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Naproxen in Medical News

Medinox Announces Clinical Results of Naproxen Prodrug

SAN DIEGO, May 26 /PRNewswire/ -- Medinox, Inc. (Carlsbad, CA) and its development partner, Logical Therapeutics, Inc. (Waltham, MA) announced the results of a double-blind, randomized, active comparator study of LT-NS001 (formerly MX-1094) vs naproxen, in subjects 45 to 70 years of age. LT-NS001...

Watson Pharmaceuticals and Elan Settle Lawsuit Over Naproxen Sodium

CORONA, Calif., March 6 /PRNewswire-FirstCall/ -- Watson Pharmaceuticals, Inc. (NYSE: WPI ), a leading specialty pharmaceutical company, announced today that it has reached a settlement with Elan Corporation, Plc on outstanding patent litigation related to Watson's generic version of Naprelan(R)...

Watson Announces District Court Ruling in Naproxen Sodium Patent Suit

CORONA, Calif., Aug. 13 /PRNewswire-FirstCall/ -- Watson Pharmaceuticals, Inc. (NYSE: WPI ), a leading specialty pharmaceutical company, announced today that the United States District Court for the Southern District of Florida ruled today that Watson's Naproxen Sodium ER tablets, the generic...

Celebrex, Naproxen Won't Prevent Mental Decline

New findings suggest daily use of naproxen might even harm cognitive function MONDAY, May 12 (HealthDay News) -- Contrary to prior studies, a new trial shows that daily use of two popular pain-relieving drugs, Celebrex and naproxen, does not prevent cognitive decline in people with a f...

AUDIO from Medialink and Bayer: Lifesaving Benefits of Low-Dose Aspirin Therapy Maintained with Naproxen Sodium

NEW YORK, Nov. 9 /PRNewswire/ -- Many Americans are currently on a low- dose aspirin therapy for its heart health benefits. But they still feel aches and pains like the rest of us, and that therapy can affect which pain relievers they can use. Listen to this report from Bayer at: http://medi...

FDA Advisers Recommend Smaller Doses of Acetaminophen

...non-steroidal anti-inflammatory drugs (NSAIDs) drugs, the agency said. NSAIDs include popular medicines such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve) and Excedrin. The purpose of the new labeling is to raise awareness of potential liver damage from acetaminophen and the potential for stom...

FDA Report Urges Tougher Acetaminophen Warning

...non-steroidal anti-inflammatory drugs (NSAIDs) drugs, the agency said. NSAIDs include popular medicines such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve) and Excedrin. The purpose of the new labeling is to raise awareness of potential liver damage from acetaminophen and the potential for stom...

Watson Pharmaceuticals Reports First Quarter 2009 Results; Raises 2009 Outlook

... quarter 2009 increased $18.4 million to $68.9 million, and includes $18.0 million related to a legal settlement with Elan Corporation, PLC related to naproxen sodium. Amortization expense for the first quarter 2009 increased $1.6 million to $21.8 million, reflecting the addition of product rights acquir...

FDA Adds New Label Warnings to Over-the-Counter Painkillers

...cording to new rules from the U.S. Food and Drug Administration (FDA). NSAIDs include popular medicines such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve) and Excedrin. "The regulations affect much of the U.S. population, because over-the-counter pain relievers and fever reducers are some of t...

Painkillers May Not Protect Against Dementia

... when they were enrolled in the study. Another 107 started using the medications heavily later on. The drugs in question include ibuprofen (Advil), naproxen (Aleve) and others. People who used the drugs extensively were 66 percent more likely to develop dementia than those who didn't, according to sta...
Naproxen in Medical Technology

Treximet(TM) (Sumatriptan and Naproxen Sodium) Tablets Approved by FDA for Acute Treatment of Migraine

Clinical studies show Treximet provided significantly more patients migraine pain relief compared to sumatriptan 85 mg LONDON, April 15 /PRNewswire-FirstCall/ -- GlaxoSmithKline (LSE: GSK) (NYSE: GSK ) and POZEN Inc. (Nasdaq: POZN ) announced today that the FDA has approved Trexi...

Lifesaving Benefits of Low-Dose Aspirin Therapy Maintained With Naproxen Sodium

Data Suggests That Millions on Aspirin Therapy Can Safely Take Aleve for Pain Without Compromising Cardiovascular Benefits BOSTON, Nov. 7 /PRNewswire/ -- Data to be presented at the 71st annual meeting of the American College of Rheumatology (ACR) showed that when over- the-counter (...

