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Natriuretic in Medical News

Newer Blood Tests May Not Improve Heart Risk Assessment

...iated phospholipase 2; midregional proadrenomedullin; midregional proatrial natriuretic peptide; and N-terminal pro-B type natriuretic peptide. Five of the biomarkers did help predict future heart problems, ...

Mayo Genomic Discovery: Protecting Kidney Function During Heart Failure

... impaired. Seven Years of Research The mapping of the human genome (2000-2003) revealed a gene that produces a protein called BNP (B-type natriuretic peptide). BNP was not only useful in diagnosing heart problems, it also proved therapeutic in treating heart failure. Unfortunately, says Dr. Simari, ...

Novel biomarkers in heart failure

... adrenomedullin hormone which is a potent vasodilator, with inotropic and natriuretic properties; assessment of mid-regional part of the proadrenomedullin (MR-pr... C-reactive protein (CRP) for anemia hemoglobin for cardiac function natriuretic peptides Biomarker assessments are used in many clinical scenarios, i...

Nile Therapeutics Reports 2009 First Quarter Financial Results

...nd, CD-NP, a novel rationally designed chimeric peptide in clinical studies for the treatment of heart failure, and CU-NP, a novel rationally designed natriuretic peptide. A key component of the company's strategy is to acquire the global rights to additional compounds to expand its portfolio. More information o...

NPs-NPR-B/pGC-cGMP signal pathway is involved in diabetic gastroparesis

... The natriuretic peptide (NP) receptor type B (NPR-B) gene was expressed in gastric smooth m...d the expression was increased in diabetic rats. These results suggest that natriuretic peptide-dependent pGC-cGMP signal is up-regulated and it may contribute to ...

New tests provide new insight into why patients are in heart failure

...ure have less of the enzyme corin needed to activate pro-ANP, or pro-atrial natriuretic peptide, a hormone made by heart muscle cells that, when active, helps redu...ss fluid and sodium. More recently a substance similar to ANP, called brain natriuretic peptide, or BNP, also is being used. As with pro-ANP, a heart experienc...

Genes That Control Body's Salt Levels Are Identified

...ip that these gene variants cause higher levels of natriuretic peptides and therefore are related to blood pressure." natriuretic peptides are compounds that help the body get rid ...variants of two genes for these peptides -- atrial natriuretic peptide (ANP) and B-type...

Nile Therapeutics to Present at the 2009 BIO CEO & Investor Conference

...nd, CD-NP, a novel rationally designed chimeric peptide in clinical studies for the treatment of heart failure, and CU-NP, a novel rationally designed natriuretic peptide. More information on Nile can be found at http://www.nilethera.com . This press release contains forward-looking statements within th...

Monitoring Protein Didn't Improve Heart Failure Outcomes

...ymptoms leads to similar survival rates in older patients TUESDAY, Jan. 27 (HealthDay News) -- Using the biomarker molecule known as brain natriuretic peptide (BNP) to guide treatment for older people with chronic heart failure did not improve the clinical outcome in most cases in a Swiss study. T...

Nile Therapeutics to Present at the 27th Annual J.P. Morgan Healthcare Conference

...re; 2NTX-99, a small molecule, pre-clinical, anti-atherothrombotic agent with nitric oxide donating properties; and CU-NP, a novel rationally designed natriuretic peptide. More information on Nile can be found at http://www.nilethera.com . This press release contains forward-looking statements within th...
Natriuretic in Medical Technology

FDA Submission of B-R-A-H-M-S MR-proANP Kryptor

... B-R-A-H-M-S MR-proANP Kryptor Test. Atrial natriuretic Peptide (ANP) is predominantly produced in the atrium of the heart and comprises 98% of the natriuretic peptides in the circulation. ANP is involved in na...g prohormone fragment: the Mid-Regional pro-Atrial natriuretic Peptide (MR-proANP). In contrast to the mature pep...

Palatin Technologies Presents PL-3994 Clinical Trial Results at the 12th Annual Scientific Meeting of the Heart Failure Association of America

...ed results from a Phase 1 clinical study with PL-3994, a novel, long-acting natriuretic peptide receptor A (NPRA) agonist under development for treatment of the ch...ptide mimetic and small molecule compounds with a focus on melanocortin and natriuretic peptide receptor systems. The melanocortin system is involved in a large an...

Nile Therapeutics Announces Dosing in Second Phase Ib Study of CD-NP in Heart Failure Patients

...ntrolled clinical study of CD-NP, a novel chimeric natriuretic peptide, in development for the treatment of acute...in 2008. About CD-NP CD-NP is a novel chimeric natriuretic peptide in clinical development for an initial ind...properties; and CU-NP, a novel rationally designed natriuretic peptide. A key component of the company's strategy...

