DNA Molecules Used To Assemble Nanoparticles
University of Michigan researchers have developed a faster, more efficient way to produce a wide variety of nanoparticle drug delivery systems, using DNA molecules to bind the particles together. Nanometer-scaled dendrimers can be assembled in many configurations by using attached lengths of single-stranded DNA molecules, which naturally bind to other DNA strands in a highly specific fash...Imaging Lymph Nodes with Nanoparticles
Accurate staging of cancers is one of the most important parts of thework up of patients for both prediction of prognosis and determinationof the most appropriate treatment. And an essential part of this workup is assessing wh...Taking Aim With Nanoparticle PEBBLEs
In what sounds like a modern-day version of the David and Goliath story, University of Michigan scientists hope to slay a big killer with pebbles. In this case, the killer is not a fearsome giant, but a dreaded disease: cancer. And the pebbles are not the kind you hurl from slingshots; they're nanoscale polymer beads known as Photonic Explorers for Biomedical use with Biologically Localized Embed...Probing The Promise And Perils Of Nanoparticles
For all its promise, the prospect of using nanoparticles in biomedical applications and consumer products has raised concerns about possible harmful effects of the miniscule materials. Scientists at the University of Michigan are addressing those concerns by investigating how certain kinds of nanoparticles damage cell membranes—enough to cause cell death in some cases—and how the damage can be pr...Gene-Nanoparticle Gene Transfer Is Better Than Viral Vector Transfer System
Nanoparticles can be used in gene therapy to transfer therapeutic genes in to brain cells //and helps in studying genetic mechanism of brain diseases. Gene-nanoparticle complexes developed by scientists at the University of Buffalo, has proved to deliver therapeutic genes directly into the brains of living mice, the transfer rate is comparatively higher to transfer rates of viral vecto...MRI with nanoparticles highly sensitive in detecting prostate cancer metastases
High-resolution MRI with magnetic nanoparticles is highly sensitive in detecting clinically occult lymph-node metastases in prostate cancer, according to a new report. In fact, routine use of this modality preoperatively could obviate many unneeded surgeries.// The nanoparticles, which are given intravenously 24 hours before scanning, work by binding to lymphatic cells. The particles only...Gold Nanoparticles: Agents For Noninvasive Cancer Therapy
Gold nanoparticles are potential and very practical agents in therapeutic applications. Researchers from the University of California, San Francisco and Georgia Institute of Technology, writing Cancer Letters // (Available online 28 September) demonstrate the efficiency of gold nanospheres as photothermal agent by selectively delivering gold nanoparticles to oral carcinoma cells that overexpress...Alzheimer's Can Be Slowed Down By Gold Nanoparticles
A combination of radiation and gold nanoparticles can help in slowing down the progress of Alzheimer's disease, according to a research conducted by scientists from Spain and Chile. The healthy brain // cells will not be affected by this. According to their study, to be published in the American Chemical Society's Nano Letters, the technique, a type of molecular surgery, has the potential to d...Gold Nanoparticles Are Good Detectors Biological Toxins
Researchers at the University of East Anglia have found that gold nanoparticles are very effective detectors of biological toxins//. These particles they say reveal the presence of poisons far faster than existing techniques that often involve shipping samples back to a lab. This they hope would help in aiding investigations at crime scenes. Researchers led by Professor David Russell...Vision Deficit in Retinitis Pigmentosa Mice Corrected with DNA Nanoparticles
CLEVELAND--(BUSINESS WIRE)--Jun 4, 2007 - Copernicus Therapeutics,Inc. announced today that a research team at University of OklahomaHealth Sciences Center, led by Dr. Muna Naash, Professor of CellBiology, demonstrated that Copernicus' DNA nanoparticles correctedvision defects in a mouse model of retinitis pigmentosa (RP). Thesefindings were presented at the American Society of Gene Therapy...Evidence of Nanoparticles Found in Plaque-Filled Arteries
ROCHESTER, Minn., April 30. 2007-- Scientific evidenceincreasingly links arterial calcification to the presence ofnanosized particles -- so small that some scientists questionwhether a nanoparticle can live and, if so, play a viable role incausing disease. A new Mayo Clinic study cites evidence showing the presence ofnanoparticles near plaque-filled arteries in animal models....