Putting microRNAs on the stem cell map
...oint where transcription factors bind to DNA and launch gene expression. This pinpointed where four master transcription factors (known as Oct4, Sox2, nanog
and Tcf3) were occupying sites where microRNA genes start to be transcribed. They found that the four core transcription factors are interacting with ...
Molecular alliance that sustains embryonic stem cell state
For example, Klfs were found to regulate the nanog
gene and other key genes that must be active for E... differentiating into virtually any type of cells. nanog
gene is one of the key pluripotency genes in ES cells.
"We suggest that nanog
and other genes are key effectors for the biologic...
To evade chemotherapy, some cancer cells mimic stem cells
The cancer stem cell markers include nanog
and BMI1, both of which contribute to stem cells d...e treatment. The researchers first determined that nanog
and BMI1 stem cell markers were more highly expres...tments shrank tumors, they increased expression of nanog
and BMI1. These treatments were not enough to comp...
Reprogramming human cells without inserting genes
...llThera turned on the existing, yet dormant, stem cell genes OCT4, SOX2 and nanog
already in the skin cells by lowering the amount of atmospheric oxygen the ...ven more surprising, the team found that the stem cell genes OCT4, SOX2 and nanog
were not completely dormant in untreated skins cells, as was presumed. Thos...
Controlling embryonic fate by association
...s found that two critical embryonic cell proteins nanog
and Oct4 associate with specific components that ...ng with histone deacetylases. NODE associates with nanog
and Oct4 to control the fate of embryonic stem cel...the parts of a car, said Songyang. If you think of nanog
as the engine that drives it, you realize that the...
Study hints at role of stem cell genes in testicular, breast cancers
...ases, OCT4 was elevated in 56 percent of cases and nanog
and STELLAR expression were elevated in 33 percent...e in normal testis, in the nine samples. OCT 4 and nanog
were the highest expressed genes in each of the se...ve shown, says Clark, that OCT 4, which works with nanog
to regulate the capacity of cells to specialize, c...
Researchers discover key to human embryonic stem-cell potential
...erating many different specialized cells and tissues. Thus, Oct4, Sox2, and nanog
are master regulators, silencing genes that are waiting to create the next generation of cells. When Oct4, Sox2, and nanog
are inactivated as the embryo begins to develop, these networks then come t...
Discarded placentas deliver researchers promising cells similar to embryonic stem cells
...term pregnancies, amniotic epithelial cells have many of the telltale surface markers that define embryonic stem cells, and also express the Oct-4 and nanog
genes that are known to be required for self-renewal and pluripotency ?the ability to develop into any type of cell.
Yet the authors are careful to...