Study Reveals Potential for NT-proBNP as a Marker to Predict Cardiovascular Risks From Anti-Inflammatory Drugs

...agnostics-sponsored pilot study evaluating the use of N-terminal pro-B-type natriuretic peptide (NT-proBNP) confirms the potential value of NT-proBNP for risk stra...anuth E, Jaffe AS, Giannitsis E. The Concentration of N-Terminal Pro-B-type natriuretic Peptide Predicts the Risk of Cardiovascular Adverse Events from Antiinflamm...

Nile Therapeutics Announces Dosing in Phase IIa Study of CD-NP in Heart Failure Patients

...'s lead product candidate, CD-NP, a novel chimeric natriuretic peptide, in development for the treatment of acute...fects of this novel, rationally designed, chimeric natriuretic peptide." About CD-NP Nile's lead compound, CD-NP, is a novel chimeric natriuretic peptide in clinical development for an initial ind...

Palatin Technologies Initiates Phase 2 Hypertension Clinical Study With PL-3994

... Palatin Technologies, Inc. (Amex: PTN ) announced today that dosing has been initiated in a Phase 2a clinical study of PL-3994, a novel, long-acting natriuretic peptide receptor A agonist, in subjects with controlled hypertension. The study is placebo-controlled and double-blinded, and will include up to fiv...

Palatin Technologies, Inc. Reports Initiation of Human Trials for the Treatment of Congestive Heart Failure

...s older than 65 years of age and an underserved medical condition." Atrial natriuretic peptide (ANP) is a naturally produced peptide hormone involved in regulatio...ger duration of action is believed to relate to diminished affinity for the natriuretic peptide clearance receptor and increased resistance to the enzyme neutral e...

UPDATE: Nile Therapeutics Announces Positive Phase 1a Results of CD-NP, a Selective NPR-B Agonist in Clinical Development for the Treatment of Heart Failure

...his study will be included in the Company's presentation today at the BIO Investor Forum in San Francisco, CA. "The development of a peptide that has natriuretic and renal effects, with relatively little effect on blood pressure, is a potentially important achievement. The results of this trial in healthy volun...

Nile Therapeutics Announces Positive Phase 1a Results of CD-NP, a Selective NPR-B Agonist in Clinical Development for the Treatment of Heart Failure

...his study will be included in the Company's presentation today at the BIO Investor Forum in San Francisco, CA. "The development of a peptide that has natriuretic and renal effects, with relatively little effect on blood pressure, is a potentially important achievement. The results of this trial in healthy volun...
Natriuretic in Medical Products

NT proBrain Natriuretic Peptide

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Brain Type Natriuretic Peptide

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

B-Type Natriuretic Peptide

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Triage BNP Test

Description:... The Triage BNP Test is the first objective measurement for CHF. Blood test measuring B-type natriuretic peptide (BNP) Cardiac hormone produced by the heart ventricles in response to ventricular volume expansion and pressure overload. Excellent hormona...
Company:Biosite

Elecsys® proBNP

Features:... Fully automated quantification of NT-proBNP - The Elecsys proBNP assay provides quantification of the N-terminal prohormone of B-type natriuretic peptide (NT-proBNP), a direct marker for ventricular (dys)function, without interference from certain drug therapies. It is fully automated and compat...
Company:Roche Diagnostics
Natriuretic in Medical Definition

Proteopathy

...ositis Amyloid β peptide (Aβ) Cataracts Crystallins Medullary thyroid carcinoma Calcitonin Cardiac atrial amyloidosis Atrial natriuretic factor Pituitary prolactinoma Prolactin Hereditary lattice corneal dystrophy Keratoepithelin Cutaneous lichen amyloidosis Kera...
Natriuretic in Medical Dictionary

Diuresis

...h dictionary and encyclopedia. ... diuresis - increased secretion of urine; if not due to increased liquid intake ... Cross-circulation study of natriuretic factors in postobstructive diuresis . ... significant, although less marked, diuresis -natriuresis in recipient animals, ... Definition of diur...
Natriuretic in Biological News

Common gene variants increase risk of hypertension, may lead to new therapies

...re involved in the production of atrial and B-type natriuretic peptides (ANP and BNP) proteins known to relax bl...d Finland; and variants associated with changes in natriuretic peptide levels were then tested in the same indivi.... "It's currently premature to advocate screening natriuretic peptide levels or gene variants to diagnose hypert...

Taking the fight against cancer to heart

...o deBold discovered that the heart produces atrial natriuretic factor (ANF), so-named because it is produced in t...same gene as ANF. He called them: Long acting natriuretic peptide, which also stimulates urine production an...gene expression of cardiac hormones, also known as natriuretic peptide hormones (ANPs) and the central role of G-...

Percutaneous aortic valve replacement safe, successful in high-risk patients

...ea more than doubled, on average, following the procedure. In addition, the severity of heart failure significantly improved, as gauged by both B-type natriuretic peptide (NT-BNP), a protein produced by the ventricles of the heart during heart failure, and New York Heart Association (NHYA) classification. After ...