Logical Therapeutics Appoints Peter A. Lankau as CEO and Director

...Line Results of its Clinical Study of LT-NS001 vs. naproxen and Achievement of Financing Milestone WALTHA...ase the GI safety risks associated with naproxen. naproxen is widely regarded as the NSAID with the most favo...s being developed to provide therapeutic levels of naproxen while avoiding high local concentrations of...

Vantia Therapeutics' Pipeline Continues to Mature

...n anti-diuretic. About dysmenorrhoea: Current treatments for dysmenorrhoea include over-the-counter (OTC) painkillers such as the NSAIDs naproxen and ibuprofen. Similar approaches are also taken by GPs and obstetrician/gynaecologists, as well as the off-label use of oral contraceptives. Vasopres...

NicOx' Naproxcinod Shows Robust Blood Pressure Results in Phase 3 Pooled Analysis

...diastolic blood pressure (SBP and DBP) compared to naproxen 500 mg bid over the whole 13 week period (p<0.0... an increase in SBP of 5 mmHg or more, compared to naproxen Over the whole 13 week period the proporti...ose SBP increased by 5 mmHg or more was higher for naproxen 500 mg bid, as compared to naproxcinod 750 mg bid ...

Third Pivotal Phase 3 Study for NicOx' Naproxcinod Shows Positive Efficacy, Safety and Blood Pressure Results

...diastolic blood pressure (SBP and DBP) compared to naproxen 500 mg bid at all time points. No stand alone stat...verall, this was lower for naproxcinod 750 mg than naproxen 500 mg bid. There was not a single serious cardiov...s of the 303 study, in contrast to the placebo and naproxen 500 mg bid arms. Pascal Pfister MD, Chief Scie...

NicOx Announces Favorable Blood Pressure Data for Naproxcinod in a Large ABPM Study

...ure profile of escalating doses of naproxcinod and naproxen in osteoarthritis (OA) patients with controlled hy...teroidal anti-inflammatory drugs (NSAIDs), such as naproxen and ibuprofen, are widely used as symptomatic trea...atment effect, as an average over week 3, 6 and 9, naproxen raised SBP by 1.5 mmHg from baseline, while naprox...

NicOx Announces Second Naproxcinod Pivotal Phase 3 Study (302) Meets Efficacy Primary Endpoints and Supports Non-Detrimental Blood Pressure Effect

...cinod 750 mg bid was statistically non-inferior to naproxen 500 mg bid on the WOMAC(TM) pain and function subs...essure at week-13 and 26, compared to baseline and naproxen 500 mg bid. Existing non-steroidal anti-inflammatory agents (NSAIDs) such as ibuprofen and naproxen have the tendency to raise blood pressure, which i...

Logical Therapeutics Inc. Commences Double-Blind, Randomized Study of Their Lead Program, LT-NS001

...kinetic studies. In all cases, LT-NS001 was well tolerated. Moreover, when the subjects were dosed twice daily with LT-NS001, plasma concentrations of naproxen were within the therapeutic range. The Company also announced the departure of founding CEO, Dr. Mitchell P. Fink, who resigned to pursue other inte...

NicOx Announces Top-Line Results From Naproxcinod 52-Week 301 Safety Extension

...signed to generate one-year safety data for both doses of naproxcinod, with naproxen 500 mg bid as an active comparator arm. Design and top-line results of th... of the general osteoarthritis population. Patients who received placebo or naproxen 500 mg bid, during the 13-week active treatment period of the 301 phase 3 s...
Naproxen in Medical Dictionary

Nonsteroidal anti-inflammatory drugs

...ation: Anti - inflammatory Drugs , Nonsteroidal (Systemic) ... Explains how Nonsteroidal Antiinflammatory Drugs (NSAIDs) such as naproxen block the production of enzymes that promote inflammation, pain, and fever. Consumer information about the medication NONSTEROIDAL ANTI - INFLA...

Drug-induced hepatitis

...he drug and the ... Definition: Drug - induced hepatitis involves inflammation of the liver caused by medication. ... as ibuprofen and naproxen may also cause drug - induced hepatitis . ... Toxic/ drug - induced hepatitis is caused after inhalation or ingestion of a toxin, ... circu...
Naproxen in Biological News

Overuse of narcotics and barbiturates may make migraine worse

...(EM sufferers), a class of drugs called triptans known to relieve migraine did not increase the risk of transformed migraine. NSAIDs (ibuprofen and naproxen sodium, for example) were protective against transition to TM for those suffering less than 10 headache days per month, but were associated with incre...

