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NPY in Medical News

Shionogi Announces Positive Top-Line Efficacy Results from Year-Long Studies of Velneperit, a Novel NPY Y5 Receptor Antagonist Being Investigated for the Treatment of Obesity

OSAKA, Japan and FLORHAM PARK, N.J., Feb. 17 /PRNewswire/ -- Shionogi & Co, Ltd. today announced that two distinct year-long studies of velneperit, a novel neuropeptide Y (NPY) Y5 receptor antagonist also known as S-2367, each met their primary endpoint of demonstrating a statistically signifi...

Scientists identify another piece of the weight-control puzzle

...ulation," explains Qingchun Tong, PhD, a postdoctoral fellow in the Lowell laboratory and the study's first author. "However, the deletion of AgRP and npy [two neuropeptides released from the AgRP neurons] produces little metabolic effect." An alternate theory proposed that release of the GABA neuro...

Your belly fat could be making you hungrier

...e food is because their brains produce the hormone npy in excessive amounts. npy is the most potent appetite stimulating hormone kn...io, has provided evidence that in obese rat models npy is also produced locally by abdominal fat. A fa...

Brain DNA 'remodeled' in alcoholism

...ation of histones, and expression of the genes for npy in the amygdala and the anxiety-like behaviors ass...ases the acetylation histones; increases levels of npy -- and reduced anxiety in the animals. Convers... activity and decrease in histones acetylation and npy levels. Importantly, blocking the observed incr...

Chemical Injections for Fat Removal

...vely to the mice they tested, researchers injected npy into a specific area. The researchers found that both npy and Y2R are activated during stress, leading to ap...e said, explaining, the novel finding here is that npy works on fat tissue, not in the brain. Thi...

Scientists Discover Key to Manipulating Fat

...tissue: endothelial cells lining blood vessels and fat cells themselves. In order to add fat selectively to the mice they tested, researchers injected npy into a specific area. They found that both players are activated during stress and lead to obesity and metabolic syndrome. Administration of Y2R block...

Blocking the Y2 Receptors can Prevent Obesity

... obesity, said Professor Herzog. We also know that npy plays a major role in other chronic stress-induced...s not much we can do about the increased levels of npy caused by stress, but we can do something about th... Basically, when we have a stress reaction, npy levels rise in our bodies, causing our heart rate ...

Molecular Basis of Obesity-Revealing the Unknown Facts

...s activity and less food seeking behaviour, which is based on locomotor activity." Bsx brings about its effect by regulating the expression of npy and AgRP, hormones of the hypothalamus that promote feeding. Without Bsx less hormones are made with the result that only rarely the mice go looking f...

$1.5 Million Grant to Yale for Narcolepsy-Neurotransmitter Study

...gnitive arousal. However, on another target, npy neurons, hypocretin directly excited the cells, by...e release of inhibitory neurotransmitters onto the npy cells. In this case, the transmitters act synergistically to excite the npy cell. Under the NIH grant, van den Pol and c...

Anorexia - Overcoming Hunger Pangs Isn’t Just About Will Powe

...nown to be neuropeptide Y (NPY). The oversupply of npy makes it hard for obese people to lose weight. In anorexia, there is a lack of npy that disrupts the balance of the npy system, making it easier to starve. It is unclear ...
NPY in Medical Technology

Emisphere Technologies, Inc. Reports Clinical Data on Oral Delivery of GLP-1 and PYY

... food ingestion. Food intake is regulated by the hypothalamus, including the melanocortin and neuropeptide Y (NPY) systems in the arcuate nucleus. The npy Y2 receptor (Y2R), a putative inhibitory presynaptic receptor, is highly expressed on NPY neurons in the arcuate nucleus, which is accessible to perip...
NPY in Biological News

Genetic variation may lead to early cardiovascular disease

...nd identified it as the neuropeptide Y (NPY) gene. npy is one of the most plentiful and important protein..., found evidence for six related variations in the npy gene that show evidence of transmission from gener...lial work showed a strong relationship between the npy genetic variants associated with coronary disease....

An essential regulator of body weight revealed

...rtant to feeding; meanwhile, the importance of the npy pathway diminished. To some extent, the field bega...n injected into the brains of rats. High levels of npy in the brain of both hungry and obese mice provided further evidence that npy was likely to stimulate feeding. Ten years ago...

Bitter or sweet? The same taste bud can tell the difference

...bud cells. Though researchers have long known that npy is active in the brain and gut, this is the first ...rain that something bitter is on the tongue, while npy sends a message that something sweet is being eaten. "We were surprised to see that npy had the exact opposite action of CCK," he said. "B...
NPY in Biological Products

Rabbit Anti-NPY Y2 Receptor Polyclonal Antibody, Unconjugated from GeneTex

Description:... Rabbit polyclonal npy Y2 Receptor antiserum This npy Y2 antibody has been extensively characterized at the spinal level and is c...
Company:GeneTex
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