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NOTCH1 in Medical News

Mutations in NOTCH1 cause an early developmental defect in the aortic valve

Dr. Srivastava and his colleagues of UT Southwestern Medical Center of Dallas// discovered that the mutation in a gene NOTCH1 is responsible for aortic valve disease. Aortic valve disease is a common heart birth defect which causes adult heart disease. The study was done in five generations of ...

Tips from the American Journal of Pathology

... notch1 Contributes to Scar Tissue in the Lungs A gro...t the University of Michigan, Ann Arbor identified notch1 as a mediator of lung fibrosis. They present their...ed myofibroblast differentiation. They found that notch1 led to an increase of myofibroblasts in the lungs,...

JCI online early table of contents: Aug. 1, 2008

...m of leukemia known as T-ALL have mutations in the notch1 gene. These mutations lead to the generation of notch1 proteins that have increased activity, however, it...e now indicated that only uncommon T-ALLassociated notch1 mutations have the ability to induce cells to beco...

Importance of Gene in Eye Development

...e of the genes that SOX2 controls is Notch1, and loss of regulation of this gene is what is partially responsible for abnormal development of the eye. notch1 is expressed in several other stem cell/progenitor populations. Therefore, SOX2 may play an important role in maintaining these populations as well. I...
NOTCH1 in Biological News

Neural stem cell gene plays crucial role in eye development

...e of the genes that SOX2 controls is Notch1, and loss of regulation of this gene is what is partially responsible for abnormal development of the eye. notch1 is expressed in several other stem cell/progenitor populations. Therefore, SOX2 may play an important role in maintaining these populations as well. ...

Sleeping beauty plays a significant role in identifying cancer genes

...me of the same genes that are mutated in cancer in mice using Sleeping Beauty are also mutated in the same form of cancer in humans. An example is the notch1 gene, which was mutated in 50 percent of mice with T cell lymphoma induced by Sleeping Beauty. The same gene is mutated in about 50 percent of people ...
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