FDA causes unnecessary scare about common painkillers

...' warnings to all prescription and over-the-counter pain relievers ?even to naproxen ?which the evidence shows is safe," said Furberg, who serves on the FDA Dru... from arthritis. The most commonly used NSAIDs are ibuprofen (Advil®), naproxen (Aleve®), and diclofenac (Voltaren®). There are more than a dozen others, i...
Naproxen in Biological Technology

Logical Therapeutics Inc. Announces Results of Phase 1b Clinical Study of its Naproxen Prodrug

WALTHAM, Mass., Aug. 18 /PRNewswire/ -- Logical Therapeutics, Inc., a biotechnology company focused on the development of medicines that treat diseases associated with poorly controlled inflammation, announced today the successful completion of its Phase 1b randomized controlled multi-dose saf...

NicOx' Naproxcinod Shows Highly Significant Reduction in Daytime Blood Pressure Versus Naproxen

New Analysis of the 104 ABPM Study Presented at the American Heart Association http://www.nicox.com SOPHIA ANTIPOLIS, France, November 12 /PRNewswire-FirstCall/ -- NicOx S.A. (Euronext Paris: COX) today announced that a new analysis of...

Supelco(R) and MIP Technologies Launch New SPE Product for the Selective Extraction of NSAIDs From Environmental Water

...nager of Sample Prep at Supelco. "Such compounds are among the most highly consumed pharmaceuticals in the world." Ibuprofen, diclofenac and naproxen are non-steroidal anti-inflammatory drugs that have analgesic and antipyretic activities. Clofibric acid is an active metabolite of clofibrate, etofib...

Vantia Therapeutics Appoints Rachel Morten as Head of Regulatory Affairs

...mber of women for whom there are currently no targeted therapies; treatments that are in common use however include over-the-counter painkillers (e.g. naproxen or ibuprofen) or oral contraceptives used 'off-label'. It is estimated that the market opportunity for a targeted drug for the prophylaxis and treatme...

Financial Results for Full Year 2008: NicOx in a Unique Position to Deliver Significant Shareholder Value

... 375 bid) were statistically non-inferior to naproxen 500 mg bid at 26 weeks, in terms of the mean...of naproxcinod 375 mg bid, naproxcinod 750 mg bid, naproxen 500 mg bid and placebo, in a large OA population. ...od lowered SBP by 2.3 mmHg from baseline and naproxen raised it by 1.5 mmHg from baseline. - In the...

NicOx Signs Agreement With DSM for the Commercial Manufacture of Naproxcinod Drug Substance

... 111 study) on November 4, where naproxcinod showed a statistically significant reduction in systolic blood pressure of 3.8 mmHg (p=0.011) compared to naproxen over the whole study period. The filing of a New Drug Application (NDA) for naproxcinod with the U.S. Food and Drug Administration (FDA) is projected ...

NicOx Reports Results for the First Three Quarters of 2008

...t all three co-primary efficacy endpoints at week-13 (p naproxcinod 750 mg bid comfortably met the main secondary endpoint of non-inferiority to naproxen 500 mg bid at week-13 and 26. Blood pressure data from the 302 study also supported naproxcinod's non- detrimental effect on blood pressure. -...

Maryland Approves Medicaid Reimbursement for ActiPatch(R)

...anti-inflammatory patch which accelerates healing. Many commonly used pharmaceutical agents including aspirin, ibuprofen (Advil, Motrin, Nuprin) and naproxen (Aleve, Anaprox, Naprosyn) with regular use and most especially long-term use, can have serious complications such as ulcers and bleeding from the gas...

NicOx Initiates Two Large ABPM Studies for Naproxcinod in Hypertensive Patients with Osteoarthritis

...ive increasing doses of either naproxcinod or naproxen at three week intervals. 24-hour blood pressu...mg bid (twice-daily), naproxcinod 750 mg bid, naproxen 250 mg bid, naproxen 500 mg bid or ibuprofen 600 mg tid. At the en...
Naproxen in Biological Dictionary

Prostaglandins

... Publication History: Continued as Prostaglandins and Other Lipid Mediators ... Explains how Nonsteroidal Antiinflammatory Drugs (NSAIDs) such as naproxen block the production of enzymes that ... Prostaglandins are produced within the ... Definitions of crucial pro-inflammatory hormones that are...
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