ucial for the organism to fight off infection.
Lund's team showed that the chemical messengers produced by B cells, such as interleukin-2 and tumor necrosis
factor, are necessary for the immune system to protect mice against Heligmosomoides polygyrus . The team also showed that B cells must be present in ...
La Jolla Institute signs exclusive license agreement with Medimmune on major asthma discovery
...0, its receptor, can substantially suppress the lung inflammation and accompanying symptoms of an asthma attack. OX40 ligand is a member of the tumor necrosis
factor (TNF) superfamily of molecules, which are signaling proteins used by inflammation-causing cells to communicate with the rest of the immune syst...
Tips from the American Journal of Pathology
...t also damages normal tissues. Autologous transplant of tissues such as fat tissue has often been used to prevent the fibrosis, organ dysfunction, and necrosis
that result from radiation treatment; however, the effects of radiation on the transplanted fat tissue had not been studied.
Dr. Cousin's group c...
Necrosis in Biological Technology
The measurement of DNA condensation and mitochondrial changes during apoptosis and necrosis in cell based assays
Key words: In Cell Analyzer • apoptosis • multiplexing • cell based assays
Apoptosis represents a gene-directed, morphologically and biochemically distinct form of programmed cell death. Inappropriate control of apoptosis is associated...
Cimzia(R) (certolizumab pegol) Provides Long-Term Remission and Response Rates in Infliximab-Refractory Crohn's Patients
...to conventional therapy. Cimzia is the only PEGylated anti-TNF alpha (Tumor necrosis
"These are important findings as Cimzia(R) shows an ext...(R) (certolizumab pegol)
Cimzia(R) is the only PEGylated anti-TNF (Tumor necrosis
Factor). Cimzia(R) has a high affinity for human TNF-alpha, selectively neu...
Nereus Pharmaceuticals Initiates ADVANCE, a Randomized Phase 2 Clinical Trial of NPI-2358 in Non-Small Cell Lung Cancer
...isolated from a marine fungus. NPI-2358 has a dual effect on tumors: it selectively attacks existing tumor blood vessels leading to hemorrhagic tumor necrosis
without affecting normal vasculature, and it has a direct apoptotic effect on tumor cells. In preclinical models of cancer, including lung, breast, s...
Cryoablation of Early Invasive Ductal Breast Cancer With MRI Confirmation Shows Promising Clinical Benefits, According to Study Presented at RSNA
...rted characteristic and reproducible
findings of signal void on post-contrast subtraction images ("black hole")
correlates with an area of coagulation necrosis
at the cryoablation site and a
surrounding uniform thin rim enhancement ("cryohalo") corresponds to a zone of
inflammation at the cryoablation margin....
New Data Suggest CIMZIA(R) (Certolizumab Pegol) Active in Treating Moderate to Severe Crohn's Patients With Fistulizing Disease
...y with CIMZIA(R) (certolizumab pegol) - the only PEGylated anti-TNFa (Tumor necrosis
Factor alpha). Additionally, the data showed that fistulas in most of these...certolizumab pegol)
CIMZIA(R) is the only PEGylated anti-TNFa (Tumour necrosis
Factor alpha). CIMZIA(R) has a high affinity for human TNF-alpha, selective...
Golimumab Phase 3 Data Show Significant Improvement In Physical Function In Patients with Rheumatoid Arthritis
...d at the American College
of Rheumatology (ACR) Annual Scientific Meeting. The first trial was in
patients who were previously treated with anti-tumor necrosis
agents and the second study was in patients who were active despite ongoing
treatment with methotrexate.
"In addition to reducing signs...
Necrosis in Biological Definition
...ll in a multicellular organism . In contrast to necrosis
, which is a form of cell death that results from ...accident or pathogenic infection (cell death by necrosis
). Instead of swelling and bursting - hence spilli...e present at each step of these pathways.
factor ( TNF ), a 157 amino acid inter-cellular si...
...evere internal bleeding, or hemorrhage .
Circulation blockage can also create many medical conditions from ischemia in the short term to tissue necrosis
and gangrene in the long term.
Hemophilia is a genetic illness that causes dysfunction in one of the blood's clotting mechanisms . This can a...
peripheral neuropathy which, particularly when combined with damaged blood vessesls, can lead to foot ulcers, and possibly progressing to necrosis
, infection and gangrene , sometimes requiring limb amputation , see below
nephropathy (due to microangiopathy ) which can lead to renal fa...
...ymptoms progress to vomiting , diarrhea , oropharyngeal lesions , conjunctivitis , organ damage (notably the kidney and liver ) by co-localized necrosis
, proteinuria (the presence of proteins in urine), and bleeding both internal and external, commonly through the gastrointestinal tract . Death o...
Single-stranded RNA satellite viruses
Sugroup 1: Chronic bee-paralysis satellite virus
Subgroup 2: Tobacco necrosis
Satellite nucleic acids
Single-stranded satellite DNAs
Double-stranded satellite RNAs
Single-stranded satellite RNAs...
Necrosis in Biological Dictionary
...Femur - Human Anatomy ... The femur (Figs. ... The femur , like other long bones, is divisible into a body and two extremities. ... Avascular necrosis
of the Femoral Head (AVN-FH) refers to a progressive weakening of the knobby head of the thigh bone ( femur ), resulting in eventual collapse of the ....