Gene therapy to lower blood pressure just enough

... blood pressure could have important benefits for individuals and for the health of the world's population as well." The gene in question -- atrial natriuretic peptide or ANP -- promises to control blood pressure through a variety of effects on key areas involved in the problem of hypertension, including the...
Natriuretic in Biological Technology

Novel Mass Spectrometry-based Assay Reveals Degradation and Low Levels of Bioactive B-type Natriuretic Peptide (BNP) in Patients with Heart Failure

TEMPE, Ariz., Oct. 16 /PRNewswire/ -- A team of researchers from Intrinsic Bioprobes Inc. has reported on a novel quantitative mass spectrometry immunoassay for the detection of bioactive B-type natriuretic peptide (BNP), in an article published online on Oct. 14 in the journal of Circulation:...

Nile Therapeutics, Inc. Announces Dosing of First Patient in Phase 2 Study of CD-NP for the Treatment of Acute Heart Failure

...nd, CD-NP, a novel rationally designed chimeric peptide in clinical studies for the treatment of heart failure, and CU-NP, a novel rationally designed natriuretic peptide. More information on Nile can be found at http://www.nilethera.com . Safe Harbor Paragraph for Forward-Looking Statements :...

Palatin Technologies, Inc. Receives U.S. Patent Allowance for Heart Failure Drug Candidate

...tent Application Number 11/694,260, titled "Cyclic natriuretic Peptide Constructs." Allowed claims cover a family of cyclic compounds that bind to natriuretic peptide receptor A (NPRA), including PL-3994, Pala...s an extended half-life, with reduced affinity for natriuretic peptide clearance receptors and increased resistan...

Nile Therapeutics, Inc. Completes $3.4 Million Private Placement

...nd, CD-NP, a novel rationally designed chimeric peptide in clinical studies for the treatment of heart failure, and CU-NP, a novel rationally designed natriuretic peptide. More information on Nile can be found at http://www.nilethera.com . Safe Harbor Paragraph for Forward-Looking Statements...

Nile Therapeutics, Inc. To Raise $3.4 Million in Private Placement

...nd, CD-NP, a novel rationally designed chimeric peptide in clinical studies for the treatment of heart failure, and CU-NP, a novel rationally designed natriuretic peptide. More information on Nile can be found at http://www.nilethera.com . Safe Harbor Paragraph for Forward-Looking Statements : T...

Nile Therapeutics CD-NP Clinical Program for Acute Heart Failure Released From Clinical Hold by FDA

...ompleted by the end of 2009. About CD-NP CD-NP is a novel chimeric natriuretic peptide in clinical development for the treatment of acute heart failure. C...for the treatment of heart failure, and CU-NP, a novel, rationally designed natriuretic peptide. A key component of the company's strategy is to acquire the global...

Nile Therapeutics Provides Update on Phase II CD-NP Clinical Trial for Acute Heart Failure

...ts. About CD-NP CD-NP is a novel chimeric natriuretic peptide in clinical development for the treatment ...ity to reduce symptoms of dyspnea, be diuretic and natriuretic and preserve or enhance renal function in heart fa...rt failure, and CU-NP, a novel rationally designed natriuretic peptide. More information on Nile can be found at ...

Nile Therapeutics Announces Information in Compliance With NASDAQ Marketplace Rule 4350 and Reiterates 2009 Objectives

...nd, CD-NP, a novel rationally designed chimeric peptide in clinical studies for the treatment of heart failure, and CU-NP, a novel rationally designed natriuretic peptide. A key component of the company's strategy is to acquire the global rights to additional compounds to expand its portfolio. More information o...

Nile Therapeutics Reports 2008 Fourth Quarter and Full Year Financial Results and Announces Conference Call on March 10, 2009

...nd, CD-NP, a novel rationally designed chimeric peptide in clinical studies for the treatment of heart failure, and CU-NP, a novel rationally designed natriuretic peptide. A key component of the company's strategy is to acquire the global rights to additional compounds to expand its portfolio. More information o...

Nile Therapeutics Announces Focus on CD-NP for Acute Heart Failure and Termination of 2NTX-99 Program

... it will focus resources on the development of its natriuretic peptide franchise, including CD-NP which is in Pha...rogram in order to focus our resources on our core natriuretic peptide program, which is showing great promise as... About CD-NP CD-NP is a novel chimeric natriuretic peptide in clinical development for the treatment ...
Natriuretic in Biological Dictionary

Peptide

...s outlined in Figure 1. ... peptide information peptides c peptide bond ... Patients with diabetes may be deficient in C peptide . ... Brain natriuretic peptide ... The number of amino acid molecules present in a peptide is indicated by a prefix. ... Peptide hormones, which function as chemi...
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