Shionogi Announces Positive Top-Line Efficacy Results from Year-Long Studies of Velneperit, a Novel NPY Y5 Receptor Antagonist Being Investigated for the Treatment of Obesity
OSAKA, Japan and FLORHAM PARK, N.J., Feb. 17 /PRNewswire/ -- Shionogi & Co, Ltd. today announced that two distinct year-long studies of velneperit, a novel neuropeptide Y (NPY) Y5 receptor antagonist also known as S-2367, each met their primary endpoint of demonstrating a statistically signifi...
Scientists identify another piece of the weight-control puzzle
...ulation," explains Qingchun Tong, PhD, a postdoctoral fellow in the Lowell laboratory and the study's first author. "However, the deletion of AgRP and npy
[two neuropeptides released from the AgRP neurons] produces little metabolic effect."
An alternate theory proposed that release of the GABA neuro...
Your belly fat could be making you hungrier
...e food is because their brains produce the hormone npy
in excessive amounts. npy
is the most potent appetite stimulating hormone kn...io, has provided evidence that in obese rat models npy
is also produced locally by abdominal fat.
Brain DNA 'remodeled' in alcoholism
...ation of histones, and expression of the genes for npy
in the amygdala and the anxiety-like behaviors ass...ases the acetylation histones; increases levels of npy
-- and reduced anxiety in the animals.
Convers... activity and decrease in histones acetylation and npy
Importantly, blocking the observed incr...
Chemical Injections for Fat Removal
...vely to the mice they tested, researchers injected npy
into a specific area. The researchers found that both npy
and Y2R are activated during stress, leading to ap...e said, explaining, the novel finding here is that npy
works on fat tissue, not in the brain.
Scientists Discover Key to Manipulating Fat
...tissue: endothelial cells lining blood vessels and fat cells themselves. In order to add fat selectively to the mice they tested, researchers injected npy
into a specific area. They found that both players are activated during stress and lead to obesity and metabolic syndrome. Administration of Y2R block...
Blocking the Y2 Receptors can Prevent Obesity
... obesity, said Professor Herzog. We also know that npy
plays a major role in other chronic stress-induced...s not much we can do about the increased levels of npy
caused by stress, but we can do something about th...
Basically, when we have a stress reaction, npy
levels rise in our bodies, causing our heart rate ...
Molecular Basis of Obesity-Revealing the Unknown Facts
...s activity and less food seeking behaviour, which is based on locomotor activity."
Bsx brings about its effect by regulating the expression of npy
and AgRP, hormones of the hypothalamus that promote feeding. Without Bsx less hormones are made with the result that only rarely the mice go looking f...
$1.5 Million Grant to Yale for Narcolepsy-Neurotransmitter Study
However, on another target, npy
neurons, hypocretin directly excited the cells, by...e release of inhibitory neurotransmitters onto the npy
cells. In this case, the transmitters act synergistically to excite the npy
Under the NIH grant, van den Pol and c...
Anorexia - Overcoming Hunger Pangs Isn’t Just About Will Powe
...nown to be neuropeptide Y (NPY). The oversupply of npy
makes it hard for obese people to lose weight. In anorexia, there is a lack of npy
that disrupts the balance of the npy
system, making it easier to starve. It is unclear ...
Genetic variation may lead to early cardiovascular disease
...nd identified it as the neuropeptide Y (NPY) gene. npy
is one of the most plentiful and important protein..., found evidence for six related variations in the npy
gene that show evidence of transmission from gener...lial work showed a strong relationship between the npy
genetic variants associated with coronary disease....
An essential regulator of body weight revealed
...rtant to feeding; meanwhile, the importance of the npy
pathway diminished. To some extent, the field bega...n injected into the brains of rats. High levels of npy
in the brain of both hungry and obese mice provided further evidence that npy
was likely to stimulate feeding.
Ten years ago...
Bitter or sweet? The same taste bud can tell the difference
...bud cells. Though researchers have long known that npy
is active in the brain and gut, this is the first ...rain that something bitter is on the tongue, while npy
sends a message that something sweet is being eaten.
"We were surprised to see that npy
had the exact opposite action of CCK," he said. "B...